Multifactorial patterns of gene expression in colonic epithelial cells predict disease phenotypes in experimental colitis

Inflammatory Bowel Diseases

Volumn 18, Issue 11, 2012, Pages 2138-2148

  Frantz, Aubrey L ^a   Bruno, Maria E C ^a   Rogier, Eric W ^a   Tuna, Halide ^a   Cohen, Donald A ^a   Bondada, Subbarao ^a   Chelvarajan, R Lakshman ^a   Brandon, J Anthony ^a   Jennings, C Darrell ^a   Kaetzel, Charlotte S ^a  

^a UNIVERSITY OF KENTUCKY   (United States)

Author keywords

biomarkers; colonic epithelial cell; experimental colitis; gene expression; inflammatory bowel disease; polymeric immunoglobulin receptor

Indexed keywords

BIOLOGICAL MARKER; ENZYME; MACROPHAGE INFLAMMATORY PROTEIN 2; SECRETORY COMPONENT; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR; UBIQUITIN MODIFYING ENZYME A20; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; COLITIS; COLON MUCOSA; CONTROLLED STUDY; DISEASE SEVERITY; DOWN REGULATION; EPITHELIUM CELL; FEMALE; GENE EXPRESSION PROFILING; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SCORING SYSTEM;

ACUTE DISEASE; ANIMALS; BIOLOGICAL MARKERS; CHRONIC DISEASE; COLITIS; DEXTRAN SULFATE; DISEASE MODELS, ANIMAL; EPITHELIAL CELLS; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE; GENE EXPRESSION PROFILING; HOMEODOMAIN PROTEINS; INTESTINAL MUCOSA; MICE; MICE, INBRED C57BL; PHENOTYPE; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 84867583227     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1002/ibd.22923     Document Type: Article

References (50)

