Hemoglobin Rambam has a constant retention time on the Tosoh G8 and interferes with the measurement of HbA1c

Clinical Chemistry and Laboratory Medicine

Volumn 50, Issue 8, 2012, Pages 1477-1478

  Henig, Clara ^a   Froom, Paul ^a   Saffuri Elias, Enas ^a   Barak, Mira ^a  

^a CLALIT HEALTH SERVICES   (Israel)

Author keywords

G8; HbA1c; Hemoglobin Rambam; Hemoglobin variant

Indexed keywords

HEMOGLOBIN A; HEMOGLOBIN A1C; HEMOGLOBIN F; HEMOGLOBIN J; HEMOGLOBIN RAMBAM; HEMOGLOBIN VARIANT; UNCLASSIFIED DRUG;

ACCURACY; ARAB; BLOOD GLUCOSE MONITORING; BLOOD SAMPLING; DNA SEQUENCE; FAMILY; HEMOGLOBIN BLOOD LEVEL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; IMMUNOASSAY; LETTER; MEASUREMENT; PHYSICIAN; POINT MUTATION; PRIORITY JOURNAL;

BLOOD CHEMICAL ANALYSIS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; HEMOGLOBIN A, GLYCOSYLATED; HEMOGLOBINS, ABNORMAL; HUMANS;

EID: 84867804083     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/cclm-2011-0933     Document Type: Letter

References (4)

1. Chapell JP, Teixeira J, Maisin D, Assink H, Barla G, Stroombants AK, et al. Multicenter evaluation of the Tosoh hbA1c G8 analyzer. Clin Chem Lab Med 2010;48:365-71.
2. Bissé E, Zorn N, Eigel A, Lizama M, Huaman-Guillen P, Marz W, et al. Hemoglobin Rambam (β69[E13]Gly→Asp), a pitfall in the assessment of diabetic control: characterization by electrospray mass spectrometry and HPLC. Clin Chem 1998;44:2172-7.
3. Salomon H, Tatarsky I, Dance N, Huehns ER, Shooter EM. A new hemoglobin variant found in a beduin tribe: hemoglobin "Rambam". Isr J Med Sci 1965;1:836-40.
4. Uaprasert N, Rojnuckarin P, Settapiboon R, Amornsiriwat S, Sutcharitchan P. Clinical and hematological characteristics of uncommon beta-globin variants in Thailand. Int J Hematol 2009;89:568-71.