Opinion of the Scientific Panel on Plant protection products and their Residues on acute dietary intake assessment of pesticide residues in fruit and vegetables

EFSA Journal

Volumn 5, Issue 8, 2007, Pages

[No Author Info available]

Author keywords

acute dietary intake; Acute Reference Dose; IESTI equations; level of protection; MRL; Pesticide; probabilistic modelling; variability factors

Indexed keywords

EID: 84867686626     PISSN: None     EISSN: 18314732     Source Type: Journal    
DOI: 10.2903/j.efsa.2007.538     Document Type: Article

References (95)

1. Ambrus A. (2006). Variability of pesticide residues in crop units. Pest Management Science 62: 693–714.
2. Anon. (1998). Report of the Joint FAO/WHO Consultation on Food Consumption and Intake Assessment of Chemicals. 10-14 February 1997. WHO Headquarters, Geneva. Final Draft, 20/2/98.
3. Boon PE, van der Voet H, van Klaveren JD (2003). Validation of a probabilistic model of dietary exposure to selected pesticides in Dutch infants. Food Additives and Contaminants 20 Suppl 1: 36–49.
4. CCPR (Codex Committee on Pesticide Residues) 2005. Report Of The Thirty-Seventh Session Of The Codex Committee On Pesticide Residues, The Hague, The Netherlands, 18-23 April 2005, ALINORM 05/28/24. Agenda Item 6: Discussion Paper On Probabilistic Modelling: MRLs Health Or Trade Limits.
5. Codex (Codex Alimentarius Commission) 2006. Codex Alimentarius Commission Procedural Manual, 16th Edition. www.codexalimentarius.net/procedural_manual.stm.
6. De Boer WJ and van der Voet H (2006). MCRA, Release 5, a web-based program for Monte Carlo Risk Assessment. On-line manual 2006-11-01, documenting MCRA Release 5.1. Biometris, RIKILT and RIVM, mcra.rikilt.wur.nl.
7. Díez C, Traag WA, Zommer P, Marinero P, Atienza J. (2006). Comparison of an acetonitrile extraction/partitioning and “dispersive solid-phase extraction” method with classical multi-residue methods for the extraction of herbicide residues in barley samples. Journal of Chromatography 1131: 11–23.
8. van Dooren MMH, Boeijen I, van Klaveren JD, van Donkersgoed G (1995). Conversie van consumeerbare voedingsmiddelen naar primaire agrarische produkten [Conversion of consumed foods into raw agricultural commodities]. Rep. 95.17, RIKILT-DLO, Wageningen, The Netherlands.
9. EFSA (European Food Safety Authority) 2005. Opinion of the Scientific Panel on plant health, Plant protection products and their Residues on a request from Commission related to the appropriate variability factor(s) to be used for acute dietary intake assessment of pesticide residues in fruit and vegetables. The EFSA Journal 177: 1–61. www.efsa.europa.eu/en/science/ppr/ppr_opinions/823.html
10. EFSA (European Food Safety Authority) 2006. Guidance of the Scientific Committee on a request from EFSA related to Uncertainties in Dietary Exposure Assessment. The EFSA Journal (2006) 438, 1–54. www.efsa.europa.eu/en/science/sc_commitee/sc_opinions/uncertainty_exp.html
11. Gibney MJ, and van der Voet H (2003). Introduction to the Monte Carlo project and the approach to the validation of probabilistic models of dietary exposure to selected food chemicals. Food Additives and Contaminants 20 (Suppl. 1): S1–S7.
12. Hamilton D, Ambrus Á, Dieterle R, Felsot A, Harris C, Petersen B, Racke K, Wong S-S, Gonzalez R, Tanaka K, Earl M, Roberts G, Bhula R (2004). Pesticide residues in food – acute dietary exposure. Pest Management Science 60: 311–339.
13. Harris CA, Mascall JR, Warren SFP, Crossley S J (1998). Summary report of the International Conference on pesticide residues variability and acute dietary risk assessment. Food Additives and Contaminants: 17, 481–485.
