Host translation at the nexus of infection and immunity

Cell Host and Microbe

Volumn 12, Issue 4, 2012, Pages 470-483

  Mohr, Ian ^a   Sonenberg, Nahum ^b  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

7 METHYLGUANOSINE; ACTIVATING TRANSCRIPTION FACTOR 3; CASEIN KINASE II; DECTIN 1; GROWTH ARREST AND DNA DAMAGE INDUCIBLE PROTEIN 153; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE EXCHANGE FACTOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INITIATION FACTOR 4E; INITIATION FACTOR 4E BINDING PROTEIN 1; INITIATION FACTOR 4G; INOSINATE DEHYDROGENASE; INTERFERON; INTERFERON REGULATORY FACTOR 7; INTERLEUKIN 10; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAMMALIAN TARGET OF RAPAMYCIN; MICRORNA; PHOSPHATIDYLINOSITOL 3 KINASE; PRION PROTEIN; PROTEIN KINASE B; PROTEIN KINASE C; SYNAPTOPHYSIN; TRANSFER RNA;

AUTOPHAGOSOME; BACTERIAL INFECTION; BACTERIAL VIRULENCE; CD8+ T LYMPHOCYTE; CYTOKINE PRODUCTION; DNA VIRUS; DROSOPHILA; EFFECTOR CELL; ENDOPLASMIC RETICULUM STRESS; ENVIRONMENTAL FACTOR; FRAMESHIFT MUTATION; GENE EXPRESSION; HEPATITIS C VIRUS; HOMEOSTASIS; HOST CELL; HOST PATHOGEN INTERACTION; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; INFECTION; INNATE IMMUNITY; METABOLIC STRESS; MYCOSIS; NONHUMAN; PATHOGENESIS; PHAGOSOME; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SUBUNIT; PROTEIN SYNTHESIS; PROTOZOAL INFECTION; REVIEW; RIBOSOME SUBUNIT; RNA DEGRADATION; RNA SPLICING; RNA TRANSLATION; SIGNAL TRANSDUCTION; TRANSLATION REGULATION; VIRUS GENE; VIRUS INFECTION; VIRUS REPLICATION; VIRUS VIRULENCE;

ANIMALS; GENE EXPRESSION; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNE EVASION; IMMUNITY, INNATE; PROTEIN BIOSYNTHESIS;

EID: 84867636500     PISSN: 19313128     EISSN: 19346069     Source Type: Journal    
DOI: 10.1016/j.chom.2012.09.006     Document Type: Review

References (130)

1. T. Alain, X. Lun, Y. Martineau, P. Sean, B. Pulendran, E. Petroulakis, F.J. Zemp, C.G. Lemay, D. Roy, and J.C. Bell Vesicular stomatitis virus oncolysis is potentiated by impairing mTORC1-dependent type I IFN production Proc. Natl. Acad. Sci. USA 107 2010 1576 1581
2. J.M. Axten, J.R. Medina, Y. Feng, A. Shu, S.P. Romeril, S.W. Grant, W.H. Li, D.A. Heerding, E. Minthorn, and T. Mencken Discovery of 7-Methyl-5-(1-{[3- (trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d] pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK) J. Med. Chem. 55 2012 7193 7207
3. J. Azevedo, D. Garcia, D. Pontier, S. Ohnesorge, A. Yu, S. Garcia, L. Braun, M. Bergdoll, M.A. Hakimi, T. Lagrange, and O. Voinnet Argonaute quenching and global changes in Dicer homeostasis caused by a pathogen-encoded GW repeat protein Genes Dev. 24 2010 904 915
4. S. Backes, J.S. Shapiro, L.R. Sabin, A.M. Pham, I. Reyes, B. Moss, S. Cherry, and B.R. Tenoever Degradation of Host MicroRNAs by Poxvirus Poly(A) Polymerase Reveals Terminal RNA Methylation as a Protective Antiviral Mechanism Cell Host Microbe 12 2012 200 210
5. Y. Bauman, D. Nachmani, A. Vitenshtein, P. Tsukerman, N. Drayman, N. Stern-Ginossar, D. Lankry, R. Gruda, and O. Mandelboim An identical miRNA of the human JC and BK polyoma viruses targets the stress-induced ligand ULBP3 to escape immune elimination Cell Host Microbe 9 2011 93 102
6. E. Beattie, E. Paoletti, and J. Tartaglia Distinct patterns of IFN sensitivity observed in cells infected with vaccinia K3L- and E3L- mutant viruses Virology 210 1995 254 263
7. L. Beretta, Y.V. Svitkin, and N. Sonenberg Rapamycin stimulates viral protein synthesis and augments the shutoff of host protein synthesis upon picornavirus infection J. Virol. 70 1996 8993 8996 (Pubitemid 26378485)
