-
1
-
-
0032929762
-
Signalling through phosphoinositide 3-kinases: The lipids take centre stage
-
Leevers SJ, Vanhaesebroeck B, Waterfield MD. Signalling through phosphoinositide 3-kinases: the lipids take centre stage. Curr Opin Cell Biol 1999;11:219-25
-
(1999)
Curr Opin Cell Biol
, vol.11
, pp. 219-225
-
-
Leevers, S.J.1
Vanhaesebroeck, B.2
Waterfield, M.D.3
-
4
-
-
84860685849
-
-
Cited 2012
-
Pharmaprojects. 2011. Available from: http://www.pharmaprojects.com [Cited 2012]
-
(2011)
Pharmaprojects
-
-
-
6
-
-
0026659883
-
Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins
-
Neeper M, Schmidt AM, Brett J, et al. Cloning and expression of a cell surface receptor for advanced glycosylation end products of proteins. J Biol Chem 1992;267:14998-5004
-
(1992)
J Biol Chem
, vol.267
, pp. 14998-15004
-
-
Neeper, M.1
Schmidt, A.M.2
Brett, J.3
-
7
-
-
66949121459
-
Ig-like transcript 3 regulates expression of proinflammatory cytokines and migration of activated t cells
-
Chang CC, Liu Z, Vlad G, et al. Ig-like transcript 3 regulates expression of proinflammatory cytokines and migration of activated t cells. J Immunol 2009;182:5208-16
-
(2009)
J Immunol
, vol.182
, pp. 5208-5216
-
-
Chang, C.C.1
Liu, Z.2
Vlad, G.3
-
8
-
-
32244436150
-
Pharmacokinetics/pharmacodynamics of nondepleting anti-cd4 monoclonal antibody (trx1) in healthy human volunteers
-
Ng C, Stefanich E, Anand B, et al. Pharmacokinetics/pharmacodynamics of nondepleting anti-cd4 monoclonal antibody (trx1) in healthy human volunteers. Pharm Res 2006;23:95-103
-
(2006)
Pharm Res
, vol.23
, pp. 95-103
-
-
Ng, C.1
Stefanich, E.2
Anand, B.3
-
11
-
-
0028244396
-
Involvement of the jak-3 janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells
-
Witthuhn BA, Silvennoinen O, Miura O, et al. Involvement of the jak-3 janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 1994;370:153-7
-
(1994)
Nature
, vol.370
, pp. 153-157
-
-
Witthuhn, B.A.1
Silvennoinen, O.2
Miura, O.3
-
12
-
-
65649084466
-
A novel jak3 inhibitor, r348, attenuates chronic airway allograft rejection
-
Velotta JB, Deuse T, Haddad M, et al. A novel jak3 inhibitor, r348, attenuates chronic airway allograft rejection. Transplantation 2009;87:653-9
-
(2009)
Transplantation
, vol.87
, pp. 653-659
-
-
Velotta, J.B.1
Deuse, T.2
Haddad, M.3
-
13
-
-
84875252630
-
-
http://www.clinicaltrials.gov/ct2/show/NCT01010542?.term=ILV-095rank=1
-
Available from: www.clinicaltrials.gov Study evaluating single dose of ilv-095 in psoriasis subjects. 2011.http://www.clinicaltrials.gov/ct2/show/ NCT01010542?term=ILV-095rank=1
-
(2011)
-
-
-
15
-
-
84856728764
-
-
Watch C. Rheumatoid arthritis. 2011.Available from: http://www. centerwatch.com/clinical-trials/results/new-therapies/nmt-details.aspx? CatID=132
-
(2011)
Rheumatoid Arthritis
-
-
Watch, C.1
-
16
-
-
84861342704
-
Orexin receptor antagonism, a new sleep-enabling paradigm: A proof-of-concept clinical trial
-
Hoever P, Dorffner G, Benes H, et al. Orexin receptor antagonism, a new sleep-enabling paradigm: a proof-of-concept clinical trial. Clin Pharmacol Ther 2012;91:975-85
-
(2012)
Clin Pharmacol Ther
, vol.91
, pp. 975-985
-
-
Hoever, P.1
Dorffner, G.2
Benes, H.3
-
17
-
-
79951508286
-
Differential effects of the dual orexin receptor antagonist almorexant and the gabaa-[alpha]1 receptor modulator zolpidem, alone or combined with ethanol, on motor performance in the rat
-
Steiner MA, Lecourt H, Strasser DS, et al. Differential effects of the dual orexin receptor antagonist almorexant and the gabaa-[alpha]1 receptor modulator zolpidem, alone or combined with ethanol, on motor performance in the rat. Neuropsychopharmacology 2011;36:848-56
-
(2011)
Neuropsychopharmacology
, vol.36
, pp. 848-856
-
-
Steiner, M.A.1
Lecourt, H.2
Strasser, D.S.3
-
18
-
-
0035884605
-
Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (adamts) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for c-terminal processing in vivo
-
Sandy JD, Verscharen C. Analysis of aggrecan in human knee cartilage and synovial fluid indicates that aggrecanase (adamts) activity is responsible for the catabolic turnover and loss of whole aggrecan whereas other protease activity is required for c-terminal processing in vivo. Biochem J 2001;358:615-26
-
(2001)
Biochem J
, vol.358
, pp. 615-626
-
-
Sandy, J.D.1
