MicroRNAs: Small but amazing, and their association with endothelin

Life Sciences

Volumn 91, Issue 13-14, 2012, Pages 475-489

  Von Brandenstein, Melanie ^a   Richter, Claudia ^a   Fries, Jochen W U ^a  

^a UNIVERSITY HOSPITAL OF COLOGNE   (Germany)

Author keywords

Biogenesis; Endothelin 1; Human disease; miRNA; miRNA regulation

Indexed keywords

DICER; ENDOTHELIN 1; MICRORNA; MICRORNA 125B; VIRUS VECTOR;

BIOGENESIS; CARDIOVASCULAR DISEASE; CONFERENCE PAPER; CYTOPLASM; GENE SEQUENCE; GENETIC REGULATION; HEMATOLOGIC DISEASE; HUMAN; INFECTION; INFLAMMATORY DISEASE; KIDNEY DISEASE; MICROARRAY ANALYSIS; NEOPLASM; NONHUMAN; PROTEIN PROTEIN INTERACTION; RNA ISOLATION; RNA TRANSLATION;

ANIMALS; BASE SEQUENCE; ENDOTHELINS; HUMANS; MICRORNAS; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 84867576189     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2012.06.025     Document Type: Conference Paper

References (193)

1. R. Agami microRNAs, RNA binding proteins and cancer Eur J Clin Invest 40 2010 370 374
2. P. Alexiou, M. Maragkakis, G.L. Papadopoulos, M. Reczko, and A.G. Hatzigeorgiou Lost in translation: an assessment and perspective for computational microRNA target identification Bioinformatics 25 2009 3049 3055
3. I. Alvarez-Garcia, and E.A. Miska MicroRNA functions in animal development and human disease Development 132 2005 4653 4662
4. V. Ambros, and H.R. Horvitz Heterochronic mutants of the nematode Caenorhabditis elegans Science 226 1984 409 416
5. V. Ambros, B. Bartel, D.P. Bartel, C.B. Burge, J.C. Carrington, and X. Chen A uniform system for microRNA annotation RNA 9 2003 277 279
6. V. Ambros, R.C. Lee, A. Lavanway, P.T. Williams, and D. Jewell MicroRNAs and other tiny endogenous RNAs in C. elegans Curr Biol 13 2003 807 818
7. R.I. Aqeilan, G.A. Calin, and C.M. Croce miR-15a and miR-16-1 in cancer: discovery, function and future perspectives Cell Death Differ 17 2009 215 220
8. J.D. Arroyo, J.R. Chevillet, E.M. Kroh, I.K. Ruf, C.C. Pritchard, and D.F. Gibson Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasma Proc Natl Acad Sci U S A 108 2011 5003 5008
9. A. Bagnato, and L. Rosano Epithelial-mesenchymal transition in ovarian cancer progression: a crucial role for the endothelin axis Cells Tissues Organs 185 2007 85 94
10. S. Bala, M. Marcos, K. Kodys, T. Csak, D. Catalano, and P. Mandrekar Up-regulation of microRNA-155 in macrophages contributes to increased tumor necrosis factor α (TNFα) production via increased mRNA half-life in alcoholic liver disease J Biol Chem 286 2010 1436 1444
11. N. Bandi, S. Zbinden, M. Gugger, M. Arnold, V. Kocher, and L. Hasan miR-15a and miR-16 are implicated in cell cycle regulation in a Rb-dependent manner and are frequently deleted or down-regulated in non-small cell lung cancer Cancer Res 69 2009 5553 5559
12. D. Banerjee, and F. Slack Control of developmental timing by small temporal RNAs: a paradigm for RNA-mediated regulation of gene expression Bioessays 24 2002 119 129
13. E.V. Barker, N.K. Cervigne, P.P. Reis, R.S. Goswami, W. Xu, and I. Weinreb microRNA evaluation of unknown primary lesions in the head and neck Mol Cancer 8 2009 127
14. E. Berezikov, W.J. Chung, J. Willis, E. Cuppen, and E.C. Lai Mammalian mirtron genes Mol Cell 28 2007 328 336
15. B.C. Bernardo, F.J. Charchar, R.C. Lin, and J.R. McMullen A MicroRNA Guide for Clinicians and Basic Scientists: Background and Experimental Techniques Heart Lung Circ 21 2011 131 142
16. E. Bernstein, S.Y. Kim, M.A. Carmell, E.P. Murchison, H. Alcorn, and M.Z. Li Dicer is essential for mouse development Nat Genet 35 2003 215 217
17. G. Berx, E. Raspe, G. Christofori, J.P. Thiery, and J.P. Sleeman Pre-EMTing metastasis? Recapitulation of morphogenetic processes in cancer Clin Exp Metastasis 24 2007 587 597
18. D. Betel, M. Wilson, A. Gabow, D.S. Marks, and C. Sander The microRNA.org resource: targets and expression Nucleic Acids Res 36 2008 D149 D153
19. D. Bonci, V. Coppola, M. Musumeci, A. Addario, R. Giuffrida, and L. Memeo The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities Nat Med 14 2008 1271 1277
