Identification of the critical amino acid residues of immunoglobulin E and immunoglobulin G epitopes in β-lactoglobulin by alanine scanning analysis

Journal of Dairy Science

Volumn 95, Issue 11, 2012, Pages 6307-6312

  Cong, Y J ^a   Li, L F ^b  

^a BEIJING TECHNOLOGY AND BUSINESS UNIVERSITY   (China)

^b PEKING UNIVERSITY THIRD HOSPITAL   (China)

Author keywords

lactoglobulin; Cow milk allergy; Critical amino acid; Epitope

Indexed keywords

ALANINE; ALLERGEN; EPITOPE; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; LACTOGLOBULIN;

ANTIBODY COMBINING SITE; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; IMMUNOLOGY; INFANT; MILK ALLERGY; PRESCHOOL CHILD;

ALANINE; ALLERGENS; BINDING SITES, ANTIBODY; CHILD, PRESCHOOL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; HUMANS; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; INFANT; LACTOGLOBULINS; MILK HYPERSENSITIVITY;

EID: 84867743653     PISSN: 00220302     EISSN: 15253198     Source Type: Journal    
DOI: 10.3168/jds.2012-5543     Document Type: Article

References (15)

1. Adams S.L., Barnett D., Walsh B.J., Pearce R.J., Hill D.J., Howden M.E.H. Human IgE-binding synthetic peptides of bovine β-lactoglobulin and a-lactalbumin. In vitro cross-reactivity of the allergens. Immunol. Cell Biol. 1991, 69:191-197.
2. Ball G., Shelton M.J., Walsh B.J., Hill D.J., Hosking C.S., Howden M.E.H. A major continuous allergenic epitope of bovine beta-lactoglobulin recognized by human IgE binding. Clin. Exp. Allergy 1994, 24:758-764.
3. Bock S.A. Prospective appraisal of complaints of adverse reactions to foods in children during the first 3 years of life. Pediatrics 1987, 79:683-688.
4. Cerecedo I., Zamora J., Shreffler W.G., Lin J., Bardina L., Dieguez M.C., Wang J., Muriel A., de la Hoz B., Sampson H.A. Mapping of the IgE and IgG4 sequential epitopes of milk allergens with a peptide microarray based immunoassay. J. Allergy Clin. Immunol. 2008, 122:589-594.
5. Heinzmann A., Blattmann S., Spuergin P., Forster J., Deichmann K.A. The recognition pattern of sequential B cell epitopes of beta-lactoglobulin does not vary with the clinical manifestations of cow's milk allergy. Int. Arch. Allergy Immunol. 1999, 120:280-286.
6. Hill D.J., Hosking C.S. The cow milk allergy complex: Overlapping disease profiles in infancy. Eur. J. Clin. Nutr. 1995, 49(Suppl. 1):1-12.
7. Järvinen K.-M., Chatchatee P., Bardina L., Beyer K., Sampson H.A. IgE and IgG binding epitopes on α-lactalbumin and β-lactoglobulin in cow's milk allergy. Int. Arch. Allergy Immunol. 2001, 126:111-118.
8. Kokkonen J., Karttunen T.J., Niinimäki A. Lymphonodular hyperplasia as a sign of food allergy in children. J. Pediatr. Gastroenterol. Nutr. 1999, 29:57-62.
9. Saalman R., Dahlgren U.I., Fällström S.P., Hanson L.A., Wold A.E., Ahlstedt S. ADCC-mediating capacity in children with cow's milk protein intolerance in relation to IgG subclass profile of serum antibodies to β-lactoglobulin. Scand. J. Immunol. 1995, 42:140-146.
10. Saarinen K.M., Juntunen-Backman K., Järvenpää A.-L., Kuitunen P., Lope L., Renlund M., Siivola M., Savilahti E. Supplementary feeding in maternity hospitals and the risk of cow's milk allergy: A prospective study of 6209 infants. J. Allergy Clin. Immunol. 1999, 104:457-461.
11. Sélo I., Clément G., Bernard H., Chatel J.M., Créminon C., Peltre G., Wal J.M. Allergy to bovine β-lactoglobulin: Specificity of human IgE to tryptic peptides. Clin. Exp. Allergy 1999, 29:1055-1063.
12. Sélo I., Négroni L., Créminon C., Yvon M., Peltre G., Wal J.M. Allergy to bovine β-lactoglobulin: Specificity of human IgE using cyanogen bromide-derived peptides. Int. Arch. Allergy Immunol. 1998, 117:20-28.
13. Tokita F. Some readings on antigenic determinants of bovine milk protein. Jpn. J. Dairy Sci. 1985, 34:229-235.
14. Wal J.M. Cow's milk allergens. Allergy 1998, 53:1013-1022.
15. Williams S.C., Badley R.A., Davis P.J., Puijk W.C., Meloen R.H. Identification of epitopes within beta lactoglobulin recognized by polyclonal antibodies using phage display and PEPSCAN. J. Immunol. Methods 1998, 213:1-17.