Insulin infusion for hyperglycaemia in very preterm infants appears safe with no effect on morbidity, mortality and long-term neurodevelopmental outcome

Journal of Maternal-Fetal and Neonatal Medicine

Volumn 25, Issue 11, 2012, Pages 2415-2418

  Heald, Alicia ^a   Abdel Latif, Mohamed E ^a,b   Kent, Alison L ^a,b  

^a The Australian National University   (Australia)

^b CANBERRA HOSPITAL   (Australia)

Author keywords

Hyperglycaemia; Insulin; Mortality; Neonate; Premature

Indexed keywords

GLUCOSE; INSULIN;

ANTHROPOMETRY; ARTICLE; BRAIN DEVELOPMENT; FEMALE; GESTATIONAL AGE; GLUCOSE BLOOD LEVEL; HUMAN; HYPERGLYCEMIA; HYPOGLYCEMIA; INFANT; INFANT MORTALITY; INSULIN INFUSION; MAJOR CLINICAL STUDY; MALE; NEWBORN INTENSIVE CARE; NEWBORN MORBIDITY; PREMATURITY; PRIORITY JOURNAL; RETROLENTAL FIBROPLASIA; RETROSPECTIVE STUDY; TREATMENT DURATION;

BRAIN; CHILD DEVELOPMENT; FEMALE; HUMANS; HYPERGLYCEMIA; INFANT, EXTREMELY PREMATURE; INFANT, NEWBORN; INFANT, PREMATURE, DISEASES; INSULIN; INSULIN INFUSION SYSTEMS; MALE; MORBIDITY; RETROSPECTIVE STUDIES; SURVIVAL ANALYSIS; TIME FACTORS; TREATMENT OUTCOME;

EID: 84867499527     PISSN: 14767058     EISSN: 14764954     Source Type: Journal    
DOI: 10.3109/14767058.2012.699115     Document Type: Article

References (31)

