메뉴 건너뛰기




Volumn 32, Issue 9, 2012, Pages 856-868

Drug dosing based on weight and body surface area: Mathematical assumptions and limitations in obese adults

Author keywords

Allometry; Body surface area; Dosing; Fat free; Ideal; Lean; Obesity; Weight

Indexed keywords

AMIKACIN; AMINOGLYCOSIDE ANTIBIOTIC AGENT; AMPHOTERICIN B; ANTICOAGULANT AGENT; ANTIINFECTIVE AGENT; ANTINEOPLASTIC AGENT; AZTREONAM; CARDIOVASCULAR AGENT; CENTRAL NERVOUS SYSTEM AGENTS; COLISTIN; DAPTOMYCIN; ENROFLOXACIN; TELAVANCIN; VANCOMYCIN;

EID: 84867600008     PISSN: 02770008     EISSN: None     Source Type: Journal    
DOI: 10.1002/j.1875-9114.2012.01108.x     Document Type: Review
Times cited : (143)

References (75)
  • 1
    • 33947330282 scopus 로고    scopus 로고
    • World Health Organization, Accessed November 18
    • World Health Organization. Global database on body mass index: BMI classification. http://apps.who.int/bmi/index.jsp?introPage=intro-3.html. Accessed November 18, 2011.
    • (2011) Global database on body mass index: BMI classification.
  • 2
    • 77955802588 scopus 로고    scopus 로고
    • Estimating the glomerular filtration rate in obese adult patients for drug dosing
    • Pai MP. Estimating the glomerular filtration rate in obese adult patients for drug dosing. Adv Chronic Kindey Dis 2010;17: e53-e62.
    • (2010) Adv Chronic Kindey Dis , vol.17
    • Pai, M.P.1
  • 3
    • 0016278917 scopus 로고
    • Case study number 25 gentamicin therapy
    • Devine B. Case study number 25 gentamicin therapy. Drug Intell Clin Pharm 1974;8:650-655.
    • (1974) Drug Intell Clin Pharm , vol.8 , pp. 650-655
    • Devine, B.1
  • 4
    • 0020625997 scopus 로고
    • Influence of weight on aminoglycoside pharmacokinetics in normal weight and morbidly obese patients
    • Bauer LA, Edwards WA, Dellinger EP, Simonowitz DA. Influence of weight on aminoglycoside pharmacokinetics in normal weight and morbidly obese patients. Eur J Clin Pharmacol 1983;24:643-647.
    • (1983) Eur J Clin Pharmacol , vol.24 , pp. 643-647
    • Bauer, L.A.1    Edwards, W.A.2    Dellinger, E.P.3    Simonowitz, D.A.4
  • 5
    • 0004245626 scopus 로고
    • London: Her Majesty's Stationery Office
    • James W. Research on obesity. London: Her Majesty's Stationery Office; 1976.
    • (1976) Research on Obesity
    • James, W.1
  • 7
    • 33744839368 scopus 로고
    • Clinical calorimetry. Tenth paper. A formula to estimate the approximate surface area if height and weight be known
    • Du Bois D, Du Bois EF. Clinical calorimetry. Tenth paper. A formula to estimate the approximate surface area if height and weight be known. Arch Intern Med 1916;17:863.
    • (1916) Arch Intern Med , vol.17 , pp. 863
    • Du Bois, D.1    Du Bois, E.F.2
  • 8
    • 0023662620 scopus 로고
    • Simplified calculation of body surfaced area
    • Mosteller RD. Simplified calculation of body surfaced area. N Engl J Med 1987;317:1098.
    • (1987) N Engl J Med , vol.317 , pp. 1098
    • Mosteller, R.D.1
  • 9
    • 3843141820 scopus 로고    scopus 로고
    • What is the best size descriptor to use for pharmacokinetic studies in the obese?
    • Green B, Duffull SB. What is the best size descriptor to use for pharmacokinetic studies in the obese? Br J Clin Pharmacol 2004;58:119-133.
    • (2004) Br J Clin Pharmacol , vol.58 , pp. 119-133
    • Green, B.1    Duffull, S.B.2
  • 11
    • 0014825326 scopus 로고
    • Estimation of human body surface area from height and weight
    • Gehan EA, George SL. Estimation of human body surface area from height and weight. Cancer Chemother Rep 1970;54:225-235.
