메뉴 건너뛰기




Volumn 7, Issue 10, 2012, Pages

Oxidized LDL Triggers Pro-Oncogenic Signaling in Human Breast Mammary Epithelial Cells Partly via Stimulation of MiR-21

Author keywords

[No Author keywords available]

Indexed keywords

CD36 ANTIGEN; CXCL16 CHEMOKINE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOXYGENASE; LIPOXYGENASE 12; LIPOXYGENASE 15; MICRORNA 21; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OXIDIZED LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN RECEPTOR 1; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; PROTEIN MSR1; PROTEIN P22; PROTEIN P47; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SCAVENGER RECEPTOR; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

EID: 84867589201     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046973     Document Type: Article
Times cited : (38)

References (50)
  • 1
    • 77953981792 scopus 로고    scopus 로고
    • Effect of obesity on breast cancer development
    • Cleary MP, Grossmann ME, Ray A, (2010) Effect of obesity on breast cancer development. Vet Pathol 47: 202-213.
    • (2010) Vet Pathol , vol.47 , pp. 202-213
    • Cleary, M.P.1    Grossmann, M.E.2    Ray, A.3
  • 2
    • 77952566578 scopus 로고    scopus 로고
    • The role of obesity, physical activity and dietary factors on the risk for breast cancer: Mexican experience
    • Romieu I, Lajous M, (2009) The role of obesity, physical activity and dietary factors on the risk for breast cancer: Mexican experience. Salud Publica Mex 51 Suppl 2: s172-180.
    • (2009) Salud Publica Mex , vol.51 , Issue.SUPPL.
    • Romieu, I.1    Lajous, M.2
  • 3
    • 33646504461 scopus 로고    scopus 로고
    • Adiponectin and cancer: a systematic review
    • Kelesidis, Kelesidis T, Mantzoros CS, (2006) Adiponectin and cancer: a systematic review. Brit J Cancer 94: 1221-1225.
    • (2006) Brit J Cancer , vol.94 , pp. 1221-1225
    • Kelesidis1    Kelesidis, T.2    Mantzoros, C.S.3
  • 4
    • 4444237280 scopus 로고    scopus 로고
    • Obesity and Cancer
    • Calle EE, Thun MJ, (2004) Obesity and Cancer. Oncogene 23: 6365-6378.
    • (2004) Oncogene , vol.23 , pp. 6365-6378
    • Calle, E.E.1    Thun, M.J.2
  • 5
    • 33745106287 scopus 로고    scopus 로고
    • Molecular links between obesity and breast cancer
    • Lorincz AM, Sukumar S, (2006) Molecular links between obesity and breast cancer. Endocr Relat Cancer 13: 279-292.
    • (2006) Endocr Relat Cancer , vol.13 , pp. 279-292
    • Lorincz, A.M.1    Sukumar, S.2
  • 6
    • 16244408061 scopus 로고    scopus 로고
    • The role of LOX-1, a novel lectin-like receptor for oxidized low density lipoprotein in atherosclerosis
    • Mehta JL, (2004) The role of LOX-1, a novel lectin-like receptor for oxidized low density lipoprotein in atherosclerosis. Can J Cardiol Suppl B pp. 32B-36B.
    • (2004) Can J Cardiol Suppl B
    • Mehta, J.L.1
  • 8
    • 0030941113 scopus 로고    scopus 로고
    • An endothelial receptor for oxidized low-density lipoprotein
    • Sawamura T, Kume N, Aoyama T, (1997) An endothelial receptor for oxidized low-density lipoprotein. Nature 386: 73-77.
    • (1997) Nature , vol.386 , pp. 73-77
    • Sawamura, T.1    Kume, N.2    Aoyama, T.3
  • 9
    • 38749118269 scopus 로고    scopus 로고
    • The lectin-like oxidized low-density-lipoprotein receptor: a pro-inflammatory factor in vascular disease
    • Dunn S, Vohra RS, Murphy JE, Homer-Vanniasinkam S, Walker JH, et al. (2008) The lectin-like oxidized low-density-lipoprotein receptor: a pro-inflammatory factor in vascular disease. Biochem J 409: 349-355.
