Lean muscle mass in classic or ovulatory PCOS: Association with central obesity and insulin resistance

Experimental and Clinical Endocrinology and Diabetes

Volumn 120, Issue 9, 2012, Pages 511-516

  Mario, F M ^a   Do Amarante, F ^b   Toscani, M K ^a,b   Spritzer, P M ^a,b,c  

^a HOSPITAL DE CLÍNICAS DE PORTO ALEGRE   (Brazil)

^b National Institute of Hormones and Women's Health   (Brazil)

^c FEDERAL UNIVERSITY OF RIO GRANDE DO SUL   (Brazil)

Author keywords

hyperandrogenemia; metabolic features; obesity; polycystic ovary syndrome

Indexed keywords

CHOLESTEROL; ESTRADIOL; GLUCOSE; INSULIN; LUTEINIZING HORMONE; TESTOSTERONE; TRIACYLGLYCEROL;

ADULT; ANTHROPOMETRY; ARTICLE; BODY MASS; CALORIC INTAKE; CHOLESTEROL BLOOD LEVEL; CLINICAL EVALUATION; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIPID STORAGE; MUSCLE MASS; OBESITY; OVARY POLYCYSTIC DISEASE; PHYSICAL ACTIVITY; PRIORITY JOURNAL; TESTOSTERONE BLOOD LEVEL; WAIST CIRCUMFERENCE;

ABSORPTIOMETRY, PHOTON; ADOLESCENT; ADULT; BODY COMPOSITION; BODY MASS INDEX; BONE DENSITY; BRAZIL; CASE-CONTROL STUDIES; FEMALE; HUMANS; INSULIN RESISTANCE; MUSCLE DEVELOPMENT; OBESITY, ABDOMINAL; OVERWEIGHT; OVULATION; POLYCYSTIC OVARY SYNDROME; SEVERITY OF ILLNESS INDEX; WAIST CIRCUMFERENCE; WHOLE BODY IMAGING; YOUNG ADULT;

EID: 84867684827     PISSN: 09477349     EISSN: 14393646     Source Type: Journal    
DOI: 10.1055/s-0032-1309006     Document Type: Article

References (47)

