Characteristics of Gait Ataxia in δ2 Glutamate Receptor Mutant Mice, ho15J

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Takeuchi, Eri ^a   Sato, Yamato ^a   Miura, Eriko ^b   Yamaura, Hiroshi ^a   Yuzaki, Michisuke ^b,c   Yanagihara, Dai ^a,c  

^a UNIVERSITY OF TOKYO   (Japan)

^b KEIO UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GLUTAMATE RECEPTOR; GLUTAMATE RECEPTOR DELTA 2; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANKLE; ARTICLE; ATAXIA; CEREBELLUM; CONTROLLED STUDY; ELECTRON MICROSCOPY; GAIT; HINDLIMB; KINEMATICS; LOCOMOTION; MALE; MORPHOMETRICS; MOUSE; MOUSE MUTANT; MUTATION; NONHUMAN; PURKINJE FIBER; SYNAPSE; TREADMILL; WILD TYPE;

ANIMALS; BIOMECHANICS; CEREBELLUM; GAIT ATAXIA; LOCOMOTION; MICE; MUTATION; PURKINJE FIBERS; RECEPTORS, GLUTAMATE; SYNAPSES;

EID: 84867536147     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047553     Document Type: Article

References (35)

1. Morton SM, Bastian AJ, (2004) Cerebellar control of balance and locomotion. Neuroscientist 10: 247-259.
2. Morton SM, Bastian AJ, (2007) Mechanisms of cerebellar gait ataxia. Cerebellum 6: 79-86.
3. Morton SM, Bastian AJ, (2003) Relative contributions of balance and voluntary leg-coordination deficits to cerebellar gait ataxia. J Neurophysiol 89: 1844-1856.
4. Aiba A, Kano M, Chen C, Stanton ME, Fox GD, et al. (1994) Deficient cerebellar long-term depression and impaired motor learning in mGluR1 mutant mice. Cell 79: 377-388.
5. Ichise T, Kano M, Hashimoto K, Yanagihara D, Nakao K, et al. (2000) mGLuR1 in cerebellar Purkinje cells essential for long-term depression, synapse elimination, and motor coordination. Science: 1832-1835.
6. Kashiwabuchi N, Ikeda K, Araki K, Hirano T, Shibuki K, et al. (1995) Impairment of motor coordination, Purkinje-cell synapse formation, and cerebellar long-term depression in GluR-delta-2 mutant mice. Cell 81: 245-252.
7. Chen C, Kano M, Abeliovich A, Chen L, Bao S, et al. (1995) Impaired motor coordination correlates with persistent multiple climbing fiber innervation in PKC gamma mutant mice. Cell: 1233-1242.
8. Miyata M, Kim HT, Hashimoto K, Lee TK, Cho SY, et al. (2001) Deficient long-term synaptic depression in the rostral cerebellum correlated with impaired motor learning in phospholipase C beta4 mutant mice. Eur J Neurosci 13: 1945-1954.
9. Kurihara H, Hashimoto K, Kano M, Takayama C, Sakimura K, et al. (1997) Impaired parallel fiber→Purkinje cell synapse stabilization during cerebellar development of mutant mice lacking the glutamate receptor delta2 subunit. J Neurosci 17: 9613-9623.
10. Hirai H, Launey T, Mikawa S, Torashima T, Yanagihara D, et al. (2003) New role of delta 2-glutamate receptors in AMPA receptor trafficking and cerebellar function. Nature Neuroscience 6: 869-876.
11. Motohashi J, Kakegawa W, Yuzaki M, (2007) Ho15J- A new hotfoot allele in a hot spot in the gene encoding the delta 2 glutamate receptor. Brain Research 1140: 153-160.
12. Brooks S, Dunnett S (2009) Tests to assess motor phenotype in mice: a user's guide. Nature Reviews Neuroscience: 519-529.
13. Hirai H, Miyazaki T, Kakegawa W, Matsuda S, Mishina M, et al. (2005) Rescue of abnormal phenotypes of the delta2 glutamate receptor-null mice by mutant delta2 transgenes. EMBO Rep 6: 90-95.
14. Gruner JA, Altman J, Spivack N, (1980) Effects of arrested cerebellar development on locomotion in the rat. Cinematographic and electromyographic analysis. Exp Brain Res 40: 361-373.