14. Hill ARC and Reynolds SL (2002). Unit-to-unit variability of pesticides residues in fruit and vegetables. Food Additives and Contaminants 19: 733–747.
15. JMPR (Joint FAO/WHO Meeting on Pesticide residues) 2002. Report of the Joint FAO/WHO Meeting on Pesticide residues (JMPR) 2002. WHO, Geneva. www.fao.org/ag/AGP/AGPP/Pesticid/a.htm.
16. JMPR (Joint FAO/WHO Meeting on Pesticide residues) 2006. Report of the Joint FAO/WHO Meeting on Pesticide residues (JMPR) 2006. WHO, Geneva. www.fao.org/ag/AGP/AGPP/Pesticid/a.htm.
17. van Klaveren JD, van Dooren MMH, Kloet D, Kuiper HA (2000). The process of intake assessment. In: Risk assessment in the food chain of children, ed. PJ Aggett, HA Kuiper, Vevey: Nestle Nutrition Services, pp. 145–61.
18. López A, Rueda C, Armentia A, Rodriguez M, Cuervo, Ociuo, LA (2003). Validation and sensitivity analysis of a probabilistic model for dietary intake assessment to pesticide residues with a Basque Country duplicate diet study. Food Additives and Contaminants 20 Suppl 1: 87–101.
19. McNamara C, Naddy B, Rohan D, Sexton J (2003). Design, development and validation of software for modelling dietary intake to food chemicals and nutrients. Food Additives and Contaminants: 20 Supplement 146.
20. NRC (National Research Council) 1993. National Research Council (National Academy of Sciences, USA. Pesticides in the diets of infants and children. National Academies Press, Washington, 1993, 386 p.
21. Rawn, D.F.K. Quade, S.C., Shields, J.B., Conca, G., Sun, W-F., Lacroix, G.M.A., Smith, M., Fouquet, A., Belanger, A. 2006. Organophosphate levels in apple composites and individual apples from a treated Canadian orchard. J. Agric. Food Chem. 54: 1943–1948.
22. SCF (Scientific Committee for Food) 1997. Opinion of the Scientific Committee for Food on: A maximum residue limit (MRL) of 0.01 kg/kg for pesticides in foods intended for infants and young children (expressed on the 19th September 1997), European Commission, Brussels. ec.europa.eu/food/fs/sc/scf/reports/scf_reports_44.pdf
23. Slob W (2006). Probabilistic dietary exposure assessment taking into account variability in both amount and frequency of consumption. Food and Chemical Toxicology 44: 933–951.
24. van der Voet H, de Boer WJ, Keizer LCP (1999). Statistical instruments for dietary risk assessment concerning acute exposure to residues and contaminants. Report August 1999, Centre for Biometry Wageningen, P.O. Box 100, NL-6700 AC Wageningen.
25. WHO, 2005. Global Environment Monitoring System - Food Contamination Monitoring and Assessment Programme (GEMS/Food): GEMS/Food Consumption Cluster Diets. www.who.int/foodsafety/chem/gems/en/index1.html
26. Anonymous (1998). Zo eet Nederland: resultaten van de Voedselconsumptiepeiling 1997-1998. Den Haag: Voedingscentrum.
27. Banasiak U, Heseker H, Sieke C, Sommerfeld C, Vohmann C (2005). Abschätzung der Aufnahme von Pflanzenschutzmittel-Rückständen in der Nahrung mit neuen Verzehrsmengen für Kinder. Bundesgesundheitsblatt 48: 84–98.
28. Becker W and Pearson M (2002). Metod och resultatanalys. Livsmedelsverket, Uppsala, Sverige, Riksmaten 1997-1998.
29. Boon PE, Tjoe Nij EIM, Koopman N, van Klaveren JD (2004). Dietary habits and exposure to pesticides in Dutch infants, Rikilt report nr 2004.017, Wageningen.