1. Azziz R., Sanchez L. A., Knochenhauer E. S. et al. Androgen excess in women: experience with over 1000 consecutive patients. J Clin Endocrinol Metab: 2004; 89 02 453 462 (Pubitemid 38269843)
2. Azziz R., Woods K. S., Reyna R. et al. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab: 2004; 89 06 2745 2749 (Pubitemid 38766360)
3. Norman R. J., Masters S. C., Hague W. et al. Metabolic approaches to the subclassification of polycystic ovary syndrome. Fertil Steril: 1995; 63 02 329 335
4. Ehrmann D. A., Liljenquist D. R., Kasza K. et al. Prevalence and predictors of the metabolic syndrome in women with polycystic ovary syndrome. J Clin Endocrinol Metab: 2006; 91 01 48 53 (Pubitemid 43069116)
5. Kirchengast S., Huber J. Body composition characteristics and body fat distribution in lean women with polycystic ovary syndrome. Hum Reprod: 2001; 16 06 1255 1260 (Pubitemid 32544700)
6. Yucel A., Noyan V., Sagsoz N. The association of serum androgens and insulin resistance with fat distribution in polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol: 2006; 126 01 81 86
7. Moran L., Norman R. J. Understanding and managing disturbances in insulin metabolism and body weight in women with polycystic ovary syndrome. Best Pract Res Clin Obstet Gynaecol: 2004; 18 05 719 736 (Pubitemid 40424607)
8. Wiltgen D., Benedetto I. G., Mastella L. S. et al. Lipid accumulation product index: a reliable marker of cardiovascular risk in polycystic ovary syndrome. Hum Reprod: 2009; 24 07 1726 1731
9. Penaforte F. R., Japur C. C., Diez-Garcia R. W. et al. Upper trunk fat assessment and its relationship with metabolic and biochemical variables and body fat in polycystic ovary syndrome. J Hum Nutr Diet: 2011; 24 01 39 46
10. Azziz R., Carmina E., Dewailly D. et al. The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. Fertil Steril: 2009; 91 02 456 488
11. Kuchenbecker W. K., Groen H., Zijlstra T. M. et al. The subcutaneous abdominal fat and not the intraabdominal fat compartment is associated with anovulation in women with obesity and infertility. J Clin Endocrinol Metab: 2010; 95 05 2107 2112
12. Toscani M., Migliavacca R., Sisson de Castro J. A. et al. Estimation of truncal adiposity using waist circumference or the sum of trunk skinfolds: a pilot study for insulin resistance screening in hirsute patients with or without polycystic ovary syndrome. Metabolism: 2007; 56 07 992 997 (Pubitemid 46890983)
13. Wiltgen D., Spritzer P. M. Variation in metabolic and cardiovascular risk in women with different polycystic ovary syndrome phenotypes. Fertil Steril: 2010; 94 06 2493 2496
14. Lecke S. B., Mattei F., Morsch D. M. et al. Abdominal subcutaneous fat gene expression and circulating levels of leptin and adiponectin in polycystic ovary syndrome. Fertil Steril: 2011; 95 06 2044 2049
15. Douchi T., Yoshimitsu N., Nagata Y. Relationships among serum testosterone levels, body fat and muscle mass distribution in women with polycystic ovary syndrome. Endocr J: 2001; 48 06 685 689 (Pubitemid 34032339)
16. Glintborg D., Andersen M., Hagen C. et al. Association of pioglitazone treatment with decreased bone mineral density in obese premenopausal patients with polycystic ovary syndrome: a randomized, placebo-controlled trial. J Clin Endocrinol Metab: 2008; 93 05 1696 1701 (Pubitemid 351656507)
17. Carmina E., Guastella E., Longo R. A. et al. Correlates of increased lean muscle mass in women with polycystic ovary syndrome. Eur J Endocrinol: 2009; 161 04 583 589
18. Forbes G. B. Longitudinal changes in adult fat-free mass: influence of body weight. Am J Clin Nutr: 1999; 70 06 1025 1031
19. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod: 2004; 19 01 41 47
20. Ferriman D., Gallwey J. D. Clinical assessment of body hair growth in women. J Clin Endocrinol Metab: 1961; 21 1440 1447
21. Chobanian A. V., Bakris G. L., Black H. R. et al. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA: 2003; 289 19 2560 2572 (Pubitemid 37430158)
22. Graff S. K., Alves B. C., Toscani M. K. et al. Benefits of pedometer-measured habitual physical activity in healthy women. J Appl Physiol Nutr Metab in press: 2011
23. Lara S., Casanova G., Spritzer P. M. Influence of habitual physical activity on body composition, fat distribution and metabolic variables in early postmenopausal women receiving hormonal therapy. Eur J Obstet Gynecol Reprod Biol: 2010; 150 01 52 56
