Cell-free repair of small cartilage defects in the Goettinger minipig: Which defect size is possible?

Knee Surgery, Sports Traumatology, Arthroscopy

Volumn 20, Issue 11, 2012, Pages 2307-2314

  Gavenis, K ^a   Schneider, U ^b   Maus, U ^a   Mumme, T ^a   Muller Rath, R ^a   Schmidt Rohlfing, Bernhard ^a   Andereya, S ^a  

^a UNIVERSITY HOSPITAL RWTH AACHEN   (Germany)

^b Arthro Nova Clinic   (Germany)

Author keywords

Cartilage tissue engineering; Cell free implant; Collagen type I gel; Goettinger minipig

Indexed keywords

COLLAGEN TYPE 1; COLLAGEN TYPE 2; TISSUE SCAFFOLD;

ANIMAL; ARTICLE; CARTILAGE; CELL MOTION; HINDLIMB; IMMUNOHISTOCHEMISTRY; INJURY; MALE; MATERIALS TESTING; METHODOLOGY; MINIPIG; ORTHOPEDIC SURGERY; SWINE; TISSUE REGENERATION;

ANIMALS; CARTILAGE; CELL MOVEMENT; COLLAGEN TYPE I; COLLAGEN TYPE II; GUIDED TISSUE REGENERATION; IMMUNOHISTOCHEMISTRY; MALE; MATERIALS TESTING; ORTHOPEDIC PROCEDURES; STIFLE; SWINE; SWINE, MINIATURE; TISSUE SCAFFOLDS;

EID: 84867845441     PISSN: 09422056     EISSN: 14337347     Source Type: Journal    
DOI: 10.1007/s00167-011-1847-8     Document Type: Article

References (32)

