Utility of intraoperative frozen section histopathology in the diagnosis of periprosthetic joint infection: A systematic review and meta-analysis

Journal of Bone and Joint Surgery

Volumn 94, Issue 18, 2012, Pages 1700-1711

  Tsaras, Geoffrey ^a   Maduka Ezeh, Awele ^b   Inwards, Carrie Y ^b   Mabry, Tad ^b   Erwin, Patricia J ^b   Murad, M Hassan ^b   Montori, Victor M ^b   West, Colin P ^b   Osmon, Douglas R ^b   Berbari, Elie F ^b  

^a UNIVERSITY OF ILLINOIS   (United States)

^b MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FROZEN SECTION; HISTOPATHOLOGY; HUMAN; INFLAMMATION; MAJOR CLINICAL STUDY; META ANALYSIS; MICROSCOPY; NEUTROPHIL; PERIPROSTHETIC JOINT INFECTION; PRIORITY JOURNAL; REVIEW; SYSTEMATIC REVIEW; TOTAL HIP PROSTHESIS; TOTAL KNEE REPLACEMENT;

EID: 84867507983     PISSN: 00219355     EISSN: 15351386     Source Type: Journal    
DOI: 10.2106/JBJS.J.00756     Document Type: Review

References (53)

1. Kurtz S, Mowat F, Ong K, Chan N, Lau E, Halpern M. Prevalence of primary and revision total hip and knee arthroplasty in the United States from 1990 through 2002. J Bone Joint Surg Am. 2005 Jul;87(7):1487-97. (Pubitemid 40917748)
2. Kurtz S, Ong K, Lau E, Mowat F, HalpernM. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. J Bone Joint Surg Am. 2007 Apr;89(4):780-5. (Pubitemid 46564282)
3. Sharkey PF, Hozack WJ, Rothman RH, Shastri S, Jacoby SM. Insall Award paper. Why are total knee arthroplasties failing today? Clin Orthop Relat Res. 2002 Nov;(404):7-13. (Pubitemid 35351042)
4. Fehring TK, Odum S, Griffin WL, Mason JB, Nadaud M. Early failures in total knee arthroplasty. Clin Orthop Relat Res 2001(392):315-8. (Pubitemid 33054961)
5. Bozic KJ, Kurtz SM, Lau E, Ong K, Chiu V, Vail TP, Rubash HE, Berry DJ. The epidemiology of revision total knee arthroplasty in the United States. Clin Orthop Relat Res. 2010 Jan;468(1):45-51. Epub 2009 Jun 25.
6. Bozic KJ, Kurtz SM, Lau E, Ong K, Vail TP, Berry DJ. The epidemiology of revision total hip arthroplasty in the United States. J Bone Joint Surg Am. 2009 Jan;91(1):128-33.
7. Trampuz A, Osmon DR, Hanssen AD, Steckelberg JM, Patel R. Molecular and antibiofilm approaches to prosthetic joint infection. Clin Orthop Relat Res. 2003 Sep;(414):69-88. (Pubitemid 37102138)
8. Del Pozo JL, Patel R. Clinical practice. Infection associated with prosthetic joints. N Engl J Med. 2009 Aug 20;361(8):787-94.
9. Morgan PM, Sharkey P, Ghanem E, Parvizi J, Clohisy JC, Burnett RS, Barrack RL. The value of intraoperative Gram stain in revision total knee arthroplasty. J Bone Joint Surg Am. 2009 Sep;91(9):2124-9.
10. Parvizi J, Ghanem E, Sharkey P, Aggarwal A, Burnett RS, Barrack RL. Diagnosis of infected total knee: findings of a multicenter database. Clin Orthop Relat Res. 2008 Nov;466(11):2628-33. Epub 2008 Sep 10.
11. Kataoka M, Torisu T, Tsumura H, Yoshida S, Takashita M. An assessment of histopathological criteria for infection in joint arthroplasty in rheumatoid synovium. Clin Rheumatol. 2002 May;21(2):159-63. (Pubitemid 34649599)
12. Banit DM, Kaufer H, Hartford JM. Intraoperative frozen section analysis in revision total joint arthroplasty. Clin Orthop Relat Res. 2002 Aug;(401):230-8. (Pubitemid 34832854)
13. Francés Borrego A, Martínez FM, Cebrian Parra JL, Grañeda DS, Crespo RG, López-Durán Stern L. Diagnosis of infection in hip and knee revision surgery: intraoperative frozen section analysis. Int Orthop. 2007 Feb;31(1):33-7. Epub 2006 Mar 18.
14. Feldman DS, Lonner JH, Desai P, Zuckerman JD. The role of intraoperative frozen sections in revision total joint arthroplasty. J Bone Joint Surg Am. 1995 Dec;77(12):1807-13. (Pubitemid 26004268)
15. Lonner JH, Desai P, Dicesare PE, Steiner G, Zuckerman JD. The reliability of analysis of intraoperative frozen sections for identifying active infection during revision hip or knee arthroplasty. J Bone Joint Surg Am. 1996 Oct;78(10):1553-8. (Pubitemid 26357528)