15. Fortier PA, Smith AM, Rossignol S, (1987) Locomotor deficits in the mutant mouse, Lurcher. Exp Brain Res 66: 271-286.
16. Leblond H, L'Esperance M, Orsal D, Rossignol S, (2003) Treadmill locomotion in the intact and spinal mouse. J Neurosci 23: 11411-11419.
17. Akay T, Acharya HJ, Fouad K, Pearson KG, (2006) Behavioral and electromyographic characterization of mice lacking EphA4 receptors. J Neurophysiol 96: 642-651.
18. Pereira JE, Cabrita AM, Filipe VM, Bulas-Cruz J, Couto PA, et al. (2006) A comparison analysis of hindlimb kinematics during overground and treadmill locomotion in rats. Behav Brain Res 172: 212-218.
19. Le Marec N, Lalonde R, (2000) Treadmill performance of mice with cerebellar lesions: 2. Lurcher mutant mice. Neurobiol Learn Mem 73: 195-206.
20. Guastavino JM, Sotelo C, Damez-Kinselle I, (1990) Hot-foot murine mutation: behavioral effects and neuroanatomical alterations. Brain Res 523: 199-210.
21. Caddy KW, Biscoe TJ, (1975) Preliminary observations on the cerebllum in the mutant mouse Lurcher. Brain Res 91: 276-280.
22. Caddy KW, Biscow TJ, (1976) The number of Purkinje cells and olive neurones in the normal and Lurcher mutant mouse. Brain Res 111: 396-398.
23. Caddy KW, Biscoe TJ, (1979) Structural and quantitative studies on the normal C3H and Lurcher mutant mouse. Philos Trans R Soc Lond B Biol Sci 287: 167-201.
24. Lalouette A, Lohof A, Sotelo C, Guénet J, Mariani J, (2001) Neurobiological effects of a null mutation depend on genetic context: comparison between two hotfoot alleles of the delta-2 ionotropic glutamate receptor. Neuroscience 105: 443-455.
25. Arshavsky YI, Gelfand IM, Orlovsky GN, (1983) The cerebellum and control of rhythmical movements. Trends in Neurosciences 6: 417-422.
26. Orlovsky GN, Deliagina TG, Grillner S (1999) Neuronal Control of Locomotion. From Mollusc to Man., New York, Oxford University Press, Role of the cerebellum in locomotor coordination, 215-236.
27. Bosco G, Poppele RE, (1993) Broad directional tuning in spinal projections to the cerebellum. J Neurophysiol 70: 863-866.
28. Bosco G, Poppele RE, (1997) Representation of multiple kinematic parameters of the cat hindlimb in spinocerebellar activity. Journal of Neurophysiology 78: 1421-1432.
29. Bosco G, Rankin A, Poppele R, (1996) Representation of passive hindlimb postures in cat spinocerebellar activity. Journal of Neurophysiology 76: 715-726.
30. Udo M, Matsukawa K, Kamei H, (1979) Effects of partial cooling of cerebellar cortex at lobules V and IV of the intermediate part in the decerebrate walking cats under monitoring vertical floor reaction forces. Brain Res 160: 559-564.
31. Udo M, Matsukawa K, Kamei H, (1979) Hyperflexion and changes in interlimb coordination of locomotion induced by cooling of the cerebellar intermediate cortex in normal cats. Brain Res 166: 405-408.
32. Udo M, Matsukawa K, Kamei H, Oda Y, (1980) Cerebellar control of locomotion: effects of cooling cerebellar intermediate cortex in high decerebrate and awake walking cats. J Neurophysiol 44: 119-134.
33. Palliyath S, Hallett M, Thomas SL, Lebiedowska MK, (1998) Gait in patients with cerebellar ataxia. Mov Disord 13: 958-964.
34. Ilg W, Golla H, Thier P, Giese M (2007) Specific influences of cerebellar dysfunctions on gait. Brain: 786-798.
35. Earhart GM, Bastian AJ, (2001) Selection and coordination of human locomotor forms following cerebellar damage. J Neurophysiol 85: 759-769.