BTK inhibitor ibrutinib is cytotoxic to myeloma and potently enhances bortezomib and lenalidomide activities through NF-κB

Cellular Signalling

Volumn 25, Issue 1, 2013, Pages 106-112

  Rushworth, Stuart A ^a   Bowles, Kristian M ^b   Barrera, Lawrence N ^a   Murray, Megan Y ^a   Zaitseva, Lyubov ^a   MacEwan, David J ^a  

^a UNIVERSITY OF EAST ANGLIA   (United Kingdom)

^b NORFOLK AND NORWICH UNIVERSITY HOSPITAL   (United Kingdom)

Author keywords

Apoptosis; Bruton's tyrosine kinase; Chemotherapy; Myeloma; Transcription factor

Indexed keywords

2 CYANO N (2,5 DIBROMOPHENYL) 3 HYDROXYCROTONAMIDE; BORTEZOMIB; BRUTON TYROSINE KINASE; BRUTON TYROSINE KINASE INHIBITOR; CASPASE; FLICE INHIBITORY PROTEIN; IBRUTINIB; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LENALIDOMIDE; LMF A13; PROTEIN BCL XL; SERINE; SURVIVIN; SYNAPTOTAGMIN I; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CANCER COMBINATION CHEMOTHERAPY; CELL NUCLEUS; CELL PROLIFERATION; CELL TRANSPORT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG INHIBITION; DRUG MECHANISM; DRUG POTENCY; DRUG POTENTIATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MULTIPLE MYELOMA; PHARMACOLOGICAL BLOCKING; PLASMA CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

AMIDES; ANTINEOPLASTIC AGENTS; BORONIC ACIDS; CASPASES; CELL SURVIVAL; HUMANS; I-KAPPA B PROTEINS; MULTIPLE MYELOMA; NF-KAPPA B; NITRILES; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; PYRAZINES; PYRAZOLES; PYRIMIDINES; RNA, MESSENGER; SIGNAL TRANSDUCTION; THALIDOMIDE; TUMOR CELLS, CULTURED;

EID: 84867589196     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2012.09.008     Document Type: Article

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