Crystal structure of Enpp1, an extracellular glycoprotein involved in bone mineralization and insulin signaling

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 42, 2012, Pages 16876-16881

  Kato, Kazuki ^a   Nishimasu, Hiroshi ^a   Okudaira, Shinichi ^b   Mihara, Emiko ^c   Ishitani, Ryuichiro ^a   Takagi, Junichi ^c   Aoki, Junken ^b   Nureki, Osamu ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b TOHOKU UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

Molecular evolution; X ray crystallography

Indexed keywords

AUTOTAXIN; ENPP1 PROTEIN; GLYCOPROTEIN; INSULIN; LYSOPHOSPHOLIPASE; LYSOPHOSPHOLIPASE D; LYSOPHOSPHOLIPID; NUCLEOTIDE; NUCLEOTIDE DERIVATIVE; NUCLEOTIDE MONOPHOSPHATE; UNCLASSIFIED DRUG;

ARTICLE; BONE MINERALIZATION; CATALYSIS; CELL FUNCTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; MUTANT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN HYDROLYSIS; PROTEIN LOCALIZATION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; X RAY DIFFRACTION;

ANIMALS; CALCIFICATION, PHYSIOLOGIC; CRYSTALLOGRAPHY, X-RAY; GLYCOPROTEINS; INSULIN; MICE; MODELS, MOLECULAR; PHOSPHORIC DIESTER HYDROLASES; PROTEIN CONFORMATION; PYROPHOSPHATASES; RIBONUCLEOTIDES; SIGNAL TRANSDUCTION; X-RAY DIFFRACTION;

EID: 84867638074     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1208017109     Document Type: Article

References (36)

