Chronic edema of the lower extremities: International consensus recommendations for compression therapy clinical research trials

International Angiology

Volumn 31, Issue 4, 2012, Pages 316-329

  Stout, N ^a   Partsch, H ^b   Szolnoky, G ^c   Forner Cordero, I ^d   Mosti, G ^e   Mortimer, P ^f   Flour, M ^g   Damstra, R ^h   Piller, N ⁱ   Geyer, M J ^j   Benigni, J P ^k   Moffat, C ^l   Cornu Thenard, A ^m   Schingale, F ⁿ   Clark, M ^o   Chauveau, M ^p  

^a WALTER REED ARMY MEDICAL CENTER   (United States)

^b Universitatsklinik fur Dermatologie   (Austria)

^c UNIVERSITY OF SZEGED   (Hungary)

^d HOSPITAL UNIVERSITARIO LA FE   (Spain)

^e Barbantini Hospital   (Italy)

^f ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^g UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^h NIJ SMELLINGHE HOSPITAL   (Netherlands)

ⁱ FLINDERS MEDICAL CENTRE   (Australia)

^j UNIVERSITY OF PITTSBURGH   (United States)

^k SERVICE D ENDOCRINOLOGIE   (France)

^l UNIVERSITY OF WEST LONDON   (United Kingdom)

^m HÔPITAL SAINT ANTOINE   (France)

ⁿ Lympho Opt Clinic   (Germany)

^o CARDIFF UNIVERSITY   (United Kingdom)

^p Boucicaut   (France)

more..

Author keywords

Compression stockings; Consensus; Edema

Indexed keywords

ANTHROPOMETRY; BED REST; BLOOD CLOT; CLINICAL RESEARCH; COMPRESSION BANDAGE; COMPRESSION STOCKING; COMPRESSION THERAPY; CONSENSUS; DIFFERENTIAL DIAGNOSIS; DISEASE DURATION; ERYSIPELAS; GOOD CLINICAL PRACTICE; HUMAN; INTERMITTENT PNEUMATIC COMPRESSION DEVICE; LEG EDEMA; LEG SWELLING; PATHOPHYSIOLOGY; PRESSURE MEASUREMENT; RASH; RECURRENT CANCER; REVIEW; TREATMENT OUTCOME;

CHRONIC DISEASE; CLINICAL TRIALS AS TOPIC; CONSENSUS; COOPERATIVE BEHAVIOR; EDEMA; EVIDENCE-BASED MEDICINE; HUMANS; INTERMITTENT PNEUMATIC COMPRESSION DEVICES; INTERNATIONAL COOPERATION; LOWER EXTREMITY; RESEARCH DESIGN; STOCKINGS, COMPRESSION; TREATMENT OUTCOME;

EID: 84867612752     PISSN: 03929590     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (105)

