Characterizing prostate tumor mouse xenografts with CEST and MT-MRI and redox scanning

Advances in Experimental Medicine and Biology

Volumn 765, Issue , 2013, Pages 39-45

  Cai, Kejia ^a   Xu, He N ^a   Singh, Anup ^a   Haris, Mohammad ^a   Reddy, Ravinder ^a   Li, Lin Z ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Fluorescence imaging; Metabolism; Mitochondrial redox state; Tumor aggressiveness

Indexed keywords

FLAVOPROTEIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CANCER CELL CULTURE; CHEMICAL EXCHANGE SATURATION TRANSFER; CHEMICAL PROCEDURES; CONFERENCE PAPER; CONTROLLED STUDY; FLUORESCENCE IMAGING; HUMAN; HUMAN CELL; IMAGE ANALYSIS; MALE; MOLECULAR IMAGING; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OXIDATION REDUCTION STATE; PRIORITY JOURNAL; PROSTATE TUMOR; TUMOR SCINTISCANNING; TUMOR XENOGRAFT; DU145 CELL LINE; MITOCHONDRIAL RESPIRATION; MULTIMODAL IMAGING; PC-3 [HUMAN PROSTATE CARCINOMA] CELL LINE; TUMOR GROWTH;

EID: 84867505507     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4614-4989-8_6     Document Type: Conference Paper

References (22)

1. Jemal A, Bray F, Center MM et al (2011) Global cancer statistics. CA Cancer J Clin 61:69
2. Li LZ, Zhou R, Xu HN et al (2009) Quantitative magnetic resonance and optical imaging biomarkers of melanoma metastatic potential. Proc Natl Acad Sci U S A 106:6608-6613
3. Li LZ, Zhou R, Zhong T et al (2007) Predicting melanoma metastatic potential by optical and magnetic resonance imaging. Adv Exp Med Biol 599:67-78
4. Grossman RI, Gomori JM, Ramer KN et al (1994) Magnetization transfer: theory and clinical applications in neuroradiology. Radiographics 14:279-290
5. Henkelman RM, Stanisz GJ, Graham SJ (2001) Magnetization transfer in MRI: a review. NMR Biomed 14:57-64
6. Sun PZ, Zhou J, Sun W et al (2006) Detection of the ischemic penumbra using pH-weighted MRI. J Cereb Blood Flow Metab 27:1129
7. Zhou J, Payen JF, Wilson DA et al (2003) Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI. Nat Med 9:1085-1090
8. Ling W, Regatte RR, Navon G et al (2008) Assessment of glycosaminoglycan concentration in vivo by chemical exchange-dependent saturation transfer (gagCEST). Proc Natl Acad Sci U S A 105:2266-2270
9. van Zijl PCM, Jones CK, Ren J et al (2007) MRI detection of glycogen in vivo by using chemical exchange saturation transfer imaging (glycoCEST). Proc Natl Acad Sci 104:4359-4364
10. Chance B, Schoener B, Oshino R et al (1979) Oxidation-reduction ratio studies of mitochondria in freeze-trapped samples. NADH and fl avoprotein fl uorescence signals. J Biol Chem 254:4764-4771
11. Quistorff B, Haselgrove JC, Chance B (1985) High spatial resolution readout of 3-D metabolic organ structure: An automated, low-temperature redox ratio-scanning instrument. Anal Biochem 148:389-400
12. Xu HN, Nioka S, Chance B et al (2011) Heterogeneity of mitochondrial redox state in premalignant pancreas in a PTEN null transgenic mouse model. Adv Exp Med Biol 201:207-213
13. Xu HN, Nioka S, Glickson JD et al (2010) Quantitative mitochondrial redox imaging of breast cancer metastatic potential. J Biomed Opt 15:036010
14. Pulukuri SM, Gondi CS, Lakka SS et al (2005) RNA interference-directed knockdown of urokinase plasminogen activator and urokinase plasminogen activator receptor inhibits prostate cancer cell invasion, survival, and tumorigenicity in vivo. J Biol Chem 280:36529-36540
15. Haris M, Cai K, Singh A et al (2010) In vivo mapping of brain myo-inositol. Neuroimage 54:2079-2085
16. Xu HN, Wu B, Nioka S et al (2009) Calibration of redox scanning for tissue samples. Proc SPIE 7174:71742F1-71742F8
17. Xu HN, Wu B, Nioka S et al (2009) Quantitative redox scanning of tissue samples using a calibration procedure. J Innov Opt Health Sci 2:375-385
18. van Zijl PCM, Zhou J, Mori N et al (2003) Mechanism of magnetization transfer during onresonance water saturation. A new approach to detect mobile proteins, peptides, and lipids. Magn Reson Med 49:440
19. van Zijl PCM, Yadav NN (2011) Chemical exchange saturation transfer (CEST): what is in a name and what isn't? Magn Reson Med 65:927
20. Woessner DE, Zhang S, Merritt ME et al (2005) Numerical solution of the Bloch equations provides insights into the optimum design of PARACEST agents for MRI. Magn Reson Med 53:790-799
21. Laniado ME, Lalani EN, Fraser SP et al (1997) Expression and functional analysis of voltageactivated Na+ channels in human prostate cancer cell lines and their contribution to invasion in vitro. Am J Pathol 150:1213-1221
22. Dai Y, Bae K, Siemann DW (2011) Impact of hypoxia on the metastatic potential of human prostate cancer cells. Int J Radiat Oncol 81:521-528