    • (1970) Cancer Chemother Rep , vol.54 , pp. 225-235
    • Gehan, E.A.1    George, S.L.2
  • 12
    • 0034830234 scopus 로고    scopus 로고
    • Body surface area prediction in normalweight and obese patients
    • Livingston EH, Lee S. Body surface area prediction in normalweight and obese patients. Am J Physiol Endocrinol Metab 2001;281:E586-E591.
    • (2001) Am J Physiol Endocrinol Metab , vol.281
    • Livingston, E.H.1    Lee, S.2
  • 13
    • 0017864678 scopus 로고
    • Geometric method for measuring body surface area. A height weight formula validated in infants, children and adults
    • Haycock GB, Schwartz GJ, Wisotsky DH. Geometric method for measuring body surface area. A height weight formula validated in infants, children and adults. J Pediatr 1978;93:62-66.
    • (1978) J Pediatr , vol.93 , pp. 62-66
    • Haycock, G.B.1    Schwartz, G.J.2    Wisotsky, D.H.3
  • 14
    • 79959376671 scopus 로고    scopus 로고
    • Implications of obesity for drug therapy: Limitations and challenges
    • Jain R, Chung SM, Jain L, et al. Implications of obesity for drug therapy: limitations and challenges. Clin Pharmacol Ther 2011;90:77-89.
    • (2011) Clin Pharmacol Ther , vol.90 , pp. 77-89
    • Jain, R.1    Chung, S.M.2    Jain, L.3
  • 15
    • 74549140993 scopus 로고    scopus 로고
    • Prevalence and trends in obesity among US adults, 1999-2008
    • Flegal KM, Carroll MD, Ogden CL, Curtin LR. Prevalence and trends in obesity among US adults, 1999-2008. JAMA 2010;303:235-241.
    • (2010) JAMA , vol.303 , pp. 235-241
    • Flegal, K.M.1    Carroll, M.D.2    Ogden, C.L.3    Curtin, L.R.4
  • 17
    • 78651023166 scopus 로고
    • Fallacy of per-weight and per-surface area standards, and their relation to spurious correlation
    • Tanner JM. Fallacy of per-weight and per-surface area standards, and their relation to spurious correlation. J Appl Physiol 1949;2:1-15.
    • (1949) J Appl Physiol , vol.2 , pp. 1-15
    • Tanner, J.M.1
  • 18
    • 0037132703 scopus 로고    scopus 로고
    • Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001
    • Baker SD, Verweij J, Rowinsky EK, et al. Role of body surface area in dosing of investigational anticancer agents in adults, 1991-2001. J Natl Cancer Inst 2002;94:1883-1888.
    • (2002) J Natl Cancer Inst , vol.94 , pp. 1883-1888
    • Baker, S.D.1    Verweij, J.2    Rowinsky, E.K.3
  • 19
    • 84855272942 scopus 로고    scopus 로고
    • AHFS, Bethesda, MD: American Society of Health Systems Pharmacists
    • AHFS. Drug information. Bethesda, MD: American Society of Health Systems Pharmacists; 2011.
    • (2011) Drug Information
  • 20
    • 16544374461 scopus 로고    scopus 로고
    • Mean body weight, height, and body mass index, United States 1960-2002
    • Ogden CL, Fryar CD, Carroll MD, et al. Mean body weight, height, and body mass index, United States 1960-2002. Adv Data 2004;347:1-17.
    • (2004) Adv Data , vol.347 , pp. 1-17
    • Ogden, C.L.1    Fryar, C.D.2    Carroll, M.D.3
  • 21
    • 62249205948 scopus 로고    scopus 로고
    • Human organ/tissue growth algorithms that include obese individuals and black/ white population organ weight similarities from autopsy data
    • Young JF, Luecke RH, Pearce BA, et al. Human organ/tissue growth algorithms that include obese individuals and black/ white population organ weight similarities from autopsy data. J Toxicol Environ Health A 2009;72:527-540.
    • (2009) J Toxicol Environ Health A , vol.72 , pp. 527-540
    • Young, J.F.1    Luecke, R.H.2    Pearce, B.A.3
  • 22
    • 34247241145 scopus 로고    scopus 로고
    • 2 body surface area normalization: Problems and implications
    • 2 body surface area normalization: problems and implications. Clin Physiol Funct Imaging 2007;27:135-137.