    • (2008) Biochem J , vol.409 , pp. 349-355
    • Dunn, S.1    Vohra, R.S.2    Murphy, J.E.3    Homer-Vanniasinkam, S.4    Walker, J.H.5
  • 10
    • 0033779395 scopus 로고    scopus 로고
    • Stimulation of NADPH Oxidase by Oxidized Low-Density Lipoprotein Induces Proliferation of Human Vascular Endothelial Cells
    • Heinloth A, Heermeier K, Raff U, Wanner C, Gallr J, (2000) Stimulation of NADPH Oxidase by Oxidized Low-Density Lipoprotein Induces Proliferation of Human Vascular Endothelial Cells. J Am Soc Nephrol 200, 11: 1819-1825.
    • (2000) J Am Soc Nephrol , vol.200 , Issue.11 , pp. 1819-1825
    • Heinloth, A.1    Heermeier, K.2    Raff, U.3    Wanner, C.4    Gallr, J.5
  • 11
    • 0037385038 scopus 로고    scopus 로고
    • Scavenger receptor class B, type I on non-malignant and malignant human epithelial cells mediates cholesteryl ester-uptake from high density lipoproteins
    • Wadsack C, Hirschmugl B, Hammer A, Levak-Frank S, Kozarsky KF, et al. (2003) Scavenger receptor class B, type I on non-malignant and malignant human epithelial cells mediates cholesteryl ester-uptake from high density lipoproteins. Int J Biochem Cell Biol 35: 441-454.
    • (2003) Int J Biochem Cell Biol , vol.35 , pp. 441-454
    • Wadsack, C.1    Hirschmugl, B.2    Hammer, A.3    Levak-Frank, S.4    Kozarsky, K.F.5
  • 12
    • 13544252784 scopus 로고    scopus 로고
    • Epithelial cells as phagocytes: apoptotic epithelial cells are engulfed by mammary alveolar epithelial cells and repress inflammatory mediator release
    • Monks J, Rosner D, Jon Geske F, Lehman L, Hanson L, et al. (2005) Epithelial cells as phagocytes: apoptotic epithelial cells are engulfed by mammary alveolar epithelial cells and repress inflammatory mediator release. Cell Death Differ 12: 107-114.
    • (2005) Cell Death Differ , vol.12 , pp. 107-114
    • Monks, J.1    Rosner, D.2    Jon Geske, F.3    Lehman, L.4    Hanson, L.5
  • 13
    • 77950509620 scopus 로고    scopus 로고
    • Transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases
    • Hirsch HA, Iliopoulos D, Joshi A, Zhang Y, Jaeger S, et al. (2010) Transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases. Cancer Cell 17: 348-361.
    • (2010) Cancer Cell , vol.17 , pp. 348-361
    • Hirsch, H.A.1    Iliopoulos, D.2    Joshi, A.3    Zhang, Y.4    Jaeger, S.5
  • 14
    • 79957592268 scopus 로고    scopus 로고
    • Oxidized LDL receptor 1 (LOX-1) as a possible link between obesity and cancer
    • Khaidakov M, Mitra S, Kadlubar S, Novelli G, Raj V, et al. (2011) Oxidized LDL receptor 1 (LOX-1) as a possible link between obesity and cancer. PLoS ONE 6 (5) (): e20277 doi:10.1371/journal.pone.0020277.
    • (2011) PLoS ONE , vol.6 , Issue.5
    • Khaidakov, M.1    Mitra, S.2    Kadlubar, S.3    Novelli, G.4    Raj, V.5
  • 15
    • 84859320008 scopus 로고    scopus 로고
    • PrimerBank: a PCR primer database for quantitative gene expression analysis
    • Wang X, Spandidos A, Wang H, Seed B, (2012) PrimerBank: a PCR primer database for quantitative gene expression analysis.Nucl. Acids Res 40 (D1) (): D1144-1149.
