Optimisation of pharmacokinetic properties in a neutral series of 11β-HSD1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 21, 2012, Pages 6756-6761

  Scott, James S ^a   Gill, Adrian L ^a   Godfrey, Linda ^a   Groombridge, Sam D ^a   Rees, Amanda ^a   Revill, John ^a   Schofield, Paul ^a   Sörme, Pernilla ^a   Stocker, Andrew ^a   Swales, John G ^a   Whittamore, Paul R O ^a  

^a ASTRAZENECA   (United Kingdom)

Author keywords

11 HSD1 inhibitors; Pharmacokinetics; Reactive metabolites

Indexed keywords

11BETA HYDROXYSTEROID DEHYDROGENASE 1; 11BETA HYDROXYSTEROID DEHYDROGENASE 1 INHIBITOR; DRUG METABOLITE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG POTENCY; METABOLIC SYNDROME X; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PHARMACOKINETICS; PROCESS OPTIMIZATION; RAT;

11-BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1; ANIMALS; DOGS; ENZYME INHIBITORS; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; PYRIDINES; RATS; SULFHYDRYL COMPOUNDS;

CANIS FAMILIARIS; RATTUS;

EID: 84867574474     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.08.070     Document Type: Article

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