20. G.M. Borchert, W. Lanier, and B.L. Davidson RNA polymerase III transcribes human microRNAs Nat Struct Mol Biol 13 2006 1097 1101
21. C.P. Bracken, P.A. Gregory, N. Kolesnikoff, A.G. Bert, J. Wang, and M.F. Shannon A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition Cancer Res 68 2008 7846 7854
22. J.C. Brase, M. Johannes, T. Schlomm, M. Falth, A. Haese, and T. Steuber Circulating miRNAs are correlated with tumor progression in prostate cancer Int J Cancer 128 2010 608 616
23. J. Brennecke, A. Stark, R.B. Russell, and S.M. Cohen Principles of microRNA-target recognition PLoS Biol 3 2005 e85
24. G.A. Calin, A. Cimmino, M. Fabbri, M. Ferracin, S.E. Wojcik, and M. Shimizu MiR-15a and miR-16-1 cluster functions in human leukemia Proc Natl Acad Sci U S A 105 2008 5166 5171
25. R.M. Carew, B. Wang, and P. Kantharidis The role of EMT in renal fibrosis Cell Tissue Res 347 2011 103 116
26. R.W. Carthew, and E.J. Sontheimer Origins and Mechanisms of miRNAs and siRNAs Cell 136 2009 642 655
27. L. Castellano, G. Giamas, J. Jacob, R.C. Coombes, W. Lucchesi, and P. Thiruchelvam The estrogen receptor-alpha-induced microRNA signature regulates itself and its transcriptional response Proc Natl Acad Sci U S A 106 2009 15732 15737
28. M. Chalfie, H.R. Horvitz, and J.E. Sulston Mutations that lead to reiterations in the cell lineages of C. elegans Cell 24 1981 59 69
29. C.J. Chang, C.H. Chao, W. Xia, J.Y. Yang, Y. Xiong, and C.W. Li p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs Nat Cell Biol 13 2011 317 323
30. S. Cheloufi, C.O. Dos Santos, M.M. Chong, and G.J. Hannon A dicer-independent miRNA biogenesis pathway that requires Ago catalysis Nature 465 2010 584 589
31. K. Chen, and N. Rajewsky Natural selection on human microRNA binding sites inferred from SNP data Nat Genet 38 2006 1452 1456
32. D.R. Cochrane, D.M. Cittelly, E.N. Howe, N.S. Spoelstra, E.L. McKinsey, and K. LaPara MicroRNAs link estrogen receptor alpha status and Dicer levels in breast cancer Horm Cancer 1 2011 306 319
33. B. Crestani Endothelin could participate in the epithelial-mesenchymal transition of alveolar type II cells (AEC) in vitro Am J Respir Cell Mol Biol 37 2007 624
34. B.N. Davis, and A. Hata Regulation of MicroRNA Biogenesis: A miRiad of mechanisms Cell Commun Signal 7 2009 18
35. B.N. Davis, and A. Hata microRNA in Cancer - The involvement of aberrant microRNA biogenesis regulatory pathways Genes Cancer 1 2011 1100 1114
36. B.N. Davis, A.C. Hilyard, G. Lagna, and A. Hata SMAD proteins control DROSHA-mediated microRNA maturation Nature 454 2008 56 61
37. B.N. Davis, A.C. Hilyard, P.H. Nguyen, G. Lagna, and A. Hata Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha Mol Cell 39 2010 373 384
38. B.N. Davis-Dusenbery, and A. Hata Mechanisms of control of microRNA biogenesis J Biochem 148 2010 381 392
39. M. de Planell-Saguer, and M.C. Rodicio Analytical aspects of microRNA in diagnostics: a review Anal Chim Acta 699 2011 134 152
40. B. Degertekin, S. Ozenirler, S. Elbeg, and G. Akyol The serum endothelin-1 level in steatosis and NASH, and its relation with severity of liver fibrosis Dig Dis Sci 52 2007 2622 2628
41. A.M. Denli, B.B. Tops, R.H. Plasterk, R.F. Ketting, and G.J. Hannon Processing of primary microRNAs by the Microprocessor complex Nature 432 2004 231 235
42. R. Derynck, and R.J. Akhurst Differentiation plasticity regulated by TGF-beta family proteins in development and disease. Nat Cell Biol 9 2007 1000 1004
43. N. Dhaun, P. Lilitkarntakul, I.M. Macintyre, E. Muilwijk, N.R. Johnston, and D.C. Kluth Urinary endothelin-1 in chronic kidney disease and as a marker of disease activity in lupus nephritis Am J Physiol Renal Physiol 296 2009 F1477 F1483
44. W.E. Dodson, D. Alexander, M. Al-Aish, and F. De La Cruz The DiGeorge syndrome Lancet 1 1969 574 575
45. J.G. Doench, and P.A. Sharp Specificity of microRNA target selection in translational repression Genes Dev 18 2004 504 511
46. J.G. Doench, C.P. Petersen, and P.A. Sharp siRNAs can function as miRNAs Genes Dev 17 2003 438 442
47. J. Elmen, M. Lindow, S. Schutz, M. Lawrence, A. Petri, and S. Obad LNA-mediated microRNA silencing in non-human primates Nature 452 2008 896 899