1. Cherubino P, Grassi FA, Bulgheroni P, Ronga M (2003) Autologous chondrocyte implantation using a bilayer collagen membrane: a preliminary report. J Orthop Surg (Hong Kong) 11(1): 10-15.
2. Cole BJ, Pascual-Garrido C, Grumet RC (2009) Surgical management of articular cartilage defects in the knee. J Bone Joint Surg [Am] 91: 1778-1790.
3. Erggelet C, Neumann K, Endres M, Haberstroh K, Sittinger M, Kaps C (2007) Regeneration of ovine articular cartilage defects by cell-free polymer-based implants. Biomaterials 28(36): 5570-5580.
4. Erggelet C, Endres M, Neumann K, Morawietz L, Ringe J, Haberstroh K, Sittinger M, Kaps C (2009) Formation of cartilage repair tissue in articular cartilage defects pretreated with microfracture and covered with cell-free polymer-based implants. J Orthop Res 27(10): 1353-1360.
5. Filardo G, Kon E, Di Martino A, Iacono F, Marcacci M (2011) Arthroscopic second-generation autologous chondrocyte implantation: a prospective 7-year follow-up study. Am J Sports Med 39(10): 2153-2160.
6. Fuss M, Ehlers EM, Russlies M, Rohwedel J, Behrens P (2000) Characteristics of human chondrocytes, osteoblasts and fibroblasts seeded onto a type I/III collagen sponge under different culture conditions. A light, scanning and transmission electron microscopy study. Ann Anat 182: 303.
7. Gavenis K, Schmidt-Rohlfing B, Andereya S, Mumme T, Schneider U, Mueller-Rath R (2010) A cell-free collagen type I device for the treatment of focal cartilage defects. Artif Organs 34(1): 79-83.
8. Gotterbarm T, Breusch SJ, Schneider U, Jung M (2008) The minipig model for experimental chondral and osteochondral defect repair in tissue engineering: retrospective analysis of 180 defects. Lab Anim 42: 71.
9. Guettler JH, Demetropoulos CK, Yang KH, Jurist KA (2004) Osteochondral defects in the human knee: influence of defect size on cartilage rim stress and load redistribution to surrounding cartilage. Am J Sports Med 32(6): 1451-1458.
10. Hurtig M, Chubinskaya S, Dickey J, Rueger D (2009) BMP-7 protects against progression of cartilage degeneration after impact injury. J Orthop Res 27(5): 602-611.
11. Iwasa J, Ochi M, Uchio Y, Katsube K, Adachi N, Kawasaki K (2003) Effects of cell density on proliferation and matrix synthesis of chondrocytes embedded in atelocollagen gel. Artif Organs 27: 249.
12. Jung M, Tuischer JS, Sergi C, Gotterbarm T, Pohl J, Richter W, Simank HG (2006) Local application of a collagen type I/hyaluronate matrix and growth and differentiation factor 5 influences the closure of osteochondral defects in a minipig model by enchondral ossification. Growth Factor 24(4): 225-232.
13. Jung M, Kaszap B, Redöhl A, Steck E, Breusch S, Richter W, Gotterbarm T (2009) Enhanced early tissue regeneration after matrix-assisted autologous mesenchymal stem cell transplantation in full thickness chondral defects in a minipig model. Cell Transplant 18(8): 923-932.
14. Lee KB, Hui JH, Song IC, Ardany L, Lee EH (2007) Injectable mesenchymal stem cell therapy for large cartilage defects-a porcine model. Stem Cells 25(11): 2964-2971.
15. Lind M, Larsen A (2008) Equal cartilage repair response between autologous chondrocytes in a collagen scaffold and minced cartilage under a collagen scaffold: an in vivo study in goats. Connect Tissue Res 49(6): 437-442.
16. Liu W, Liu F, Zhao W, Kim JM, Wang Z, Vrahas MS (2011) Osteochondral autograft transplantation for acute osteochondral fractures associated with an ankle fracture. Foot Ankle Int 32(4): 437-442.
17. Masuoka K, Asazuma T, Ishihara M, Sato M, Hattori H, Ishihara M, Yoshihara Y, Matsui T, Takase B, Kikuchi M, Nemoto K (2005) Tissue engineering of articular cartilage using an allograft of cultured chondrocytes in a membrane-sealed atelocollagen honeycomb-shaped scaffold (ACHMS scaffold). J Biomed Mater Res B Appl Biomater 75: 177.
18. Mithoefer K, McAdams T, Williams RJ et al (2009) Clinical efficacy of the microfracture technique for articular cartilage repair in the knee: an evidence-based systematic analysis. Am J Sports Med 37(10): 2053-2063.
19. Morales TI (2007) Chondrocyte moves: clever strategies? Osteoarthr Cartil 15(8): 861-871.
20. Muehleman C, Li J, Abe Y, Pfister B, Sah RL, Phipps R, Masuda K (2009) Effect of risedronate in a minipig cartilage defect model with allograft. J Orthop Res 27(3): 360-365.
21. Necas A, Plánka L, Srnec R, Crha M, Hlucilová J, Klíma J, Starý D, Kren L, Amler E, Vojtová L, Jancár J, Gál P (2010) Quality of newly formed cartilaginous tissue in defects of articular surface after transplantation of mesenchymal stem cells in a composite scaffold based on collagen I with chitosan micro- and nanofibres. Physiol Res 59(4): 605-614.
22. Niemeyer P, Pestka JM, Erggelet C, Steinwachs M, Salzmann GM, Südkamp NP (2011) Comparison of arthroscopic and open assessment of size and grade of cartilage defects of the knee. Arthroscopy 27(1): 46-51.
23. Ossendorf C, Steinwachs MR, Kreuz PC, Osterhoff G, Lahm A, Ducommun PP, Erggelet C (2011) Autologous chondrocyte implantation (ACI) for the treatment of large and complex cartilage lesions of the knee. Sports Med Arthrosc Rehabil Ther Technol 21: 3-11.
24. Peterbauer-Scherb A, van Griensven M, Meinl A, Gabriel C, Redl H, Wolbank S (2010) Isolation of pig bone marrow mesenchymal stem cells suitable for one-step procedures in chondrogenic regeneration. J Tissue Eng Regen Med 4(6): 485-490.
25. Petersen JP, Ueblacker P, Goepfert C, Adamietz P, Baumbach K, Stork A, Rueger JM, Poertner R, Amling M, Meenen NM (2008) Long term results after implantation of tissue engineered cartilage for the treatment of osteochondral lesions in a minipig model. J Mater Sci Mater Med 19(5): 2029-2038.
26. Rampichová M, Filová E, Varga F, Lytvynets A, Prosecká E, Koláčná L, Motlík J, Nečas A, Vajner L, Uhlík J, Amler E (2010) Fibrin/hyaluronic acid composite hydrogels as appropriate scaffolds for in vivo artificial cartilage implantation. ASAIO J 56(6): 563-568.
27. Schagemann JC, Erggelet C, Chung HW, Lahm A, Kurz H, Mrosek EH (2009) Cell-laden and cell-free biopolymer hydrogel for the treatment of osteochondral defects in a sheep model. Tissue Eng Part A 15(1): 75-82.
28. Schinhan M, Gruber M, Vavken P, Dorotka R, Samouh L, Chiari C, Gruebl-Barabas R, Nehrer S (2011) Critical-size defect induces unicompartmental osteoarthritis in a stable ovine knee. J Orthop Res 4. doi: 10. 1002/jor. 21521.
29. Schneider U, Schmidt-Rohlfing B, Gavenis K, Maus U, Mueller-Rath R, Andereya S (2011) A comparative study of 3 different cartilage repair techniques. Knee Surg Sports Traumatol Arthrosc 19(12): 2145-2152.
30. van Assche D, Staes F, van Caspel D, Vanlauwe J, Bellemans J, Saris DB, Luyten FP (2010) Autologous chondrocyte implantation versus microfracture for knee cartilage injury: a prospective randomized trial, with 2-year follow-up. Knee Surg Sports Traumatol Arthrosc 18(4): 486-495.
31. White LM, Sussman MS, Hurtig M, Probyn L, Tomlinson G, Kandel R (2006) Cartilage T2 assessment: differentiation of normal hyaline cartilage and reparative tissue after arthroscopic cartilage repair in equine subjects. Radiology 241(2): 407-414.
32. Zantop T, Petersen W (2009) Arthroscopic implantation of a matrix to cover large chondral defect during microfracture. Arthroscopy 25(11): 1354-1360.