8. M. Biton, A. Levin, M. Slyper, I. Alkalay, E. Horwitz, H. Mor, S. Kredo-Russo, T. Avnit-Sagi, G. Cojocaru, and F. Zreik Epithelial microRNAs regulate gut mucosal immunity via epithelium-T cell crosstalk Nat. Immunol. 12 2011 239 246
9. J.B. Bliska, and A. Casadevall Intracellular pathogenic bacteria and fungi - a case of convergent evolution? Nat. Rev. Microbiol. 7 2009 165 171
10. C. Bogdan, J. Mattner, and U. Schleicher The role of type I interferons in non-viral infections Immunol. Rev. 202 2004 33 48 (Pubitemid 39576903)
11. V. Camarena, M. Kobayashi, J.Y. Kim, P. Roehm, R. Perez, J. Gardner, A.C. Wilson, I. Mohr, and M.V. Chao Nature and duration of growth factor signaling through receptor tyrosine kinases regulates HSV-1 latency in neurons Cell Host Microbe 8 2010 320 330
12. W. Cao, S. Manicassamy, H. Tang, S.P. Kasturi, A. Pirani, N. Murthy, and B. Pulendran Toll-like receptor-mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway Nat. Immunol. 9 2008 1157 1164
13. D. Cazalla, T. Yario, and J.A. Steitz Down-regulation of a host microRNA by a Herpesvirus saimiri noncoding RNA Science 328 2010 1563 1566
14. S. Chakrabarti, P. Liehl, N. Buchon, and B. Lemaitre Infection-induced host translational blockage inhibits immune responses and epithelial renewal in the Drosophila gut Cell Host Microbe 12 2012 60 70
15. C. Chassin, M. Kocur, J. Pott, C.U. Duerr, D. Gütle, M. Lotz, and M.W. Hornef miR-146a mediates protective innate immune tolerance in the neonate intestine Cell Host Microbe 8 2010 358 368
16. J. Chou, E.R. Kern, R.J. Whitley, and B.R. Roizman Mapping of herpes simplex virus-1 neurovirulence to gamma 134.5, a gene nonessential for growth in culture Science 250 1990 1262 1266 (Pubitemid 120031840)
17. A.J. Clippinger, and J.C. Alwine Dynein mediates the localization and activation of mTOR in normal and human cytomegalovirus-infected cells Genes Dev. 26 2012 2015 2026
18. R. Colina, M. Costa-Mattioli, R.J. Dowling, M. Jaramillo, L.H. Tai, C.J. Breitbach, Y. Martineau, O. Larsson, L. Rong, and Y.V. Svitkin Translational control of the innate immune response through IRF-7 Nature 452 2008 323 328 (Pubitemid 351430792)
19. R. Cuesta, Q. Xi, and R.J. Schneider Adenovirus-specific translation by displacement of kinase Mnk1 from cap-initiation complex eIF4F EMBO J. 19 2000 3465 3474 (Pubitemid 30428224)
20. C.J. Decker, and R. Parker P-bodies and stress granules: possible roles in the control of translation and mRNA degradation Cold Spring Harb. Perspect. Biol. 4 2012 in press
21. J. Deng, H.P. Harding, B. Raught, A.C. Gingras, J.J. Berlanga, D. Scheuner, R.J. Kaufman, D. Ron, and N. Sonenberg Activation of GCN2 in UV-irradiated cells inhibits translation Curr. Biol. 12 2002 1279 1286 (Pubitemid 34869877)
22. T.E. Dever, and R. Green The elongation, termination, and recycling phases of translation in eukaryotes Cold Spring Harb. Perspect. Biol. 4 2012 a013706
23. S.E. Dmitriev, I.M. Terenin, D.E. Andreev, P.A. Ivanov, J.E. Dunaevsky, W.C. Merrick, and I.N. Shatsky GTP-independent tRNA delivery to the ribosomal P-site by a novel eukaryotic translation factor J. Biol. Chem. 285 2010 26779 26787
24. J. Doudna, and P. Sarnow Translation initiation by viral internal ribosome entry sites M. Mathews, N. Sonenberg, J.W.B. Hershey, Translational Control in Biology and Medicine 2007 Cold Spring Harbor Laboratory Press Cold Spring Harbor, New York 129 153
25. T.L. Dunbar, Z. Yan, K.M. Balla, M.G. Smelkinson, and E.R. Troemel C. elegans detects pathogen-induced translational inhibition to activate immune signaling Cell Host Microbe 11 2012 375 386
