The cardiac safety research consortium ECG database

Journal of Electrocardiology

Volumn 45, Issue 6, 2012, Pages 690-692

  Kligfield, Paul ^a   Green, Cynthia L ^b  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Agorithm testing; CSRC; Database; Drug development; ECG; QT interval; Thorough QT study; TQT

Indexed keywords

MOXIFLOXACIN;

ARTICLE; CARDIAC SAFETY RESEARCH CONSORTIUM; CLINICAL RESEARCH; ELECTROCARDIOGRAM; GENOTYPE; HEART REPOLARIZATION; HOLTER MONITORING; HUMAN; LONG QT SYNDROME; PRIORITY JOURNAL; QRS COMPLEX; QT PROLONGATION; TELEMETRY;

ADULT; AGED; AGED, 80 AND OVER; DATABASE MANAGEMENT SYSTEMS; DATABASES, FACTUAL; ELECTROCARDIOGRAPHY; FEMALE; HEALTH RECORDS, PERSONAL; HUMANS; LONG QT SYNDROME; MALE; MIDDLE AGED; PATIENT SAFETY; PREVALENCE; UNITED STATES;

EID: 84867856806     PISSN: 00220736     EISSN: 15328430     Source Type: Journal    
DOI: 10.1016/j.jelectrocard.2012.07.012     Document Type: Article

References (7)

1. CSRC scientific rationale and mission statement http://www.cardiac- safety.org/about-us (accessed 6/18/12)
2. CSRC ECG warehouse database use statement of principles https://www.cardiac-safety.org/ecg-database/CSRCECGData082610Final.pdf/view (accessed 6/18/12)
3. http://www.fda.gov/ScienceResearch/SpecialTopics/CriticalPathInitiative/ default.htm (accessed 6/18/12)
4. Food and Drug Administration, HHS International Conference on Harmonisation; guidance on E14 clinical evaluation of QT/QTc interval prolongation and proarrhythmic potential for non-antiarrhythmic drugs; availability. Notice Fed Regist 70 2005 61134
5. R.R. Shah Drugs, QTc interval prolongation and final ICH E14 guideline: an important milestone with challenges ahead Drug Saf 28 2005 1009
6. P. Kligfield, C.L. Green, and J. Mortara The Cardiac Safety Research Consortium electrocardiogram warehouse: thorough QT database specifications and principles of use for algorithm development and testing Am Heart J 160 2010 1023
7. C.L. Green, P. Kligfield, and S. George Detection of QT prolongation using a novel electrocardiographic analysis algorithm applying intelligent automation: prospective blinded evaluation using the Cardiac Safety Research Consortium electrocardiographic database Am Heart J 163 2012 365