30. BVL (Bundesamt für Verbraucherschutz und Lebensmittelsicherheit) 2004. Lebensmittel-Monitoring 1995-2002. Berlin.
31. De Boer WJ and van der Voet H (2006). MCRA release 5, a web-based program for Monte Carlo Risk Assessment. Report January 2006. Biometris and RIKILT, Wageningen University and Research Centre, Wageningen. Manual available at mcra.rikilt.wur.nl.
32. EC (Commission of the European Commmunities) 1997a. Appendix A. Metabolism and distribution in plants, Doc. 7028/VI/95 rev.3 (22/7/1997), ec.europa.eu/food/plant/protection/resources/app-a.pdf
33. EC (Commission of the European Commmunities) 1997b. Appendix F: Metabolism and distribution in domestic animals. Doc. 7030/VI/95 - Rev.3 (22/7/1997). ec.europa.eu/food/plant/protection/resources/app-f.pdf
34. EFSA (European Food Safety Authority) 2005a. EPCO MANUAL Part E EPCO Working Documents - Technical Advice No E4, revision 4. Working Document for preparation of the “List of End points” for chemical active substances Developed within the framework of the European Food Safety Authority's Peer Review as being part of the European Commission's Programme on possible inclusion of active substances of plant protection products in Annex I of Council Directive 91/414/EEC. www.efsa.europa.eu/en/science/praper/praper_guidance.html.
35. EFSA (European Food Safety Authority) 2005b. Opinion of the Scientific Panel on plant health, Plant protection products and their Residues on a request from Commission related to the appropriate variability factor(s) to be used for acute dietary intake assessment of pesticide residues in fruit and vegetables. The EFSA Journal 177: 1–61. www.efsa.europa.eu/en/science/ppr/ppr_opinions/823.html
36. EFSA (European Food Safety Authority) 2006. Guidance of the Scientific Committee on a request from EFSA related to Uncertainties in Dietary Exposure Assessment. The EFSA Journal (2006) 438, 1–54. www.efsa.europa.eu/en/science/sc_commitee/sc_opinions/uncertainty_exp.html
37. Enghardt Barbieri H, Pearson M and Becker W (2006). Riksmaten - barn 2003, Livsmedels- och näringsintag bland barn i Sverige. Livsmedelsverket, Uppsala, Sverige.
38. EFSA (European Food Safety Authority) 2007. Reasoned opinion on the potential chronic and acute risk to consumers' health arising from proposed temporary EU MRLs, EFSA_acutechronic_model.xls, http://www.efsa.europa.eu/en/science/praper/maximumresiduelevels/mrlopinion.html
39. FAO, 2002. Submission and evaluation of pesticide residues data for the estimation of maximum residue levels in food and feed. FAO Plant Production and Protection Paper 170. Rome.
40. FAO/WHO (2002). Pesticide residues in food - 2002, Report of the Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group on Pesticide Residues Rome, Italy, 16-25 September 2002, www.fao.org/ag/agp/agpp/pesticid/jmpr/Download/2002rep/2002JMPRReport2.pdf
41. GenStat (2005). GenStat for Windows. Release 8.1, eight edition, VSN International Ltd., Oxford.
42. Gregory JR, Collins DL, Davies PSW, Hughes JM, Clarke PC (1995). National Diet and Nutrition Survey: children aged 1½ to 4½ years. Volume 1: Report of the diet and nutrition survey. London, England: Her Majesty's Stationary Office.
43. Harris CA, Mascall JR, Warren SFP, Crossley S J (1998). Summary report of the International Conference on pesticide residues variability and acute dietary risk assessment. Food Additives and Contaminants: 17, 481–485.
44. Heseker H, Oepping A, Vohmann C, (2003). Verzehrstudie zur Ermittlung der Lebensmittelaufnahme von Säuglingen und Kleinkindern für die Abschätzung eines akuten Toxizitätsrisikos durch Rückstände von Pflanzenschutzmitteln (VELS), Forschungsbericht. Universität Paderborn.