    • (2007) Clin Physiol Funct Imaging , Issue.27 , pp. 135-137
    • Heaf, J.G.1
  • 23
    • 34250682264 scopus 로고    scopus 로고
    • A comparison of direct vs. self-report measures for assessing height, weight and body mass index: A systematic review
    • Gorber SC, Tremblay M, Moher D, Gorber B. A comparison of direct vs. self-report measures for assessing height, weight and body mass index: a systematic review. Obes Rev 2007;8:307-326.
    • (2007) Obes Rev , vol.8 , pp. 307-326
    • Gorber, S.C.1    Tremblay, M.2    Moher, D.3    Gorber, B.4
  • 25
    • 34250190937 scopus 로고    scopus 로고
    • The mysterious trend in American heights in the 20th century
    • Komlos J, Lauderdale BE. The mysterious trend in American heights in the 20th century. Ann Hum Biol 2007;34:206-215.
    • (2007) Ann Hum Biol , vol.34 , pp. 206-215
    • Komlos, J.1    Lauderdale, B.E.2
  • 27
    • 66749185818 scopus 로고    scopus 로고
    • Progress in genome-wide association studies of human height
    • Hirschhorn JN, Lettre G. Progress in genome-wide association studies of human height. Horm Res 2009;71(Suppl 2):5-13.
    • (2009) Horm Res , vol.71 , Issue.SUPPL. 2 , pp. 5-13
    • Hirschhorn, J.N.1    Lettre, G.2
  • 29
    • 44449133335 scopus 로고    scopus 로고
    • Adolphe Quetelet (1796-1874)-The average man and indices of obesity
    • Eknoyan G. Adolphe Quetelet (1796-1874)-the average man and indices of obesity. Nephrol Dial Transplant 2008;23:47-51.
    • (2008) Nephrol Dial Transplant , vol.23 , pp. 47-51
    • Eknoyan, G.1
  • 30
    • 0022253659 scopus 로고
    • Health implications of obesity. National Institutes of Health Consensus Development Conference Statement
    • National Institutes of Health
    • National Institutes of Health. Health implications of obesity. National Institutes of Health Consensus Development Conference Statement. Ann Intern Med 1985;103:147-151.
    • (1985) Ann Intern Med , vol.103 , pp. 147-151
  • 31
    • 0021282180 scopus 로고
    • Weight-height indices and percent body fat among U.S Navy divers
    • Dembert ML, Jekel JF, Mooney LW. Weight-height indices and percent body fat among U.S. Navy divers. Aviat Space Environ Med 1984;55:391-395.
    • (1984) Aviat Space Environ Med , vol.55 , pp. 391-395
    • Dembert, M.L.1    Jekel, J.F.2    Mooney, L.W.3
  • 32
    • 0021813909 scopus 로고
    • Quetelet's index (W/H2) as a measure of fatness
    • Garrow JS, Webster J. Quetelet's index (W/H2) as a measure of fatness. Int J Obes 1985;9:147-153.
    • (1985) Int J Obes , vol.9 , pp. 147-153
    • Garrow, J.S.1    Webster, J.2
  • 33
    • 0344838355 scopus 로고    scopus 로고
    • Development of predictive equations for body density of sumo wrestlers using B-mode ultrasound for the determination of subcutaneous fat thickness
    • Saito K, Nakaji S, Umeda T, Shimoyama T, Sugawara K, Yamamoto Y. Development of predictive equations for body density of sumo wrestlers using B-mode ultrasound for the determination of subcutaneous fat thickness. Br J Sports Med 2003;37:144-148.
    • (2003) Br J Sports Med , vol.37 , pp. 144-148
    • Saito, K.1    Nakaji, S.2    Umeda, T.3    Shimoyama, T.4    Sugawara, K.5    Yamamoto, Y.6
  • 35
    • 77953311159 scopus 로고    scopus 로고
    • Theoretical versus empirical allometry: Facts behind theories and application to pharmacokinetics
    • Mahmood I. Theoretical versus empirical allometry: facts behind theories and application to pharmacokinetics. J Pharm Sci 2010;99:2927-2933.
    • (2010) J Pharm Sci , vol.99 , pp. 2927-2933
    • Mahmood, I.1
  • 36
    • 0010693586 scopus 로고
    • Lysergic Acid Diethylamide: Its effects on a male asiatic elephant
    • West LJ, Pierce CM, Thomas WD. Lysergic Acid Diethylamide: its effects on a male asiatic elephant. Science 1962;138:1100-1103.
