Tumor characteristics and recurrence patterns in triple negative breast cancer: A comparison between younger (<65) and elderly (≥65) patients

European Journal of Cancer

Volumn 48, Issue 16, 2012, Pages 2962-2968

  Königsberg, Robert ^a,b   Pfeiler, Georg ^c   Klement, Tatjana ^c   Hammerschmid, Nicole ^c   Brunner, Andreas ^d   Zeillinger, Robert ^e   Singer, Christian ^c   Dittrich, Christian ^a,b  

^a LUDWIG BOLTZMANN INSTITUTE FOR LUNG VASCULAR RESEARCH   (Austria)

^b KAISER FRANZ JOSEF HOSPITAL   (Austria)

^c UNIV KLIN FÜR FRAUENHEILKUNDE   (Austria)

^d Landesklinikum Thermenregion Moedling ^*  (Austria)

^e MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

Bone metastases; Chemotherapy; Elderly; Local recurrence; Lymph node metastases; Triple negative breast cancer

Indexed keywords

ANTHRACYCLINE ANTIBIOTIC AGENT; CYCLOPHOSPHAMIDE; FLUOROURACIL; METHOTREXATE; TAXANE DERIVATIVE;

ADJUVANT THERAPY; ADULT; AGED; AGING; ARTICLE; BONE METASTASIS; BREAST CANCER; CANCER CHEMOTHERAPY; CANCER GRADING; CANCER PATIENT; CANCER RADIOTHERAPY; CANCER SURGERY; CLINICAL FEATURE; CONTROLLED STUDY; DISTANT METASTASIS; ELECTRONIC MEDICAL RECORD; FEMALE; GERIATRIC PATIENT; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MEDICAL RECORD REVIEW; METASTASIS; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; TRIPLE NEGATIVE BREAST CANCER; TUMOR VOLUME; VISCERAL METASTASIS;

ADULT; AGE FACTORS; AGED; AGED, 80 AND OVER; AUSTRIA; BONE NEOPLASMS; BRAIN NEOPLASMS; BREAST NEOPLASMS; CARCINOMA; CHEMOTHERAPY, ADJUVANT; CHI-SQUARE DISTRIBUTION; FEMALE; HUMANS; LIVER NEOPLASMS; LUNG NEOPLASMS; LYMPHATIC METASTASIS; MASTECTOMY; MIDDLE AGED; NEOADJUVANT THERAPY; NEOPLASM GRADING; NEOPLASM RECURRENCE, LOCAL; RADIOTHERAPY, ADJUVANT; RECEPTOR, ERBB-2; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; RETROSPECTIVE STUDIES; RISK ASSESSMENT; RISK FACTORS; TIME FACTORS; TREATMENT OUTCOME; TUMOR BURDEN; TUMOR MARKERS, BIOLOGICAL;

EID: 84867582998     PISSN: 09598049     EISSN: 18790852     Source Type: Journal    
DOI: 10.1016/j.ejca.2012.04.019     Document Type: Article

References (36)

