A phase i study of the metal ionophore clioquinol in patients with advanced hematologic malignancies

Clinical Lymphoma, Myeloma and Leukemia

Volumn 12, Issue 5, 2012, Pages 330-336

  Schimmer, Aaron D ^a   Jitkova, Yulia ^a   Gronda, Marcela ^a   Wang, Zezhou ^a   Brandwein, Joseph ^a   Chen, Christine ^a   Gupta, Vikas ^a   Schuh, Andre ^a   Yee, Karen ^a   Chen, Jian ^b   Ackloo, Suzanne ^b   Booth, Tristan ^c   Keays, Sharon ^c   Minden, Mark D ^a  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b Ontario Cancer Biomarker Network   (Canada)

^c INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

Author keywords

Copper; Neuropathy; Pharmacodynamics; Pharmacokinetics; Proteasome

Indexed keywords

CLIOQUINOL; PROTEASOME;

ABDOMINAL PAIN; ACUTE GRANULOCYTIC LEUKEMIA; ACUTE LYMPHOBLASTIC LEUKEMIA; ADULT; ADVANCED CANCER; AGED; ARTICLE; CANCER PATIENT; CHRONIC LYMPHATIC LEUKEMIA; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CREATININE BLOOD LEVEL; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG DOSE ESCALATION; DRUG DOSE INCREASE; DRUG WITHDRAWAL; FATIGUE; FEMALE; HEMATOLOGIC MALIGNANCY; HODGKIN DISEASE; HUMAN; KIDNEY FAILURE; MALE; MULTIPLE CYCLE TREATMENT; MULTIPLE MYELOMA; MYELODYSPLASTIC SYNDROME; NAUSEA AND VOMITING; NONHODGKIN LYMPHOMA; PARESTHESIA; SENSORY NEUROPATHY; SIDE EFFECT;

ADULT; AGED; AGED, 80 AND OVER; CLIOQUINOL; DRUG ADMINISTRATION SCHEDULE; FEMALE; FOLLOW-UP STUDIES; HEMATOLOGIC NEOPLASMS; HUMANS; IONOPHORES; MALE; MIDDLE AGED; PROTEASOME ENDOPEPTIDASE COMPLEX;

EID: 84867433249     PISSN: 21522650     EISSN: 21522669     Source Type: Journal    
DOI: 10.1016/j.clml.2012.05.005     Document Type: Article

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