    • (1962) Science , vol.138 , pp. 1100-1103
    • West, L.J.1    Pierce, C.M.2    Thomas, W.D.3
  • 37
    • 0024227409 scopus 로고
    • Extrapolation of animal toxicity data to man
    • Vocci F, Farber T. Extrapolation of animal toxicity data to man. Regul Toxicol Pharmacol 1988;8:389-398.
    • (1988) Regul Toxicol Pharmacol , vol.8 , pp. 389-398
    • Vocci, F.1    Farber, T.2
  • 38
    • 84957355538 scopus 로고
    • Body size and metabolic rate
    • Kleiber M. Body size and metabolic rate. Physiol Rev 1947;27 (4):511-541.
    • (1947) Physiol Rev , vol.27 , Issue.4 , pp. 511-541
    • Kleiber, M.1
  • 41
    • 77950396034 scopus 로고    scopus 로고
    • Physiology: There is no single p
    • White CR. Physiology: there is no single p. Nature 2010;464:691-693.
    • (2010) Nature , vol.464 , pp. 691-693
    • White, C.R.1
  • 42
    • 0026555107 scopus 로고
    • Single-dose pharmacokinetics and antibacterial activity of daptomycin, a new lipopeptide antibiotic, in healthy volunteers
    • Woodworth JR, Nyhart EH Jr, Brier GL, Wolny JD, Black HR. Single-dose pharmacokinetics and antibacterial activity of daptomycin, a new lipopeptide antibiotic, in healthy volunteers. Antimicrob Agents Chemother 1992;36:318-325.
    • (1992) Antimicrob Agents Chemother , vol.36 , pp. 318-325
    • Woodworth, J.R.1    Nyhart Jr., E.H.2    Brier, G.L.3    Wolny, J.D.4    Black, H.R.5
  • 43
    • 67349255204 scopus 로고    scopus 로고
    • Informative study designs to identify true parameter-covariate relationships
    • Han PY, Kirkpatrick CM, Green B. Informative study designs to identify true parameter-covariate relationships. J Pharmacokinet Pharmacodyn 2009;36:147-163.
    • (2009) J Pharmacokinet Pharmacodyn , vol.36 , pp. 147-163
    • Han, P.Y.1    Kirkpatrick, C.M.2    Green, B.3
  • 44
    • 0001146529 scopus 로고
    • The use of body surface area as a criterion of drug dosage in cancer chemotherapy
    • Pinkel D. The use of body surface area as a criterion of drug dosage in cancer chemotherapy. Cancer Res 1958;18:853-856.
    • (1958) Cancer Res , vol.18 , pp. 853-856
    • Pinkel, D.1
  • 45
    • 79955019141 scopus 로고    scopus 로고
    • Analytic theories of allometric scaling
    • Agutter PS, Tuszynski JA. Analytic theories of allometric scaling. J Exp Biol 2011;214:1055-1062.
    • (2011) J Exp Biol , vol.214 , pp. 1055-1062
    • Agutter, P.S.1    Tuszynski, J.A.2
  • 46
    • 0033522952 scopus 로고    scopus 로고
    • The fourth dimension of life: Fractal geometry and allometric scaling of organisms
    • West GB, Brown JH, Enquist BJ. The fourth dimension of life: fractal geometry and allometric scaling of organisms. Science 1999;284:1677-1679.
    • (1999) Science , vol.284 , pp. 1677-1679
    • West, G.B.1    Brown, J.H.2    Enquist, B.J.3
  • 48
    • 0033841371 scopus 로고    scopus 로고
    • The origin of the "ideal" body weight equations
    • Pai MP, Paloucek FP. The origin of the "ideal" body weight equations. Ann Pharmacother 2000;34(9):1066-1069.
    • (2000) Ann Pharmacother , vol.34 , Issue.9 , pp. 1066-1069
    • Pai, M.P.1    Paloucek, F.P.2
  • 49
    • 34249003675 scopus 로고    scopus 로고
    • From average to ideal. The evolution of the height and weight table in the. United States, 1836-1943
    • Czerniawski AM. From Average to Ideal. The Evolution of the Height and Weight Table in the. United States, 1836-1943. Soc Sci Hist 2007;31:273-296.
    • Soc Sci Hist , vol.2007 , Issue.31 , pp. 273-296
    • Czerniawski, A.M.1
  • 50
    • 78650093920 scopus 로고    scopus 로고
    • Body composition phenotypes in pathways to obesity and the metabolic syndrome
    • Dulloo AG, Jacquet J, Solinas G, Montani JP, Schutz Y. Body composition phenotypes in pathways to obesity and the metabolic syndrome. Int J Obes (Lond) 2010;34(Suppl 2):S4-S17.
