Strategies for targeting the gingipain secretion system of Porphyromonas gingivalis

Journal of Oral Biosciences

Volumn 54, Issue 3, 2012, Pages 155-159

  Saiki, Keitarou ^a   Konishi, Kiyoshi ^a  

^a NIPPON DENTAL UNIVERSITY   (Japan)

Author keywords

Gingipain; LPS; Porphyromonas; Secretion

Indexed keywords

EID: 84867578231     PISSN: 13490079     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.job.2012.03.003     Document Type: Review

References (42)

1. Christersson LA, Fransson CL, Dunford RG, Zambon JJ. Subgingival distribution of periodontal pathogenic microorganisms in adult periodontitis. J Period-ontol 1992;63:418-25.
2. Socransky SS, Haffajee AD. The bacterial etiology of destructive periodontal disease: current concepts. J Periodontol 1992;63:322-31.
3. Darveau RP. Periodontitis: a polymicrobial disruption of host homeostasis. Nat Rev Microbiol 2010;8:481-90.
4. Lamont RJ, Jenkinson HF. Life below the gum line: pathogenic mechanisms of Porphyromonas gingivalis. Microbiol Mol Biol Rev 1998;62:1244-63.
5. Curtis MA, Kuramitsu HK, Lantz M, Macrina FL, Nakayama K, Potempa J, Reynolds EC, Aduse-Opoku J. Molecular genetics and nomenclature of proteases of Porphyromonas gingivalis. J Periodontal Res. 1999;34:464-72.
6. Banbula A, Bugno M, Goldstein J, Yen J, Nelson D, Travis J, Potempa J. Emerging family of proline-specific peptidases of Porphyromonas gingivalis: purification and characterization of serine dipeptidyl peptidase, a structural and functional homologue of mammalian prolyl dipeptidyl peptidase IV. Infect Immun 2000;68:1176-82.
7. Banbula A, Yen J, Oleksy A, Mak P, Bugno M, Travis J, Potempa J. Porphyr-omonas gingivalis DPP-7 represents a novel type of dipeptidylpeptidase. J Biol Chem 2001;276:6299-305.
8. Ohara-Nemoto Y, Shimoyama Y, Kimura S, Kon A, Haraga H, Ono T, Nemoto TK. Asp- and Glu-specific novel dipeptidyl peptidase 11 of Porphyromonas gingivalis ensures utilization of proteinaceous energy sources. J Biol Chem 2011;286:38115-27.
9. Banbula A, Mak P, Bugno M, Silberring J, Dubin A, Nelson D, Travis J, Potempa J. Prolyl tripeptidyl peptidase from Porphyromonas gingivalis. A novel enzyme with possible pathological implications for the development of periodontitis. J Biol Chem 1999;274:9246-52.
10. Chen Y-Y, Cross KJ, Paolini RA, Fielding JE, Slakeski N, Reynolds EC. CPG70 is a novel basic metallocarboxypeptidase with C-terminal polycystic kidney disease domains from Porphyromonas gingivalis. J Biol Chem 2002;277:23433-40.
11. Guo Y, Nguyen K-A, Potempa J. Dichotomy of gingipains action as virulence factors: from cleaving substrates with the precision of a surgeon's knife to a meat chopper-like brutal degradation of proteins. Periodontol 2000 2010:15-44.
12. Seddon SV, Shah HN, Hardie JM, Robinson JP. Chemically defined and minimal media for Bacteroides gingivalis. Curr Microbiol 1988;17:147-9.
13. Takahashi N, Sato T. Preferential utilization of dipeptides by Porphyromonas gingivalis. J Dent Res 2001;80:1425-9.
14. Socransky SS, Dzink JL, Smith CM. Chemically defined medium for oral microorganisms. J Clin Microbiol 1985;22:303-5.
15. Wyss C. Growth of Porphyromonas gingivalis, Treponema denticola, T. pectino-vorum, T. socranskii, and T. vincentii in a chemically defined medium. J Clin Microbiol 1992;30:2225-9.