48. A. Epanchintsev, P. Jung, A. Menssen, and H. Hermeking Inducible microRNA expression by an all-in-one episomal vector system Nucleic Acids Res 34 2006 e119
49. C. Esau, X. Kang, E. Peralta, E. Hanson, E.G. Marcusson, and L.V. Ravichandran MicroRNA-143 regulates adipocyte differentiation J Biol Chem 279 2004 52361 52365
50. A. Etheridge, I. Lee, L. Hood, D. Galas, and K. Wang Extracellular microRNA: A new source of biomarkers Mutat Res 717 2011 85 90
51. C.R. Faehnle, and L. Joshua-Tor Argonautes confront new small RNAs Curr Opin Chem Biol 11 2007 569 577
52. B.C. Farrell, E.M. Power, and K.W. Mc Dermott Developmentally regulated expression of Sox9 and microRNAs 124, 128 and 23 in neuroepithelial stem cells in the developing spinal cord Int J Dev Neurosci 29 2010 31 36
53. P. Fasanaro, S. Greco, M. Ivan, M.C. Capogrossi, and F. Martelli microRNA: emerging therapeutic targets in acute ischemic diseases Pharmacol Ther 125 2009 92 104
54. M.J. Ford, I.A. Anton, and D.P. Lane Nuclear protein with sequence homology to translation initiation factor eIF-4A Nature 332 1988 736 738
55. J.J. Forman, A. Legesse-Miller, and H.A. Coller A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence Proc Natl Acad Sci U S A 105 2008 14879 14884
56. R.C. Friedman, K.K. Farh, C.B. Burge, and D.P. Bartel Most mammalian mRNAs are conserved targets of microRNAs Genome Res 19 2009 92 105
57. T. Fukuda, K. Yamagata, S. Fujiyama, T. Matsumoto, I. Koshida, and K. Yoshimura DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAs Nat Cell Biol 9 2007 604 611
58. F.V. Fuller-Pace, and S. Ali The DEAD box RNA helicases p68 (Ddx5) and p72 (Ddx17): novel transcriptional co-regulators Biochem Soc Trans 36 2008 609 612
59. S. Gilad, E. Meiri, Y. Yogev, S. Benjamin, D. Lebanony, and N. Yerushalmi Serum microRNAs are promising novel biomarkers PLoS One 3 2008 e3148
60. R.E. Gilbert, and M.E. Cooper The tubulointerstitium in progressive diabetic kidney disease: more than an aftermath of glomerular injury? Kidney Int 56 1999 1627 1637
61. C. Gonsalves, and V.K. Kalra Endothelin-1-induced macrophage inflammatory protein-1beta expression in monocytic cells involves hypoxia-inducible factor-1alpha and AP-1 and is negatively regulated by microRNA-195 J Immunol 185 2010 6253 6264
62. R.I. Gregory, T.P. Chendrimada, N. Cooch, and R. Shiekhattar Human RISC couples microRNA biogenesis and posttranscriptional gene silencing Cell 123 2005 631 640
63. S. Griffiths-Jones miRBase: the microRNA sequence database Methods Mol Biol 342 2006 129 138
64. A. Grishok, A.E. Pasquinelli, D. Conte, N. Li, S. Parrish, and I. Ha Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing Cell 106 2001 23 34
65. D. Grun, Y.L. Wang, D. Langenberger, K.C. Gunsalus, and N. Rajewsky microRNA target predictions across seven Drosophila species and comparison to mammalian targets PLoS Comput Biol 1 2005 e13
66. P.B. Gupta, C.L. Chaffer, and R.A. Weinberg Cancer stem cells: mirage or reality? Nat Med 15 2009 1010 1012
67. C. Gwizdek, B. Ossareh-Nazari, A.M. Brownawell, A. Doglio, E. Bertrand, and I.G. Macara Exportin-5 mediates nuclear export of minihelix-containing RNAs J Biol Chem 278 2003 5505 5508
68. A.D. Haase, L. Jaskiewicz, H. Zhang, S. Laine, R. Sack, and A. Gatignol TRBP, a regulator of cellular PKR and HIV-1 virus expression, interacts with Dicer and functions in RNA silencing EMBO Rep 6 2005 961 967
69. J. Han, Y. Lee, K.H. Yeom, Y.K. Kim, H. Jin, and V.N. Kim The Drosha-DGCR8 complex in primary microRNA processing Genes Dev 18 2004 3016 3027
70. E.K. Hanson, H. Lubenow, and J. Ballantyne Identification of forensically relevant body fluids using a panel of differentially expressed microRNAs Anal Biochem 387 2009 303 314
71. B. Hocher, C. Thone-Reineke, P. Rohmeiss, F. Schmager, T. Slowinski, and V. Burst Endothelin-1 transgenic mice develop glomerulosclerosis, interstitial fibrosis, and renal cysts but not hypertension J Clin Invest 99 1997 1380 1389
72. B. Hocher, R. Zart, A. Schwarz, V. Vogt, C. Braun, and C. Thone-Reineke Renal endothelin system in polycystic kidney disease J Am Soc Nephrol 9 1998 1169 1177