    • (2010) Int J Obes (Lond) , vol.34 , Issue.SUPPL. 2
    • Dulloo, A.G.1    Jacquet, J.2    Solinas, G.3    Montani, J.P.4    Schutz, Y.5
  • 52
    • 0023943265 scopus 로고
    • Predicting creatinine clearance and renal drug clearance in obese patients from estimated fat-free body mass
    • Salazar DE, Corcoran GB. Predicting creatinine clearance and renal drug clearance in obese patients from estimated fat-free body mass. Am J Med 1988;84:1053-1060.
    • (1988) Am J Med , vol.84 , pp. 1053-1060
    • Salazar, D.E.1    Corcoran, G.B.2
  • 53
    • 80051820779 scopus 로고    scopus 로고
    • Simplified estimation of aminoglycoside pharmacokinetics in underweight and obese adult patients
    • Pai MP, Nafziger AN, Bertino JS Jr. Simplified estimation of aminoglycoside pharmacokinetics in underweight and obese adult patients. Antimicrob Agents Chemother 2011;55:4006-4011.
    • (2011) Antimicrob Agents Chemother , vol.55 , pp. 4006-4011
    • Pai, M.P.1    Nafziger, A.N.2    Bertino Jr., J.S.3
  • 54
    • 0032553486 scopus 로고    scopus 로고
    • Interspecies scaling of renally secreted drugs
    • Mahmood I. Interspecies scaling of renally secreted drugs. Life Sci 1998;63:2365-2371.
    • (1998) Life Sci , vol.63 , pp. 2365-2371
    • Mahmood, I.1
  • 55
    • 85046914133 scopus 로고    scopus 로고
    • Allometric scaling of xenobiotic clearance: Uncertainty versus universality
    • Hu TM, Hayton WL. Allometric scaling of xenobiotic clearance: uncertainty versus universality. AAPS PharmSci 2001;3:E29.
    • (2001) AAPS PharmSci , vol.3
    • Hu, T.M.1    Hayton, W.L.2
  • 57
    • 79956123094 scopus 로고    scopus 로고
    • Prediction of human renal clearance from preclinical species for a diverse set of drugs that exhibit both active secretion and net reabsorption
    • Paine SW, Ménochet K, Denton R, McGinnity DF, Riley RJ. Prediction of human renal clearance from preclinical species for a diverse set of drugs that exhibit both active secretion and net reabsorption. Drug Metab Dispos 2011;39:1008-1013.
    • (2011) Drug Metab Dispos , vol.39 , pp. 1008-1013
    • Paine, S.W.1    Ménochet, K.2    Denton, R.3    McGinnity, D.F.4    Riley, R.J.5
  • 58
    • 0037156937 scopus 로고    scopus 로고
    • How to calculate the dose of chemotherapy
    • Gurney H. How to calculate the dose of chemotherapy. Br J Cancer 2002;86:1297-1302.
    • (2002) Br J Cancer , vol.86 , pp. 1297-1302
    • Gurney, H.1
  • 60
    • 84857612698 scopus 로고    scopus 로고
    • Chemotherapy dose reductions in obese patients with colorectal cancer
    • Chambers P, Daniels SH, Thompson LC, Stephens RJ. Chemotherapy dose reductions in obese patients with colorectal cancer. Ann Oncol 2012;23:748-753.
    • (2012) Ann Oncol , vol.23 , pp. 748-753
    • Chambers, P.1    Daniels, S.H.2    Thompson, L.C.3    Stephens, R.J.4
  • 61
    • 78650969715 scopus 로고    scopus 로고
    • Effect of obesity on survival of women with breast cancer: Systematic review and metaanalysis
    • Protani M, Coory M, Martin JH. Effect of obesity on survival of women with breast cancer: systematic review and metaanalysis. Breast Cancer Res Treat 2010;123:627-635.
    • (2010) Breast Cancer Res Treat , vol.123 , pp. 627-635
    • Protani, M.1    Coory, M.2    Martin, J.H.3
  • 62
    • 1442332174 scopus 로고    scopus 로고
    • Impact of body mass index on outcomes and treatment-related toxicity in patients with stage II and III rectal cancer: Findings from Intergroup Trial 0114
    • Meyerhardt JA, Tepper JE, Niedzwiecki D, et al. Impact of body mass index on outcomes and treatment-related toxicity in patients with stage II and III rectal cancer: findings from Intergroup Trial 0114. J Clin Oncol 2004;22:648-657.
