Transforming a drug/H+ antiporter into a polyamine importer by a single mutation

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 42, 2012, Pages 16894-16899

  Brill, Shlomo ^a   Falk, Ofir Sade ^a   Schuldiner, Shimon ^a  

^a HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

Ion coupled transporters; Membrane proteins; Putrescine; SMR multidrug transporters

Indexed keywords

ANTIPORTER; EMRE PROTEIN; ERYTHROMYCIN; GLYCINE; MULTIDRUG RESISTANCE PROTEIN; NORFLOXACIN; POLYAMINE; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; CONTROLLED STUDY; ELECTROCHEMISTRY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; MOLECULAR RECOGNITION; MUTATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN TRANSPORT;

ANTIPORTERS; CARBON RADIOISOTOPES; DIRECTED MOLECULAR EVOLUTION; DRUG RESISTANCE, MULTIPLE, BACTERIAL; ERYTHROMYCIN; ESCHERICHIA COLI; ESCHERICHIA COLI PROTEINS; MUTAGENESIS; MUTATION; NORFLOXACIN; PLASMIDS; POLYAMINES; PROTEOLIPIDS; PUTRESCINE;

EID: 84867635731     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1211831109     Document Type: Article

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