26. N.C. Elde, S.J. Child, A.P. Geballe, and H.S. Malik Protein kinase R reveals an evolutionary model for defeating viral mimicry Nature 457 2009 485 489
27. K.A. Estes, T.L. Dunbar, J.R. Powell, F.M. Ausubel, and E.R. Troemel bZIP transcription factor zip-2 mediates an early response to Pseudomonas aeruginosa infection in Caenorhabditis elegans Proc. Natl. Acad. Sci. USA 107 2010 2153 2158
28. M.R. Fabian, and N. Sonenberg The mechanics of miRNA-mediated gene silencing: a look under the hood of miRISC Nat. Struct. Mol. Biol. 19 2012 586 593
29. D. Feigenblum, and R.J. Schneider Modification of eukaryotic initiation factor 4F during infection by influenza virus J. Virol. 67 1993 3027 3035 (Pubitemid 23143670)
30. P. Feng, D.N. Everly Jr., and G.S. Read mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A J. Virol. 79 2005 9651 9664 (Pubitemid 41022308)
31. J.V. Fetten, N. Roy, and E. Gilboa A frameshift mutation at the NH2 terminus of the nucleoprotein gene does not affect generation of cytotoxic T lymphocyte epitopes J. Immunol. 147 1991 2697 2705
32. M.F. Fontana, S. Banga, K.C. Barry, X. Shen, Y. Tan, Z.Q. Luo, and R.E. Vance Secreted bacterial effectors that inhibit host protein synthesis are critical for induction of the innate immune response to virulent Legionella pneumophila PLoS Pathog. 7 2011 e1001289
33. L. Furic, L. Rong, O. Larsson, I.H. Koumakpayi, K. Yoshida, A. Brueschke, E. Petroulakis, N. Robichaud, M. Pollak, and L.A. Gaboury eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression Proc. Natl. Acad. Sci. USA 107 2010 14134 14139
34. M.M. Gaglia, S. Covarrubias, W. Wong, and B.A. Glaunsinger A common strategy for host RNA degradation by divergent viruses J. Virol. 86 2012 9527 9530
35. M.A. Gomez, I. Contreras, M. Hallé, M.L. Tremblay, R.W. McMaster, and M. Olivier Leishmania GP63 alters host signaling through cleavage-activated protein tyrosine phosphatases Sci. Signal. 2 2009 ra58
36. E. Gottwein, D.L. Corcoran, N. Mukherjee, R.L. Skalsky, M. Hafner, J.D. Nusbaum, P. Shamulailatpam, C.L. Love, S.S. Dave, and T. Tuschl Viral microRNA targetome of KSHV-infected primary effusion lymphoma cell lines Cell Host Microbe 10 2011 515 526
37. R. Groppo, B.A. Brown, and A.C. Palmenberg Mutational analysis of the EMCV 2A protein identifies a nuclear localization signal and an eIF4E binding site Virology 410 2011 257 267
38. M.A. Hakimi, and D. Cannella Apicomplexan parasites and subversion of the host cell microRNA pathway Trends Parasitol. 27 2011 481 486
39. B. Herdy, M. Jaramillo, Y.V. Svitkin, A.B. Rosenfeld, M. Kobayashi, D. Walsh, T. Alain, P. Sean, N. Robichaud, and I. Topisirovic Translational control of the activation of transcription factor NF-κB and production of type I interferon by phosphorylation of the translation factor eIF4E Nat. Immunol. 13 2012 543 550
40. A.G. Hinnebusch Molecular mechanism of scanning and start codon selection in eukaryotes Microbiol. Mol. Biol. Rev. 75 2011 434 467
41. A.G. Hinnebusch, and J.R. Lorsch The Mechanism of Eukaryotic Translation Initiation: New Insights and Challenges Cold Spring Harb. Perspect. Biol. 2012 10.1101/cshperspect.a011544 Published online July 18, 2012
42. B.C. Ho, S.L. Yu, J.J. Chen, S.Y. Chang, B.S. Yan, Q.S. Hong, S. Singh, C.L. Kao, H.Y. Chen, and K.Y. Su Enterovirus-induced miR-141 contributes to shutoff of host protein translation by targeting the translation initiation factor eIF4E Cell Host Microbe 9 2011 58 69
43. C. Huang, K.G. Lokugamage, J.M. Rozovics, K. Narayanan, B.L. Semler, and S. Makino SARS coronavirus nsp1 protein induces template-dependent endonucleolytic cleavage of mRNAs: viral mRNAs are resistant to nsp1-induced RNA cleavage PLoS Pathog. 7 2011 e1002433