    • (2004) J Clin Oncol , vol.22 , pp. 648-657
    • Meyerhardt, J.A.1    Tepper, J.E.2    Niedzwiecki, D.3
  • 63
    • 0023718829 scopus 로고
    • Excessive aminoglycoside nephrotoxicity in obese patients
    • Corcoran GB, Salazar DE, Schentag JJ. Excessive aminoglycoside nephrotoxicity in obese patients. Am J Med 1988;85:279.
    • (1988) Am J Med , vol.85 , pp. 279
    • Corcoran, G.B.1    Salazar, D.E.2    Schentag, J.J.3
  • 64
    • 0035173531 scopus 로고    scopus 로고
    • The epidemiology of nephrotoxicity associated with conventional amphotericin B therapy
    • Harbarth S, Pestotnik SL, Lloyd JF, Burke JP, Samore MH. The epidemiology of nephrotoxicity associated with conventional amphotericin B therapy. Am J Med 2001;111:528-534.
    • (2001) Am J Med , vol.111 , pp. 528-534
    • Harbarth, S.1    Pestotnik, S.L.2    Lloyd, J.F.3    Burke, J.P.4    Samore, M.H.5
  • 66
    • 67651113645 scopus 로고    scopus 로고
    • Relationship between initial vancomycin concentrationtime profile and nephrotoxicity among hospitalized patients
    • Lodise TP, Patel N, Lomaestro BM, Rodvold KA, Drusano GL. Relationship between initial vancomycin concentrationtime profile and nephrotoxicity among hospitalized patients. Clin Infect Dis 2009;49:507-514.
    • (2009) Clin Infect Dis , vol.49 , pp. 507-514
    • Lodise, T.P.1    Patel, N.2    Lomaestro, B.M.3    Rodvold, K.A.4    Drusano, G.L.5
  • 68
    • 67651093746 scopus 로고    scopus 로고
    • Safety of high-dose intravenous daptomycin treatment: Three-year cumulative experience in a clinical program
    • Figueroa DA, Mangini E, Amodio-Groton M, et al. Safety of high-dose intravenous daptomycin treatment: three-year cumulative experience in a clinical program. Clin Infect Dis 2009;49:177-180.
    • (2009) Clin Infect Dis , vol.49 , pp. 177-180
    • Figueroa, D.A.1    Mangini, E.2    Amodio-Groton, M.3
  • 69
    • 77952983904 scopus 로고    scopus 로고
    • Daptomycin exposure and the probability of elevations in the creatine phosphokinase level: Data from a randomized trial of patients with bacteremia and endocarditis
    • Bhavnani SM, Rubino CM, Ambrose PG, Drusano GL. Daptomycin exposure and the probability of elevations in the creatine phosphokinase level: data from a randomized trial of patients with bacteremia and endocarditis. Clin Infect Dis 2010;50:1568-1574.
    • (2010) Clin Infect Dis , vol.50 , pp. 1568-1574
    • Bhavnani, S.M.1    Rubino, C.M.2    Ambrose, P.G.3    Drusano, G.L.4
  • 73
    • 0034932457 scopus 로고    scopus 로고
    • Pharmacokinetics, metabolism, and excretion of linezolid following an oral dose of [(14)C]linezolid to healthy human subjects
    • Slatter JG, Stalker DJ, Feenstra KL, et al. Pharmacokinetics, metabolism, and excretion of linezolid following an oral dose of [(14)C]linezolid to healthy human subjects. Drug Metab Dispos 2001;29:1136-1145.
    • (2001) Drug Metab Dispos , vol.29 , pp. 1136-1145
    • Slatter, J.G.1    Stalker, D.J.2    Feenstra, K.L.3
  • 75
    • 69549138004 scopus 로고    scopus 로고
    • Population pharmacokinetic analysis of linezolid in patients with infectious disease: Application to lower body weight and elderly patients
    • Abe S, Chiba K, Cirincione B, Grasela TH, Ito K, Suwa T. Population pharmacokinetic analysis of linezolid in patients with infectious disease: application to lower body weight and elderly patients. J Clin Pharmacol 2009;49:1071-1078.
    • (2009) J Clin Pharmacol , vol.49 , pp. 1071-1078
    • Abe, S.1    Chiba, K.2    Cirincione, B.3    Grasela, T.H.4    Ito, K.5    Suwa, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.