Intrathecal application of autologous bone marrow cell preparations in Parkinsonian syndromes

Movement Disorders

Volumn 27, Issue 12, 2012, Pages 1552-1555

  Storch, Alexander ^a,b,c   Csoti, Ilona ^d   Eggert, Karla ^e   Henriksen, Tove ^f   Plate, Annika ^g   Lorrain, Michael ^h   Oertel, Wolfgang H ^e   Antonini, Angelo ⁱ  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b GERMAN CENTER FOR NEURODEGENERATIVE DISEASES DZNE   (Germany)

^c CENTER FOR REGENERATIVE THERAPIES DRESDEN   (Germany)

^d Parkinson Center Leun Biskirchen   (Germany)

^e PHILIPPS UNIVERSITY MARBURG   (Germany)

^f BISPEBJERG HOSPITAL   (Denmark)

^g UNIVERSITY OF MUNICH   (Germany)

^h Neurological Practice Düsseldorf   (Germany)

ⁱ IRCCS SAN CAMILLO HOSPITAL   (Italy)

Author keywords

Autologous transplantation; Bone marrow; CD34+ cells; Intrathecal application; Mesenchymal stem cells; Mesodermal stromal cells; Multiple system atrophy; Parkinson's disease

Indexed keywords

ANTIPARKINSON AGENT;

ADULT; AGED; ARTICLE; AUTOLOGOUS BONE MARROW TRANSPLANTATION; CLINICAL ARTICLE; CLINICAL FEATURE; DAILY LIFE ACTIVITY; DISEASE EXACERBATION; FEMALE; HUMAN; INTRATHECAL DRUG ADMINISTRATION; MALE; MOTOR PERFORMANCE; OUTCOME ASSESSMENT; PARKINSON DISEASE; PATIENT SAFETY; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SHY DRAGER SYNDROME;

ADULT; AGED; BONE MARROW CELLS; BONE MARROW TRANSPLANTATION; FEMALE; HUMANS; INJECTIONS, SPINAL; MALE; MIDDLE AGED; PARKINSONIAN DISORDERS; RETROSPECTIVE STUDIES; TREATMENT OUTCOME;

EID: 84867744061     PISSN: 08853185     EISSN: 15318257     Source Type: Journal    
DOI: 10.1002/mds.24920     Document Type: Article

References (26)

1. Lindvall O, Sawle G, Widner H, et al. Evidence for long-term survival and function of dopaminergic grafts in progressive Parkinson's disease. Ann Neurol 1994; 35: 172-180.
2. Piccini P, Brooks DJ, Bjorklund A, et al. Dopamine release from nigral transplants visualized in vivo in a Parkinson's patient. Nat Neurosci 1999; 2: 1137-1140.
3. Freed CR, Greene PE, Breeze RE, et al. Transplantation of embryonic dopamine neurons for severe Parkinson's disease. N Engl J Med 2001; 344: 710-719.
4. Olanow CW, Goetz CG, Kordower JH, et al. A double-blind controlled trial of bilateral fetal nigral transplantation in Parkinson's disease. Ann Neurol 2003; 54: 403-414.
5. Meyer AK, Maisel M, Hermann A, Stirl K, Storch A. Restorative approaches in Parkinson's disease: which cell type wins the race? J Neurol Sci 2010; 289: 93-103.
6. Lindvall O, Kokaia Z. Prospects of stem cell therapy for replacing dopamine neurons in Parkinson's disease. Trends Pharmacol Sci 2009; 30: 260-267.
7. Kim YJ, Park HJ, Lee G, et al. Neuroprotective effects of human mesenchymal stem cells on dopaminergic neurons through anti-inflammatory action. Glia 2009; 57: 13-23.
8. Habisch HJ, Janowski M, Binder D, et al. Intrathecal application of neuroectodermally converted stem cells into a mouse model of ALS: limited intraparenchymal migration and survival narrows therapeutic effects. J Neural Transm 2007; 114: 1395-1406.
9. Hoehn MM, Yahr MD. Parkinsonism: onset, progression and mortality. Neurology 1967; 17: 427-442.
10. Fahn S, Elton RL, Committee UD. The Unified Parkinson's Disease Rating Scale. In: Fahn S, Marsden CD, Calne DB, eds. Recent developments in Parkinson's disease. Florham Park, NJ: Macmillan Healthcare Information; 1987: 153-163, 293-304.
11. Guy W. ECDEU assessment manual for psychopharmacology. Rockville, MD: Department of Health, Education and Welfare; 1976.
12. Tomlinson CL, Stowe R, Patel S, Rick C, Gray R, Clarke CE. Systematic review of levodopa dose equivalency reporting in Parkinson's disease. Mov Disord 2010; 25: 2649-2653.
13. Venkataramana NK, Kumar SK, Balaraju S, et al. Open-labeled study of unilateral autologous bone-marrow-derived mesenchymal stem cell transplantation in Parkinson's disease. Transl Res 2010; 155: 62-70.
14. Friedenstein AJ, Gorskaja JF, Kulagina NN. Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp Hematol 1976; 4: 267-274.
15. Mezey E, Chandross KJ, Harta G, Maki RA, McKercher SR. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 2000; 290: 1779-1782.
16. Hermann A, Maisel M, Storch A. Epigenetic conversion of human adult bone mesodermal stromal cells into neuroectodermal cell types for replacement therapy of neurodegenerative disorders. Expert Opin Biol Ther 2006; 6: 653-670.
17. Cogle CR, Yachnis AT, Laywell ED, et al. Bone marrow transdifferentiation in brain after transplantation: a retrospective study. Lancet 2004; 363: 1432-1437.
18. Danielyan L, Schafer R, von Ameln-Mayerhofer A, et al. Therapeutic efficacy of intranasally delivered mesenchymal stem cells in a rat model of Parkinson disease. Rejuvenation Res 2011; 14: 3-16.
19. Kishk NA, Gabr H, Hamdy S, et al. Case control series of intrathecal autologous bone marrow mesenchymal stem cell therapy for chronic spinal cord injury. Neurorehabil Neural Repair 2010; 24: 702-708.
20. Saito F, Nakatani T, Iwase M, et al. Spinal cord injury treatment with intrathecal autologous bone marrow stromal cell transplantation: the first clinical trial case report. J Trauma 2008; 64: 53-59.
21. Yamout B, Hourani R, Salti H, et al. Bone marrow mesenchymal stem cell transplantation in patients with multiple sclerosis: a pilot study. J Neuroimmunol 2010; 227: 185-189.
22. Siddiq S, Pamphilon D, Brunskill S, Doree C, Hyde C, Stanworth S. Bone marrow harvest versus peripheral stem cell collection for haemopoietic stem cell donation in healthy donors. Cochrane Database Syst Rev 2009( 1): CD006406.
23. Braun LA, Cohen M. Use of complementary medicines by cardiac surgery patients; undisclosed and undetected. Heart Lung Circ 2011; 20: 305-311.
24. Armstrong T, Cohen MZ, Hess KR, et al. Complementary and alternative medicine use and quality of life in patients with primary brain tumors. J Pain Symptom Manage 2006; 32: 148-154.
25. Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992; 55: 181-184.
26. Gilman S, Wenning GK, Low PA, et al. Second consensus statement on the diagnosis of multiple system atrophy. Neurology 2008; 71: 670-676.