Motherisk Rounds. Negative Impact of Non-Evidence-Based Information Received by Women Taking Antidepressants During Pregnancy From Health Care Providers and Others

Journal of Obstetrics and Gynaecology Canada

Volumn 34, Issue 1, 2012, Pages 66-71

  Mulder, Eva ^a   Davis, Amy ^a   Gawley, Laura ^b   Bowen, Angela ^b   Einarson, Adrienne ^a  

^a HOSPITAL FOR SICK CHILDREN   (Canada)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Antidepressant therapy; Pregnancy; Safety

Indexed keywords

ANTIDEPRESSANT AGENT;

ARTICLE; DRUG USE; FEMALE; HEALTH CARE PERSONNEL; HEALTH IMPACT ASSESSMENT; HUMAN; INFORMATION; NEGATIVE INFORMATION; PREGNANCY; PREGNANT WOMAN; QUESTIONNAIRE; TREATMENT WITHDRAWAL; CANADA; CONSUMER HEALTH INFORMATION; DECISION MAKING; DEPRESSION; EVIDENCE BASED MEDICINE; PATIENT COMPLIANCE; PREGNANCY COMPLICATION; STANDARD;

ANTIDEPRESSIVE AGENTS; CONSUMER HEALTH INFORMATION; DECISION MAKING; DEPRESSIVE DISORDER; EVIDENCE-BASED MEDICINE; FEMALE; HEALTH PERSONNEL; HUMANS; MEDICATION ADHERENCE; ONTARIO; PREGNANCY; PREGNANCY COMPLICATIONS; QUESTIONNAIRES; SASKATCHEWAN;

EID: 84867661342     PISSN: 17012163     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1701-2163(16)35136-2     Document Type: Article

References (24)

1. Grigoriadis S., Robinson G.E. Gender issues in depression. Ann Clin Psychiatry 2007, 19:247-255.
2. Bennett H.A., Einarson A., Taddio A., Koren G., Einarson T.R. Prevalence of depression during pregnancy: systematic review. Obstet Gynecol 2004, 103:698-709.
3. Bonari L., Koren G., Einarson T.R., Jasper J.D., Taddio A., Einarson A. Use of antidepressants by pregnant women: evaluation of perception of risk, efficacy of evidence based counseling and determinants of decision making. Arch Womens Ment Health 2005, 8:214-220.
4. Einarson T.R., Einarson A. Newer antidepressants in pregnancy and rates of major malformations: a meta-analysis of prospective comparative studies. Pharmacoepidemiol Drug Saf 2005, 14:823-827.
5. GlaxoSmithKline Advisory October 2005. 2011, Available at, Accessed November 8. http://www.hc-sc.gc.ca/dhp-mps/medeff/advisories-avis/prof/_2005/paxil_3_hpc-cps-eng.php.
6. Cole J.A., Ephross S.A., Cosmatos I.S., Walker A.M. Paroxetine in the first trimester and the prevalence of congenital malformations. Pharmacoepidemiol Drug Saf 2007, 16:1075-1085.
7. Kallen B.A., Otterblad Olausson P. Maternal use of selective serotonin re-uptake inhibitors in early pregnancy and infant congenital malformations. Birth Defects Res A Clin Mol Teratol 2007, 79:301-308.
8. Diav-Citrin O., Shechtman S., Weinbaum D., Arnon J., Di Gianantonio E., Clementi M., et al. Paroxetine and fluoxetine in pregnancy: controlled study [abstract]. Reprod Toxicol 2005, 20:459.
9. Einarson A., Pistelli A., DeSantis M., Malm H., Paulus W.E., Panchaud A., et al. Evaluation of the risk of congenital cardiovascular defects associated with use of paroxetine during pregnancy. Am J Psychiatry 2008, 165(6):749-752.
10. United States Food and Drug Administration. Public health advisory: paroxetine. 2011, Available at, Accessed November 11. http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/2005/ucm108527.htm.
11. Health Canada. Advisory: paroxetine. 2011, Available at, Accessed November 6. http://www.hc-sc.gc.ca/dhp-mps/medeff/advisories-avis/public/_2005/paxil_3_pa-ap-eng.php.
12. Einarson A, Schachtschneider AK, Halil R, Bollano E, Koren G. SSRIs and other antidepressant use during pregnancy and potential neonatal adverse effects: impact of a public health advisory and subsequent reports in the news media. BMC Pregnancy Childbirth 2005 May 20;5:11.
13. The American College of Obstetricians and Gynecologists Committee on Obstetric Practice. Committee opinion no. 354: treatment with selective serotonin reuptake inhibitors during pregnancy. Obstet Gynecol 2006, 108:1601-1603.
14. Lyszkiewicz D.A., Gerichhausen S., Bjornsdottir I., Einarson T.R., Koren G., Einarson A. Evidence based information on drug use during pregnancy: a survey of community pharmacists in three countries;. Pharm World Sci 2001, 23(2):76-81.
15. CBC News. Stigma of mental illness common among Canadians: report. [article based on the 8th annual national report card on health care August 2008, Canadian Medical Association.] 2008, Accessed: October 7. http://www.cbc.ca/health/story/2008/08/15/mental-health.html.
16. Canadian Medical Association. 8th annual national report card on health care. August 2008. 2008, Available at, Accessed: October 7. http://www.cma.ca/multimedia/CMA/Content_Images/Inside_cma/Annual_Meeting/2008/GC_Bulletin/National_Report_Card_EN.pdf.
17. Alonso J., Buron A., Bruaerts R., He Y., Posada-Villa J., Lepine J.P., et al. Association of perceived stigma and mood and anxiety disorders: results from the World Mental Health Surveys. Acta Psychiatr Scand 2008, 118:305-314.
18. Griffiths K.M., Christensen H., Jorm A.F. Predictors of depression stigma. BMC Psychiatry 2008, 8:25.
19. Wang J., Lai D. The relationship between mental health literacy, personal contacts and personal stigma against depression. J Affect Disord 2008, 110(1,2):191-196.
20. Baggley A., Navioz Y., Maltepe C., Koren G., Einarson A. Determinants of women's decision making on whether to treat nausea and vomiting of pregnancy pharmacologically. J Midwifery Womens Health 2004, 49:350-354.
21. Einarson A., Choi J., Einarson T.R., Koren G. Incidence of major malformations in infants following antidepressant exposure in pregnancy: results of a large prospective cohort study. Can J Psychiatry 2009, 54:242-246.
22. Choi J., Einarson T.R., Koren G. Rates of spontaneous and therapeutic abortions following use of antidepressants in pregnancy: results from a large prospective database. J Obstet Gynaecol Can 2009, 31:452-456.
23. Einarson A., Choi J., Einarson T.R., Koren G. Adverse effects of antidepressant use in pregnancy: an evaluation of fetal growth and preterm birth. Depress Anxiety 2010, 27:35-38.
24. Philo A. Canadian regulation on fetal exposure to psychotropic drugs-public input needed. Breath [blog] November 7, 2009 2011, Available at, Accessed November 8. http://momsandmeds.wordpress.com.