44. I.D. Iliev, V.A. Funari, K.D. Taylor, Q. Nguyen, C.N. Reyes, S.P. Strom, J. Brown, C.A. Becker, P.R. Fleshner, and M. Dubinsky Interactions between commensal fungi and the C-type lectin receptor Dectin-1 influence colitis Science 336 2012 1314 1317
45. J.A. Isler, A.H. Skalet, and J.C. Alwine Human cytomegalovirus infection activates and regulates the unfolded protein response J. Virol. 79 2005 6890 6899 (Pubitemid 40684492)
46. B.W. Jagger, H.M. Wise, J.C. Kash, K.A. Walters, N.M. Wills, Y.L. Xiao, R.L. Dunfee, L.M. Schwartzman, A. Ozinsky, and G.L. Bell An overlapping protein-coding region in influenza A virus segment 3 modulates the host response Science 337 2012 199 204
47. M. Jaramillo, M.A. Gomez, O. Larsson, M.T. Shio, I. Topisirovic, I. Contreras, R. Luxenburg, A. Rosenfeld, R. Colina, and R.W. McMaster Leishmania repression of host translation through mTOR cleavage is required for parasite survival and infection Cell Host Microbe 9 2011 331 341
48. J.D.G. Jones, and J.L. Dangl The plant immune system Nature 444 2006 323 329 (Pubitemid 44764102)
49. P.B. Joshi, B.L. Kelly, S. Kamhawi, D.L. Sacks, and W.R. McMaster Targeted gene deletion in Leishmania major identifies leishmanolysin (GP63) as a virulence factor Mol. Biochem. Parasitol. 120 2002 33 40 (Pubitemid 34159290)
50. S. Joshi, S. Kaur, A.J. Redig, K. Goldsborough, K. David, T. Ueda, R. Watanabe-Fukunaga, D.P. Baker, E.N. Fish, R. Fukunaga, and L.C. Platanias Type I interferon (IFN)-dependent activation of Mnk1 and its role in the generation of growth inhibitory responses Proc. Natl. Acad. Sci. USA 106 2009 12097 12102
51. I. Jurak, L.B. Silverstein, M. Sharma, and D.M. Coen Herpes simplex virus is equipped with RNA- and protein-based mechanisms to repress the expression of ATRX, an effector of intrinsic immunity J. Virol. 86 2012 10093 10102 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db= PubMed&list-uids=22013031&dopt=Abstract
52. W. Kamitani, C. Huang, K. Narayanan, K.G. Lokugamage, and S. Makino A two-pronged strategy to suppress host protein synthesis by SARS coronavirus Nsp1 protein Nat. Struct. Mol. Biol. 16 2009 1134 1140
53. S. Kim, S. Lee, J. Shin, Y. Kim, I. Evnouchidou, D. Kim, Y.K. Kim, Y.E. Kim, J.H. Ahn, and S.R. Riddell Human cytomegalovirus microRNA miR-US4-1 inhibits CD8(+) T cell responses by targeting the aminopeptidase ERAP1 Nat. Immunol. 12 2011 984 991
54. M. Kobayashi, A.C. Wilson, M.V. Chao, and I. Mohr Control of viral latency in neurons by axonal mTOR signaling and the 4E-BP translation repressor Genes Dev. 26 2012 1527 1532
55. M.F. Kramer, W.J. Cook, F.P. Roth, J. Zhu, H. Holman, D.M. Knipe, and D.M. Coen Latent herpes simplex virus infection of sensory neurons alters neuronal gene expression J. Virol. 77 2003 9533 9541 (Pubitemid 37011048)
56. B. Kroczynska, B. Sharma, E.A. Eklund, E.N. Fish, and L.C. Platanias Regulatory effects of programmed cell death 4 (PDCD4) protein in interferon (IFN)-stimulated gene expression and generation of type I IFN responses Mol. Cell. Biol. 32 2012 2809 2822
57. L.M. Kronstad, and B.A. Glaunsinger Diverse virus-host interactions influence RNA-based regulation during γ-herpesvirus infection Curr. Opin. Microbiol. 15 2012 506 511
58. H.J. Kwun, S.R. da Silva, H. Qin, R.L. Ferris, R. Tan, Y. Chang, and P.S. Moore The central repeat domain 1 of Kaposi's sarcoma-associated herpesvirus (KSHV) latency associated-nuclear antigen 1 (LANA1) prevents cis MHC class I peptide presentation Virology 412 2011 357 365
59. M. Laplante, and D.M. Sabatini mTOR signaling in growth control and disease Cell 149 2012 274 293