73. H.R. Horvitz, and J.E. Sulston Isolation and genetic characterization of cell-lineage mutants of the nematode Caenorhabditis elegans Genetics 96 1980 435 454
74. M.P. Hunter, N. Ismail, X. Zhang, B.D. Aguda, E.J. Lee, and L. Yu Detection of microRNA expression in human peripheral blood microvesicles PLoS One 3 2008 e3694
75. D. Iliopoulos, H.A. Hirsch, and K. Struhl An epigenetic switch involving NF-kappaB, Lin28, Let-7 MicroRNA, and IL6 links inflammation to cell transformation Cell 139 2009 693 706
76. R. Jain, P.W. Shaul, Z. Borok, and B.C. Willis Endothelin-1 induces alveolar epithelial-mesenchymal transition through endothelin type A receptor-mediated production of TGF-beta1 Am J Respir Cell Mol Biol 37 2007 38 47
77. S. Jorgensen, A. Baker, S. Moller, and B.S. Nielsen Robust one-day in situ hybridization protocol for detection of microRNAs in paraffin samples using LNA probes Methods 52 2010 375 381
78. V.N. Kim MicroRNA precursors in motion: exportin-5 mediates their nuclear export Trends Cell Biol 14 2004 156 159
79. K. Kim, Y.S. Lee, D. Harris, K. Nakahara, and R.W. Carthew The RNAi pathway initiated by Dicer-2 in Drosophila Cold Spring Harb Symp Quant Biol 71 2006 39 44
80. S. Kim, W. Hwang do, and D.S. Lee A study of microRNAs in silico and in vivo: bioimaging of microRNA biogenesis and regulation FEBS J 276 2009 2165 2174
81. J.A. Kirkpatrick Jr., and A.M. DiGeorge Congenital absence of the thymus Am J Roentgenol Radium Ther Nucl Med 103 1968 32 37
82. S. Kobayashi, R. Tang, B. Wang, T. Opgenorth, E. Stein, and E. Shapiro Localization of endothelin receptors in the human prostate J Urol 151 1994 763 766
83. K.H. Kok, M.H. Ng, Y.P. Ching, and D.Y. Jin Human TRBP and PACT directly interact with each other and associate with dicer to facilitate the production of small interfering RNA J Biol Chem 282 2007 17649 17657
84. W. Kong, H. Yang, L. He, J.J. Zhao, D. Coppola, and W.S. Dalton MicroRNA-155 is regulated by the transforming growth factor beta/Smad pathway and contributes to epithelial cell plasticity by targeting RhoA Mol Cell Biol 28 2008 6773 6784
85. N. Kosaka, H. Iguchi, and T. Ochiya Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis Cancer Sci 101 2010 2087 2092
86. N. Kosaka, H. Izumi, K. Sekine, and T. Ochiya microRNA as a new immune-regulatory agent in breast milk Silence 1 2010 7
87. E. Koscianska, J. Starega-Roslan, and W.J. Krzyzosiak The Role of Dicer Protein Partners in the Processing of MicroRNA Precursors PLoS One 6 2011 e28548
88. A. Krek, D. Grun, M.N. Poy, R. Wolf, L. Rosenberg, and E.J. Epstein Combinatorial microRNA target predictions Nat Genet 37 2005 495 500
89. J. Krol, K. Sobczak, U. Wilczynska, M. Drath, A. Jasinska, and D. Kaczynska Structural features of microRNA (miRNA) precursors and their relevance to miRNA biogenesis and small interfering RNA/short hairpin RNA design J Biol Chem 279 2004 42230 42239
90. J. Krutzfeldt, N. Rajewsky, R. Braich, K.G. Rajeev, T. Tuschl, and M. Manoharan Silencing of microRNAs in vivo with 'antagomirs' Nature 438 2005 685 689
91. A. Kuehbacher, C. Urbich, A.M. Zeiher, and S. Dimmeler Role of Dicer and Drosha for endothelial microRNA expression and angiogenesis Circ Res 101 2007 59 68
92. M. Kurowska-Stolarska, S. Alivernini, L.E. Ballantine, D.L. Asquith, N.L. Millar, and D.S. Gilchrist MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis Proc Natl Acad Sci U S A 108 2011 11193 11198
93. A.K. Lagendijk, M.J. Goumans, S.B. Burkhard, and J. Bakkers MicroRNA-23 restricts cardiac valve formation by inhibiting Has2 and extracellular hyaluronic acid production Circ Res 109 2011 649 657
94. K. Laghmani, P.A. Preisig, and R.J. Alpern The role of endothelin in proximal tubule proton secretion and the adaptation to a chronic metabolic acidosis J Nephrol 15 Suppl. 5 2002 S75 S87
95. M. Lagos-Quintana, R. Rauhut, W. Lendeckel, and T. Tuschl Identification of novel genes coding for small expressed RNAs Science 294 2001 853 858