16. Milner P, Batten JE, Curtis MA. Development of a simple chemically defined medium for Porphyromonas gingivalis: requirement for a-ketoglutarate. FEMS Microbiol Lett 1996;140:125-30.
17. Shi Y, Ratnayake DB, Okamoto K, Abe N, Yamamoto K, Nakayama K. Genetic analyses of proteolysis, hemoglobin binding, and hemagglutination of Por-phyromonas gingivalis. Construction of mutants with a combination of rgpA, rgpB, kgp, and hagA. J Biol Chem 1999;274:17955-60.
18. Grenier D, Imbeault S, Plamondon P, Grenier G, Nakayama K, Mayrand D. Role of gingipains in growth of Porphyromonas gingivalis in the presence of human serum albumin. Infect Immun 2001;69:5166-72.
19. Curtis MA, Opoku JA, Rangarajan M, Gallagher A, Sterne JAC, Reid CR, Evans HEA, Samuelsson B. Attenuation of the virulence of Porphyromonas gingivalis by using a specific synthetic Kgp protease inhibitor. Infect Immun 2002;70:6968-75.
20. Sato K, Sakai E, Veith PD, Shoji M, Kikuchi Y, Yukitake H, Ohara N, Naito M, Okamoto K, Reynolds EC, Nakayama K. Identification of a new membrane- associated protein that influences transport/maturation of gingipains and adhesins of Porphyromonas gingivalis. J Biol Chem 2005;280:8668-77.
21. Oda H, Saiki K, Numabe Y, Konishi K. Effect of g-immunoglobulin on the asaccharolytic growth of Porphyromonas gingivalis. J Periodontal Res 2007;42:438-42.
22. Nakayama K, Kadowaki T, Okamoto K, Yamamoto K. Construction and characterization of arginine-specific cysteine proteinase (Arg-gingipain)- deficient mutants of Porphyromonas gingivalis. Evidence for significant contribution of Arg-gingipain to virulence. J Biol Chem 1995;270:23619-26.
23. Oda H, Saiki K, Tonosaki M, Yajima A, Konishi K. Participation of the secreted dipeptidyl and tripeptidyl aminopeptidases in asaccharolytic growth of Porphyromonas gingivalis. J Periodontal Res 2009;44:362-7.
24. Seers CA, Slakeski N, Veith PD, Nikolof T, Chen Y-Y, Dashper SG, Reynolds EC. The RgpB C-terminal domain has a role in attachment of RgpB to the outer membrane and belongs to a novel C-terminal-domain family found in Porphyromonas gingivalis. J Bacteriol 2006;188:6376-86.
25. Nelson KE, Fleischmann RD, DeBoy RT, Paulsen IT, Fouts DE, Eisen JA, Daugherty SC, Dodson RJ, Durkin AS, Gwinn M, Haft DH, Kolonay JF, Nelson WC, Mason T, Tallon L, Gray J, Granger D, Tettelin H, Dong H, Galvin JL, Duncan MJ, Dewhirst FE, Fraser CM. Complete genome sequence of the oral pathogenic bacterium Porphyromonas gingivalis strain W83. J Bacteriol 2003;185:5591-601.
26. Zhang Y, Wang T, Chen W, Yilmaz O, Park Y, Jung I-Y, Hackett M, Lamont RJ. Differential protein expression by Porphyromonas gingivalis in response to secreted epithelial cell components. Proteomics 2005;5:198-211.
27. Cerdeño-Tárraga AM, Patrick S, Crossman LC, Blakely G, Abratt V, Lennard N, Poxton I, Duerden B, Harris B, Quail MA, Barron A, Clark L, Corton C, Doggett J, Holden MT, Larke N, Line A, Lord A, Norbertczak H, Ormond D, Price C, Rabbinowitsch E, Woodward J, Barrell B, Parkhill J. Extensive DNA inversions in the B. fragilis genome control variable gene expression. Science 2005;307:1463-5.
