Pulmonary tumor thrombotic microangiopathy diagnosed antemortem and treated with combination chemotherapy

Internal Medicine

Volumn 51, Issue 19, 2012, Pages 2767-2770

  Kayatani, Hiroe ^a   Matsuo, Kiyoshi ^a   Ueda, Yusuke ^a   Matsushita, Mizuho ^a   Fujiwara, Keiichi ^a   Yonei, Toshiro ^a   Yamadori, Ichiro ^a   Shigematsu, Hisayuki ^a   Andou, Akio ^a   Sato, Toshio ^a  

^a NATIONAL HOSPITAL ORGANIZATION OKAYAMA MEDICAL CENTER   (Japan)

Author keywords

Cancer of unknown primary; Combination chemotherapy; Pulmonary hyperten sion; Pulmonary tumor thrombotic microangiopathy

Indexed keywords

C REACTIVE PROTEIN; CA 19-9 ANTIGEN; CISPLATIN; CYTOKERATIN 20; CYTOKERATIN 7; CYTOKERATIN AE1; CYTOKERATIN AE3; D DIMER; FLUORODEOXYGLUCOSE F 18; GEMCITABINE; GIMERACIL PLUS OTERACIL POTASSIUM PLUS TEGAFUR;

ADULT; ARTICLE; BLOOD CLOTTING; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; COUGHING; DEATH; DISSEMINATED INTRAVASCULAR CLOTTING; ECHOCARDIOGRAPHY; ELECTROCARDIOGRAPHY; HUMAN; HUMAN TISSUE; HYPERPLASIA; IMMUNOHISTOCHEMISTRY; LUNG BIOPSY; LUNG TUMOR; MALE; MULTIPLE CYCLE TREATMENT; POSITRON EMISSION TOMOGRAPHY; PULMONARY HYPERTENSION; SIGNET RING CARCINOMA; THROMBOTIC THROMBOCYTOPENIC PURPURA; VIDEO ASSISTED THORACOSCOPIC SURGERY;

ADULT; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; BIOPSY; CARCINOMA, SIGNET RING CELL; CISPLATIN; DRUG COMBINATIONS; FATAL OUTCOME; HUMANS; HYPERTENSION, PULMONARY; LUNG NEOPLASMS; MALE; NEOPLASMS, UNKNOWN PRIMARY; OXONIC ACID; PULMONARY ARTERY; TEGAFUR; THORACIC SURGERY, VIDEO-ASSISTED; THROMBOTIC MICROANGIOPATHIES; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84867821575     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.51.7682     Document Type: Article

References (15)

1. von Herbay A, Illes A, Waldherr R, Otto HF. Pulmonary tumor thrombotic microangiopathy with pulmonary hypertension. Cancer 66: 587-592, 1990.
2. Miyano S, Izumi S, Takeda Y, et al. Pulmonary tumor thrombotic microangiopathy. J Clin Oncol 25: 597-599, 2007.
3. Chinen K, Fujino T, Horita A, Sakamoto A, Yasunori F. Pulmo-nary tumor thrombotic microangiopathy caused by an ovarian can-cer expressing tissue factor and vascular endothelial growth factor. Pathol Res Pract 205: 63-68, 2009.
4. Chinen K, Kazumoto T, Ohkura Y, Matsubara O, Tsuchiya E. Pul-monary tumor thrombotic microangiopathy caused by a gastric carcinoma expressing vascular endothelial growth factor and tissue factor. Pathol Int 55: 27-31, 2005.
5. Keenan NG, Nicholson AG, Oldershaw PJ. Fatal acute pulmonary hypertension caused by pulmonary tumor thrombotic microan-giopathy. Int J Cardiol 124: e11-e13, 2008.
6. Hibbert M, Braude S. Tumor microembolism presenting as "pri-mary pulmonary hypertension". Thorax 53: 1016-1017, 1997.
7. Kridel R, Myit S, Pache JC, Gaspoz JM. Pulmonary tumor embo-lism: a rare cause of acute right heart failure with elevated D-dimers. J Thorac Oncol 3: 1482-1483, 2008.
8. Malani AK, Gupta C, Kutty AV, Betlej T. Pulmonary microan-giopathy from metastatic gallbladder carcinoma: an unusual cause of severe pulmonary hypertension. Dig Dis Sci 52: 555-557, 2007.
9. Ueda A, Fuse N, Fujii S, et al. Pulmonary tumor thrombotic mi-croangiopathy associated with esophageal squamous cell carci-noma. Intern Med 50: 2807-2810, 2011.
10. Franquet T, Giménez A, Prats R, Rodríguez-Arias JM, Rodríguez C. Thrombotic Microangiopathy of pulmonary tumors: a vascular cause of tree-in-bud pattern on CT. AJR 179: 897-899, 2002.
11. Sakashita N, Yokose C, Fuji K, Matsumoto M, Ohnishi K, Takeya M. Pulmonary tumor thrombotic microangiopathy resulting from metastatic signet ring cell carcinoma of the stomach. Pathol Int 57: 383-387, 2007.
12. Hara A, Ichinoe M, Ogawa T, Shiraishi H, Okayasu I. A micro-scopic adenocarsinoma of the stomach with pulmonary tumor thrombotic microangiopathy in a 17-year-old male. Pathol Res Pract 201: 457-461, 2005.
13. Kanazawa H, Eguchi Y, Nomura N, Yoshikawa J. Analysis of vas-cular endpthelial growth factor levels in induced sputum samples from patients with cough variant asthma. Ann Allergy Asthma Im-munol 95: 266-271, 2005.
14. Chinen K, Kazumoto T, Ohkura Y, Matsubara O, Tsuchiya E. Pul-monary tumor thrombotic microangiopathy caused by a gastric carcinoma expressing vascular endothelial growth factor and tissue factor. Pathol Int 55: 27-31, 2005.
15. Chinen K, Fujino T, Horita A, Sakamoto A, Fujioka Y. Pulmonary tumor thrombotic microangiopathy caused by an ovarian cancer expressing tissue factor and vascular endothelial growth factor. Pa-thol Res Pract 205: 63-68, 2009.