    • (2012) Nucl. Acids Res , vol.40 , Issue.D1
    • Wang, X.1    Spandidos, A.2    Wang, H.3    Seed, B.4
  • 16
    • 14044268133 scopus 로고    scopus 로고
    • Essential roles of lipoxygenases in LDL oxidation and development of atherosclerosis
    • Takahashi Y, Zhu H, Yoshimoto T, (2005) Essential roles of lipoxygenases in LDL oxidation and development of atherosclerosis. Antioxid Redox Signal 7: 425-431.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 425-431
    • Takahashi, Y.1    Zhu, H.2    Yoshimoto, T.3
  • 17
    • 36049027675 scopus 로고    scopus 로고
    • Small concentrations of ox-LDL induce capillary tube formation from endothelial cells via LOX-1-dependent redox-sensitive pathway
    • Dandapat A, Hu C, Sun L, Mehta JL, (2007) Small concentrations of ox-LDL induce capillary tube formation from endothelial cells via LOX-1-dependent redox-sensitive pathway. Arterioscler Thromb Vasc Biol 27: 2435-2442.
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 2435-2442
    • Dandapat, A.1    Hu, C.2    Sun, L.3    Mehta, J.L.4
  • 18
    • 44449173623 scopus 로고    scopus 로고
    • Elevated soluble lectin-like oxidized LDL receptor-1 (sLOX-1) levels in obese postmenopausal women
    • Brinkley TE, Kume N, Mitsuoka H, Phares DA, Hagberg JM, (2008) Elevated soluble lectin-like oxidized LDL receptor-1 (sLOX-1) levels in obese postmenopausal women. Obesity (Silver Spring) 16: 1454-1456.
    • (2008) Obesity (Silver Spring) , vol.16 , pp. 1454-1456
    • Brinkley, T.E.1    Kume, N.2    Mitsuoka, H.3    Phares, D.A.4    Hagberg, J.M.5
  • 19
    • 78650881826 scopus 로고    scopus 로고
    • Elevated oxidized low-density lipoprotein concentrations in postmenopausal women with the metabolic syndrome
    • Park SH, Kim JY, Lee JH, Park HY, (2011) Elevated oxidized low-density lipoprotein concentrations in postmenopausal women with the metabolic syndrome. Clin Chim Acta 412: 435-440.
    • (2011) Clin Chim Acta , vol.412 , pp. 435-440
    • Park, S.H.1    Kim, J.Y.2    Lee, J.H.3    Park, H.Y.4
  • 20
    • 59849086158 scopus 로고    scopus 로고
    • Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2
    • Bae YS, Lee JH, Choi SH, Kim S, Almazan F, et al. (2009) Macrophages generate reactive oxygen species in response to minimally oxidized low-density lipoprotein: toll-like receptor 4- and spleen tyrosine kinase-dependent activation of NADPH oxidase 2. Circ Res 104: 210-8.
    • (2009) Circ Res , vol.104 , pp. 210-218
    • Bae, Y.S.1    Lee, J.H.2    Choi, S.H.3    Kim, S.4    Almazan, F.5
  • 21
    • 34147182364 scopus 로고    scopus 로고
    • Resveratrol attenuates oxLDL-stimulated NADPH oxidase activity and protects endothelial cells from oxidative functional damages
    • Chow SE, Hshu YC, Wang JS, Chen JK, (2007) Resveratrol attenuates oxLDL-stimulated NADPH oxidase activity and protects endothelial cells from oxidative functional damages. J Appl Physiol 102: 1520-1527.