45. Lyhne (2005). Danskernes kostvaner 2000-2003, hovedresultater, Publikation nr. 11. Danmarks Fødevareforskning, Afdeling for Ernæring, Søborg, Danmark, ISBN 87-988795-5-3.
46. McNamara C, Naddy B, Rohan D, Sexton J (2003). Design, development and validation of software for modelling dietary intake to food chemicals and nutrients. Food Additives and Contaminants: 20 Supplement 116.
47. Nusser SM, Carriquiry AL, Dodd KW, Fuller WA (1996). A semi-parametric transformation approach to estimating usual daily intake distributions. Journal of the American Statistical Association 91: 1440–1449.
48. Nusser SM, Fuller WA, Guenther PM (1997). Estimating usual dietary intake distributions: adjusting for measurement error and nonnormality in 24-hour food intake data. In: Lyberg L, Biemer P, Collins M, DeLeeuw E, Dippo C, Schwartz N, and Trewin D (editors), Survey Measurement and Process Quality, Wiley, New York. p. 689–709.
49. OECD (2006). Environment, Health and Safety Publications, Series on Testing and Assessment No. 63 and Series on Pesticides No. 31, GUIDANCE DOCUMENT ON THE DEFINITION OF RESIDUE, ENV/JM/MONO(2006)31. appli1.oecd.org/olis/2006doc.nsf/linkto/env-jm-mono(2006)31.
50. Prüße U, Hüther L, Hohgardt K (2002). Mittlere Gewichte einzelner Obst- und Gemüseerzeugnisse. Bonn: BVL.
51. PSD (Pesticides Safety Directorate) 2000. Pesticides Residue Committee Monitoring Reports, www.pesticides.gov.uk/prc.asp?id=738
52. PSD (Pesticides Safety Directorate) 2006. The National Estimate of Short Term Intake (NESTI) model for short term consumer intake calculations. www.pesticides.gov.uk/approvals.asp?id=1687.
53. Rückstands-Höchstmengenverordnung (RHmV) 1999. Anlage 4, Liste B Lebensmittel pflanzlicher Herkunft. BGBl. I 1999 p. 2082.
54. Ruprich J (2005). The Czech national database of food consumption for individuals – SISP04. National Institute of Public Health in Prague, database of CHPR.
55. Slob W (2006). Probabilistic dietary exposure assessment taking into account variability in both amount and frequency of consumption. Food and Chemical Toxicology 44: 933–951.
56. Solecki R, Davies L, Dellarco V, Dewhurst I, van Raaij M, Tritscher A (2005). Guidance on setting of acute reference dose (ARfD) for pesticides. Food and Chemical Toxicology: 43, 1569–159.
57. Spiegelhalter D, Thomas A, Best N, Lunn D. (2004). WinBUGS user manual, version 1.4.1 www.mrc-bsu.cam.ac.uk/bugs.
58. Turrini A, Saba A, Perrone D, Cialfa E, D'Amicis A. (2001). Food consumption patterns in Italy: the INN-CA Study 1994-1996, Eur J Clin Nutr: Jul, 55(7), 571–88.
59. Volatier J-L (2000). Enquête INCA individuelle et nationale sur les consommations alimentaires. Agence Française de Sécurité Sanitaire des Aliments (AFSSA). Tech & Doc, Paris.
60. WHO, 1998. Report of the Joint FAO/WHO Consultation on Food Consumption and Intake Assessment of Chemicals. 10-14 February 1997. WHO Headquarters, Geneva. Final Draft, 20/2/98.
61. Anonymous (1998). Zo eet Nederland: resultaten van de Voedselconsumptiepeiling 1997-1998. Den Haag: Voedingscentrum.
62. Banasiak U, Heseker H, Sieke C, Sommerfeld C, Vohmann C (2005). Abschätzung der Aufnahme von Pflanzenschutzmittel-Rückständen in der Nahrung mit neuen Verzehrsmengen für Kinder. Bundesgesundheitsblatt 48: 84–98.
