Differential effects of inhaled methacholine on circumferential wall and vascular smooth muscle of third-generation airways in awake sheep

Journal of Applied Physiology

Volumn 113, Issue 8, 2012, Pages 1233-1242

  McLeod, Damian ^a,b   Parsons, Gibbe ^c   Gunther, Robert ^c   Quail, Anthony ^a,b   Cottee, David ^a,b   White, Saxon ^a,b  

^a UNIVERSITY OF NEWCASTLE   (Australia)

^b JOHN HUNTER HOSPITAL   (Australia)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Bronchial circulation; Evolutionary lung protection; Neuroparacrine inhibition; Prostanoids; Sonomicrometry

Indexed keywords

CHOLINERGIC RECEPTOR; CHOLINERGIC RECEPTOR STIMULATING AGENT; IPRATROPIUM BROMIDE; METHACHOLINE CHLORIDE;

ANIMAL; ARTERIAL PRESSURE; ARTICLE; BLOOD FLOW; BREATHING; BRONCHIAL ARTERY; BRONCHUS; DRUG EFFECT; EPITHELIUM CELL; FEMALE; HEMODYNAMICS; INHALATIONAL DRUG ADMINISTRATION; LUNG CIRCULATION; METABOLISM; PHYSIOLOGY; RESPIRATORY TRACT MUCOSA; SHEEP; VASCULAR SMOOTH MUSCLE; VASCULARIZATION; WAKEFULNESS;

ADMINISTRATION, INHALATION; ANIMALS; ARTERIAL PRESSURE; BRONCHI; BRONCHIAL ARTERIES; CHOLINERGIC AGONISTS; EPITHELIAL CELLS; FEMALE; HEMODYNAMICS; IPRATROPIUM; METHACHOLINE CHLORIDE; MUSCLE, SMOOTH, VASCULAR; PULMONARY CIRCULATION; RECEPTORS, CHOLINERGIC; REGIONAL BLOOD FLOW; RESPIRATION; RESPIRATORY MUCOSA; SHEEP; WAKEFULNESS;

EID: 84867540477     PISSN: 87507587     EISSN: 15221601     Source Type: Journal    
DOI: 10.1152/japplphysiol.00133.2012     Document Type: Article

References (44)