    • (2007) J Appl Physiol , vol.102 , pp. 1520-1527
    • Chow, S.E.1    Hshu, Y.C.2    Wang, J.S.3    Chen, J.K.4
  • 22
    • 18044367138 scopus 로고    scopus 로고
    • Mutagenic effects of 4-hydroxynonenal triacetate, a chemically protected form of the lipid peroxidation product 4-hydroxynonenal, as assayed in L5178Y/Tk+/- mouse lymphoma cells
    • Singh SP, Chen T, Chen L, Mei N, McLain E, et al. (2005) Mutagenic effects of 4-hydroxynonenal triacetate, a chemically protected form of the lipid peroxidation product 4-hydroxynonenal, as assayed in L5178Y/Tk+/- mouse lymphoma cells. J Pharmacol Exp Ther 313: 855-861.
    • (2005) J Pharmacol Exp Ther , vol.313 , pp. 855-861
    • Singh, S.P.1    Chen, T.2    Chen, L.3    Mei, N.4    McLain, E.5
  • 23
    • 71949129504 scopus 로고    scopus 로고
    • Elevated malondialdehyde correlates with the extent of primary tumor and predicts poor prognosis of oropharyngeal cancer
    • Salzman R, Pácal L, Tomandl J, Kanková K, Tóthová E, et al. (2009) Elevated malondialdehyde correlates with the extent of primary tumor and predicts poor prognosis of oropharyngeal cancer. Anticancer Res 29: 4227-4231.
    • (2009) Anticancer Res , vol.29 , pp. 4227-4231
    • Salzman, R.1    Pácal, L.2    Tomandl, J.3    Kanková, K.4    Tóthová, E.5
  • 24
    • 14044268133 scopus 로고    scopus 로고
    • Essential roles of lipoxygenases in LDL oxidation and development of atherosclerosis
    • Takahashi Y, Zhu H, Yoshimoto T, (2005) Essential roles of lipoxygenases in LDL oxidation and development of atherosclerosis. Antioxid Redox Signal 7: 425-431.
    • (2005) Antioxid Redox Signal , vol.7 , pp. 425-431
    • Takahashi, Y.1    Zhu, H.2    Yoshimoto, T.3
  • 25
    • 0011172276 scopus 로고
    • A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein
    • Parthasarathy S, Wieland E, Steinberg D, (1989) A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein. Proc Natl Acad Sci U S A 86: 1046-1050.
    • (1989) Proc Natl Acad Sci U S A , vol.86 , pp. 1046-1050
    • Parthasarathy, S.1    Wieland, E.2    Steinberg, D.3
  • 26
    • 0025756633 scopus 로고
    • Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages
    • Rankin SM, Parthasarathy S, Steinberg DJ, (1991) Evidence for a dominant role of lipoxygenase(s) in the oxidation of LDL by mouse peritoneal macrophages. Lipid Res 324: 449-56.
    • (1991) Lipid Res , vol.324 , pp. 449-456
    • Rankin, S.M.1    Parthasarathy, S.2    Steinberg, D.J.3
  • 27
    • 82455192248 scopus 로고    scopus 로고
    • Role of 12-lipoxygenase in regulation of ovarian cancer cell proliferation and survival
    • Guo AM, Liu X, Al-Wahab Z, Maddippati KR, Ali-Fehmi R, et al. (2011) Role of 12-lipoxygenase in regulation of ovarian cancer cell proliferation and survival. Cancer Chemother Pharmacol 68: 1273-1283.
    • (2011) Cancer Chemother Pharmacol , vol.68 , pp. 1273-1283
    • Guo, A.M.1    Liu, X.2    Al-Wahab, Z.3    Maddippati, K.R.4    Ali-Fehmi, R.5
  • 28
    • 79952319204 scopus 로고    scopus 로고
    • Arachidonate 12-lipoxygenase may serve as a potential marker and therapeutic target for prostate cancer stem cells
    • Yin B, Yang Y, Zhao Z, Zeng Y, Mooney SM, et al. (2011) Arachidonate 12-lipoxygenase may serve as a potential marker and therapeutic target for prostate cancer stem cells. Int J Oncol 38: 1041-1046.