96. S. Lall, D. Grun, A. Krek, K. Chen, Y.L. Wang, and C.N. Dewey A genome-wide map of conserved microRNA targets in C. elegans Curr Biol 16 2006 460 471
97. G.M. Lamm, S.M. Nicol, F.V. Fuller-Pace, and A.I. Lamond p72: a human nuclear DEAD box protein highly related to p68 Nucleic Acids Res 24 1996 3739 3747
98. N.C. Lau, L.P. Lim, E.G. Weinstein, and D.P. Bartel An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans Science 294 2001 858 862
99. M.T. Le, C. Teh, N. Shyh-Chang, H. Xie, B. Zhou, and V. Korzh MicroRNA-125b is a novel negative regulator of p53 Genes Dev 23 2009 862 876
100. R.C. Lee, R.L. Feinbaum, and V. Ambros The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14 Cell 75 1993 843 854
101. Y. Lee, K. Jeon, J.T. Lee, S. Kim, and V.N. Kim MicroRNA maturation: stepwise processing and subcellular localization EMBO J 21 2002 4663 4670
102. Y. Lee, C. Ahn, J. Han, H. Choi, J. Kim, and J. Yim The nuclear RNase III Drosha initiates microRNA processing Nature 425 2003 415 419
103. Y. Lee, M. Kim, J. Han, K.H. Yeom, S. Lee, and S.H. Baek MicroRNA genes are transcribed by RNA polymerase II EMBO J 23 2004 4051 4060
104. Y. Lee, I. Hur, S.Y. Park, Y.K. Kim, M.R. Suh, and V.N. Kim The role of PACT in the RNA silencing pathway EMBO J 25 2006 522 532
105. S.O. Lee, T. Masyuk, P. Splinter, J.M. Banales, A. Masyuk, and A. Stroope MicroRNA15a modulates expression of the cell-cycle regulator Cdc25A and affects hepatic cystogenesis in a rat model of polycystic kidney disease J Clin Invest 118 2008 3714 3724
106. K.A. Lennox, and M.A. Behlke Chemical modification and design of anti-miRNA oligonucleotides Gene Ther 18 2011 1111 1120
107. A.J. Levine, C.A. Finlay, and P.W. Hinds P53 is a tumor suppressor gene Cell 116 2004 S67 S69 [1 p following S69]
108. B.P. Lewis, I.H. Shih, M.W. Jones-Rhoades, D.P. Bartel, and C.B. Burge Prediction of mammalian microRNA targets Cell 115 2003 787 798
109. B.P. Lewis, C.B. Burge, and D.P. Bartel Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets Cell 120 2005 15 20
110. H. Lin, J. Qian, A.C. Castillo, B. Long, K.T. Keyes, and G. Chen Effect of miR-23 on oxidant-induced injury in human retinal pigment epithelial cells Invest Ophthalmol Vis Sci 52 2011 6308 6314
111. P. Linder, P.F. Lasko, M. Ashburner, P. Leroy, P.J. Nielsen, and K. Nishi Birth of the D-E-A-D box Nature 337 1989 121 122
112. S.D. Linnstaedt, E. Gottwein, R.L. Skalsky, M.A. Luftig, and B.R. Cullen Virally induced cellular microRNA miR-155 plays a key role in B-cell immortalization by Epstein-Barr virus J Virol 84 2010 11670 11678
113. J. Liu, M.A. Valencia-Sanchez, G.J. Hannon, and R. Parker MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies Nat Cell Biol 7 2005 719 723
114. E. Lund, S. Guttinger, A. Calado, J.E. Dahlberg, and U. Kutay Nuclear export of microRNA precursors Science 303 2004 95 98
115. I.J. MacRae, K. Zhou, and J.A. Doudna Structural determinants of RNA recognition and cleavage by Dicer Nat Struct Mol Biol 14 2007 934 940
116. S.A. Mani, W. Guo, M.J. Liao, E.N. Eaton, A. Ayyanan, and A.Y. Zhou The epithelial-mesenchymal transition generates cells with properties of stem cells Cell 133 2008 704 715
117. M. Maragkakis, M. Reczko, V.A. Simossis, P. Alexiou, G.L. Papadopoulos, and T. Dalamagas DIANA-microT web server: elucidating microRNA functions through target prediction Nucleic Acids Res 37 2009 W273 W276
118. M. Maragkakis, P. Alexiou, G.L. Papadopoulos, M. Reczko, T. Dalamagas, and G. Giannopoulos Accurate microRNA target prediction correlates with protein repression levels BMC Bioinformatics 10 2009 295
119. G. Martello, A. Rosato, F. Ferrari, A. Manfrin, M. Cordenonsi, and S. Dupont A MicroRNA targeting dicer for metastasis control Cell 141 2010 1195 1207
120. S.A. Melo, S. Ropero, C. Moutinho, L.A. Aaltonen, H. Yamamoto, and G.A. Calin A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function Nat Genet 41 2009 365 370
121. P.S. Mitchell, R.K. Parkin, E.M. Kroh, B.R. Fritz, S.K. Wyman, and E.L. Pogosova-Agadjanyan Circulating microRNAs as stable blood-based markers for cancer detection Proc Natl Acad Sci U S A 105 2008 10513 10518