1. Barker J, Chediak AD, Baier H, Wanner A. Tracheal mucosal blood flow responses to autonomic agonists. J Appl Physiol 65: 829-834, 1988.
2. Beny JL, Chabaud F. Kinins and endothelium-dependent hyperpolarization in porcine coronary arteries. In: Vasodilatation, edited by Vanhoutte P. Amsterdam: Harwood Academic, 1996, p. 41-49.
3. Bény JL, Pacicca C. Bidirectional electrical communication between smooth muscle and endothelial cells in the pig coronary artery. Am J Physiol Heart Circ Physiol 266: H1465-H1472, 1994.
4. Bishop R, McLeod D, McIlveen S, Blake R, Gunther R, Davis J, Talken L, Cottee D, Quail A, Parsons G, White S. Effects of graded exercise on bronchial blood flow and airway dimensions in sheep. Pulm Pharmacol Ther 20: 178-189, 2007.
5. Bishop R, McLeod D, McIlveen S, Blake R, Gunther R, Davis J, Talken L, Cottee D, Quail A, Parsons G, White S. Long-term measurement of bronchial vascular resistance in awake sheep and dogs. Arch Physiol Biochem 111: 315-316, 2003.
6. Brown RV, Hilton JG. The effectiveness of the baroreceptor reflexes under different anaesthetics. J Pharmacol Exp Ther 118: 198-203, 1956.
7. Brunn G, Wessler I, Racke K. Mucosa-dependent muscarinic liberation of prostaglandins from rat isolated trachea. Br J Pharmacol 116: 1991-1998, 1995.
8. Bullimore SR, Siddiqui S, Donovan G, JGM, Sneyd J, Bates JHT, Lauzon AM. Could an increase in airway smooth muscle shortening velocity cause airway hyperresponsiveness? Am J Physiol Lung Cell Mol Physiol 300: L121-L131, 2011.
9. Charan N, Carvalho P, Johnson SR, Thompson WH, Lakshminarayan S. Effect of aerosolized acetylcholine on bronchial blood flow. J Appl Physiol 85: 432-436, 1998.
10. Charan NB, Wolf J, Henrichs M, Williams J, Sullivan R, Ashworth L. Are inhaled drugs delivered to the bronchial smooth muscle through the bronchial circulation? Arch Physiol Biochem 111: 331-333, 2003.
11. Corcoran TE, Dauber JH, Chigier N, Iacono AT. Improving drug delivery from medical nebulizers: the effects of increased nebulizer flow rates and reservoirs. J Aerosol Med 15: 271-282, 2002.
12. Cottee DB, Quail AW, Porges WL, Moore PG, White SW. Effects of anaesthesia on regional coronary control mechanisms. Clin Exp Pharmacol Physiol 27: 1034-1038, 2000.
13. Exley KA. Depression of autonomic ganglia by barbiturates. Br J Pharmacol Chemother 9: 170-181, 1954.
14. Gosens R, Zaagsma J, Meurs H, Halayko AJ. Muscarinic receptor signaling in the pathophysiology of asthma and COPD. Respir Res 7: 73-88, 2006.
15. Hennessy E, White S, Van der Touw T, Quail A, Porges W, Glenfield P. Control of resting bronchial hemodynamics in the awake dog. Am J Physiol Heart Circ Physiol 265: H649-H660, 1993.
16. Heyder J. Deposition of inhaled particles in the human respiratory tract and consequences for regional targeting in respiratory drug therapy. Proc Am Thorac Soc 1: 315-320, 2004.
17. Holtzman M, Hahn H, Sasaki K, Skoogh B, Graf P, Fabbri L, Nadel J. Selective effect of general anesthetics on reflex bronchoconstrictor responses in dogs. J Appl Physiol 53: 126-133, 1982.
18. Hornof W, O'Callaghan MW, Gunther RA, Howard R, Fisher P, Raabe O, Cross CE. Lung clearance of 99m Tc-DTPA aerosol in conscious sheep. Respir Physiol 72: 375-390, 1988.
19. Korner PI. Central nervous control of autonomic cardiovascular function. In: Handbook of Physiology, The Cardiovascular System, edited by Berne RM. Bethesda, MD: American Physiological Society, 1979, p. 691-739.
20. Korner PI, Shaw JA, West MJ, Oliver JA, Hilder RG. Integrative reflex control of heart rate in the rabbit during hypoxia and hyperventilation. Circ Res 33: 63-73, 1973.
21. Lakshaminarayan S, Jindal SK, Kirk W, Butler J. Increases in bronchial blood flow following bronchoconstriction with methacholine and prostaglandin F2α in dogs. Chest 87: 183s-184s, 1985.
22. Le Brun PP, de Boer AH, Heijerman HG, Frijlink HW. A review of the technical aspects of drug nebulization. Pharm World Sci 22: 75-81, 2000.
23. McIlveen S, White S, Parsons G. Autonomic control of bronchial circulation in awake sheep during rest and behaviour. Clin Exp Pharmacol Physiol 24: 940-947, 1997.
24. McIlveen S, White SW, Quail AW, McLeod D, Parsons GH. Integration of baroreflex and autoregulation control of bronchial blood flow in awake dogs. Acta Physiol(Oxf) 203: 299-310, 2011.
25. Mitchell HW, Gray PR. Assessment of the dynamic relationship between external diameter and lumen flow in isolated bronchi. Respir Physiol 116: 67-76, 1999.
26. Moore P. Fentanyl influence on baroreflex control of circumflex coronary conductance. Clin Exp Pharmacol Physiol 27: 1028-1033, 2000.
27. Parsons GH, Kramer GC, Link DP, Lantz BMT, Gunther RA, Green JF, Cross CE. Studies of reactivity and distribution of bronchial blood flow in sheep. Chest 87, Suppl: 180s-182s, 1985.
28. Pedley TJ, Schroter RC, Sudlow MF. The prediction of pressure drop and variation of resistance within the human bronchial airways. Respir Physiol 9: 387-405, 1970.
29. Peiss CN, Manning JW. Effects of sodium pentobarbital on electrical and reflex activation of the cardiovascular system. Circ Res 14: 228-235, 1964.
30. Prakash YS, Thompson MA, Vaa B, Matabdin I, Peterson TE, He T, Pabelick CM. Caveolins and intracellular calcium regulation in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol 293: L1118-L1126, 2007.
31. Quail AW, Cottee DBF, White SW. Limitations of a pulsed Doppler velocimeter for blood flow measurement in small vessels. J Appl Physiol 75: 2745-2754, 1993.
32. Racke K, Matthiesen S. The airway cholinergic system: physiology and pharmacology. Pulm Pharmacol Ther 17: 181-198, 2004.
33. Rau JL. Design principles of liquid nebulization devices currently in use. Respir Care 47: 1257-1275, 2002.
34. Schultz H, Pisarri T, Coleridge H, Coleridge J. Carotid sinus baroreceptors modulate tracheal smooth muscle tension in dogs. Circ Res 60: 337-345, 1987.
35. Scuri M, McCaskill V, Chediak AD, Abraham WN, Wanner A. Effect of inhaled and intravenous acetylcholine on bronchial blood flow in anesthetized sheep. J Appl Physiol 80: 341-344, 1996.
36. Wessler I, Kirkpatrick CJ. Acetylcholine beyond neurons: the nonneuronal cholinergic system in humans. Br J Pharmacol 154: 1558-1571, 2008.
37. Wessler I, Kirkpatrick CJ, Racke K. The cholinergic "pitfall": acetylcholine, a universal cell molecule in biological systems, including humans. Clin Exp Pharmacol Physiol 26: 198-205, 1999.
38. White S, Franklin D. Reflex cardiovascular response to noxious gaseous stimuli in unanaesthetized rabbits. Physiologist 12: A392, 1969.
39. White SW, McRitchie RJ. Nasopharyngeal reflexes: integrative analysis of evoked respiratory and cardiovascular effects. Aust J Exp Biol Med Sci 51: 17-31, 1973.
40. White SW, Parsons GH. Baroreflexes and the bronchial circulation in awake sheep; absence of control through cholinoceptor and adrenoceptor autonomic mechanisms. Am J Respir Crit Care Med 151: A522, 1995.
41. White SW, Pitsillides KF, Parsons GH, Hayes SG, Gunther RA, Cottee DB. Coronary-bronchial blood flow and airway dimensions in exercise-induced syndromes. Clin Exp Pharmacol Physiol 28: 472-478, 2001.
42. Widdicombe J. Reflexes from the upper respiratory tract. In: Handbook of Physiology, The Respiratory System. Bethesda, MD: American Physiological Society, 1993, p. 363-394.
43. Widdicombe JG. Respiratory reflexes. In: Handbook of Physiology, Respiration, edited by Fenn WO, Rahn H. Washington, DC: American Physiological Society, 1964, p. 589-619.
44. Wong MS, Vanhoutte PM. COX-mediated endothelium-dependent contractions: from the past to recent discoveries. Acta Pharmacol Sin 31: 1095-1102, 2010.