    • (2011) Int J Oncol , vol.38 , pp. 1041-1046
    • Yin, B.1    Yang, Y.2    Zhao, Z.3    Zeng, Y.4    Mooney, S.M.5
  • 29
    • 0031154097 scopus 로고    scopus 로고
    • Increased 12-lipoxygenase expression in breast cancer tissues and cells. Regulation by Epidermal Growth Factor
    • Natarajan R, Esworthy R, Bai W, Gu JL, Wilczynski S, et al. (1997) Increased 12-lipoxygenase expression in breast cancer tissues and cells. Regulation by Epidermal Growth Factor. J. Clin. Endocrinol. Metab 82: 1790-1798.
    • (1997) J. Clin. Endocrinol. Metab , vol.82 , pp. 1790-1798
    • Natarajan, R.1    Esworthy, R.2    Bai, W.3    Gu, J.L.4    Wilczynski, S.5
  • 30
    • 0032561157 scopus 로고    scopus 로고
    • Enhanced angiogenesis and growth of 12-lipoxygenase gene-transfected MCF-7 human breast cancer cells in athymic nude mice
    • Connolly JM, Rose DP, (1998) Enhanced angiogenesis and growth of 12-lipoxygenase gene-transfected MCF-7 human breast cancer cells in athymic nude mice. Cancer Lett 132: 107-112.
    • (1998) Cancer Lett , vol.132 , pp. 107-112
    • Connolly, J.M.1    Rose, D.P.2
  • 31
    • 40549104132 scopus 로고    scopus 로고
    • Platelet-type 12-lipoxygenase accelerates tumor promotion of mouse epidermal cells through enhancement of cloning efficiency
    • Piao YS, Du YC, Oshima H, Jin JC, Nomura M, et al. (2008) Platelet-type 12-lipoxygenase accelerates tumor promotion of mouse epidermal cells through enhancement of cloning efficiency. Carcinogenesis 29: 440-447.
    • (2008) Carcinogenesis , vol.29 , pp. 440-447
    • Piao, Y.S.1    Du, Y.C.2    Oshima, H.3    Jin, J.C.4    Nomura, M.5
  • 32
    • 0036384212 scopus 로고    scopus 로고
    • The mechanisms of lipoxygenase inhibitor-induced apoptosis in human breast cancer cells
    • Tong WG, Ding XZ, Adrian TE, (2002) The mechanisms of lipoxygenase inhibitor-induced apoptosis in human breast cancer cells. Biochem Biophys Res Comm 296: 942-948.
    • (2002) Biochem Biophys Res Comm , vol.296 , pp. 942-948
    • Tong, W.G.1    Ding, X.Z.2    Adrian, T.E.3
  • 33
    • 83855160815 scopus 로고    scopus 로고
    • 15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in?
    • Zuo X, Shureiqi I, (2011) 15-Lipoxygenase-1 as a tumor suppressor gene in colon cancer: is the verdict in? Cancer Metastasis Rev 30: 481-491.
    • (2011) Cancer Metastasis Rev , vol.30 , pp. 481-491
    • Zuo, X.1    Shureiqi, I.2
  • 34
    • 33749612562 scopus 로고    scopus 로고
    • What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis?
    • Fürstenberger G, Krieg P, Müller-Decker K, Habenicht AJ, (2006) What are cyclooxygenases and lipoxygenases doing in the driver's seat of carcinogenesis? Int J Cancer 119: 2247-2254.
    • (2006) Int J Cancer , vol.119 , pp. 2247-2254
    • Fürstenberger, G.1    Krieg, P.2    Müller-Decker, K.3    Habenicht, A.J.4
  • 35
    • 1842610142 scopus 로고    scopus 로고
    • 15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells
    • Yoshinaga M, Buchanan FG, DuBois RN, (2004) 15-LOX-1 inhibits p21 (Cip/WAF 1) expression by enhancing MEK-ERK 1/2 signaling in colon carcinoma cells. Prostaglandins Other Lipid Mediat 73: 111-122.