28. Saiki K, Konishi K. Identification of a Porphyromonas gingivalis novel protein Sov required for the secretion of gingipains. Microbiol Immunol 2007;51:483-91.
29. Saiki K, Konishi K. The role of Sov protein in the secretion of gingipain protease virulence factors of Porphyromonas gingivalis. FEMS Microbiol Lett 2010;302:166-74.
30. Ishiguro I, Saiki K, Konishi K. PG27 is a novel membrane protein essential for a Porphyromonas gingivalis protease secretion system. FEMS Microbiol Lett 2009;292:261-7.
31. Saiki K, Konishi K. Identification of a novel Porphyromonas gingivalis outer membrane protein PG534, required for the production of active gingipains. FEMS Microbiol Lett 2010;310:168-74.
32. Naito M, Hirakawa H, Yamashita A, Ohara N, Shoji M, Yukitake H, Nakayama K, Toh H, Yoshimura F, Kuhara S, Hattori M, Hayashi T, Nakayama K. Determination of the genome sequence of Porphyromonas gingivalis strain ATCC 33277 and genomic comparison with strain W83 revealed extensive genome rearrangements in P. gingivalis. DNA Res 2008;15:215-25.
33. Chen Y-Y, Peng B, Yang Q, Glew MD, Veith PD, Cross KJ, Goldie KN, Chen D, O'Brien-Simpson N, Dashper SG, Reynolds EC. The outer membrane protein LptO is essential for the O-deacylation of LPS and the co-ordinated secretion and attachment of A-LPS and CTD proteins in Porphyromonas gingivalis. Mol Microbiol 2011;79:1380-401.
34. Park Y, Yilmaz ö, Jung I-Y, Lamont RJ. Identification of Porphyromonas gingivalis genes specifically expressed in human gingival epithelial cells by using differential display reverse transcription-PCR. Infect Immun 2004;72:3752-8.
35. Abaibou H, Chen Z, Olango GJ, Liu Y, Edwards J, Fletcher HM. vimA gene downstream of recA is involved in virulence modulation in Porphyromonas gingivalis W83. Infect Immun 2001;69:325-35.
36. Shoji M, Ratnayake DB, Shi Y, Kadowaki T, Yamamoto K, Yoshimura F, Akamine A, Curtis MA, Nakayama K. Construction and characterization of a nonpigmented mutant of Porphyromonas gingivalis: cell surface polysacchar-ide as an anchorage for gingipains. Microbiology 2002;148:1183-91.
37. Vanterpool E, Roy F, Fletcher HM. The vimE gene downstream of vimA is independently expressed and is involved in modulating proteolytic activity in Porphyromonas gingivalis W83. Infect Immun 2004;72:5555-64.
38. Vanterpool E, Roy F, Sandberg L, Fletcher HM. Altered gingipain maturation in vimA- and vimE-defective isogenic mutants of Porphyromonas gingivalis. Infect Immun 2005;73:1357-66.
39. Vanterpool E, Roy F, Fletcher HM. Inactivation of vimF, a putative glycosyltrans-ferase gene downstream of vimE, alters glycosylation and activation of the gingipains in Porphyromonas gingivalis W83. Infect Immun 2005;73:3971-82.
40. Sato K, Kido N, Murakami Y, Hoover CI, Nakayama K, Yoshimura F. Lipopolysaccharide biosynthesis-related genes are required for colony pigmentation of Porphyromonas gingivalis. Microbiology 2009;155:1282-93.
41. Sato K, Naito M, Yukitake H, Hirakawa H, Shoji M, McBride MJ, Rhodes RG, Nakayama K. A protein secretion system linked to bacteroidete gliding motility and pathogenesis. Proc Natl Acad Sci USA 2010;107:276-81.
42. Ishiguro I, Saiki K, Konishi K. Analysis of Porphyromonas gingivalis PG27 by deletion and intragenic suppressor mutation analyses. Mol Oral Microbiol 2011;26:321-35.