1. Partsch H, Stout N, Forner-Cordero I, Flour M, Moffatt C, Szuba A et al. Clinical trials needed to evaluate compression therapy in breast cancer related lymphedema (BCRL). Proposals from an expert group. Int Angiol 2010;29:442-53.
2. Moffatt CJ, Franks PJ, Doherty DC, Williams AF, Badger C, Jeffs E et al. Lymphoedema: an underestimated health problem. QJM 2003;96:731-8. (Pubitemid 37259362)
3. Rabe E, Pannier-Fischer F, Bromen K, Schuldt K, Stang A, Poncar C et al. [Bonn Vein Study by the German Society of Phlebology - Epidemiological study to investigate the prevalence and severity of chronic venous disorders in the urban and rural residential populations]. Phlebologie 2003;32:1-14.
4. Martin-Pfitzenmeyer I, Gauthier S, Bailly M, Loi N, Popitean L, d'Athis P et al. Prognostic factors in stage D heart failure in the very elderly. Gerontology 2009;55:719-26.
5. Bouchard J, Soroko SB, Chertow GM, Himmelfarb J, Ikizler TA, Paganini EP et al. Fluid accumulation, survival and recovery of kidney function in critically ill patients with acute kidney injury. Kidney Int 2009;76:422-7.
6. Del Rio-Santiago VJ, Rodriguez-Ospina L, Cordova HR, Vicenty SI. Congestive heart failure and renal complications. Bol Asoc Med PR 2008;100:29-37.
7. McLafferty RB, Lohr JM, Caprini JA, Passman MA, Padberg FT, Rooke TW et al. Results of the national pilot screening program for venous disease by the American Venous Forum. J Vasc Surg 2007;45:142-8.
8. Starling EH. On the absorption of fluids from the connective tissue spaces. J Physiol 1896;19:312-26.
9. Levick JR, Michel CC. Microvascular fluid exchange and the revised Starling principle. Cardiovasc Res 2010;87:198-210.
10. Casley-Smith JR, Casley-Smith JR. The pathophysiology of lymphedema and the action of benzopyrones in reducing it. Lymphology 1988;21:190-4. (Pubitemid 19024771)
11. Rutkowski JM, Markhus CE, Gyenge CC, Alitalo K, Wiig H, Swartz MA. Dermal collagen and lipid deposition correlate with tissue swelling and hydraulic conductivity in murine primary lymphedema. Am J Pathol 2010;176:1122-9.
12. nd ed. Munchen (Germany): Elsevier GmbH, Urban & Fisher Verlag; 2006.
13. Mortimer PS. Evaluation of lymphatic function: abnormal lymph drainage in venous disease. Int Angiol 1995;14(3Suppl l):32-5. (Pubitemid 26047741)
14. Felty CL, Rooke TW. Compression therapy for chronic venous insufficiency. Semin Vasc Surg 2005;18:36-40. (Pubitemid 40386977)
15. Cho S, Atwood JE. Peripheral edema. Am J Med 2002;113:580-6. (Pubitemid 35379914)
16. Keeley V. Pharmacological treatment for chronic oedema. Br J Community Nurs 2008;13:S4-S6, S8-10.
17. Mortimer PS, Levick JR. Chronic peripheral oedema: the critical role of the lymphatic system. Clin Med 2004;4:448-53. (Pubitemid 39457274)
18. Herschthal J, Kirsner RS. Current management of venous ulcers: an evidence-based review. Surg Technol Int 2008;17:77-83.
19. Al Gahtani FH, Al-Diab AI, Isnani AC. Practices and perceptions of physicians to prescribing elastic compression stockings in a single center in Saudi Arabia. Saudi Med J 2009;30:1465-8.
20. Arpaia G, Carpenedo M, Pistelli R, Mastrogiacomo O, Cimminiello C, Agnelli G. Attitudes to prescribing compression stockings for patients with acute dvt: the MASTER registry. J Thromb Thrombolysis 2009;28:389-93.
21. Maylor ME. Accurate selection of compression and antiembolic hosiery. Br J Nurs 2001;10:1172-84.
22. Herouy Y, Kahle B, Idzko M, Eberth I, Norgauer J, Pannier F et al. Tight junctions and compression therapy in chronic venous insufficiency. Int J Mol Med 2006;18:215-9.
23. Armstrong S, Woollons S. Compression hosiery. Prof Nurse 1998;14:49-56.
24. Moffatt C, Kommala D, Dourdin N, Choe Y. Venous leg ulcers: patient concordance with compression therapy and its impact on healing and prevention of recurrence. Int Wound J 2009;6:386-93.
