Liver Test Results Do Not Identify Liver Disease in Adults With α1-Antitrypsin Deficiency

Clinical Gastroenterology and Hepatology

Volumn 10, Issue 11, 2012, Pages 1278-1283

  Clark, Virginia C ^a   Dhanasekaran, Renumathy ^a   Brantly, Mark ^a   Rouhani, Farshid ^a   Schreck, Pamela ^a   Nelson, David R ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Cirrhosis; Diagnostic factor; Prognosis; Protease inhibitor

Indexed keywords

ALANINE AMINOTRANSFERASE; GAMMA GLUTAMYLTRANSFERASE;

ADULT; AGED; ALCOHOL CONSUMPTION; ALPHA 1 ANTITRYPSIN DEFICIENCY; ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; FEMALE; HUMAN; LIVER DISEASE; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; PREVALENCE; RISK FACTOR; SENSITIVITY AND SPECIFICITY; SEX DIFFERENCE; TISSUE SECTION;

ADULT; AGED; AGED, 80 AND OVER; ALANINE TRANSAMINASE; ALPHA 1-ANTITRYPSIN DEFICIENCY; CLINICAL LABORATORY TECHNIQUES; DIAGNOSTIC TESTS, ROUTINE; FEMALE; HUMANS; LIVER CIRRHOSIS; MALE; MIDDLE AGED; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 84867671425     PISSN: 15423565     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cgh.2012.07.007     Document Type: Article

References (24)

1. Blank C.A., Brantly M. Clinical features and molecular characteristics of alpha 1-antitrypsin deficiency. Ann Allergy 1994, 72:105-120.
2. Teckman J.H., Lindblad D. Alpha-1-antitrypsin deficiency: diagnosis, pathophysiology, and management. Curr Gastroenterol Rep 2006, 8:14-20.
3. Eriksson S., Carlson J., Velez R. Risk of cirrhosis and primary liver cancer in alpha 1-antitrypsin deficiency. N Engl J Med 1986, 314:736-739.
4. American Thoracic Society/European Respiratory Society statement: standards for the diagnosis and management of individuals with alpha-1 antitrypsin deficiency. Am J Respir Crit Care Med 2003, 168:818-900. American Thoracic Society/European Respiratory Society.
5. Sveger T. Liver disease in alpha1-antitrypsin deficiency detected by screening of 200,000 infants. N Engl J Med 1976, 294:1316-1321.
6. Sveger T. Prospective study of children with alpha 1-antitrypsin deficiency: eight-year-old follow-up. J Pediatr 1984, 104:91-94.
7. Sveger T. The natural history of liver disease in alpha 1-antitrypsin deficient children. Acta Paediatr Scand 1988, 77:847-851.
8. Sveger T., Eriksson S. The liver in adolescents with alpha 1-antitrypsin deficiency. Hepatology 1995, 22:514-517.
9. Bernspång E., Carlson J., Piitulainen E. The liver in 30-year-old individuals with alpha(1)-antitrypsin deficiency. Scand J Gastroenterol 2009, 44:1349-1355.
10. Browne R.J., Mannino D.M., Khoury M.J. Alpha 1-antitrypsin deficiency deaths in the United States from 1979-1991: an analysis using multiple-cause mortality data. Chest 1996, 110:78-83.
11. Stoller J.K., Tomashefski J., Crystal R.G., et al. Mortality in individuals with severe deficiency of alpha1-antitrypsin: findings from the National Heart, Lung, and Blood Institute registry. Chest 2005, 127:1196-1204.
12. Prati D., Taioli E., Zanella A., et al. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med 2002, 137:1-10.
13. Ekeowa U.I., Freeke J., Miranda E., et al. Defining the mechanism of polymerization in the serpinopathies. Proc Natl Acad Sci U S A 2010, 107:17146-17151.
14. Hidvegi T., Ewing M., Hale P., et al. An autophagy-enhancing drug promotes degradation of mutant alpha1-antitrypsin Z and reduces hepatic fibrosis. Science 2010, 329:229-232.
15. McElvaney N.G., Stoller J.K., Buist A.S., et al. Baseline characteristics of enrollees in the National Heart, Lung and Blood Institute registry of alpha 1-antitrypsin deficiency: Alpha 1-Antitrypsin Deficiency Registry Study Group. Chest 1997, 111:394-403.
16. Bowlus C.L., Willner I., Zern M.A., et al. Factors associated with advanced liver disease in adults with alpha1-antitrypsin deficiency. Clin Gastroenterol Hepatol 2005, 3:390-396.
17. Strange C., Stoller J.K., Sandhaus R.A., et al. Results of a survey of patients with alpha-1 antitrypsin deficiency. Respiration 2006, 73:185-190.
18. Eriksson S. Alpha 1-antitrypsin deficiency and liver cirrhosis in adults: an analysis of 35 Swedish autopsied cases. Acta Med Scand 1987, 221:461-467.
19. Cox D.W., Smyth S. Risk for liver disease in adults with alpha 1-antitrypsin deficiency. Am J Med 1983, 74:221-227.
20. Larsson C. Natural history and life expectancy in severe alpha1-antitrypsin deficiency, Pi Z. Acta Med Scand 1978, 204:345-351.
21. Tanash H.A., Nilsson P.M., Nilsson J.A., et al. Clinical course and prognosis of never-smokers with severe alpha-1-antitrypsin deficiency (PiZZ). Thorax 2008, 63:1091-1095.
22. Hay J.E., Czaja A.J., Rakela J., et al. The nature of unexplained chronic aminotransferase elevations of a mild to moderate degree in asymptomatic patients. Hepatology 1989, 9:193-197.
23. Haber M.M., West A.B., Haber A.D., et al. Relationship of aminotransferases to liver histological status in chronic hepatitis C. Am J Gastroenterol 1995, 90:1250-1257.
24. Propst T., Propst A., Dietze O., et al. High prevalence of viral infection in adults with homozygous and heterozygous alpha 1-antitrypsin deficiency and chronic liver disease. Ann Intern Med 1992, 117:641-645.