122. K. Miyoshi, T.N. Okada, H. Siomi, and M.C. Siomi Characterization of the miRNA-RISC loading complex and miRNA-RISC formed in the Drosophila miRNA pathway RNA 15 2009 1282 1291
123. R.L. Montgomery, and E. van Rooij MicroRNA regulation as a therapeutic strategy for cardiovascular disease Curr Drug Targets 11 2010 936 942
124. Y. Murakami, H. Toyoda, M. Tanaka, M. Kuroda, Y. Harada, and F. Matsuda The progression of liver fibrosis is related with overexpression of the miR-199 and 200 families PLoS One 6 2011 e16081
125. M. Musumeci, V. Coppola, A. Addario, M. Patrizii, M. Maugeri-Sacca, and L. Memeo Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancer Oncogene 30 2011 4231 4242
126. P.T. Nelson, A.G. Hatzigeorgiou, and Z. Mourelatos miRNP:mRNA association in polyribosomes in a human neuronal cell line RNA 10 2004 387 394
127. J.B. Nelson, M.S. Udan, G. Guruli, and B.R. Pflug Endothelin-1 inhibits apoptosis in prostate cancer Neoplasia 7 2005 631 637
128. P.C. Nett, J. Ortmann, J. Celeiro, E. Haas, R. Hofmann-Lehmann, and L. Tornillo Transcriptional regulation of vascular bone morphogenetic protein by endothelin receptors in early autoimmune diabetes mellitus Life Sci 78 2006 2213 2218
129. M.A. Newman, J.M. Thomson, and S.M. Hammond Lin-28 interaction with the Let-7 precursor loop mediates regulated microRNA processing RNA 14 2008 1539 1549
130. S. Oba, S. Kumano, E. Suzuki, H. Nishimatsu, M. Takahashi, and H. Takamori miR-200b precursor can ameliorate renal tubulointerstitial fibrosis PLoS One 5 2010 e13614
131. G. Obernosterer, J. Martinez, and M. Alenius Locked nucleic acid-based in situ detection of microRNAs in mouse tissue sections Nat Protoc 2 2007 1508 1514
132. R.M. O'Connell, D. Kahn, W.S. Gibson, J.L. Round, R.L. Scholz, and A.A. Chaudhuri MicroRNA-155 promotes autoimmune inflammation by enhancing inflammatory T cell development Immunity 33 2010 607 619
133. K. Okamura, J.W. Hagen, H. Duan, D.M. Tyler, and E.C. Lai The mirtron pathway generates microRNA-class regulatory RNAs in Drosophila Cell 130 2007 89 100
134. A.C. Ong, L.J. Newby, and M.R. Dashwood Expression and cellular localisation of renal endothelin-1 and endothelin receptor subtypes in autosomal-dominant polycystic kidney disease Nephron Exp Nephrol 93 2003 e80
135. K. Pardali, and A. Moustakas Actions of TGF-beta as tumor suppressor and pro-metastatic factor in human cancer Biochim Biophys Acta 1775 2007 21 62
136. D.M. Patrick, R.L. Montgomery, X. Qi, S. Obad, S. Kauppinen, and J.A. Hill Stress-dependent cardiac remodeling occurs in the absence of microRNA-21 in mice J Clin Invest 120 2010 3912 3916
137. H. Peinado, D. Olmeda, and A. Cano Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 7 2007 415 428
138. J.T. Pena, C. Sohn-Lee, S.H. Rouhanifard, J. Ludwig, M. Hafner, and A. Mihailovic miRNA in situ hybridization in formaldehyde and EDC-fixed tissues Nat Methods 6 2009 139 141
139. M. Petersen, C.B. Nielsen, K.E. Nielsen, G.A. Jensen, K. Bondensgaard, and S.K. Singh The conformations of locked nucleic acids (LNA) J Mol Recognit 13 2000 44 53
140. I.P. Pogribny, A. Starlard-Davenport, V.P. Tryndyak, T. Han, S.A. Ross, and I. Rusyn Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice Lab Invest 90 2010 1437 1446
141. K. Polyak, and R.A. Weinberg Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traits Nat Rev Cancer 9 2009 265 273
142. E.R. Porrello, B.A. Johnson, A.B. Aurora, E. Simpson, Y.J. Nam, and S.J. Matkovich MiR-15 family regulates postnatal mitotic arrest of cardiomyocytes Circ Res 109 2011 670 679
143. G. Rastelli, J.W. Kirklin, and J.L. Titus Anatomic observations on complete form of persistent common atrioventricular canal with special reference to atrioventricular valves Mayo Clin Proc 41 1966 296 308
144. B.J. Reinhart, F.J. Slack, M. Basson, A.E. Pasquinelli, J.C. Bettinger, and A.E. Rougvie The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans Nature 403 2000 901 906
145. A.M. Roccaro, A. Sacco, B. Thompson, X. Leleu, A.K. Azab, and F. Azab MicroRNAs 15a and 16 regulate tumor proliferation in multiple myeloma Blood 113 2009 6669 6680