1. Khor B, Gardet A, Xavier RJ,. Genetics and pathogenesis of inflammatory bowel disease. Nature. 2011; 474: 307-317.
2. Maloy KJ, Powrie F,. Intestinal homeostasis and its breakdown in inflammatory bowel disease. Nature. 2011; 474: 298-306.
3. Kaser A, Zeissig S, Blumberg RS,. Genes and environment: how will our concepts on the pathophysiology of IBD develop in the future? Dig Dis. 2008; 28: 395-405.
4. Barnes MJ, Powrie F,. Regulatory T cells reinforce intestinal homeostasis. Immunity. 2009; 31: 401-411.
5. McGuckin MA, Eri R, Simms LA, et al. Intestinal barrier dysfunction in inflammatory bowel diseases. Inflamm Bowel Dis. 2009; 15: 100-113.
6. Roda G, Sartini A, Zambon E, et al. Intestinal epithelial cells in inflammatory bowel diseases. World J Gastroenterol. 2010; 16: 4264-4271.
7. Cario E,. Innate immune signalling at intestinal mucosal surfaces: a fine line between host protection and destruction. Curr Opin Gastroenterol. 2008; 24: 725-732.
8. Gersemann M, Wehkamp J, Fellermann K, et al. Crohn's disease-defect in innate defence. World J Gastroenterol. 2008; 14: 5499-5503.
9. Hisamatsu T, Ogata H, Hibi T, et al. Innate immunity in inflammatory bowel disease: state of the art. Curr Opin Gastroenterol. 2008; 24: 448-454.
10. Abraham C, Medzhitov R,. Interactions between the host innate immune system and microbes in inflammatory bowel disease. Gastroenterology. 2011; 140: 1729-1737.
11. Scaldaferri F, Correale C, Gasbarrini A, et al. Mucosal biomarkers in inflammatory bowel disease: key pathogenic players or disease predictors? World J Gastroenterol. 2010; 16: 2616-2625.
12. Siddiqui KR, Laffont S, Powrie F,. E-cadherin marks a subset of inflammatory dendritic cells that promote T cell-mediated colitis. Immunity. 2010; 32: 557-567.
13. Singh K, Chaturvedi R, Barry DP, et al. The apolipoprotein E-mimetic peptide COG112 inhibits NF-κB signaling, proinflammatory cytokine expression, and disease activity in murine models of colitis. J Biol Chem. 2011; 286: 3839-3850.
14. Alex P, Zachos NC, Nguyen T, et al. Distinct cytokine patterns identified from multiplex profiles of murine DSS and TNBS-induced colitis. Inflamm Bowel Dis. 2009; 15: 341-352.
15. McBee ME, Zeng Y, Parry N, et al. Multivariate modeling identifies neutrophil- and Th17-related factors as differential serum biomarkers of chronic murine colitis. PLoS One. 2010; 5: e13277.
16. Arsenescu R, Bruno ME, Rogier EW, et al. Signature biomarkers in Crohn's disease: toward a molecular classification. Mucosal Immunol. 2008; 1: 399-411.
17. te Velde AA, de Kort F, Sterrenburg E, et al. Comparative analysis of colonic gene expression of three experimental colitis models mimicking inflammatory bowel disease. Inflamm Bowel Dis. 2007; 13: 325-330.
18. Ostanin DV, Bao J, Koboziev I, et al. T cell transfer model of chronic colitis: concepts, considerations, and tricks of the trade. Am J Physiol Gastrointest Liver Physiol. 2009; 296: G135-146.
19. Powrie F, Leach MW, Mauze S, et al. Phenotypically distinct subsets of CD4+ T cells induce or protect from chronic intestinal inflammation in C. B-17 scid mice. Int Immunol. 1993; 5: 1461-1471.
20. Singh B, Read S, Asseman C, et al. Control of intestinal inflammation by regulatory T cells. Immunol Rev. 2001; 182: 190-200.
21. Trobonjaca Z, Leithauser F, Moller P, et al. MHC-II-independent CD4+ T cells induce colitis in immunodeficient RAG-/- hosts. J Immunol. 2001; 166: 3804-3812.
22. Qualls JE, Tuna H, Kaplan AM, et al. Suppression of experimental colitis in mice by CD11c+ dendritic cells. Inflamm Bowel Dis. 2009; 15: 236-247.
23. Murthy AK, Dubose CN, Banas JA, et al. Contribution of polymeric immunoglobulin receptor to regulation of intestinal inflammation in dextran sulfate sodium-induced colitis. J Gastroenterol Hepatol. 2006; 21: 1372-1380.
24. Park CM, Reid PE, Walker DC, et al. A simple, practical 'swiss roll' method of preparing tissues for paraffin or methacrylate embedding. J Microsc. 1987; 145: 115-120.
25. Weigmann B, Tubbe I, Seidel D, et al. Isolation and subsequent analysis of murine lamina propria mononuclear cells from colonic tissue. Nat Protoc. 2007; 2: 2307-2311.