25. Berliner E, Ozbilgin B, Zarin DA. A systematic review of pneumatic compression for treatment of chronic venous insufficiency and venous ulcers. J Vasc Surg 2003;37:539-44. (Pubitemid 36350896)
26. Partsch H, Flour M, Smith PC. Indications for compression therapy in venous and lymphatic disease consensus based on experimental data and scientific evidence. Under the auspices of the IUP. Int Angiol 2008;27:193-219.
27. Nelson EA, Mani R, Vowden K. Intermittent pneumatic compression for treating venous leg ulcers. Cochrane Database of Systematic Reviews 2008, Issue 2. Art. No.: CD001899. DOI: 10.1002/14651858.CD001899.pub2.
28. Belczak CE, de Godoy JM, Ramos RN, de Oliveira MA, Belczak SQ, Caffaro RA. Is the wearing of elastic stockings for half a day as effective as wearing them for the entire day? Br J Dermatol 2010;162:42-5.
29. Badger CM, Preston NJ, Seers K, Mortimer PS. Antibiotics /anti-inflammatories for reducing acute inflammatory episodes in lymphoedema of the limbs. Cochrane Database Syst Rev 2009;1:CD003143.
30. Partsch H, Blättler W. Compression and walking versus bed rest in the treatment of proximal deep venous thrombosis with low molecular weight heparin. J Vasc Surg 2000;32:861-9.
31. Raţiu A, Motoc A, Pǎ;scuţ D, Crişan DC, Anca T, Pǎ;scuţ M. Compression and walking compared with bed rest in the treatment of proximal deep venous thrombosis during pregnancy. Rev Med Chir Soc Med Nat Iasi 2009;113:795-8.
32. Lewis M, Morgan K. Managing chronic oedema: a collaborative community approach. Br J Community Nurs 2008;13:S25-6, S28-32.
33. Green T. Understanding body image in patients with chronic oedema. Br J Community Nurs 2008;13:S15-18.
34. Pain SJ, Vowler SL, Purushotham AD. Is physical function a more appropriate measure than volume excess in the assessment of breast cancer-related lymphoedema (BCRL)? Eur J Cancer 2003;39:2168-72. (Pubitemid 37297741)
35. Castonguay G. Short-stretch or four-layer compression bandages: an overview of the literature. Ostomy Wound Manage 2008;54:50-5.
36. Brizzio E, Amsler F, Lun B, Blattler W. Comparison of low-strength compression stockings with bandages for the treatment of recalcitrant venous ulcers. J Vasc Surg 2010;51:410-6.
37. Benigni JP, Lazareth I, Parpex P, Gerard JL, Alves M, Vin F et al. Efficacy, safety and acceptability of a new two-layer bandage system for venous leg ulcers. J Wound Care 2007;16:385-90.
38. Diehm C, Trampisch HJ, Lange S, Schmidt C. Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiency. Lancet 1996;347:292-4. (Pubitemid 26041041)
39. Vayssairat M, Ziani E, Houot B. [Placebo controlled efficacy of class 1 elastic stockings in chronic venous insufficiency of the lower limbs]. J Mal Vasc 2000;25:256-62.
40. Benigni JP, Sadoun S, Allaert FA, Vin F. Efficacy of Class 1 elastic compression stockings in the early stages of chronic venous disease. A comparative study. Int Angiol 2003;22:383-92. (Pubitemid 38324807)
41. Clarke MJ, Hopewell S, Juszczak E, Eisinga A, Kjeldstrøm M. Compression stockings for preventing deep vein thrombosis in airline passengers. Cochrane Database of Systematic Reviews 2006;2:CD004002. DOI: 10.1002/14651858.CD004002.pub2.
42. Amsler F, Blattler W. Compression therapy for occupational leg symptoms and chronic venous disorders - a meta-analysis of randomised controlled trials. Eur J Vasc Endovasc Surg 2008;35:366-72. (Pubitemid 351264788)
43. Vanscheidt W, Ukat A, Partsch H. Dose-response of compression therapy for chronic venous edema-higher pressures are associated with greater volume reduction: two randomized clinical studies. J Vasc Surg 2009;49:395-402.
44. Damstra RJ, Partsch H. Compression therapy in breast cancer-related lymphedema: A randomized, controlled comparative study of relation between volume and interface pressure changes. J Vasc Surg 2009;49:1256-63.
45. Blattler W, Partsch H. Leg compression and ambulation is better than bed rest for the treatment of acute deep venous thrombosis. Int Angiol 2003;22:393-400. (Pubitemid 38324808)