1. i and osteopontin mediate pathologic calcification associated with defective PC-1 and ANK expression. J Bone Miner Res 18:994-1004.
2. Johnson K, et al. (1999) Matrix vesicle plasma cell membrane glycoprotein-1 regulates mineralization by murine osteoblastic MC3T3 cells. J Bone Miner Res 14:883-892. (Pubitemid 29262882)
3. Hessle L, et al. (2002) Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. Proc Natl Acad Sci USA 99:9445-9449. (Pubitemid 34764633)
4. Okawa A, et al. (1998) Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nat Genet 19:271-273. (Pubitemid 28309341)
5. Rutsch F, et al. (2003) Mutations in ENPP1 are associated with 'idiopathic' infantile arterial calcification. Nat Genet 34:379-381. (Pubitemid 36935330)
6. Ruf N, Uhlenberg B, Terkeltaub R, Nürnberg P, Rutsch F (2005) The mutational spectrum of ENPP1 as arising after the analysis of 23 unrelated patients with generalized arterial calcification of infancy (GACI). Hum Mutat 25:98.
7. Rutsch F, et al.; GACI Study Group (2008) Hypophosphatemia, hyperphosphaturia, and bisphosphonate treatment are associated with survival beyond infancy in generalized arterial calcification of infancy. Circ Cardiovasc Genet 1:133-140.
8. Maddux BA, et al. (1995) Membrane glycoprotein PC-1 and insulin resistance in non-insulin-dependent diabetes mellitus. Nature 373:448-451.
9. Grupe A, Alleman J, Goldfine ID, Sadick M, Stewart TA (1995) Inhibition of insulin receptor phosphorylation by PC-1 is not mediated by the hydrolysis of adenosine triphosphate or the generation of adenosine. J Biol Chem 270:22085-22088.
10. Frittitta L, et al. (1998) Elevated PC-1 content in cultured skin fibroblasts correlates with decreased in vivo and in vitro insulin action in nondiabetic subjects: Evidence that PC-1 may be an intrinsic factor in impaired insulin receptor signaling. Diabetes 47:1095-1100. (Pubitemid 28294552)
11. Abate N, et al. (2006) Mechanisms of disease: Ectonucleotide pyrophosphatase phosphodiesterase 1 as a 'gatekeeper' of insulin receptors. Nat Clin Pract Endocrinol Metab 2:694-701. (Pubitemid 44901190)
12. Dong H, et al. (2005) Increased hepatic levels of the insulin receptor inhibitor, PC-1/ NPP1, induce insulin resistance and glucose intolerance. Diabetes 54:367-372.
13. Goldfine ID, Maddux BA, Youngren JF, Trischitta V, Frittitta L (1999) Role of PC-1 in the etiology of insulin resistance. Ann N Y Acad Sci 892:204-222.
14. Maddux BA, Goldfine ID (2000) Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor á-subunit. Diabetes 49:13-19. (Pubitemid 30022918)
15. Meyre D, et al. (2005) Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes. Nat Genet 37:863-867. (Pubitemid 41077112)
16. Frittitta L, et al. (2001) A cluster of three single nucleotide polymorphisms in the 3′-untranslated region of human glycoprotein PC-1 gene stabilizes PC-1 mRNA and is associated with increased PC-1 protein content and insulin resistance-related abnormalities. Diabetes 50:1952-1955. (Pubitemid 33641619)
17. Costanzo BV, et al. (2001) The Q allele variant (GLN121) of membrane glycoprotein PC-1 interacts with the insulin receptor and inhibits insulin signaling more effectively than the common K allele variant (LYS121). Diabetes 50:831-836. (Pubitemid 32242641)
18. Gijsbers R, Ceulemans H, Bollen M (2003) Functional characterization of the non-catalytic ectodomains of the nucleotide pyrophosphatase/ phosphodiesterase NPP1. Biochem J 371:321-330. (Pubitemid 36547614)
19. Sakoda H, et al. (1999) No correlation of plasma cell 1 overexpression with insulin resistance in diabetic rats and 3T3-L1 adipocytes. Diabetes 48:1365-1371. (Pubitemid 29297297)
20. Weedon MN, et al. (2006) No evidence of association of ENPP1 variants with type 2 diabetes or obesity in a study of 8,089 U.K. Caucasians. Diabetes 55:3175-3179. (Pubitemid 44923658)
21. Lyon HN, et al. (2006) Common variants in the ENPP1 gene are not reproducibly associated with diabetes or obesity. Diabetes 55:3180-3184. (Pubitemid 44923659)
22. Stefan C, Jansen S, Bollen M (2005) NPP-type ectophosphodiesterases: Unity in diversity. Trends Biochem Sci 30:542-550. (Pubitemid 41356492)
23. Goding JW, Grobben B, Slegers H (2003) Physiological and pathophysiological functions of the ecto-nucleotide pyrophosphatase/ phosphodiesterase family. Biochim Biophys Acta 1638:1-19. (Pubitemid 36577366)
24. Umezu-Goto M, et al. (2002) Autotaxin has lysophospholipase D activity leading to tumor cell growth and motility by lysophosphatidic acid production. J Cell Biol 158:227-233.
25. Nishimasu H, et al. (2011) Crystal structure of autotaxin and insight into GPCR activation by lipid mediators. Nat Struct Mol Biol 18:205-212.
26. Hausmann J, et al. (2011) Structural basis of substrate discrimination and integrin binding by autotaxin. Nat Struct Mol Biol 18:198-204.
27. Nishimasu H, Ishitani R, Aoki J, Nureki O (2012) A 3D view of autotaxin. Trends Pharmacol Sci 33:138-145.
28. Zalatan JG, Fenn TD, Brunger AT, Herschlag D (2006) Structural and functional comparisons of nucleotide pyrophosphatase/phosphodiesterase and alkaline phosphatase: Implications for mechanism and evolution. Biochemistry 45:9788-9803. (Pubitemid 44257425)
29. Gijsbers R, Ceulemans H, Stalmans W, Bollen M (2001) Structural and catalytic similarities between nucleotide pyrophosphatases/phosphodiesterases and alkaline phosphatases. J Biol Chem 276:1361-1368. (Pubitemid 32096567)
30. Cimpean A, Stefan C, Gijsbers R, Stalmans W, Bollen M (2004) Substrate-specifying determinants of the nucleotide pyrophosphatases/ phosphodiesterases NPP1 and NPP2. Biochem J 381:71-77. (Pubitemid 38932212)
31. Bollen M, Gijsbers R, Ceulemans H, Stalmans W, Stefan C (2000) Nucleotide pyrophosphatases/phosphodiesterases on the move. Crit Rev Biochem Mol Biol 35:393-432. (Pubitemid 32095990)
32. Levy-Litan V, et al. (2010) Autosomal-recessive hypophosphatemic rickets is associated with an inactivation mutation in the ENPP1 gene. Am J Hum Genet 86:273-278.
33. Zhou A, Huntington JA, Pannu NS, Carrell RW, Read RJ (2003) How vitronectin binds PAI-1 to modulate fibrinolysis and cell migration. Nat Struct Biol 10:541-544. (Pubitemid 36792905)
34. Huai Q, et al. (2008) Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes. Nat Struct Mol Biol 15:422-423. (Pubitemid 351483393)
35. Koyama M, Nishimasu H, Ishitani R, Nureki O (2012) Molecular dynamics simulation of autotaxin: Roles of the nuclease-like domain and the glycan modification. J Phys Chem B 116:11798-11808.
36. Kato K, et al. (2012) Expression, purification, crystallization and preliminary X-ray crystallographic analysis of Enpp1. Acta Crystallogr Sect F Struct Biol Cryst Commun 68:778-782.