Mortality and socioeconomic status in adults with childhood onset GH deficiency (GHD) is highly dependent on the primary cause of GHD

European Journal of Endocrinology

Volumn 167, Issue 5, 2012, Pages 663-670

  Stochholm, Kirstine ^a   Juul, Svend ^b   Christiansen, Jens Sandahl ^a   Gravholt, Claus Hjøbjerg ^a  

^a AARHUS UNIVERSITY HOSPITAL   (Denmark)

^b AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ADULT; ARTICLE; CAUSE OF DEATH; CHILDHOOD DISEASE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE REGISTRY; DISEASE SEVERITY; EDUCATIONAL STATUS; FEMALE; GROWTH HORMONE DEFICIENCY; HIGH RISK POPULATION; HUMAN; LOWEST INCOME GROUP; MAJOR CLINICAL STUDY; MALE; MARRIAGE; MORTALITY; OFFENDER; OUTCOME ASSESSMENT; PARENTHOOD; PRIORITY JOURNAL; RETIREMENT; SEX DIFFERENCE; SEX RATIO; SOCIAL STATUS;

ADULT; AGE OF ONSET; AGED; CASE-CONTROL STUDIES; CHILD; DENMARK; EDUCATIONAL STATUS; FEMALE; HUMAN GROWTH HORMONE; HUMANS; INCOME; KAPLAN-MEIER ESTIMATE; LOGISTIC MODELS; MALE; MARITAL STATUS; METABOLIC DISEASES; MIDDLE AGED; ODDS RATIO; PARENTS; PROPORTIONAL HAZARDS MODELS; REGISTRIES; RETIREMENT; SOCIAL CLASS;

EID: 84867530338     PISSN: 08044643     EISSN: 1479683X     Source Type: Journal    
DOI: 10.1530/EJE-11-1084     Document Type: Article

References (31)