46. Brandjes DP, Büller HR, Heijboer H, Huisman MV, de Rijk M, Jagt H et al. Randomised trial of effect of compression stockings in patients with symptomatic proximal-vein thrombosis. Lancet 1997;349:759-62. (Pubitemid 27122458)
47. Prandoni P, Lensing AW, Prins MH, Frulla M, Marchiori A, Bernardi E et al. Below-knee elastic compression stockings to prevent the post-thrombotic syndrome: a randomized, controlled trial. Ann Intern Med 2004;141:249-56.
48. Kolbach DN, Sandbrink MWC, Hamulyak K, Prins MH, Neumann MHAM. Non-pharmaceutical measures for prevention of post-thrombotic syndrome. Cochrane Database of Systematic Reviews 2003;3:CD004174. DOI: 10.1002/14651858.CD004174. pub2.
49. Kolbach DN, Sandbrink MWC, Prins MH, Neumann MHAM. Compression therapy for treating stage I and II (Widmer) post-thrombotic syndrome. Cochrane Database of Systematic Reviews 2003;4:CD004177. DOI: 10.1002/14651858.CD004177.
50. Partsch H, Kaulich M, Mayer W. Immediate mobilisation in acute vein thrombosis reduces post-thrombotic syndrome. Int Angiol 2004;23:206-12. (Pubitemid 40090113)
51. Arpaia G, Cimminiello C, Mastrogiacomo O, de Gaudenzi E. Efficacy of elastic compression stockings used early or after resolution of the edema on recanalization after deep venous thrombosis: the COM.PRE Trial. Blood Coagul Fibrinolysis 2007;18:131-7. (Pubitemid 46232833)
52. Roumen-Klappe EM, den Heijer M, van Rossum J, Wollersheim H, van der Vleuten C, Thien T, et al. Multilayer compression bandaging in the acute phase of deep-vein thrombosis has no effect on the development of the post-thrombotic syndrome. J Thromb Thrombolysis 2009;27:400-5.
53. Badger CM, Peacock JL, Mortimer PS. A randomized, controlled, parallel-group clinical trial comparing multilayer bandaging followed by hosiery versus hosiery alone in the treatment of patients with lymphedema of the limb. Cancer 2000;88:2832-7. (Pubitemid 30417946)
54. Damstra RJ, Brouwer ER, Partsch H. Controlled, comparative study of relation between volume changes and interface pressure under short-stretch bandages in leg lymphedema patients. Dermatol Surg 2008;34:773-8. (Pubitemid 351792288)
55. Yasuhara H, Shigematsu H, Muto T. A study of the advantages of elastic stockings for leg lymphedema. Int Angiol 1996;15:272-7. (Pubitemid 26413851)
56. World Health Organization. International Classification of Functioning, Disability and Health: ICF. Geneva (Switzerland): World Health Organization; 2001.
57. Hudak PL, Amadio PC, Bombardier C. Development of an upper extremity outcome measure: the DASH (disabilities of the arm, shoulder and hand) [corrected]. The Upper Extremity Collaborative Group (UECG). Am J Ind Med 1996;29:602-8. Erratum in: Am J Ind Med 1996;30:372.
58. Mosti G, Mattaliano V, Partsch H. Inelastic compression increases venous ejection fraction more than elastic bandages in patients with superficial venous reflux. Phlebology 2008;23:287-94.
59. Pierce C, McLeod KJ. Feasibility of treatment of lower limb edema with calf muscle pump stimulation in chronic heart failure. Eur J Cardiovasc Nurs 2009;8:345-8.
60. Olszewski WL. Contractility patterns of human leg lymphatics in various stages of obstructive lymphedema. Ann N Y Acad Sci 2008;1131:110-8. (Pubitemid 351758508)
61. Foldi E, Sauerwald A, Hennig B. Effect of complex decongestive physiotherapy on gene expression for the inflammatory response in peripheral lymphedema. Lymphology 2000;33:19-23. (Pubitemid 30198825)
62. Beidler SK, Douillet CD, Berndt DF, Keagy BA, Rich PB, Marston WA. Inflammatory cytokine levels in chronic venous insufficiency ulcer tissue before and after compression therapy. J Vasc Surg 2009;49:1013-20.
63. Murphy MA, Joyce WP, Condron C, Bouchier-Hayes D. A reduction in serum cytokine levels parallels healing of venous ulcers in patients undergoing compression therapy. Eur J Vasc Endovasc Surg 2002;23:349-352. (Pubitemid 41079447)