63. Becker W and Pearson M (2002). Metod och resultatanalys. Livsmedelsverket, Uppsala, Sverige, Riksmaten 1997-1998.
64. Boon PE, Tjoe Nij EIM, Koopman N, van Klaveren JD (2004). Dietary habits and exposure to pesticides in Dutch infants, Rikilt report nr 2004.017, Wageningen.
65. BVL (Bundesamt für Verbraucherschutz und Lebensmittelsicherheit) 2004. Lebensmittel-Monitoring 1995-2002. Berlin.
66. De Boer WJ and van der Voet H (2006). MCRA release 5, a web-based program for Monte Carlo Risk Assessment. Report January 2006. Biometris and RIKILT, Wageningen University and Research Centre, Wageningen. Manual available at mcra.rikilt.wur.nl.
67. EC (Commission of the European Commmunities) 1997a. Appendix A. Metabolism and distribution in plants, Doc. 7028/VI/95 rev.3 (22/7/1997), ec.europa.eu/food/plant/protection/resources/app-a.pdf
68. EC (Commission of the European Commmunities) 1997b. Appendix F: Metabolism and distribution in domestic animals. Doc. 7030/VI/95 - Rev.3 (22/7/1997). ec.europa.eu/food/plant/protection/resources/app-f.pdf
69. EFSA (European Food Safety Authority) 2005a. EPCO MANUAL Part E EPCO Working Documents - Technical Advice No E4, revision 4. Working Document for preparation of the “List of End points” for chemical active substances Developed within the framework of the European Food Safety Authority's Peer Review as being part of the European Commission's Programme on possible inclusion of active substances of plant protection products in Annex I of Council Directive 91/414/EEC. www.efsa.europa.eu/en/science/praper/praper_guidance.html.
70. EFSA (European Food Safety Authority) 2005b. Opinion of the Scientific Panel on plant health, Plant protection products and their Residues on a request from Commission related to the appropriate variability factor(s) to be used for acute dietary intake assessment of pesticide residues in fruit and vegetables. The EFSA Journal 177: 1–61. www.efsa.europa.eu/en/science/ppr/ppr_opinions/823.html
71. EFSA (European Food Safety Authority) 2006. Guidance of the Scientific Committee on a request from EFSA related to Uncertainties in Dietary Exposure Assessment. The EFSA Journal (2006) 438, 1–54. www.efsa.europa.eu/en/science/sc_commitee/sc_opinions/uncertainty_exp.html
72. Enghardt Barbieri H, Pearson M and Becker W (2006). Riksmaten - barn 2003, Livsmedels- och näringsintag bland barn i Sverige. Livsmedelsverket, Uppsala, Sverige.
73. EFSA (European Food Safety Authority) 2007. Reasoned opinion on the potential chronic and acute risk to consumers' health arising from proposed temporary EU MRLs, EFSA_acutechronic_model.xls, http://www.efsa.europa.eu/en/science/praper/maximumresiduelevels/mrlopinion.html
74. FAO, 2002. Submission and evaluation of pesticide residues data for the estimation of maximum residue levels in food and feed. FAO Plant Production and Protection Paper 170. Rome.
75. FAO/WHO (2002). Pesticide residues in food - 2002, Report of the Joint Meeting of the FAO Panel of Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group on Pesticide Residues Rome, Italy, 16-25 September 2002, www.fao.org/ag/agp/agpp/pesticid/jmpr/Download/2002rep/2002JMPRReport2.pdf
76. GenStat (2005). GenStat for Windows. Release 8.1, eight edition, VSN International Ltd., Oxford.
77. Gregory JR, Collins DL, Davies PSW, Hughes JM, Clarke PC (1995). National Diet and Nutrition Survey: children aged 1½ to 4½ years. Volume 1: Report of the diet and nutrition survey. London, England: Her Majesty's Stationary Office.
78. Harris CA, Mascall JR, Warren SFP, Crossley S J (1998). Summary report of the International Conference on pesticide residues variability and acute dietary risk assessment. Food Additives and Contaminants: 17, 481–485.