Verscharen, C.2
-
19
-
-
30544448357
-
Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanaseand matrix metalloproteinase-generated aggrecan fragments
-
Struglics A, Larsson S, Pratta MA, et al. Human osteoarthritis synovial fluid and joint cartilage contain both aggrecanaseand matrix metalloproteinase-generated aggrecan fragments. Osteoarthritis Cartilage 2006;14:101-13
-
(2006)
Osteoarthritis Cartilage
, vol.14
, pp. 101-113
-
-
Struglics, A.1
Larsson, S.2
Pratta, M.A.3
-
20
-
-
84875233618
-
-
Adl5859 hcl
-
Adl5859 hcl. Available from: http://www.selleckchem.com/products/ADL- 5859.html
-
-
-
-
23
-
-
33745698507
-
Mn-001, a novel oral anti-inflammatory agent, suppresses bladder hyperactivity in a rat model
-
Rajasekaran M, Locke KW, Parsons CL. Mn-001, a novel oral anti-inflammatory agent, suppresses bladder hyperactivity in a rat model. BJU Int 2006;98:430-4
-
(2006)
BJU Int
, vol.98
, pp. 430-434
-
-
Rajasekaran, M.1
Locke, K.W.2
Parsons, C.L.3
-
24
-
-
74549139733
-
Potential for long-acting muscarinic antagonists in chronic obstructive pulmonary disease
-
Joos GF. Potential for long-acting muscarinic antagonists in chronic obstructive pulmonary disease. Expert Opin Investig Drugs 2010;19:257-64
-
(2010)
Expert Opin Investig Drugs
, vol.19
, pp. 257-264
-
-
Joos, G.F.1
-
25
-
-
80052996062
-
Inhaled muscarinic antagonists for respiratory diseases: A review of patents and current developments (2006-2010)
-
Prat M, Gavalda A, Fonquerna S, Miralpeix M. Inhaled muscarinic antagonists for respiratory diseases: a review of patents and current developments (2006-2010). Expert Opin Ther Patents 2011; 21:1543-73
-
(2011)
Expert Opin Ther Patents
, vol.21
, pp. 1543-1573
-
-
Prat, M.1
Gavalda, A.2
Fonquerna, S.3
Miralpeix, M.4
-
26
-
-
77953028976
-
The short, the long and the "ultra-long": Why duration of bronchodilator action matters in chronic obstructive pulmonary disease
-
Beeh K, Beier J. The short, the long and the "ultra-long": why duration of bronchodilator action matters in chronic obstructive pulmonary disease. Adv Ther 2010;27:150-9
-
(2010)
Adv Ther
, vol.27
, pp. 150-159
-
-
Beeh, K.1
Beier, J.2
-
27
-
-
77953771000
-
Pharmacology of pf-4191834, a novel, selective non-redox 5-lipoxygenase inhibitor effective in inflammation and pain
-
Masferrer JL, Zweifel BS, Hardy M, et al. Pharmacology of pf-4191834, a novel, selective non-redox 5-lipoxygenase inhibitor effective in inflammation and pain. J Pharmacol Exp Ther 2010; 334:294-301
-
(2010)
J Pharmacol Exp Ther
, vol.334
, pp. 294-301
-
-
Masferrer, J.L.1
Zweifel, B.S.2
Hardy, M.3
-
28
-
-
80053911301
-
Inhalation by design: Novel tertiary amine muscarinic m3 receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease
-
Glossop PA, Watson CAL, Price DA, et al. Inhalation by design: novel tertiary amine muscarinic m3 receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease. J Med Chem 2011;54:6888-904
-
(2011)
J Med Chem
, vol.54
, pp. 6888-6904
-
-
Glossop, P.A.1
Watson, C.A.L.2
Price, D.A.3
-
29
-
-
84875247924
-
-
Allvoices
-
Allvoices. Astellas to cease darexaban maleate development. 2011.Available from: http://www.allvoices.com/news/10475532-astellas-tocease- darexaban-maleate-development
-
(2011)
Astellas to Cease Darexaban Maleate Development
-
-
-
30
-
-
84875261651
-
-
Zeneca A. A phase i, single centre, double-blind, randomised, placebo-controlled, parallel-group, 2-part study to assess the safety, tolerability and pharmacokinetics of single and multiple ascending inhaled doses of azd9819 in healthy subjects. 2011. Available from: http://www. astrazenecaclinicaltrials. com/-mshost800325/content/clinical-trials/resources/ pdf/D3020C00001
-
(2011)
A Phase I, Single Centre, Double-blind, Randomised, Placebo-controlled, Parallel-group, 2-part Study to Assess the Safety, Tolerability and Pharmacokinetics of Single and Multiple Ascending Inhaled Doses of azd9819 in Healthy Subjects
-
-
Zeneca, A.1
-
31
-
-
80053169347
-
Azd9668: Pharmacological characterization of a novel oral inhibitor of neutrophil elastase
-
Stevens T, Ekholm K, Granse M, et al. Azd9668: pharmacological characterization of a novel oral inhibitor of neutrophil elastase. J Pharmacol Exp Ther 2011;339:313-20
-
(2011)
J Pharmacol Exp Ther
, vol.339
, pp. 313-320
-
-
Stevens, T.1
Ekholm, K.2
Granse, M.3
|