64. Miranda F Jr, Perez MC, Castiglioni ML, Juliano Y, Amorim JE, Nakano LC et al. Effect of sequential interminent pneumatic compression on both leg lymphedema volume and on lymph transport as semi-quantitatively evaluated by lymphoscintigraphy. Lymphology 2001;34:135-41. (Pubitemid 32801936)
65. Stout Gergich NL, Pfalzer LA, McGarvey C, Springer B, Gerber LH, Soballe P. Preoperative assessment enables the early diagnosis and successful treatment of lymphedema. Cancer 2008;112:2809-19. (Pubitemid 351969228)
66. Hagan MJ, Lambert SM. A randomised crossover study of low-ankle-pressure graduated-compression tights in reducing flight-induced ankle oedema. Med J Aust 2008;188:81-4.
67. Brorson H, Ohlin K, Olsson G, Svensson B, Svensson H. Controlled compression and liposuction treatment for lower extremity lymphedema. Lymphology 2008;41:52-63. (Pubitemid 352031245)
68. Lymphoedema Framework. Best Practice for the management of lymphoedema. International consensus. London: MEP Ltd; 2006.
69. Partsch H, Clark M, Mosti G, Steinlechner E, Schuren J, Abel M et al. Classification of compression bandages: practical aspects. Dermatol Surg 2008;34:600-9. (Pubitemid 351569478)
70. Mosti G, Mattaliano V, Partsch H. Influence of different materials in multicomponent bandages on pressure and stiffness of the final bandage. Dermatol Surg 2008;34:631-9. (Pubitemid 351569482)
71. Partsch H, Clark M, Bassez S, Benigni JP, Becker F, Blazek V et al. Measurement of lower leg compression in vivo: recommendations for the performance of measurements of interface pressure and stiffness: consensus statement. Dermatol Surg 2006;32:224-32.
72. Partsch H. Intermittent pneumatic compression in immobile patients. Int Wound J 2008;5:389-97. (Pubitemid 351874522)
73. Kalodiki E, Giannoukas AD.Intermittent pneumatic compression (IPC) in the treatment of peripheral arterial occlusive disease (PAOD) - A useful tool or just another device? Eur J Vasc Endovasc Surg 2007;33:309-10. (Pubitemid 46196399)
74. The Cochrane Collaboration [Internet]. Oxford (UK): Update Software Ltd. c 2001-2010. Structure of a Cochrane Review; 2010 [cited 2010 Sept 30]. Available from: http://www.cochrane.org/cochrane-reviews/review-structure.html
75. Chen YW, Tsai HJ, Hung HC, Tsauo JY. Reliability study of measurements for lymphedema in breast cancer patients. Am J Phys Med Rehabil 2008;87:33-8.
76. Gebruers N, Truijen S, Engelborghs S, De Deyn PP. Volumetric evaluation of upper extremities in 250 healthy persons. Clin Physiol Funct Imaging 2007;27:17-22. (Pubitemid 44921635)
77. Damstra RJ, Glazenburg EJ, Hop WC. Validation of the inverse water volumetry method: A new gold standard for arm volume measurements. Breast Cancer Res Treat 2006;99:267-73. (Pubitemid 44337918)
78. Karges JR, Mark BE, Stikeleather SJ, Worrell TW Concurrent validity of upper-extremity volume estimates: comparison of calculated volume derived from girth measurements and water displacement volume. Phys. Ther 2003;83:134-45. (Pubitemid 36169384)
79. Taylor R, Jayasinghe UW, Koelmeyer L, Ung O, Boyages J. Reliability and validity of arm volume measurements for assessment of lymphedema. Phys Ther 2006;86:205-14. (Pubitemid 43190716)
80. Megens AM, Harris SR, Kim-Sing C, McKenzie DC. Measurement of upper extremity volume in women after axillary dissection for breast cancer. Arch Phys Med Rehabil 2001;82:1639-44. (Pubitemid 33126666)
81. Sander AP, Hajer NM, Hemenway K, Miller AC. Upper-extremity volume measurements in women with lymphedema: a comparison of measurements obtained via water displacement with geometrically determined volume. Phys Ther 2002;82:1201-12. (Pubitemid 35425213)
82. Tierney S, Aslam M, Rennie K, Grace P. Infrared optoelectronic volumetry, the ideal way to measure limb volume. Eur J Vasc Endovasc Surg 1996;12: 412-7. (Pubitemid 27032783)
83. Stanton AW, Northfield JW, Holroyd B, Mortimer PS, Levick JR. Validation of an optoelectronic limb volumeter (Perometer). Lymphology 1997;30:77-97. (Pubitemid 27283750)