16. Pandey R, Drakoulakis E, Athanasou NA. An assessment of the histological criteria used to diagnose infection in hip revision arthroplasty tissues. J Clin Pathol. 1999 Feb;52(2):118-23. (Pubitemid 29062346)
17. Devillé WL, Buntinx F, Bouter LM, Montori VM, de Vet HC, van der Windt DA,Bezemer PD. Conducting systematic reviews of diagnostic studies: didactic guidelines. BMC Med Res Methodol. 2002 Jul 3;2:9.
18. Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gøtzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. Ann Intern Med. 2009 Aug 18;151(4):W65-94. Epub 2009 Jul 20.
19. Whiting P, Rutjes AW, Reitsma JB, Bossuyt PM, Kleijnen J. The development of QUADAS: a tool for the quality assessment of studies of diagnostic accuracy included in systematic reviews. BMC Med Res Methodol. 2003 Nov 10;3:25.
20. Glas AS, Lijmer JG, Prins MH, Bonsel GJ, Bossuyt PM. The diagnostic odds ratio: a single indicator of test performance. J Clin Epidemiol. 2003 Nov;56(11):1129-35. (Pubitemid 37386338)
21. Bhandari M, Guyatt GH. How to appraise a diagnostic test. World J Surg. 2005 May;29(5):561-6. (Pubitemid 41187389)
22. Kester AD, Buntinx F. Meta-analysis of ROC curves. Med Decis Making. 2000 Oct-Dec;20(4):430-9.
23. DerSimonian R, Laird N. Meta-analysis in clinical trials. Control Clin Trials. 1986;7(3):177-88. (Pubitemid 17189972)
24. Higgins JP, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ. 2003 Sep 6;327(7414):557-60. (Pubitemid 37088507)
25. Altman DG, Bland JM. Interaction revisited: the difference between two estimates. BMJ. 2003 Jan 25;326(7382):219. (Pubitemid 36143396)
26. Fagan TJ. Letter: Nomogram for Bayes theorem. N Engl J Med. 1975 Jul 31;293(5):257.
27. Pons M, Anglés F, Sánchez C, Matamala A, Cuchi E, Salavert M, Forcada P, Ferrer H. Infected total hip arthroplasty-the value of intraoperative histology. Int Orthop. 1999;23(1):34-6. (Pubitemid 29322234)
28. Shokeir MO, Duncan CP, O'Connell JX. Revision hip arthroplasty. A histologic review. Int J Surg Pathol. 1996 Apr;3(4):247-56. (Pubitemid 126497463)
29. Abdul-Karim FW, McGinnis MG, Kraay M, Emancipator SN, Goldberg V. Frozen section biopsy assessment for the presence of polymorphonuclear leukocytes in patients undergoing revision of arthroplasties. Mod Pathol. 1998 May;11(5):427-31. (Pubitemid 28224443)
30. Athanasou NA, Pandey R, de Steiger R, Crook D, Smith PM. Diagnosis of infection by frozen section during revision arthroplasty. J Bone Joint Surg Br. 1995 Jan;77(1):28-33.
31. Bori G, Soriano A, García S, Gallart X, Casanova L, Mallofre C, Almela M, Martínez JA, Riba J, Mensa J. Low sensitivity of histology to predict the presence of microorganisms in suspected aseptic loosening of a joint prosthesis. Mod Pathol. 2006 Jun;19(6):874-7. (Pubitemid 43780458)
32. Della Valle CJ, Sporer SM, Jacobs JJ, Berger RA, Rosenberg AG, Paprosky WG. Preoperative testing for sepsis before revision total knee arthroplasty. J Arthroplasty. 2007 Sep;22(6 Suppl 2):90-3. Epub 2007 Jul 26.
33. Fehring TK, Cohen B. Aspiration as a guide to sepsis in revision total hip arthroplasty. J Arthroplasty. 1996 Aug;11(5):543-7. (Pubitemid 26303535)
34. Fehring TK, McAlister JA Jr. Frozen histologic section as a guide to sepsis in revision joint arthroplasty. Clin Orthop Relat Res. 1994 Jul;(304):229-37. (Pubitemid 24230690)
35. Fink B, Makowiak C, Fuerst M, Berger I, Schäfer P, Frommelt L. The value of synovial biopsy, joint aspiration and C-reactive protein in the diagnosis of late periprosthetic infection of total knee replacements. J Bone Joint Surg Br. 2008 Jul;90(7):874-8. (Pubitemid 352009773)
36. Kanner WA, Saleh KJ, Frierson HF Jr. Reassessment of the usefulness of frozen section analysis for hip and knee joint revisions. Am J Clin Pathol. 2008 Sep;130(3):363-8.