24. Friedewald W. T., Levy R. I., Fredrickson D. S. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem: 1972; 18 06 499 502
25. Matthews D. R., Hosker J. P., Rudenski A. S. et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia: 1985; 28 07 412 419 (Pubitemid 15018832)
26. Kahn H. S. The "lipid accumulation producto" performs better than the body mass index for recognizing cardiovascular risk: a population-based comparison. BMC Cardiovasc Disord: 2005; 5 26
27. Maturana M. A., Moreira R. M., Spritzer P. M. Lipid accumulation product (LAP) is related to androgenicity and cardiovascular risk factors in postmenopausal women. Maturitas: 2011; 70 04 395 399
28. Zanolla A. F., Olinto M. T., Henn R. L. et al. Assessment of reproducibility and validity of a food frequency questionnaire in a sample of adults living in Porto Alegre, Rio Grande do Sul State, Brazil. Cad Saude Publica: 2009; 25 04 840 848
29. Baim S., Binkley N., Bilezikian J. P. et al. Official Positions of the International Society for Clinical Densitometry and executive summary of the 2007 ISCD Position Development Conference. J Clin Densitom: 2008; 11 01 75 91 (Pubitemid 351602189)
30. Ibanez L., de Zegher F. Ethinylestradiol-drospirenone, flutamide-metformin, or both for adolescents and women with hyperinsulinemic hyperandrogenism: opposite effects on adipocytokines and body adiposity. J Clin Endocrinol Metab: 2004; 89 04 1592 1597 (Pubitemid 38507907)
31. McKittrick M. Diet and Polycystic Ovary Syndrome. Nutr Today: 2002; 37 02 63 69
32. Ehrmann D. A. Polycystic ovary syndrome. N Engl J Med: 2005; 352 12 1223 1236
33. Vrbikova J., Hainer V. Obesity and polycystic ovary syndrome. Obes Facts: 2009; 2 01 26 35
34. Spritzer P. M., Wiltgen D. Prevalence of metabolic syndrome in patients of south of Brazil with polycystic ovary syndrome (PCOS). Arq Bras Endocrinol Metabol: 2007; 51 01 146 147
35. Carmina E. The spectrum of androgen excess disorders. Fertil Steril: 2006; 85 06 1582 1585 (Pubitemid 43816433)
36. Carmina E., Chu M. C., Longo R. A. et al. Phenotypic variation in hyperandrogenic women influences the findings of abnormal metabolic and cardiovascular risk parameters. J Clin Endocrinol Metab: 2005; 90 05 2545 2549 (Pubitemid 40686289)
37. Guastella E., Longo R. A., Carmina E. Clinical and endocrine characteristics of the main polycystic ovary syndrome phenotypes. Fertil Steril: 2010; 94 06 2197 2201
38. Peppa M., Koliaki C., Nikolopoulos P. et al. Skeletal muscle insulin resistance in endocrine disease. J Biomed Biotechnol: 2010; 2010 527850
39. Corbould A., Zhao H., Mirzoeva S. et al. Enhanced mitogenic signaling in skeletal muscle of women with polycystic ovary syndrome. Diabetes: 2006; 55 03 751 759 (Pubitemid 43343232)
40. Dobs A. S., Nguyen T., Pace C. et al. Differential effects of oral estrogen versus oral estrogen-androgen replacement therapy on body composition in postmenopausal women. J Clin Endocrinol Metab: 2002; 87 04 1509 1516 (Pubitemid 34615230)
41. Ballor D. L., Poehlman E. T. Exercise-training enhances fat-free mass preservation during diet-induced weight loss: a meta-analytical finding. Int J Obes Relat Metab Disord: 1994; 18 01 35 40 (Pubitemid 24029243)
42. Ryan A. S., Pratley R. E., Elahi D. et al. Resistive training increases fat-free mass and maintains RMR despite weight loss in postmenopausal women. J Appl Physiol: 1995; 79 03 818 823
43. Noyan V., Yucel A., Sagsoz N. The association of bone mineral density with insulin resistance in patients with polycystic ovary syndrome. Eur J Obstet Gynecol Reprod Biol: 2004; 115 02 200 205 (Pubitemid 38953039)
44. Pocock N., Eisman J., Gwinn T. et al. Muscle strength, physical fitness, and weight but not age predict femoral neck bone mass. J Bone Miner Res: 1989; 4 03 441 448 (Pubitemid 19162014)
45. Marin R. V., Pedrosa M. A., Moreira-Pfrimer L. D. et al. Association between lean mass and handgrip strength with bone mineral density in physically active postmenopausal women. J Clin Densitom: 2010; 13 01 96 101
46. Wang M. C., Bachrach L. K., Van Loan M. et al. The relative contributions of lean tissue mass and fat mass to bone density in young women. Bone: 2005; 37 04 474 481 (Pubitemid 41317320)
47. Ho-Pham L. T., Nguyen N. D., Lai T. Q. et al. Contributions of lean mass and fat mass to bone mineral density: a study in postmenopausal women. BMC Musculoskelet Disord: 2010; 11 59