60. A. Levitin, A. Marcil, G. Tettweiler, M.J. Laforest, U. Oberholzer, A.M. Alarco, D.Y. Thomas, P. Lasko, and M. Whiteway Drosophila melanogaster Thor and response to Candida albicans infection Eukaryot. Cell 6 2007 658 663 (Pubitemid 46697546)
61. Y. Li, J. Dai, M. Song, P. Fitzgerald-Bocarsly, and M. Kiledjian Dcp2 decapping protein modulates mRNA stability of the critical interferon regulatory factor (IRF) IRF-7 Mol. Cell. Biol. 32 2012 1164 1172
62. V. Libri, A. Helwak, P. Miesen, D. Santhakumar, J.G. Borger, G. Kudla, F. Grey, D. Tollervey, and A.H. Buck Murine cytomegalovirus encodes a miR-27 inhibitor disguised as a target Proc. Natl. Acad. Sci. USA 109 2012 279 284
63. Y.J. Lim, J.A. Choi, H.H. Choi, S.N. Cho, H.J. Kim, E.K. Jo, J.K. Park, and C.H. Song Endoplasmic reticulum stress pathway-mediated apoptosis in macrophages contributes to the survival of Mycobacterium tuberculosis PLoS ONE 6 2011 e28531
64. P.T. Liu, M. Wheelwright, R. Teles, E. Komisopoulou, K. Edfeldt, B. Ferguson, M.D. Mehta, A. Vazirnia, T.H. Rea, and E.N. Sarno MicroRNA-21 targets the vitamin D-dependent antimicrobial pathway in leprosy Nat. Med. 18 2012 267 273
65. L. Lu, A.-P. Han, and J.-J. Chen Translation initiation control by heme-regulated eukaryotic initiation factor 2α kinase in erythroid cells under cytoplasmic stresses Mol. Cell. Biol. 21 2001 7971 7980 (Pubitemid 33051789)
66. F. Ma, S. Xu, X. Liu, Q. Zhang, X. Xu, M. Liu, M. Hua, N. Li, H. Yao, and X. Cao The microRNA miR-29 controls innate and adaptive immune responses to intracellular bacterial infection by targeting interferon-γ Nat. Immunol. 12 2011 861 869
67. K. Malathi, B. Dong, M. Gale Jr., and R.H. Silverman Small self-RNA generated by RNase L amplifies antiviral innate immunity Nature 448 2007 816 819 (Pubitemid 47266340)
68. L. Martínez-Solano, C. Nombela, G. Molero, and C. Gil Differential protein expression of murine macrophages upon interaction with Candida albicans Proteomics 6 Suppl 1 2006 S133 S144
69. D.L. McEwan, N.V. Kirienko, and F.M. Ausubel Host translational inhibition by Pseudomonas aeruginosa Exotoxin A Triggers an immune response in Caenorhabditis elegans Cell Host Microbe 11 2012 364 374
70. C. McKinney, C. Perez, and I. Mohr Poly(A) binding protein abundance regulates eukaryotic translation initiation factor 4F assembly in human cytomegalovirus-infected cells Proc. Natl. Acad. Sci. USA 109 2012 5627 5632
71. I. Mohr, and Y. Gluzman A herpesvirus genetic element which affects translation in the absence of the viral GADD34 function EMBO J. 15 1996 4759 4766 (Pubitemid 26294594)
72. J.A. Moreno, H. Radford, D. Peretti, J.R. Steinert, N. Verity, M.G. Martin, M. Halliday, J. Morgan, D. Dinsdale, and C.A. Ortori Sustained translational repression by eIF2α-P mediates prion neurodegeneration Nature 485 2012 507 511
73. M. Mulvey, V. Camarena, and I. Mohr Full resistance of herpes simplex virus type 1-infected primary human cells to alpha interferon requires both the Us11 and gamma(1)34.5 gene products J. Virol. 78 2004 10193 10196 (Pubitemid 39187137)
74. J.A. Murphy, R.J. Duerst, T.J. Smith, and L.A. Morrison Herpes simplex virus type 2 virion host shutoff protein regulates alpha/beta interferon but not adaptive immune responses during primary infection in vivo J. Virol. 77 2003 9337 9345 (Pubitemid 37011030)
75. D. Nachmani, N. Stern-Ginossar, R. Sarid, and O. Mandelboim Diverse herpesvirus microRNAs target the stress-induced immune ligand MICB to escape recognition by natural killer cells Cell Host Microbe 5 2009 376 385
76. L. Navarro, F. Jay, K. Nomura, S.Y. He, and O. Voinnet Suppression of the microRNA pathway by bacterial effector proteins Science 321 2008 964 967