    • (2004) Prostaglandins Other Lipid Mediat , vol.73 , pp. 111-122
    • Yoshinaga, M.1    Buchanan, F.G.2    DuBois, R.N.3
  • 37
    • 0032854497 scopus 로고    scopus 로고
    • Decreased 13-S-hydroxyoctadecadienoic acid levels and 15-lipoxygenase-1 expression in human colon cancers
    • Shureiqi I, Wojno KJ, Poore JA, Reddy RG, Moussalli MJ, et al. (1999) Decreased 13-S-hydroxyoctadecadienoic acid levels and 15-lipoxygenase-1 expression in human colon cancers. Carcinogenesis 20: 1985-1895.
    • (1999) Carcinogenesis , vol.20 , pp. 1895-1985
    • Shureiqi, I.1    Wojno, K.J.2    Poore, J.A.3    Reddy, R.G.4    Moussalli, M.J.5
  • 38
    • 18544364362 scopus 로고    scopus 로고
    • Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells
    • Tang S, Bhatia B, Maldonado CJ, Yang P, Newman RA, et al. (2002) Evidence that arachidonate 15-lipoxygenase 2 is a negative cell cycle regulator in normal prostate epithelial cells. J Biol Chem 277: 16189-16201.
    • (2002) J Biol Chem , vol.277 , pp. 16189-16201
    • Tang, S.1    Bhatia, B.2    Maldonado, C.J.3    Yang, P.4    Newman, R.A.5
  • 39
    • 79953162175 scopus 로고    scopus 로고
    • Oxidized LDL at low concentration promotes in-vitro angiogenesis and activates nitric oxide synthase through PI3K/Akt/eNOS pathway in human coronary artery endothelial cells
    • Yu S, Wong SL, Lau CW, Huang Y, Yu CM, (2011) Oxidized LDL at low concentration promotes in-vitro angiogenesis and activates nitric oxide synthase through PI3K/Akt/eNOS pathway in human coronary artery endothelial cells. Biochem Biophys Res Commun 407: 44-48.
    • (2011) Biochem Biophys Res Commun , vol.407 , pp. 44-48
    • Yu, S.1    Wong, S.L.2    Lau, C.W.3    Huang, Y.4    Yu, C.M.5
  • 40
    • 76749145061 scopus 로고    scopus 로고
    • OxLDL stimulates lipoprotein-associated phospholipase A2 expression in THP-1 monocytes via PI3K and p38 MAPK pathways
    • Wang WY, Li J, Yang D, Xu W, Zha RP, et al. (2010) OxLDL stimulates lipoprotein-associated phospholipase A2 expression in THP-1 monocytes via PI3K and p38 MAPK pathways. Cardiovasc Res 85: 845-852.
    • (2010) Cardiovasc Res , vol.85 , pp. 845-852
    • Wang, W.Y.1    Li, J.2    Yang, D.3    Xu, W.4    Zha, R.P.5
  • 41
    • 77953000495 scopus 로고    scopus 로고
    • Oxidized low-density lipoprotein-induced proinflammatory cytokine response in macrophages are suppressed by CD4CD25(+)Foxp3(+) regulatory T cells through downregulating toll like receptor 2-mediated activation of NF-kappaB
    • Li M, Lin J, Wang Z, He S, Ma X, et al. (2010) Oxidized low-density lipoprotein-induced proinflammatory cytokine response in macrophages are suppressed by CD4CD25(+)Foxp3(+) regulatory T cells through downregulating toll like receptor 2-mediated activation of NF-kappaB. Cell Physiol Biochem 25: 649-656.