84. Godoy JM, Silva SH, Godoy MF. Sensitivity and specificity of combined perimetric and volumetric evaluations in the diagnosis of arm lymphedema. Prague Med Rep 2007;108:243-7.
85. Liu NF, Wang CG. The role of magnetic resonance imaging in diagnosis of peripheral lymphatic disorders. Lymphology 1998;31:119-27.
86. Tomczak H, Nyka W, Lass P. Lymphoedema: lympho-scintigraphy versus other diagnostic techniques - a clinician's point of view. Nucl Med Rev Cent East Eur 2005;8:37-43. (Pubitemid 40916653)
87. Witte CL, Witte MH. Diagnostic and interventional imaging of lymphatic disorders. Int Angiol 1999;18:25-30. (Pubitemid 29253665)
88. Warren AG, Janz BA, Slavin SA, Borud LJ. The use of bioimpedance analysis to evaluate lymphedema. Ann Plast Surg 2007;58:541-3. (Pubitemid 46659146)
89. Cornish BH, Bunce IH, Ward LC, Jones LC, Thomas BJ. Bioelectrical impedance for monitoring the efficacy of lymphoedema treatment programmes. Breast Cancer Res Treat 1996;38:169-76. (Pubitemid 26102144)
90. Cornish BH, Thomas BJ, Ward LC, Hirst C, Bunce IH. A new technique for the quantification of peripheral edema with application in both unilateral and bilateral cases. Angiology 2002;53:41-47. (Pubitemid 34141889)
91. Brown J. A clinically useful method for evaluating lymphedema. Clin J Oncol Nurs 2004;8:35-8.
92. Cornish BH, Chapman M, Hirst C, Mirolo B, Bunce IH, Ward LC et al. Early diagnosis of lymphedema using multiple frequency bioimpedance. Lymphology 2001;34:2-11. (Pubitemid 32549826)
93. Bagheri S, Ohlin K, Olsson G, Brorson H. Tissue tonometry before and after liposuction of arm lymphedema following breast cancer. Lymphat Res Biol 2005;3:66-80. (Pubitemid 41386629)
94. Geyer MJ, Brienza DM, Chib V, Wang J. Quantifying fibrosis in venous disease: mechanical properties of lipodermatosclerotic and healthy tissue. Adv Skin Wound Care 2004;17:131-42.
95. Huang YP, Zheng YP, Leung SF, Choi AP. High frequency ultrasound assessment of skin fibrosis: clinical results. Ultrasound Med Biol 2007;33:1191-8. (Pubitemid 47102529)
96. Medical Compression Hosiery Quality Assurance, RALGZ 387/1. Deutsches Institut für Gütesicherung und Kennzeichnung e.V.; Beuth Verlag, Berlin 2000. Avalaible from: http://www.medirus.ru/templates/images/ rubrics/ral-gz-387-l-hosiery-0108.pdf
97. Augustin M, Bross F, Földi E, Vanscheidt W, Zschocke I. Development, validation and clinical use of the FLQA-I, a disease-specific quality of life questionnaire for patients with lymphedema. Vasa 2005;34:31-5. (Pubitemid 40321813)
98. Van Hecke A, Grypdonck M, Defloor T. Guidelines for the management of venous leg ulcers: a gap analysis. J Eval Clin Pract 2008;14:812-22.
99. Zon R, Meropol NJ, Catalano RB, Schilsky RL. American Society of Clinical Oncology Statement on minimum standards and exemplary attributes of clinical trial sites. J Clin Oncol 2008;26:2562-7.
100. Sarzotti-Kelsoe M, Cox J, Cleland N, Denny T, Hural J, Needham L et al. Evaluation and recommendations on good clinical laboratory practice guidelines for phase I-III clinical trials. PLoS Med 2009;6:e1000067.
101. Reveiz L, Krleza-Jerić K. CONSORT 2010. Lancet 2010;376:230.
102. Scottish Intercollegiate Guidelines Network. SIGN 50. A guideline developers handbook. [Internet]. Edinburgh (United Kingdom): Scottish Intercollegiate Guidelines Network; 2008 Jan [cited 2011 Feb 5]. 112 p. Avalaible from: http://www.sign.ac.uk/pdf/sign50.pdf
103. Trotti A, Colevas AD, Setser A, Rusch V, Jaques D, Budach V et al. CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment. Semin Radiat Oncol 2003;13:176-81.
104. Vignes S, Arrault M. [Adverse effects of compression in treatment of limb lymphedema]. J Mal Vasc 2009;34:338-45.
105. Chauveau M, Fullana JM, Gelade P, Vicaut E, Flaud P. Digital simulation of venous and lymphatic edema, of the effects of compression. J Mal Vasc 2011;36:9-15.