77. R.M. O'Connell, D.S. Rao, and D. Baltimore microRNA regulation of inflammatory responses Annu. Rev. Immunol. 30 2012 295 312
78. S. Parrish, and B. Moss Characterization of a vaccinia virus mutant with a deletion of the D10R gene encoding a putative negative regulator of gene expression J. Virol. 80 2006 553 561 (Pubitemid 43062867)
79. S. Parrish, W. Resch, and B. Moss Vaccinia virus D10 protein has mRNA decapping activity, providing a mechanism for control of host and viral gene expression Proc. Natl. Acad. Sci. USA 104 2007 2139 2144 (Pubitemid 46391365)
80. S. Parrish, M. Hurchalla, S.W. Liu, and B. Moss The African swine fever virus g5R protein possesses mRNA decapping activity Virology 393 2009 177 182
81. A. Parsyan, Y. Svitkin, D. Shahbazian, C. Gkogkas, P. Lasko, W.C. Merrick, and N. Sonenberg mRNA helicases: the tacticians of translational control Nat. Rev. Mol. Cell Biol. 12 2011 235 245
82. T.J. Pasieka, B. Lu, S.D. Crosby, K.M. Wylie, L.A. Morrison, D.E. Alexander, V.D. Menachery, and D.A. Leib Herpes simplex virus virion host shutoff attenuates establishment of the antiviral state J. Virol. 82 2008 5527 5535 (Pubitemid 351705260)
83. C. Perez, C. McKinney, U. Chulunbaatar, and I. Mohr Translational control of the abundance of cytoplasmic poly(A) binding protein in human cytomegalovirus-infected cells J. Virol. 85 2011 156 164
84. J.S. Pfingsten, A.E. Castile, and J.S. Kieft Mechanistic role of structurally dynamic regions in Dicistroviridae IGR IRESs J. Mol. Biol. 395 2010 205 217
85. H. Pillich, M. Loose, K.P. Zimmer, and T. Chakraborty Activation of the unfolded protein response by Listeria monocytogenes Cell. Microbiol. 14 2012 949 964
86. J. Piotrowska, S.J. Hansen, N. Park, K. Jamka, P. Sarnow, and K.E. Gustin Stable formation of compositionally unique stress granules in virus-infected cells J. Virol. 84 2010 3654 3665
87. Q.M. Qin, J. Luo, X. Lin, J. Pei, L. Li, T.A. Ficht, and P. de Figueiredo Functional analysis of host factors that mediate the intracellular lifestyle of Cryptococcus neoformans PLoS Pathog. 7 2011 e1002078
88. G.S. Read, and N. Frenkel Herpes simplex virus mutants defective in the virion-associated shutoff of host polypeptide synthesis and exhibiting abnormal synthesis of alpha (immediate early) viral polypeptides J. Virol. 46 1983 498 512 (Pubitemid 13130022)
89. J.M. Richner, K. Clyde, A.C. Pezda, B.Y. Cheng, T. Wang, G.R. Kumar, S. Covarrubias, L. Coscoy, and B. Glaunsinger Global mRNA degradation during lytic gammaherpesvirus infection contributes to establishment of viral latency PLoS Pathog. 7 2011 e1002150
90. K.J. Riley, G.S. Rabinowitz, T.A. Yario, J.M. Luna, R.B. Darnell, and J.A. Steitz EBV and human microRNAs co-target oncogenic and apoptotic viral and human genes during latency EMBO J. 31 2012 2207 2221
91. D. Ron, and P. Walter Signal integration in the endoplasmic reticulum unfolded protein response Nat. Rev. Mol. Cell Biol. 8 2007 519 529 (Pubitemid 46985379)
92. S. Rothenburg, E.J. Seo, J.S. Gibbs, T.E. Dever, and K. Dittmar Rapid evolution of protein kinase PKR alters sensitivity to viral inhibitors Nat. Struct. Mol. Biol. 16 2009 63 70
93. A. Ruggieri, E. Dazert, P. Metz, S. Hofmann, J.P. Bergeest, J. Mazur, P. Bankhead, M.S. Hiet, S. Kallis, and G. Alvisi Dynamic oscillation of translation and stress granule formation mark the cellular response to virus infection Cell Host Microbe 12 2012 71 85
94. A.J. Sadler, and B.R. Williams Interferon-inducible antiviral effectors Nat. Rev. Immunol. 8 2008 559 568 (Pubitemid 351913674)
95. L.N. Schulte, A. Eulalio, H.J. Mollenkopf, R. Reinhardt, and J. Vogel Analysis of the host microRNA response to Salmonella uncovers the control of major cytokines by the let-7 family EMBO J. 30 2011 1977 1989
