Synthesis and in vivo pharmacokinetic evaluation of degradable shell cross-linked polymer nanoparticles with poly(carboxybetaine) versus poly(ethylene glycol) surface-grafted coatings

ACS Nano

Volumn 6, Issue 10, 2012, Pages 8970-8982

  Li, Ang ^a   Luehmann, Hannah P ^b   Sun, Guorong ^a   Samarajeewa, Sandani ^a   Zou, Jiong ^a   Zhang, Shiyi ^a   Zhang, Fuwu ^a   Welch, Michael J ^b   Liu, Yongjian ^b   Wooley, Karen L ^a  

^a TEXAS A AND M UNIVERSITY   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

biodistribution; nanomedicine; pharmacokinetics; poly(carboxybetaine); poly(ethylene glycol); radiolabeling; shell cross linked knedel like nanoparticles

Indexed keywords

AMPHIPHILIC BLOCK COPOLYMERS; BIODISTRIBUTIONS; BIOMEDICAL APPLICATIONS; BLOOD CIRCULATION; CARBOXYBETAINE; CROSS-LINKED POLYMERS; IN-VIVO; MACROCYCLICS; NANOGRAMS; NONFOULING; POLY LACTIC ACID; POLY(ACRYLIC ACID ); POLYMER MATERIALS; RADIOLABELING; SHELL CROSS-LINKING; SPECIFIC ACTIVITY; SUPRAMOLECULAR ASSEMBLIES; TRANSLATIONAL RESEARCH;

BLOCK COPOLYMERS; CARDIOVASCULAR SYSTEM; COATINGS; GRAFTING (CHEMICAL); LACTIC ACID; MEDICAL APPLICATIONS; MEDICAL NANOTECHNOLOGY; NANOPARTICLES; ORGANIC ACIDS; ORGANIC POLLUTANTS; ORGANIC POLYMERS; PHARMACOKINETICS; POLYCHLORINATED BIPHENYLS; POLYETHYLENE OXIDES; SHELLS (STRUCTURES); SYNTHESIS (CHEMICAL);

POLYETHYLENE GLYCOLS;

BETAINE; BIOMATERIAL; MACROGOL DERIVATIVE; NANOPARTICLE; POLYCARBOXYBETAINE METHACRYLATE; POLYMETHACRYLIC ACID DERIVATIVE;

ANIMAL; ANTIBODY SPECIFICITY; ARTICLE; BIODEGRADABLE IMPLANT; C57BL MOUSE; CHEMISTRY; METABOLIC CLEARANCE RATE; MOUSE; SYNTHESIS; TISSUE DISTRIBUTION;

ABSORBABLE IMPLANTS; ANIMALS; BETAINE; COATED MATERIALS, BIOCOMPATIBLE; METABOLIC CLEARANCE RATE; MICE; MICE, INBRED C57BL; NANOPARTICLES; ORGAN SPECIFICITY; POLYETHYLENE GLYCOLS; POLYMETHACRYLIC ACIDS; TISSUE DISTRIBUTION;

EID: 84867760514     PISSN: 19360851     EISSN: 1936086X     Source Type: Journal    
DOI: 10.1021/nn303030t     Document Type: Article

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