146. L. Rosano, F. Spinella, V. Di Castro, S. Dedhar, M.R. Nicotra, and P.G. Natali Integrin-linked kinase functions as a downstream mediator of endothelin-1 to promote invasive behavior in ovarian carcinoma Mol Cancer Ther 5 2006 833 842
147. L. Rosano, R. Cianfrocca, F. Spinella, V. Di Castro, M.R. Nicotra, and A. Lucidi Acquisition of chemoresistance and EMT phenotype is linked with activation of the endothelin A receptor pathway in ovarian carcinoma cells Clin Cancer Res 17 2011 2350 2360
148. J.J. Rossi Mammalian Dicer finds a partner EMBO Rep 6 2005 927 929
149. S. Roush, and F.J. Slack The let-7 family of microRNAs Trends Cell Biol 18 2008 505 516
150. M. Roy-Beaudry, J. Martel-Pelletier, J.P. Pelletier, K.N. M'Barek, S. Christgau, and F. Shipkolye Endothelin 1 promotes osteoarthritic cartilage degradation via matrix metalloprotease 1 and matrix metalloprotease 13 induction Arthritis Rheum 48 2003 2855 2864
151. J.G. Ruby, C.H. Jan, and D.P. Bartel Intronic microRNA precursors that bypass Drosha processing Nature 448 2007 83 86
152. V. Rusinov, V. Baev, I.N. Minkov, and M. Tabler MicroInspector: a web tool for detection of miRNA binding sites in an RNA sequence Nucleic Acids Res 33 2005 W696 W700
153. G. Ruvkun, V. Ambros, A. Coulson, R. Waterston, J. Sulston, and H.R. Horvitz Molecular genetics of the Caenorhabditis elegans heterochronic gene lin-14 Genetics 121 1989 501 516
154. K. Saito, A. Ishizuka, H. Siomi, and M.C. Siomi Processing of pre-microRNAs by the Dicer-1-Loquacious complex in Drosophila cells PLoS Biol 3 2005 e235
155. S. Sakamoto, K. Aoki, T. Higuchi, H. Todaka, K. Morisawa, and N. Tamaki The NF90-NF45 complex functions as a negative regulator in the microRNA processing pathway Mol Cell Biol 29 2009 3754 3769
156. C. Sandhu, D.M. Peehl, and J. Slingerland p16INK4A mediates cyclin dependent kinase 4 and 6 inhibition in senescent prostatic epithelial cells Cancer Res 60 2000 2616 2622
157. M. Selbach, B. Schwanhausser, N. Thierfelder, Z. Fang, R. Khanin, and N. Rajewsky Widespread changes in protein synthesis induced by microRNAs Nature 455 2008 58 63
158. A.G. Seto The road toward microRNA therapeutics Int J Biochem Cell Biol 42 2010 1298 1305
159. A.N. Silahtaroglu, D. Nolting, L. Dyrskjot, E. Berezikov, M. Moller, and N. Tommerup Detection of microRNAs in frozen tissue sections by fluorescence in situ hybridization using locked nucleic acid probes and tyramide signal amplification Nat Protoc 2 2007 2520 2528
160. E. Silverman, G. Edwalds-Gilbert, and R.J. Lin DExD/H-box proteins and their partners: helping RNA helicases unwind Gene 312 2003 1 16
161. R. Song, S. Ro, and W. Yan In situ hybridization detection of microRNAs Methods Mol Biol 629 2010 287 294
162. J. Stratmann, C.J. Wang, S. Gnosa, A. Wallin, D. Hinselwood, and X.F. Sun Dicer and miRNA in relation to clinicopathological variables in colorectal cancer patients BMC Cancer 11 2011 345
163. H.I. Suzuki, and K. Miyazono Emerging complexity of microRNA generation cascades J Biochem 149 2010 15 25
164. H.I. Suzuki, K. Yamagata, K. Sugimoto, T. Iwamoto, S. Kato, and K. Miyazono Modulation of microRNA processing by p53 Nature 460 2009 529 533
165. J. Tao, D. Wu, P. Li, B. Xu, Q. Lu, and W. Zhang microRNA-18a, a member of the oncogenic miR-17-92 cluster, targets Dicer and suppresses cell proliferation in bladder cancer T24 cells Mol Med Report 5 2011 167 172
166. D. Teixeira, U. Sheth, M.A. Valencia-Sanchez, M. Brengues, and R. Parker Processing bodies require RNA for assembly and contain nontranslating mRNAs RNA 11 2005 371 382
167. J.P. Thiery Epithelial-mesenchymal transitions in tumour progression Nat Rev Cancer 2 2002 442 454
168. J.P. Thiery, and J.P. Sleeman Complex networks orchestrate epithelial-mesenchymal transitions Nat Rev Mol Cell Biol 7 2006 131 142
169. R.C. Thompson, M. Herscovitch, I. Zhao, T.J. Ford, and T.D. Gilmore NF-kappaB down-regulates expression of the B-lymphoma marker CD10 through a miR-155/PU.1 pathway J Biol Chem 286 2010 1675 1682
170. P.M. Van Wynsberghe, Z.S. Kai, K.B. Massirer, V.H. Burton, G.W. Yeo, and A.E. Pasquinelli LIN-28 co-transcriptionally binds primary let-7 to regulate miRNA maturation in Caenorhabditis elegans Nat Struct Mol Biol 18 2011 302 308