96. T.A. Seimon, M.J. Kim, A. Blumenthal, J. Koo, S. Ehrt, H. Wainwright, L.G. Bekker, G. Kaplan, C. Nathan, I. Tabas, and D.G. Russell Induction of ER stress in macrophages of tuberculosis granulomas PLoS ONE 5 2010 e12772
97. F.J. Sheedy, E. Palsson-McDermott, E.J. Hennessy, C. Martin, J.J. O'Leary, Q. Ruan, D.S. Johnson, Y. Chen, and L.A. O'Neill Negative regulation of TLR4 via targeting of the proinflammatory tumor suppressor PDCD4 by the microRNA miR-21 Nat. Immunol. 11 2010 141 147
98. N. Shrestha, W. Bahnan, D.J. Wiley, G. Barber, K.A. Fields, and K. Schesser Eukaryotic initiation factor 2 (eIF2) signaling regulates proinflammatory cytokine expression and bacterial invasion J. Biol. Chem. 287 2012 28738 28744
99. M.A. Skabkin, O.V. Skabkina, V. Dhote, A.A. Komar, C.U. Hellen, and T.V. Pestova Activities of Ligatin and MCT-1/DENR in eukaryotic translation initiation and ribosomal recycling Genes Dev. 24 2010 1787 1801
100. R.L. Skalsky, and B.R. Cullen Viruses, microRNAs, and host interactions Annu. Rev. Microbiol. 64 2010 123 141
101. R.L. Skalsky, D.L. Corcoran, E. Gottwein, C.L. Frank, D. Kang, M. Hafner, J.D. Nusbaum, R. Feederle, H.J. Delecluse, and M.A. Luftig The viral and cellular microRNA targetome in lymphoblastoid cell lines PLoS Pathog. 8 2012 e1002484
102. C.M. Spahn, E. Jan, A. Mulder, R.A. Grassucci, P. Sarnow, and J. Frank Cryo-EM visualization of a viral internal ribosome entry site bound to human ribosomes: the IRES functions as an RNA-based translation factor Cell 118 2004 465 475 (Pubitemid 39485666)
103. S.H. Speck, and D. Ganem Viral latency and its regulation: lessons from the gamma-herpesviruses Cell Host Microbe 8 2010 100 115
104. S.R. Starck, and N. Shastri Non-conventional sources of peptides presented by MHC class I Cell. Mol. Life Sci. 68 2011 1471 1479
105. S.R. Starck, V. Jiang, M. Pavon-Eternod, S. Prasad, B. McCarthy, T. Pan, and N. Shastri Leucine-tRNA initiates at CUG start codons for protein synthesis and presentation by MHC class I Science 336 2012 1719 1723
106. N. Stern-Ginossar, N. Elefant, A. Zimmermann, D.G. Wolf, N. Saleh, M. Biton, E. Horwitz, Z. Prokocimer, M. Prichard, and G. Hahn Host immune system gene targeting by a viral miRNA Science 317 2007 376 381 (Pubitemid 47106378)
107. M.F. Stinski Synthesis of proteins and glycoproteins in cells infected with human cytomegalovirus J. Virol. 23 1977 751 767 (Pubitemid 8172794)
108. Z. Tallóczy, W. Jiang, H.W. Virgin 4th, D.A. Leib, D. Scheuner, R.J. Kaufman, E.L. Eskelinen, and B. Levine Regulation of starvation- and virus-induced autophagy by the eIF2α kinase signaling pathway Proc. Natl. Acad. Sci. USA 99 2002 190 195 (Pubitemid 34060339)
109. M.W. Tan, S. Mahajan-Miklos, and F.M. Ausubel Killing of Caenorhabditis elegans by Pseudomonas aeruginosa used to model mammalian bacterial pathogenesis Proc. Natl. Acad. Sci. USA 96 1999 715 720 (Pubitemid 29061274)
110. I. Tattoli, M.T. Sorbara, D. Vuckovic, A. Ling, F. Soares, L.A. Carneiro, C. Yang, A. Emili, D.J. Philpott, and S.E. Girardin Amino acid starvation induced by invasive bacterial pathogens triggers an innate host defense program Cell Host Microbe 11 2012 563 575
111. J. Tellam, C. Smith, M. Rist, N. Webb, L. Cooper, T. Vuocolo, G. Connolly, D.C. Tscharke, M.P. Devoy, and R. Khanna Regulation of protein translation through mRNA structure influences MHC class I loading and T cell recognition Proc. Natl. Acad. Sci. USA 105 2008 9319 9324
112. V. Truniger, and M.A. Aranda Recessive resistance to plant viruses Adv. Virus Res. 75 2009 119 159