26. Bruno ME, Rogier EW, Frantz AL, et al. Regulation of the polymeric immunoglobulin receptor in intestinal epithelial cells by Enterobacteriaceae: implications for mucosal homeostasis. Immunol Invest. 2010; 39: 356-382.
27. Ringnér M,. What is principal component analysis? Nat Biotechnol. 2008; 26: 303-304.
28. Shembade N, Ma A, Harhaj EW,. Inhibition of NF-κB signaling by A20 through disruption of ubiquitin enzyme complexes. Science. 2010; 327: 1135-1139.
29. Qualls JE, Kaplan AM, van Rooijen N, et al. Suppression of experimental colitis by intestinal mononuclear phagocytes. J Leukoc Biol. 2006; 80: 802-815.
30. Saleh M, Elson CO,. Experimental inflammatory bowel disease: insights into the host-microbiota dialog. Immunity. 2011; 34: 293-302.
31. Ni J, Chen SF, Hollander D,. Effects of dextran sulphate sodium on intestinal epithelial cells and intestinal lymphocytes. Gut. 1996; 39: 234-241.
32. Dieleman LA, Ridwan BU, Tennyson GS, et al. Dextran sulfate sodium-induced colitis occurs in severe combined immunodeficient mice. Gastroenterology. 1994; 107: 1643-1652.
33. Kim TW, Seo JN, Suh YH, et al. Involvement of lymphocytes in dextran sulfate sodium-induced experimental colitis. World J Gastroenterol. 2006; 12: 302-305.
34. Boden EK, Snapper SB,. Regulatory T cells in inflammatory bowel disease. Curr Opin Gastroenterol. 2008; 24: 733-741.
35. Pasparakis M,. IKK/NF-κB signaling in intestinal epithelial cells controls immune homeostasis in the gut. Mucosal Immunol. 2008; 1 (Suppl 1): S54-57.
36. Pasparakis M,. Regulation of tissue homeostasis by NF-κB signalling: implications for inflammatory diseases. Nat Rev Immunol. 2009; 9: 778-788.
37. Wullaert A, Bonnet MC, Pasparakis M,. NF-κB in the regulation of epithelial homeostasis and inflammation. Cell Res. 2011; 21: 146-158.
38. Eckmann L, Nebelsiek T, Fingerle AA, et al. Opposing functions of IKKβ during acute and chronic intestinal inflammation. Proc Natl Acad Sci U S A. 2008; 105: 15058-15063.
39. Kawada M, Arihiro A, Mizoguchi E,. Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease. World J Gastroenterol. 2007; 13: 5581-5593.
40. Kaetzel CS,. The polymeric immunoglobulin receptor: bridging innate and adaptive immune responses at mucosal surfaces. Immunol Rev. 2005; 206: 83-99.
41. Norderhaug IN, Johansen FE, Schjerven H, et al. Regulation of the formation and external transport of secretory immunoglobulins. Crit Rev Immunol. 1999; 19: 481-508.
42. Macpherson AJ, McCoy KD, Johansen FE, et al. The immune geography of IgA induction and function. Mucosal Immunol. 2008; 1: 11-22.
43. Kaetzel CS, Robinson JK, Chintalacharuvu KR, et al. The polymeric immunoglobulin receptor (secretory component) mediates transport of immune complexes across epithelial cells: a local defense function for IgA. Proc Natl Acad Sci U S A. 1991; 88: 8796-8800.
44. Peeters AJ, van den Wall Bake AW, Daha MR, et al. Inflammatory bowel disease and ankylosing spondylitis associated with cutaneous vasculitis, glomerulonephritis, and circulating IgA immune complexes. Ann Rheum Dis. 1990; 49: 638-640.
45. Phalipon A, Corthésy B,. Novel functions of the polymeric Ig receptor: well beyond transport of immunoglobulins. Trends Immunol. 2003; 24: 55-58.
46. Corthésy B,. Roundtrip ticket for secretory IgA: role in mucosal homeostasis? J Immunol. 2007; 178: 27-32.
47. Bruno ME, Frantz AL, Rogier EW, et al. Regulation of the polymeric immunoglobulin receptor by the classical and alternative NF-κB pathways in intestinal epithelial cells. Mucosal Immunol. 2011; 4: 468-478.
48. Swaminath A, Lebwohl B, Capiak KM, et al. Practice patterns in the use of anti-tumor necrosis factor alpha agents in the management of Crohn's disease: a US national practice survey comparing experts and non-experts. Dig Dis Sci. 2011; 56: 1160-1164.
49. Ricciardelli I, Lindley KJ, Londei M, et al. Anti tumour necrosis-alpha therapy increases the number of FOXP3 regulatory T cells in children affected by Crohn's disease. Immunology. 2008; 125: 178-183.
50. Clark M, Colombel JF, Feagan BC, et al. American gastroenterological association consensus development conference on the use of biologics in the treatment of inflammatory bowel disease, June 21-23, 2006. Gastroenterology. 2007; 133: 312-339.