Efficacy of a reformulated inactivated chimeric PCV1-2 vaccine based on clinical, virological, pathological and immunological examination under field conditions

Vaccine

Volumn 30, Issue 47, 2012, Pages 6671-6677

  Seo, Hwi Won ^a   Han, Kiwon ^a   Oh, Yeonsu ^a   Park, Changhoon ^a   Chae, Chanhee ^a  

^a Seoul National University   (South Korea)

Author keywords

Chimeric porcine circovirus 1 2 vaccine; Porcine circovirus type 2; Porcine circovirus associated disease; Postweaning multisystemic wasting syndrome; Vaccine efficacy

Indexed keywords

FOSTERA; GAMMA INTERFERON; NEUTRALIZING ANTIBODY; PORCINE CIRCOVIRUS 1-2 VACCINE; UNCLASSIFIED DRUG; VIRUS VACCINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD ANALYSIS; CIRCOVIRUS; CLINICAL EXAMINATION; CONTROLLED STUDY; DRUG EFFICACY; ENZYME LINKED IMMUNOSPOT ASSAY; FARM ANIMAL; HISTOPATHOLOGY; IMMUNOLOGY; IMMUNOPATHOLOGY; LYMPHOID TISSUE; MORTALITY; NONHUMAN; NOSE SMEAR; POSTWEANING MULTISYSTEMIC WASTING SYNDROME; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SECRETORY CELL; SEROLOGY; SWINE; VIROLOGY; VIRUS LOAD; WEIGHT GAIN;

ANIMALS; ANTIBODIES, NEUTRALIZING; ANTIBODIES, VIRAL; ANTIGENS, VIRAL; CIRCOVIRIDAE INFECTIONS; CIRCOVIRUS; DNA, VIRAL; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; INTERFERON-GAMMA; LYMPHOCYTE SUBSETS; PORCINE POSTWEANING MULTISYSTEMIC WASTING SYNDROME; REPUBLIC OF KOREA; SWINE; VACCINATION; VACCINES, INACTIVATED; VIRAL VACCINES;

EID: 84867445915     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2012.08.065     Document Type: Article

References (22)

1. Chae C. Postweaning multisystemic wasting syndrome: a review of aetiology, diagnosis and pathology. Vet J 2004, 168:41-49.
2. Chae C. A review of porcine circovirus 2-associated syndromes and diseases. Vet J 2005, 169:326-336.
3. Chae C. Porcine circovirus type 2 and its associated disease in Korea. Virus Res 2012, 164:107-113.
4. Fraile L., Grau-Roma L., Sarasola P., Sinovas N., Nofrarias M., Lopez-Jimenez R., et al. Inactivated PCV2 one shot vaccine applied in 3-week-old piglets: Improvement of production parameters and interaction with maternally derived immunity. Vaccine 2012, 30:1986-1992.
5. Kixmoller M., Ritzmann M., Eddicks M., Saalmuller A., Elbers K., Fachinger V. Reduction of PMWS-associated clinical signs and co-infections by vaccination against PCV2. Vaccine 2008, 26:3443-3451.
6. Lyoo K., Joo H., Caldwell B., Kim H., Davies P.R., Torrison J. Comparative efficacy of three commercial PCV2 vaccines in conventionally reared pigs. Vet J 2012, 189:58-62.
7. Martelli P., Ferrari L., Morganti M., De-Angelis E., Bonilauri P., Guazzetti S., et al. One dose of a porcine circovirus 2 subunit vaccine induces humoral and cell-mediated immunity and protects against porcine circovirus-associated disease under field conditions. Vet Microbiol 2011, 149:339-351.
8. Segalés J., Urniza A., Alegre A., Bru T., Crisci E., Nofrarías M., et al. A genetically engineered chimeric vaccine against porcine circovirus type 2 (PCV2) improves clinical, pathological and virological outcomes in postweaning multisystemic wasting syndrome affected farms. Vaccine 2009, 27:7313-7321.
9. Gagnon C.A., Music N., Fontaine G., Tremblay D., Harel J. Emergence of a new type of porcine circovirus in swine (PCV): a type 1 and type 2 PCV recombinant. Vet Microbiol 2010, 144:18-23.
10. Fort M., Sibila M., Perez-Martin E., Nofrarias M., Mateu E., Segalés J. One dose of a porcine circovirus 2 (PCV2) sub-unit vaccine administered to 3-week-old conventional piglets elicits cell-mediated immunity and significantly reduces PCV2 viremia in an experimental model. Vaccine 2009, 27:4031-4037.
11. Allan G.M., Mackie D.P., McNair J., Adair B.M., McNulty M.S. Production, preliminary characterisation and applications of monoclonal antibodies to porcine circovirus. Vet Immunol Immunopathol 1994, 43:357-371.
12. Pogranichnyy R.M., Yoon K.J., Harms P.A., Swenson S.L., Zimmerman J.J., Sorden S.D. Characterization of immune response of young pigs to porcine circovirus type 2 infection. Viral Immunol 2000, 13:143-153.
13. Gagnon C.A., Del-Castillo J.R., Music N., Fontaine G., Harel J., Tremblay D. Development and use of a multiplex real-time quantitative polymerase chain reaction assay for detection and differentiation of Porcine circovirus-2 genotypes 2a and 2b in an epidemiological survey. J Vet Diagn Invest 2008, 20:545-558.
14. Rodriguez-Arrioja G.M., Segalés J., Balasch M., Rosell C., Quintant J., Folch J.M., et al. Serum antibodies to porcine circovirus type 1 and type 2 in pigs with and without PMWS. Vet Rec 2000, 146:762-764.
15. Diaz I., Mateu E. Use of ELISPOT and ELISA to evaluate IFN-γ, IL-10 and IL-4 responses in conventional pigs. Vet Immunol Immunopathol 2005, 106:107-112.
16. Williams P.P. Immunomodulating effects of intestinal absorbed maternal colostral leukocytes by neonatal pigs. Can Vet Res 1993, 57:1-8.
17. Kim J., Chae C. Expression of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 in porcine circovirus 2-induced granulomatous inflammation. J Comp Pathol 2004, 131:121-126.
18. Kim D., Kim C.H., Han K., Seo H.W., Oh Y., Park C., et al. Comparative efficacy of commercial Mycoplasma hyopneumoniae and porcine circovirus 2 (PCV2) vaccines in pigs experimentally infected with M. hyopneumoniae and PCV2. Vaccine 2011, 29:3206-3212.
19. Patterson A.R., Ramamoorthy S., Madson D.M., Meng X.J., Halbur P.G., Opriessnig T. Shedding and infection dynamics of porcine circovirus type 2 (PCV2) after experimental infection. Vet Microbiol 2011, 149:91-98.
20. Nielsen J., Vincent I.E., Bøtner A., Ladekjær-Mikkelsen A-S., Allan G., Summerfield A., et al. Association of lymphopenia with porcine circovirus type 2 induced postweaning multisystemic wasting syndrome (PMWS). Vet Immunol Immunopathol 2003, 92:97-111.
21. Segalés J., Alonso F., Rosell C., Pastor J., Chianini F., Campos E., et al. Changes in peripheral blood leukocyte populations in pigs with natural postweaning multisystemic wasting syndrome (PMWS). Vet Immunol Immunopathol 2001, 81:37-44.
22. Opriessnig T., Patterson A.R., Elsener J., Meng X.J., Halbur P.G. Influence of maternal antibodies on efficacy of porcine circovirus type 2 (PCV2) vaccination to protect pigs from experimental infection with PCV2. Clin Vaccine Immunol 2008, 15:397-401.