171. E. Varallyay, J. Burgyan, and Z. Havelda MicroRNA detection by northern blotting using locked nucleic acid probes Nat Protoc 3 2008 190 196
172. D. Vergara, B. Merlot, J.P. Lucot, P. Collinet, D. Vinatier, and I. Fournier Epithelial-mesenchymal transition in ovarian cancer Cancer Lett 291 2009 59 66
173. M.G. von Brandenstein, A. Ngum Abety, R. Depping, T. Roth, M. Koehler, and H.P. Dienes A p38-p65 transcription complex induced by endothelin-1 mediates signal transduction in cancer cells Biochim Biophys Acta 1783 2008 1613 1622
174. M. von Brandenstein, R. Depping, E. Schafer, H.P. Dienes, and J.W. Fries Protein kinase C alpha regulates nuclear pri-microRNA 15a release as part of endothelin signaling Biochim Biophys Acta 1813 2011 1793 1802
175. M. von Brandenstein, J.J. Pandarakalam, L. Kroon, H. Loeser, J. Herden, and G. Braun MicroRNA 15a, Inversely Correlated to PKCalpha, Is a Potential Marker to Differentiate between Benign and Malignant Renal Tumors in Biopsy and Urine Samples. Am J Pathol 180 2012 1787 1797
176. G. Wang, L.S. Tam, E.K. Li, B.C. Kwan, K.M. Chow, and C.C. Luk Serum and urinary cell-free MiR-146a and MiR-155 in patients with systemic lupus erythematosus J Rheumatol 37 2010 2516 2522
177. J. Weiler, J. Hunziker, and J. Hall Anti-miRNA oligonucleotides (AMOs): ammunition to target miRNAs implicated in human disease? Gene Ther 13 2006 496 502
178. U. Wellner, J. Schubert, U.C. Burk, O. Schmalhofer, F. Zhu, and A. Sonntag The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs Nat Cell Biol 11 2009 1487 1495
179. B. Wightman, I. Ha, and G. Ruvkun Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegans Cell 75 1993 855 862
180. L.M. Wulfken, R. Moritz, C. Ohlmann, S. Holdenrieder, V. Jung, and F. Becker MicroRNAs in renal cell carcinoma: diagnostic implications of serum miR-1233 levels PLoS One 6 2011 e25787
181. K. Yamagata, S. Fujiyama, S. Ito, T. Ueda, T. Murata, and M. Naitou Maturation of microRNA is hormonally regulated by a nuclear receptor Mol Cell 36 2009 340 347
182. K.S. Yan, S. Yan, A. Farooq, A. Han, L. Zeng, and M.M. Zhou Structure and conserved RNA binding of the PAZ domain Nature 426 2003 468 474
183. W.J. Yang, D.D. Yang, S. Na, G.E. Sandusky, Q. Zhang, and G. Zhao Dicer is required for embryonic angiogenesis during mouse development J Biol Chem 280 2005 9330 9335
184. S. Yeligar, H. Tsukamoto, and V.K. Kalra Ethanol-induced expression of ET-1 and ET-BR in liver sinusoidal endothelial cells and human endothelial cells involves hypoxia-inducible factor-1alpha and microrNA-199 J Immunol 183 2009 5232 5243
185. R. Yi, Y. Qin, I.G. Macara, and B.R. Cullen Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAs Genes Dev 17 2003 3011 3016
186. Q. Yin, X. Wang, C. Fewell, J. Cameron, H. Zhu, and M. Baddoo MicroRNA miR-155 inhibits bone morphogenetic protein (BMP) signaling and BMP-mediated Epstein-Barr virus reactivation J Virol 84 2010 6318 6327
187. J. Yu, F. Wang, G.H. Yang, F.L. Wang, Y.N. Ma, and Z.W. Du Human microRNA clusters: genomic organization and expression profile in leukemia cell lines Biochem Biophys Res Commun 349 2006 59 68
188. P.D. Zamore, T. Tuschl, P.A. Sharp, and D.P. Bartel RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals Cell 101 2000 25 33
189. M. Zeisberg, and R. Kalluri The role of epithelial-to-mesenchymal transition in renal fibrosis J Mol Med (Berl) 82 2004 175 181
190. Y. Zeng, and B.R. Cullen Structural requirements for pre-microRNA binding and nuclear export by Exportin 5 Nucleic Acids Res 32 2004 4776 4785
191. Y. Zeng, and B.R. Cullen Efficient processing of primary microRNA hairpins by Drosha requires flanking nonstructured RNA sequences J Biol Chem 280 2005 27595 27603
192. H. Zhang, F.A. Kolb, V. Brondani, E. Billy, and W. Filipowicz Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATP EMBO J 21 2002 5875 5885
193. Q. Zhou, R. Gallagher, R. Ufret-Vincenty, X. Li, E.N. Olson, and S. Wang Regulation of angiogenesis and choroidal neovascularization by members of