1. Ng SM, May JE, Emmerson AJ. Continuous insulin infusion in hyperglycaemic extremely-low-birth-weight neonates. Biol Neonate 2005;87:269-272. (Pubitemid 41094912)
2. Ogilvy-Stuart AL, Beardsall K. Management of hyperglycaemia in the preterm infant. Arch Dis Child Fetal Neonatal Ed 2010;95:F126-F131.
3. Beardsall K, Ogilvy-Stuart AL, Frystyk J, Chen J W, Thompson M, Ahluwalia J, Ong KK, Dunger DB. Early elective insulin therapy can reduce hyperglycemia and increase insulin-like growth factor-I levels in very low birth weight infants. J Pediatr 2007;151:611-7, 617.e1.
4. Kao LS, Morris BH, Lally KP, Stewart CD, Huseby V, Kennedy KA. Hyperglycemia and morbidity and mortality in extremely low birth weight infants. J Perinatol 2006;26:730-736. (Pubitemid 44811506)
5. Sinclair JC, Bottino M, Cowett RM. Interventions for treatment of neonatal hyperglycaemia in very low birth weight infants. Cochrane Database Syst Rev 2009; CD007615.
6. Beardsall K, Vanhaesebrouck S, Ogilvy-Stuart AL, Vanhole C, Palmer CR, van Weissenbruch M, Midgley P, et al. Early insulin therapy in very-low-birth-weight infants. N Engl J Med 2008;359:1873-1884.
7. Griffiths R. The abilities of young children. A comprehensive system of mental measurement for the first 8 years of life. Buckinghamshire: The test agency limited, 1994.
8. Bayley N. The Bayley scales of infant development. Second edition. San Antonio: The Psychological Corporation, 1993.
9. Amiel-Tison C, Stewart A. Follow-up studies during the first five years of life: a pervasive assessment of neurological function. Arch Dis Child 1989;64:496-502. (Pubitemid 19105095)
10. Kitchen W, Ford G, Orgill A, Rickards A, Astbury J, Lissenden J, Bajuk B, et al. Outcome in infants of birth weight 500 to 999 g: a continuing regional study of 5-year-old survivors. J Pediatr 1987;111:761-766. (Pubitemid 18017912)
11. Parry G, Tucker J, Tarnow-Mordi W; UK Neonatal Staffing Study Collaborative Group. CRIB II: an update of the clinical risk index for babies score. Lancet 2003;361:1789-1791. (Pubitemid 36638429)
12. Shennan AT, Dunn MS, Ohlsson A, Lennox K, Hoskins EM. Abnormal pulmonary outcomes in premature infants: prediction from oxygen requirement in the neonatal period. Pediatrics 1988;82:527-532.
13. Papile LA, Burstein J, Burstein R, Koffler H. Incidence and evolution of subependymal and intraventricular hemorrhage: a study of infants with birth weights less than 1,500 gm. J Pediatr 1978;92:529-534. (Pubitemid 8293290)
14. Bell MJ, Ternberg JL, Feigin RD, Keating JP, Marshall R, Barton L, Brotherton T. Neonatal necrotizing enterocolitis. Therapeutic decisions based upon clinical staging. Ann Surg 1978;187:1-7.
15. Flynn JT. An international classification of retinopathy of prematurity: clinical experience. Trans Am Ophthalmol Soc 1984;82:218-238. (Pubitemid 15102503)
16. National Perinatal Epidemiology Unit. Disability and care: measurement of health status at two years. A report of two working groups convened by the National Perinatal Epidemiology Unit and the former Oxford Regional Health Authority. Oxford:National Perinatal Epidemiology Unit:1994.
17. The Victorian Infant Collaborative Study Group. Postnatal corticosteroids and sensorineural outcome at 5 years of age. J Paediatr Child Health 2000; 36: 256-261.
18. The Victorian Infant Collaborative Study Group. Outcome at 2 years of children 23-27 weeks' gestation born in Victoria in 1991-92. J Paediatr Child Health 1997; 33: 161-165.
19. Kleinbaum D. Logistic regression: a self-learning text. New York:Springer-Verlag, 1994.
20. Hosmer D, Lemeshow S. Applied logistic regression. Wiley: New York, 1989.
21. Collins JW Jr, Hoppe M, Brown K, Edidin DV, Padbury J, Ogata ES. A controlled trial of insulin infusion and parenteral nutrition in extremely low birth weight infants with glucose intolerance. J Pediatr 1991;118:921-927.
22. Seri I. Management of hypotension and low systemic blood flow in the very low birth weight neonate during the first postnatal week. J Perinatol 2006;26 Suppl 1:S8-13; discussion S22.
23. Efird MM, Heerens AT, Gordon PV, Bose CL, Young DA. A randomized-controlled trial of prophylactic hydrocortisone supplementation for the prevention of hypotension in extremely low birth weight infants. J Perinatol 2005;25:119-124. (Pubitemid 40277384)
24. Binder ND, Raschko PK, Benda GI, Reynolds J W. Insulin infusion with parenteral nutrition in extremely low birth weight infants with hyperglycemia. J Pediatr 1989;114:273-280. (Pubitemid 19059125)
25. Hays S P, Smith EO, Sunehag AL. Hyperglycemia is a risk factor for early death and morbidity in extremely low birth-weight infants. Pediatrics 2006;118:1811-1818. (Pubitemid 46393660)
26. Williams AF. Hypoglycaemia of the newborn: a review. Bull World Health Organ 1997;75:261-290. (Pubitemid 27373566)
27. Finfer S, Chittock DR, Su SY, Blair D, Foster D, Dhingra V, Bellomo R, et al.; NICE-SUGAR Study Investigators. Intensive versus conventional glucose control in critically ill patients. N Engl J Med 2009;360:1283-1297.
28. Krinsley JS. Association between hyperglycemia and increased hospital mortality in a heterogeneous population of critically ill patients. Mayo Clin Proc 2003;78:1471-1478. (Pubitemid 37475630)
29. Wiener RS, Wiener DC, Larson RJ. Benefits and risks of tight glucose control in critically ill adults: a meta-analysis. JAMA 2008;300:933-944.
30. Van den Berghe G, Wilmer A, Hermans G, Meersseman W, Wouters PJ, Milants I, Van Wijngaerden E, et al. Intensive insulin therapy in the medical ICU. N Engl J Med 2006;354:449-461. (Pubitemid 43200296)
31. Vlasselaers D, Milants I, Desmet L, Wouters PJ, Vanhorebeek I, van den Heuvel I, Mesotten D, et al. Intensive insulin therapy for patients in paediatric intensive care: a prospective, randomised controlled study. Lancet 2009;373:547-556.