1. H.B. Muss, S. Woolf, and D. Berry Adjuvant chemotherapy in older and younger women with lymph node-positive breast cancer JAMA 293 9 2005 1073 1081
2. M.A. Schonberg, E.R. Marcantonio, and D. Li Breast cancer among the oldest old: tumor characteristics, treatment choices, and survival J Clin Oncol 28 12 2010 2038 2045
3. X. Du, and J.S. Goodwin Patterns of use of chemotherapy for breast cancer in older women: findings from Medicare claims data J Clin Oncol 19 5 2001 1455 1461
4. H.B. Muss, D.A. Berry, and C.T. Cirrincione Adjuvant chemotherapy in older women with early-stage breast cancer N Engl J Med 360 20 2009 2055 2065
5. C. Bouchardy, E. Rapiti, and G. Fioretta Undertreatment strongly decreases prognosis of breast cancer in elderly women J Clin Oncol 21 19 2003 3580 3587
6. H.B. Muss Adjuvant treatment of elderly breast cancer patients Breast 16 Suppl. 2 2007 S159 S165
7. H.B. Muss Coming of age: breast cancer in seniors Oncologist 15 Suppl. 5 2010 57 65
8. A. Ring, I. Sestak, and M. Baum Influence of comorbidities and age on risk of death without recurrence: a retrospective analysis of the arimidex, tamoxifen alone or in combination trial J Clin Oncol 1029 32 2011 4266 4272
9. S.G. Diab, R.M. Elledge, and G.M. Clark Tumor characteristics and clinical outcome of elderly women with breast cancer J Natl Cancer Inst 92 7 2000 550 556
10. W.C. Taylor, and H.B. Muss Recent advances: adjuvant therapy for older women with breast cancer Cancer J 16 4 2010 289 293
11. A. Berghoff, Z. Bago-Horvath, and C. De Vries Brain metastases free survival differs between breast cancer subtypes Br J Cancer 106 3 2012 Jan 31 440 446
12. W.D. Foulkes, I.E. Smith, and J.S. Reis-Filho Triple-negative breast cancer N Engl J Med 363 20 2010 1938 1948
13. R. Dent, M. Trudeau, and K.I. Pritchard Triple-negative breast cancer: clinical features and patterns of recurrence Clin Cancer Res 13 15 Pt 1 2007 4429 4434
14. M. Smid, Y. Wang, and Y. Zhang Subtypes of breast cancer show preferential site of relapse Cancer Res 68 9 2008 3108 3114
15. A. Ring, M. Reed, and R. Leonard The treatment of early breast cancer in women over the age of 70 Br J Cancer 105 2 2011 189 193
16. R. Konigsberg, E. Obermayr, and G. Bises Detection of EpCAM positive and negative circulating tumor cells in metastatic breast cancer patients Acta Oncol 50 5 2011 700 710
17. P. Regitnig, A. Reiner, and H.P. Dinges Quality assurance for detection of estrogen and progesterone receptors by immunohistochemistry in Austrian pathology laboratories Virchows Arch 441 4 2002 328 334
18. M.E. Hammond, D.F. Hayes, and M. Dowsett American Society of Clinical Oncology/College of American Pathologists guideline recommendations for immunohistochemical testing of estrogen and progesterone receptors in breast cancer J Clin Oncol 28 16 2010 2784 2795
19. L.M. McShane, D.G. Altman, W. Sauerbrei, S.E. Taube, M. Gion, and G.M. Clark REporting recommendations for tumor MARKer prognostic studies (REMARK) Breast Cancer Res Treat 100 2 2006 229 235
20. G. Bonadonna Karnofsky memorial lecture. Conceptual and practical advances in the management of breast cancer J Clin Oncol 7 10 1989 1380 1397
21. R.T. Greenlee, M.B. Hill-Harmon, T. Murray, and M. Thun Cancer statistics, 2001 CA Cancer J Clin 51 1 2001 15 36
22. R. Dent, W.M. Hanna, and M. Trudeau Pattern of metastatic spread in triple-negative breast cancer Breast Cancer Res Treat 115 2 2009 423 428
23. L. Biganzoli, H. Wildiers, and C. Oakman Management of elderly individuals with breast cancer: update of the recommendations of the International Society of Geriatric Oncology (SIOG) and the European Society of Breast Cancer Specialists (EUSOMA) Lancet Oncol 13 4 2012 e148 e160
24. C. Liedtke, C. Mazouni, and K.R. Hess Response to neoadjuvant therapy and long-term survival in patients with triple-negative breast cancer J Clin Oncol 26 8 2008 1275 1281
25. K.R. Bauer, M. Brown, R.D. Cress, C.A. Parise, and V. Caggiano Descriptive analysis of estrogen receptor (ER)-negative, progesterone receptor (PR)-negative, and HER2-negative invasive breast cancer, the so-called triple-negative phenotype: a population-based study from the California cancer Registry Cancer 109 9 2007 1721 1728
26. S.M. Rodriguez-Pinilla, D. Sarrio, and E. Honrado Prognostic significance of basal-like phenotype and fascin expression in node-negative invasive breast carcinomas Clin Cancer Res 12 5 2006 1533 1539
27. C.M. Perou Molecular stratification of triple-negative breast cancers Oncologist 15 Suppl. 5 2010 39 48
28. B. Weigelt, and J.S. Reis-Filho Histological and molecular types of breast cancer: is there a unifying taxonomy? Nat Rev Clin Oncol 6 12 2009 718 730
29. B. Kreike, M. van Kouwenhove, and H. Horlings Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas Breast Cancer Res 9 5 2007 R65
30. M. Tischkowitz, J.S. Brunet, and L.R. Begin Use of immunohistochemical markers can refine prognosis in triple negative breast cancer BMC Cancer 7 2007 134
31. Dreyer G, Vandorpe T, Smeets A, et al. Triple-negative breast cancer: clinical characteristics in the different histological subtypes. San Antonio Breast Cancer Symposium 2010 [abstr. P3-10-05].
32. C.A. Livasy, G. Karaca, and R. Nanda Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma Mod Pathol 19 2 2006 264 271
33. Early Breast Cancer Trialists Collaborative Group (EBCTCG) Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials Lancet 365 9472 2005 1687 1717
34. M. Schneider, I.H. Zuckerman, and E. Onukwugha Chemotherapy treatment and survival in older women with estrogen receptor-negative metastatic breast cancer: a population-based analysis J Am Geriatr Soc 59 4 2011 637 646
35. L.C. Harlan, L.X. Clegg, J. Abrams, J.L. Stevens, and R. Ballard-Barbash Community-based use of chemotherapy and hormonal therapy for early-stage breast cancer: 1987-2000 J Clin Oncol 24 6 2006 872 877
36. K. Cheung, B.M. Syed, and A.R. Green Clinical outcome of triple-negative primary breast cancer in older women: comparison with their younger counterparts J Clin Oncol 29 Suppl. 2011 [abstr. 1057]