Neuropeptide y (NPY): Genetic variation in the human promoter alters glucocorticoid signaling, yielding increased NPY secretion and stress responses

Journal of the American College of Cardiology

Volumn 60, Issue 17, 2012, Pages 1678-1689

  Zhang, Kuixing ^a   Rao, Fangwen ^a   Pablo Miramontes Gonzalez, Jose ^a   Hightower, C Makena ^a   Vaught, Brian ^a   Chen, Yuhong ^a   Greenwood, Tiffany A ^a   Schork, Andrew J ^a   Wang, Lei ^a   Mahata, Manjula ^a   Stridsberg, Mats ^b   Khandrika, Srikrishna ^a   Biswas, Nilima ^a   Fung, Maple M ^a   Waalen, Jill ^c   Middelberg, Rita P ^c   Heath, Andrew C ^d   Montgomery, Grant W ^d   Martin, Nicholas G ^d   Whitfield, John B ^d   Baker, Dewleen G ^a,e   Schork, Nicholas J ^c   Nievergelt, Caroline M ^a,e   O'Connor, Daniel T ^a   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UPPSALA UNIVERSITY   (Sweden)

^c SCRIPPS RESEARCH INSTITUTE   (United States)

^d QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^e VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

genetics; glucocorticoid receptor; hypertension; neuropeptide Y

Indexed keywords

GLUCOCORTICOID; NEUROPEPTIDE Y;

ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; BIOGEOGRAPHIC REGION; BLOOD PRESSURE; CARDIOVASCULAR RISK; CHROMAFFIN CELL; DIASTOLIC BLOOD PRESSURE; ENVIRONMENTAL STRESS; EXON; FEMALE; GEL MOBILITY SHIFT ASSAY; GENE; GENE EXPRESSION; GENE FUNCTION; GENE LOCUS; GENE SEQUENCE; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC POLYMORPHISM; GENETIC REGULATION; GENETIC TRAIT; GENETIC TRANSCRIPTION; GENETIC VARIABILITY; HAPLOTYPE; HORMONE RESPONSE; HUMAN; HYPERTENSION; IN VIVO STUDY; INTRON; MALE; NPY GENE; POPULATION RESEARCH; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; SITE DIRECTED MUTAGENESIS; STRESS; SYMPATHOCHROMAFFIN CELL; SYSTEMIC VASCULAR RESISTANCE; SYSTOLIC BLOOD PRESSURE; UNTRANSLATED REGION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALLELES; DNA; ELECTROPHORETIC MOBILITY SHIFT ASSAY; FEMALE; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; GENOTYPE; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; NEUROPEPTIDE Y; PROMOTER REGIONS, GENETIC; RECEPTORS, GLUCOCORTICOID; SIGNAL TRANSDUCTION; STRESS, PSYCHOLOGICAL;

EID: 84867579424     PISSN: 07351097     EISSN: 15583597     Source Type: Journal    
DOI: 10.1016/j.jacc.2012.06.042     Document Type: Article

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