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Volumn 92, Issue 5, 2012, Pages 548-550

Models of excellence: Improving oncology drug development

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC AGENT; BEVACIZUMAB; CAPECITABINE; CARBOPLATIN; FLUOROURACIL; FOLINIC ACID; MOTESANIB; PACLITAXEL; PLACEBO;

EID: 84867768598     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2012.99     Document Type: Review
Times cited : (12)

References (10)
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    • Application of clinical trial simulation to compare proof-of-concept study designs for drugs with slow onset of effect; An example in Alzheimer's disease
    • Lockwood, P. et al. Application of clinical trial simulation to compare proof-of-concept study designs for drugs with slow onset of effect; an example in Alzheimer's disease. Pharm. Res. 23, 2050-2059 (2006).
    • (2006) Pharm. Res. , vol.23 , pp. 2050-2059
    • Lockwood, P.1
  • 3
    • 73949122617 scopus 로고    scopus 로고
    • The Rheumatoid Arthritis Drug Development Model: A case study in Bayesian clinical trial simulation
    • Nixon, R.M. et al. The Rheumatoid Arthritis Drug Development Model: a case study in Bayesian clinical trial simulation. Pharm. Stat. 8, 371-389 (2009).
    • (2009) Pharm. Stat. , vol.8 , pp. 371-389
    • Nixon, R.M.1
  • 4
    • 67651171223 scopus 로고    scopus 로고
    • Elucidation of relationship between tumor size and survival in non-small-cell lung cancer patients can aid early decision making in clinical drug development
    • Wang, Y. et al. Elucidation of relationship between tumor size and survival in non-small-cell lung cancer patients can aid early decision making in clinical drug development. Clin. Pharmacol. Ther. 86, 167-174 (2009).
    • (2009) Clin. Pharmacol. Ther. , vol.86 , pp. 167-174
    • Wang, Y.1
  • 5
    • 70249134646 scopus 로고    scopus 로고
    • Model-based prediction of phase III overall survival in colorectal cancer on the basis of phase II tumor dynamics
    • Claret, L. et al. Model-based prediction of phase III overall survival in colorectal cancer on the basis of phase II tumor dynamics. J. Clin. Oncol. 27, 4103-4108 (2009).
    • (2009) J. Clin. Oncol. , vol.27 , pp. 4103-4108
    • Claret, L.1
  • 6
    • 84867879434 scopus 로고    scopus 로고
    • Simulations using a drug-disease modeling framework and phase II data predict phase III survival outcome in first-line non-small-cell lung cancer
    • Claret, L. et al. Simulations using a drug-disease modeling framework and phase II data predict phase III survival outcome in first-line non-small-cell lung cancer. Clin. Pharmacol. Ther. 92, 631-634 (2012).
    • (2012) Clin. Pharmacol. Ther. , vol.92 , pp. 631-634
    • Claret, L.1
  • 8
    • 80054760826 scopus 로고    scopus 로고
    • An international, randomized, placebo-controlled, doubleblind phase III study (MONET1) of motesanib plus carboplatin/paclitaxel (C/P) in patients with advanced nonsquamous non-small cell lung cancer (NSCLC) [abstr.]
    • Scagliotti, G. et al. An international, randomized, placebo-controlled, doubleblind phase III study (MONET1) of motesanib plus carboplatin/paclitaxel (C/P) in patients with advanced nonsquamous non-small cell lung cancer (NSCLC) [abstr.]. J. Clin. Oncol. 29 (suppl.) LAB7512 (2011).
    • (2011) J. Clin. Oncol. , vol.29 , Issue.SUPPL.
    • Scagliotti, G.1
  • 10
    • 84859438491 scopus 로고    scopus 로고
    • Adaptive clinical trials in oncology
    • Berry, D.A. Adaptive clinical trials in oncology. Nat. Rev. Clin. Oncol. 9, 199-207 (2011).
    • (2011) Nat. Rev. Clin. Oncol. , vol.9 , pp. 199-207
    • Berry, D.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.