    • (2010) Cell Physiol Biochem , vol.25 , pp. 649-656
    • Li, M.1    Lin, J.2    Wang, Z.3    He, S.4    Ma, X.5
  • 43
    • 5444227865 scopus 로고    scopus 로고
    • Guilty as charged; B-RAF is a human oncogene
    • Garnett MJ, Marais R, (2004) Guilty as charged; B-RAF is a human oncogene. Cancer Cell 6: 313-319.
    • (2004) Cancer Cell , vol.6 , pp. 313-319
    • Garnett, M.J.1    Marais, R.2
  • 44
    • 33947594129 scopus 로고    scopus 로고
    • Hyperactive Ras in developmental disorders and cancer
    • Schubbert S, Shannon K, Bollag G, (2007) Hyperactive Ras in developmental disorders and cancer. Nat Rev Cancer 7: 295-308.
    • (2007) Nat Rev Cancer , vol.7 , pp. 295-308
    • Schubbert, S.1    Shannon, K.2    Bollag, G.3
  • 45
    • 0034899503 scopus 로고    scopus 로고
    • Hyperactivation of MAPK induces loss of ERalpha expression in breast cancer cells
    • Oh AS, Lorant LA, Holloway JN, Miller DL, Kern FG, et al. (2001) Hyperactivation of MAPK induces loss of ERalpha expression in breast cancer cells. Mol Endocrinol 15: 1344-1359.
    • (2001) Mol Endocrinol , vol.15 , pp. 1344-1359
    • Oh, A.S.1    Lorant, L.A.2    Holloway, J.N.3    Miller, D.L.4    Kern, F.G.5
  • 46
    • 78649992541 scopus 로고    scopus 로고
    • MicroRNA-21 as therapeutic target in cancer and cardiovascular disease
    • Bonci D, (2010) MicroRNA-21 as therapeutic target in cancer and cardiovascular disease. Recent Pat Cardiovasc Drug Discov 5: 156-161.
    • (2010) Recent Pat Cardiovasc Drug Discov , vol.5 , pp. 156-161
    • Bonci, D.1
  • 47
    • 34247495591 scopus 로고    scopus 로고
    • miR-21-mediated tumor growth
    • Si ML, Zhu S, Wu H, Lu Z, Wu F, et al. (2007) miR-21-mediated tumor growth. Oncogene 26: 2799-2803.
    • (2007) Oncogene , vol.26 , pp. 2799-2803
    • Si, M.L.1    Zhu, S.2    Wu, H.3    Lu, Z.4    Wu, F.5
  • 48
    • 55549120234 scopus 로고    scopus 로고
    • MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis
    • Yan LX, Huang XF, Shao Q, Huang MY, Deng L, et al. (2008) MicroRNA miR-21 overexpression in human breast cancer is associated with advanced clinical stage, lymph node metastasis and patient poor prognosis. RNA 14: 2348-2360.
    • (2008) RNA , vol.14 , pp. 2348-2360
    • Yan, L.X.1    Huang, X.F.2    Shao, Q.3    Huang, M.Y.4    Deng, L.5
  • 49
    • 23844555119 scopus 로고    scopus 로고
    • MicroRNA gene expression deregulation in human breast cancer
    • Iorio MV, Ferracin M, Liu CG, Veronese A, Spizzo R, et al. (2005) MicroRNA gene expression deregulation in human breast cancer. Cancer Res 65: 7065-7070.
    • (2005) Cancer Res , vol.65 , pp. 7065-7070
    • Iorio, M.V.1    Ferracin, M.2    Liu, C.G.3    Veronese, A.4    Spizzo, R.5
  • 50
    • 77956339881 scopus 로고    scopus 로고
    • OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma
    • Medina PP, Nolde M, Slack FJ, (2010) OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma. Nature 467: 86-90.
    • (2010) Nature , vol.467 , pp. 86-90
    • Medina, P.P.1    Nolde, M.2    Slack, F.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.