79. Heseker H, Oepping A, Vohmann C, (2003). Verzehrstudie zur Ermittlung der Lebensmittelaufnahme von Säuglingen und Kleinkindern für die Abschätzung eines akuten Toxizitätsrisikos durch Rückstände von Pflanzenschutzmitteln (VELS), Forschungsbericht. Universität Paderborn.
80. Lyhne (2005). Danskernes kostvaner 2000-2003, hovedresultater, Publikation nr. 11. Danmarks Fødevareforskning, Afdeling for Ernæring, Søborg, Danmark, ISBN 87-988795-5-3.
81. McNamara C, Naddy B, Rohan D, Sexton J (2003). Design, development and validation of software for modelling dietary intake to food chemicals and nutrients. Food Additives and Contaminants: 20 Supplement 116.
82. Nusser SM, Carriquiry AL, Dodd KW, Fuller WA (1996). A semi-parametric transformation approach to estimating usual daily intake distributions. Journal of the American Statistical Association 91: 1440–1449.
83. Nusser SM, Fuller WA, Guenther PM (1997). Estimating usual dietary intake distributions: adjusting for measurement error and nonnormality in 24-hour food intake data. In: Lyberg L, Biemer P, Collins M, DeLeeuw E, Dippo C, Schwartz N, and Trewin D (editors), Survey Measurement and Process Quality, Wiley, New York. p. 689–709.
84. OECD (2006). Environment, Health and Safety Publications, Series on Testing and Assessment No. 63 and Series on Pesticides No. 31, GUIDANCE DOCUMENT ON THE DEFINITION OF RESIDUE, ENV/JM/MONO(2006)31. appli1.oecd.org/olis/2006doc.nsf/linkto/env-jm-mono(2006)31.
85. Prüße U, Hüther L, Hohgardt K (2002). Mittlere Gewichte einzelner Obst- und Gemüseerzeugnisse. Bonn: BVL.
86. PSD (Pesticides Safety Directorate) 2000. Pesticides Residue Committee Monitoring Reports, www.pesticides.gov.uk/prc.asp?id=738
87. PSD (Pesticides Safety Directorate) 2006. The National Estimate of Short Term Intake (NESTI) model for short term consumer intake calculations. www.pesticides.gov.uk/approvals.asp?id=1687.
88. Rückstands-Höchstmengenverordnung (RHmV) 1999. Anlage 4, Liste B Lebensmittel pflanzlicher Herkunft. BGBl. I 1999 p. 2082.
89. Ruprich J (2005). The Czech national database of food consumption for individuals – SISP04. National Institute of Public Health in Prague, database of CHPR.
90. Slob W (2006). Probabilistic dietary exposure assessment taking into account variability in both amount and frequency of consumption. Food and Chemical Toxicology 44: 933–951.
91. Solecki R, Davies L, Dellarco V, Dewhurst I, van Raaij M, Tritscher A (2005). Guidance on setting of acute reference dose (ARfD) for pesticides. Food and Chemical Toxicology: 43, 1569–159.
92. Spiegelhalter D, Thomas A, Best N, Lunn D. (2004). WinBUGS user manual, version 1.4.1 www.mrc-bsu.cam.ac.uk/bugs.
93. Turrini A, Saba A, Perrone D, Cialfa E, D'Amicis A. (2001). Food consumption patterns in Italy: the INN-CA Study 1994-1996, Eur J Clin Nutr: Jul, 55(7), 571–88.
94. Volatier J-L (2000). Enquête INCA individuelle et nationale sur les consommations alimentaires. Agence Française de Sécurité Sanitaire des Aliments (AFSSA). Tech & Doc, Paris.
95. WHO, 1998. Report of the Joint FAO/WHO Consultation on Food Consumption and Intake Assessment of Chemicals. 10-14 February 1997. WHO Headquarters, Geneva. Final Draft, 20/2/98.