37. Ko PS, Ip D, Chow KP, Cheung F, Lee OB, Lam JJ. The role of intraoperative frozen section in decision making in revision hip and knee arthroplasties in a local community hospital. J Arthroplasty. 2005 Feb;20(2):189-95. (Pubitemid 40342705)
38. Malhotra R, Morgan DA. Role of core biopsy in diagnosing infection before revision hip arthroplasty. J Arthroplasty. 2004 Jan;19(1):78-87. (Pubitemid 38112337)
39. Mirra JM, Marder RA, Amstutz HC. The pathology of failed total joint arthroplasty. Clin Orthop Relat Res. 1982 Oct;(170):175-83. (Pubitemid 12034337)
40. Morawietz L, Classen RA, Schröder JH, Dynybil C, Perka C, Skwara A, Neidel J, Gehrke T, Frommelt L, Hansen T, Otto M, Barden B, Aigner T, Stiehl P, Schubert T, Meyer-Scholten C, König A, Ströbel P, Rader CP, Kirschner S, Lintner F, Rüther W, Bos I, Hendrich C, Kriegsmann J, Krenn V. Proposal for a histopathological consensus classification of the periprosthetic interface membrane. J Clin Pathol. 2006 Jun;59(6):591-7. (Pubitemid 43886042)
41. Müller M, Morawietz L, Hasart O, Strube P, Perka C, Tohtz S. [Histopathological diagnosis of periprosthetic joint infection following total hip arthroplasty: use of a standardized classification system of the periprosthetic interface membrane]. Orthopade. 2009 Nov;38(11):1087-96. German.
42. Nilsdotter-Augustinsson A, Briheim G, Herder A, Ljunghusen O, Wahlström O, Ohman L. Inflammatory response in 85 patients with loosened hip prostheses: a prospective study comparing inflammatory markers in patients with aseptic and septic prosthetic loosening. Acta Orthop. 2007 Oct;78(5):629-39. (Pubitemid 350034939)
43. Nuñez LV, Buttaro MA, Morandi A, Pusso R, Piccaluga F. Frozen sections of samples taken intraoperatively for diagnosis of infection in revision hip surgery. Acta Orthop. 2007 Apr;78(2):226-30. (Pubitemid 46676664)
44. Savarino L, Tigani D, Baldini N, Bochicchio V, Giunti A. Pre-operative diagnosis of infection in total knee arthroplasty: an algorithm. Knee Surg Sports Traumatol Arthrosc. 2009 Jun;17(6):667-75. Epub 2009 Mar 4.
45. Schäfer P, Fink B, Sandow D, Margull A, Berger I, Frommelt L. Prolonged bacterial culture to identify late periprosthetic joint infection: a promising strategy. Clin Infect Dis. 2008 Dec 1;47(11):1403-9.
46. Schinsky MF, Della Valle CJ, Sporer SM, Paprosky WG. Perioperative testing for joint infection in patients undergoing revision total hip arthroplasty. J Bone Joint Surg Am. 2008 Sep;90(9):1869-75.
47. Tohtz SW, Müller M, Morawietz L, Winkler T, Perka C. Validity of frozen sectionsfor analysis of periprosthetic loosening membranes. Clin Orthop Relat Res. 2010 Mar;468(3):762-8. Epub 2009 Sep 19.
48. Berbari EF, Hanssen AD, Duffy MC, Steckelberg JM, Ilstrup DM, Harmsen WS, Osmon DR. Risk factors for prosthetic joint infection: case-control study. Clin Infect Dis. 1998 Nov;27(5):1247-54. (Pubitemid 29242479)
49. Betsch BY, Eggli S, Siebenrock KA, Täuber MG, Mühlemann K. Treatment of joint prosthesis infection in accordance with current recommendations improves outcome. Clin Infect Dis. 2008 Apr 15;46(8):1221-6. (Pubitemid 351589906)
50. Trampuz A, Piper KE, Jacobson MJ, Hanssen AD, Unni KK, Osmon DR, Mandrekar JN, Cockerill FR, Steckelberg JM, Greenleaf JF, Patel R. Sonication of removed hip and knee prostheses for diagnosis of infection. N Engl J Med. 2007 Aug 16;357(7):654-63. (Pubitemid 47267235)
51. Marculescu CE, Berbari EF, Hanssen AD, Steckelberg JM, Harmsen SW, Mandrekar JN, Osmon DR. Outcome of prosthetic joint infections treated with debridement and retention of components. Clin Infect Dis. 2006 Feb 15;42(4):471-8. Epub 2006 Jan 5.
52. Parvizi J, Ghanem E, Menashe S, Barrack RL, Bauer TW. Periprosthetic infection: what are the diagnostic challenges? J Bone Joint Surg Am. 2006 Dec;88 Suppl 4:138-47. (Pubitemid 44901982)
53. Bauer TW, Brooks PJ, Sakai H, Krebs V, Borden L. A diagnostic algorithm for detecting an infected hip arthroplasty. Orthopedics. 2003 Sep;26(9):929-30. (Pubitemid 37161504)