Temporary antiretroviral treatment during primary HIV-1 infection has a positive impact on health-related quality of life: Data from the Primo-SHM cohort study

HIV Medicine

Volumn 13, Issue 10, 2012, Pages 630-635

  Grijsen, M L ^a   Koster, G T ^a   van Vonderen, M G A ^b   van Kasteren, M ^c   Kootstra, G J ^d   Steingrover, R ^a   de Wolf, F ^e   Prins, J M ^a   Nieuwkerk, P T ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b MEDICAL CENTER LEEUWARDEN   (Netherlands)

^c Microvida Laboratory for Medical Microbiology and Immunology   (Netherlands)

^d MEDISCH SPECTRUM TWENTE   (Netherlands)

^e STICHTING HIV MONITORING   (Netherlands)

Author keywords

Acute HIV infection; Combination antiretroviral therapy; Health related quality of life; Primary HIV infection

Indexed keywords

EFAVIRENZ; EMTRICITABINE; LAMIVUDINE PLUS ZIDOVUDINE; LOPINAVIR PLUS RITONAVIR;

ARTICLE; COHORT ANALYSIS; COMBINATION CHEMOTHERAPY; DRUG EFFECT; DRUG EFFICACY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; MAJOR CLINICAL STUDY; MULTICENTER STUDY; PRIORITY JOURNAL; PROSPECTIVE STUDY; QUALITY OF LIFE; SYMPTOM; TREATMENT OUTCOME;

ADOLESCENT; ADULT; ANTI-HIV AGENTS; COHORT STUDIES; DISEASE PROGRESSION; DRUG ADMINISTRATION SCHEDULE; FEMALE; HEALTH STATUS; HIV SEROPOSITIVITY; HIV-1; HUMANS; LINEAR MODELS; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; QUALITY OF LIFE; QUESTIONNAIRES; TIME FACTORS; VIRAL LOAD; YOUNG ADULT;

EID: 84867566962     PISSN: 14642662     EISSN: 14681293     Source Type: Journal    
DOI: 10.1111/j.1468-1293.2012.01020.x     Document Type: Article

References (14)

1. Grijsen ML, Steingrover R, Wit FWNM etal. No treatment versus 24 or 60 Weeks of antiretroviral treatment during primary HIV infection: the randomized Primo-SHM trial. PLoS Med 2012; 9: e1001196.
2. Fidler S, Investigators ST. The effect of short-course antiretroviral therapy in primary HIV infection: final results from an international randomised controlled trial; SPARTAC. 6th IAS Conference on HIV Pathogenesis, Treatment and Prevention. Rome, Italy, July 2011 [Abstract WELBX06].
3. Hogan CM, Degruttola V, Sun X etal. The setpoint study (ACTG A5217): effect of immediate versus deferred antiretroviral therapy on virologic set point in recently HIV-1-infected individuals. J Infect Dis 2012; 205: 87-96.
4. Fidler S, Fox J, Porter K, Weber J. Primary HIV infection: to treat or not to treat? Curr Opin Infect Dis 2008; 21: 4-10.
5. Nieuwkerk PT, Reijers MH, Weigel HM, Lange JM, Sprangers MA. Quality of life in maintenance vs prolonged induction therapy for HIV. JAMA 2000; 284: 178-179.
6. Bell SK, Little SJ, Rosenberg ES. Clinical management of acute HIV infection: best practice remains unknown. J Infect Dis 2010; 202 (Suppl. 2): S278-S288.
7. Bucciardini R, Fragola V, Massella M etal. Health-related quality of life outcomes in HIV-infected patients starting different combination regimens in a randomized multinational trial: the INITIO-QoL substudy. AIDS Res Hum Retroviruses 2007; 23: 1215-1222.
8. Carrieri P, Spire B, Duran S etal. Health-related quality of life after 1 year of highly active antiretroviral therapy. J Acquir Immune Defic Syndr 2003; 32: 38-47.
9. Nieuwkerk PT, Gisolf EH, Colebunders R, Wu AW, Danner SA, Sprangers MA. Quality of life in asymptomatic- and symptomatic HIV infected patients in a trial of ritonavir/saquinavir therapy. The Prometheus Study Group. AIDS 2000; 14: 181-187.
10. Nieuwkerk PT, Gisolf EH, Reijers MH, Lange JM, Danner SA, Sprangers MA. Long-term quality of life outcomes in three antiretroviral treatment strategies for HIV-1 infection. AIDS 2001; 15: 1985-1991.
11. Steingrover R, Pogany K, Fernandez Garcia E etal. HIV-1 viral rebound dynamics after a single treatment interruption depends on time of initiation of highly active antiretroviral therapy. AIDS 2008; 22: 1583-1588.
12. Wu AW, Rubin HR, Mathews WC etal. A health status questionnaire using 30 items from the Medical Outcomes Study. Preliminary validation in persons with early HIV infection. Med Care 1991; 29: 786-798.
13. Revicki DA, Sorensen S, Wu AW. Reliability and validity of physical and mental health summary scores from the Medical Outcomes Study HIV Health Survey. Med Care 1998; 36: 126-137.
14. Johnson MO, Stallworth T, Neilands TB. The drugs or the disease? Causal attributions of symptoms held by HIV- positive adults on HAART. AIDS Behav 2003; 7: 109-117.