113. I. Ventoso, M.A. Sanz, S. Molina, J.J. Berlanga, L. Carrasco, and M. Esteban Translational resistance of late alphavirus mRNA to eIF2α phosphorylation: a strategy to overcome the antiviral effect of protein kinase PKR Genes Dev. 20 2006 87 100 (Pubitemid 43042670)
114. D. Walsh, and I. Mohr Assembly of an active translation initiation factor complex by a viral protein Genes Dev. 20 2006 461 472 (Pubitemid 43244400)
115. D. Walsh, and I. Mohr Viral subversion of the host protein synthesis machinery Nat. Rev. Microbiol. 9 2011 860 875
116. D. Walsh, C. Arias, C. Perez, D. Halladin, M. Escandon, T. Ueda, R. Watanabe-Fukunaga, R. Fukunaga, and I. Mohr Eukaryotic translation initiation factor 4F architectural alterations accompany translation initiation factor redistribution in poxvirus-infected cells Mol. Cell. Biol. 28 2008 2648 2658 (Pubitemid 351542365)
117. D. Walsh, M. Mathews, and I. Mohr Tinkering with translation: Protein synthesis in virus-infected cells J.W.B. Hershey, N. Sonenberg, M.B. Mathews, Protein Synthesis and Translational Control 2012 Cold Spring Harbor Laboratory Press Cold Spring Harbor, New York 299 326
118. T. Weichhart, G. Costantino, M. Poglitsch, M. Rosner, M. Zeyda, K.M. Stuhlmeier, T. Kolbe, T.M. Stulnig, W.H. Hörl, and M. Hengstschläger The TSC-mTOR signaling pathway regulates the innate inflammatory response Immunity 29 2008 565 577
119. J.P. White, and R.E. Lloyd Regulation of stress granules in virus systems Trends Microbiol. 20 2012 175 183
120. J.P. White, A.M. Cardenas, W.E. Marissen, and R.E. Lloyd Inhibition of cytoplasmic mRNA stress granule formation by a viral proteinase Cell Host Microbe 2 2007 295 305 (Pubitemid 350056396)
121. A.C. Wilson, and I. Mohr A cultured affair: HSV latency and reactivation in neurons Trends Microbiol. 2012 10.1016/j.tim.2012.08.005 Published online September 7, 2012
122. J.E. Wilson, T.V. Pestova, C.U. Hellen, and P. Sarnow Initiation of protein synthesis from the A site of the ribosome Cell 102 2000 511 520
123. J.J. Wolfson, K.L. May, C.M. Thorpe, D.M. Jandhyala, J.C. Paton, and A.W. Paton Subtilase cytotoxin activates PERK, IRE1 and ATF6 endoplasmic reticulum stress-signalling pathways Cell. Microbiol. 10 2008 1775 1786
124. S. Won, C. Eidenschenk, C.N. Arnold, O.M. Siggs, L. Sun, K. Brandl, T.-M. Mullen, G.R. Nemerow, E.M.Y. Moresco, and B. Beutler Increased susceptibility to DNA virus infection in mice with a GCN2 mutation J. Virol. 86 2012 1802 1808
125. C.W. Woo, D. Cui, J. Arellano, B. Dorweiler, H. Harding, K.A. Fitzgerald, D. Ron, and I. Tabas Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling Nat. Cell Biol. 11 2009 1473 1480
126. C.W. Woo, L. Kutzler, S.R. Kimball, and I. Tabas Toll-like receptor activation suppresses ER stress factor CHOP and translation inhibition through activation of eIF2B Nat. Cell Biol. 14 2012 192 200
127. J.W. Yewdell DRiPs solidify: progress in understanding endogenous MHC class I antigen processing Trends Immunol. 32 2011 548 558
128. Y. Yin, B. Manoury, and R. Fåhraeus Self-inhibition of synthesis and antigen presentation by Epstein-Barr virus-encoded EBNA1 Science 301 2003 1371 1374 (Pubitemid 37075811)
129. K. Zhang, X. Shen, J. Wu, K. Sakaki, T. Saunders, D.T. Rutkowski, S.H. Back, and R.J. Kaufman Endoplasmic reticulum stress activates cleavage of CREBH to induce a systemic inflammatory response Cell 124 2006 587 599 (Pubitemid 43199443)
130. L. Zhao, B.K. Jha, A. Wu, R. Elliott, J. Ziebuhr, A.E. Gorbalenya, R.H. Silverman, and S.R. Weiss Antagonism of the interferon-induced OAS-RNase L pathway by murine coronavirus ns2 protein is required for virus replication and liver pathology Cell Host Microbe 11 2012 607 616