1. Raben M. Growth hormone. 2. Clinical use of human growth hormone. New England Journal of Medicine 1962 266 82-86. (doi:10.1056/NEJM196201112660207)
2. Svensson J, Bengtsson BA, Rosen T, Oden A & Johannsson G. Malignant disease and cardiovascular morbidity in hypopituitary adults with or without growth hormone replacement therapy. Journal of Clinical Endocrinology and Metabolism 2004 89 3306-3312. (doi:10.1210/jc.2003-031601)
3. Tomlinson JW, Holden N, Hills RK, Wheatley K, Clayton RN, Bates AS, Sheppard MC & Stewart PM. Association between premature mortality and hypopituitarism. West Midlands Prospective Hypopituitary Study Group. Lancet 2001 357 425-431. (doi:10.1016/S0140-6736(00)04006-X)
4. Stochholm K, Gravholt C, Laursen T, Laurberg P, Andersen M, Kristensen L, Feldt-Rasmussen U, Christiansen J, Frydenberg M & Green A. Mortality in growth hormone deficiency - a nationwide study. European Journal of Endocrinology 2007 157 9-18. (doi:10.1530/EJE-07-0013)
5. Stochholm K, Laursen T, Green A, Laurberg P, Andersen M, Kristensen L, Feldt-Rasmussen U, Christiansen S, Frydenberg M & Gravholt C. Morbidity and GH deficiency: a nationwide study. European Journal of Endocrinology 2008 158 447-457. (doi:10.1530/EJE-07-0523)
6. Bulow B, Attewell R, Hagmar L, Malmstrom P, Nordstrom CH & Erfurth EM. Postoperative prognosis in craniopharyngioma with respect to cardiovascular mortality, survival, and tumor recurrence. Journal of Clinical Endocrinology and Metabolism 1998 83 3897-3904. (doi:10.1210/jc.83.11.3897)
7. Erfurth EM, Bulow B, Svahn-Tapper G, Norrving B, Odh K, Mikoczy Z, Bjork J & Hagmar L. Risk factors for cerebrovascular deaths in patients operated and irradiated for pituitary tumors. Journal of Clinical Endocrinology and Metabolism 2002 87 4892-4899. (doi:10.1210/jc.2002-020526)
8. Colao A, Di Somma C, Cuocolo A, Filippella M, Rota F, Acampa W, Savastano S, Salvatore M & Lombardi G. The severity of growth hormone deficiency correlates with the severity of cardiac impairment in 100 adult patients with hypopituitarism: an observational, case-control study. Journal of Clinical Endocrinology and Metabolism 2004 89 5998-6004. (doi:10.1210/jc.2004-1042)
9. Stochholm K, Gravholt C, Laursen T, Jorgensen JO, Laurberg P, Andersen M, Kristensen L, Feldt-Rasmussen U, Christiansen J, Frydenberg M & Green A. Incidence of GH deficiency - a nationwide study. European Journal of Endocrinology 2006 155 61-71. (doi:10.1530/eje.1.02191)
10. Dean H, McTaggart T, Fish D & Friesen H. The educational, vocational, and marital status of growth hormone-deficient adults treated with growth hormone during childhood. American Journal of Diseases of Children 1985 139 1105-1110. (Pubitemid 16258036)
11. Galatzer A, Aran O, Beit-Halachmi N, Nofar E, Rubitchek J, Pertzelan A & Laron Z. The impact of long-term therapy by a multidisciplinary team on the education, occupation and marital status of growth hormone deficient patients after termination of therapy. Clinical Endocrinology 1987 27 191-196. (doi:10.1111/j.1365-2265.1987.tb01144.x)
12. Rikken B, van Busschbach J, le Cessie S, Manten W, Spermon T, Grobbee R & Wit J. Impaired social status of growth hormone deficient adults as compared to controls with short or normal stature. Dutch Growth Hormone Working Group. Clinical Endocrinology 1995 43 205-211. (doi:10.1111/j.1365-2265.1995. tb01916.x)
13. Takano K, Tanaka T & Saito T. Psychosocial adjustment in a large cohort of adults with growth hormone deficiency treated with growth hormone in childhood: summary of a questionnaire survey. Committee for the Study Group of Adult GH Deficiency. Acta Paediatrica. Supplement 1994 399 16-19. (doi:10.1111/j.1651-2227.1994.tb13278.x)
14. Keselman A, Martinez A, Pantano L, Bergada C & Heinrich JJ. Psychosocial outcome in growth hormone deficient patients diagnosed during childhood. Journal of Pediatric Endocrinology & Metabolism 2000 13 409-416. (doi:10.1515/JPEM.2000.13.4.409)
15. Frisch H, Hausler G, Lindenbauer S & Singer S. Psychological aspects in children and adolescents with hypopituitarism. Acta Paediatrica Scandinavica 1990 79 644-651. (doi:10.1111/j.1651-2227.1990.tb11529.x)
16. Sandberg D, Gillivray MH, Clopper RR, Fung C, LeRoux L & Alliger DE. Quality of life among formerly treated childhood-onset growth hormone-deficient adults: a comparison with unaffected siblings. Journal of Clinical Endocrinology and Metabolism 1998 83 1134-1142. (doi:10.1210/jc.83.4.1134)
17. Edwards PJ, Roberts I, Clarke MJ, Diguiseppi C, Wentz R, Kwan I, Cooper R, Felix LM & Pratap S. Methods to increase response to postal and electronic questionnaires. Cochrane Database of Systematic Reviews 2009 8 1-481. (doi:10.1002/14651858.MR000008.pub4)
18. Bojesen A, Stochholm K, Juul S & Gravholt CH. Socioeconomic trajectories affect mortality in Klinefelter syndrome. Journal of Clinical Endocrinology and Metabolism 2011 96 2098-2104. (doi:10.1210/jc.2011-0367)
19. RendallMS,WedenMM, FavreaultMM&WaldronH. The protective effect of marriage for survival: a review and update. Demography 2011 48 481-506. (doi:10.1007/s13524-011-0032-5)
20. Cutler DM, Lange F, Meara E, Richards-Shubik S & Ruhm CJ. Rising educational gradients in mortality: the role of behavioral risk factors. Journal of Health Economics 2011 30 1174-1187. (doi:10.1016/j.jhealeco.2011.06.009)
21. Drotar D, Owens R & Gotthold J. Personality adjustment of children and adolescents with hypopituitarism. Child Psychiatry and Human Development 1980 11 59-66. (doi:10.1007/BF00705871)
22. Holmes CS, Thompson RG & Hayford JT. Factors related to grade retention in children with short stature. Child: Care, Health and Development 1984 10 199-210. (doi:10.1111/j.1365-2214.1984.tb00179.x)
23. Baum HB, Katznelson L, Sherman JC, Biller BM, Hayden DL, Schoenfeld DA, Cannistraro KE & Klibanski A. Effects of physiological growth hormone (GH) therapy on cognition and quality of life in patients with adult-onset GH deficiency. Journal of Clinical Endocrinology and Metabolism 1998 83 3184-3189. (doi:10.1210/jc.83.9.3184)
24. McGauley GA. Quality of life assessment before and after growth hormone treatment in adults with growth hormone deficiency. Acta Paediatrica Scandinavica. Supplement 1989 356 70-72. (doi:10.1111/j.1651-2227.1989.tb11249. x)
25. Burman P, Broman JE, Hetta J, Wiklund I, Erfurth EM, Hagg E & Karlsson FA. Quality of life in adults with growth hormone (GH) deficiency: response to treatment with recombinant human GH in a placebo-controlled 21-month trial. Journal of Clinical Endocrinology and Metabolism 1995 80 3585-3590. (doi:10.1210/jc.80.12.3585)
26. Rosen T, Wiren L, Wilhelmsen L, Wiklund I & Bengtsson BA. Decreased psychological well-being in adult patients with growth hormone deficiency. Clinical Endocrinology 1994 40 111-116. (doi:10.1111/j.1365-2265.1994.tb02452.x)
27. Wiren L, Whalley D, McKenna S & Wilhelmsen L. Application of a disease-specific, quality-of-life measure (QoL-AGHDA) in growth hormone-deficient adults and a random population sample in Sweden: validation of the measure by rasch analysis. Clinical Endocrinology 2000 52 143-152. (doi:10.1046/j.1365-2265.2000.00899.x)
28. Badia X, Lucas A, Sanmarti A, Roset M & Ulied A. One-year follow-up of quality of life in adults with untreated growth hormone deficiency. Clinical Endocrinology 1998 49 765-771. (doi:10.1046/j.1365-2265.1998.00634.x)
29. Ross JL. Effects of growth hormone on cognitive function. Hormone Research in Paediatrics 2005 64 89-94. (doi:10.1159/000089323)
30. Stochholm K, Hjerrild B, Mortensen K, Juul S, Frydenberg M & Gravholt C. Socio-economic parameters and mortality in Turner syndrome. European Journal of Endocrinology 2012 166 1013-1019. (doi:10.1530/EJE-11-1066)
31. Schoemaker MJ, Swerdlow AJ, Higgins CD, Wright AF & Jacobs PA. Mortality in women with Turner syndrome in Great Britain: a national cohort study. Journal of Clinical Endocrinology and Metabolism 2008 93 4735-4742. (doi:10.1210/jc.2008-1049)