Comparison of Hematopoietic Stem Cells Derived from Fresh and Cryopreserved Whole Cord Blood in the Generation of Humanized Mice

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Scholbach, Johanna ^a   Schulz, Anett ^b   Westphal, Florian ^a   Egger, Dietmar ^c   Wege, Anja Kathrin ^d   Patties, Ina ^a   Köberle, Margarethe ^a   Sack, Ulrich ^b   Lange, Franziska ^b  

^a UNIVERSITY OF LEIPZIG   (Germany)

^b FRAUNHOFER INSTITUTE FOR CELL THERAPY AND IMMUNOLOGY   (Germany)

^c VITA34 AG   (Germany)

^d UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD3 ANTIBODY; CD34 ANTIGEN; CD45 ANTIGEN; IMMUNOGLOBULIN M ANTIBODY;

ANIMAL CELL; ANIMAL TISSUE; ANTIGEN PURIFICATION; ARTICLE; CD34 SELECTION; CELL DIFFERENTIATION; CELL ISOLATION; CELL MATURATION; CELL PROLIFERATION; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; CRYOPRESERVATION; FEMALE; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IMMUNOSTIMULATION; MONOCYTE; MOUSE; NONHUMAN; NORMAL HUMAN; T LYMPHOCYTE SUBPOPULATION; UMBILICAL CORD BLOOD;

ANIMALS; ANTIGENS, CD34; BLOOD PRESERVATION; CELL PROLIFERATION; CELL SEPARATION; CRYOPRESERVATION; FETAL BLOOD; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HUMANS; IMMUNOGLOBULINS; LYMPHOCYTES; MICE; MICE, INBRED NOD; MICE, SCID; MICE, TRANSGENIC;

EID: 84867409622     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046772     Document Type: Article

References (33)

1. Brehm MA, Shultz LD, Greiner DL, (2010) Humanized mouse models to study human diseases. Curr Opin Endocrinol Diabetes Obes 17: 120-125.
2. Wege AK, Ernst W, Eckl J, Frankenberger B, Vollmann-Zwerenz A, et al. (2011) Humanized tumor mice-A new model to study and manipulate the immune response in advanced cancer therapy. Int J Cancer.
3. Nomura T, Nakajima H, Hongyo T, Taniguchi E, Fukuda K, et al. (1997) Induction of cancer, actinic keratosis, and specific p53 mutations by UVB light in human skin maintained in severe combined immunodeficient mice. Cancer Res 57: 2081-2084.
4. Melkus MW, Estes JD, Padgett-Thomas A, Gatlin J, Denton PW, et al. (2006) Humanized mice mount specific adaptive and innate immune responses to EBV and TSST-1. Nat Med 12: 1316-1322.
5. Sun Z, Denton PW, Estes JD, Othieno FA, Wei BL, et al. (2007) Intrarectal transmission, systemic infection, and CD4+ T cell depletion in humanized mice infected with HIV-1. J Exp Med 204: 705-714.
6. Shultz LD, Ishikawa F, Greiner DL, (2007) Humanized mice in translational biomedical research. Nat Rev Immunol 7: 118-130.
7. Shultz LD, Lyons BL, Burzenski LM, Gott B, Chen X, et al. (2005) Human lymphoid and myeloid cell development in NOD/LtSz-scid IL2R gamma null mice engrafted with mobilized human hemopoietic stem cells. J Immunol 174: 6477-6489.
8. Yahata T, Ando K, Nakamura Y, Ueyama Y, Shimamura K, et al. (2002) Functional human T lymphocyte development from cord blood CD34+ cells in nonobese diabetic/Shi-scid, IL-2 receptor gamma null mice. J Immunol 169: 204-209.
9. Ishikawa F, Yasukawa M, Lyons B, Yoshida S, Miyamoto T, et al. (2005) Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice. Blood 106: 1565-1573.
10. Macchiarini F, Manz MG, Palucka AK, Shultz LD, (2005) Humanized mice: are we there yet? J Exp Med 202: 1307-1311.
11. Koo GC, Hasan A, O'Reilly RJ, (2009) Use of humanized severe combined immunodeficient mice for human vaccine development. Expert Rev Vaccines 8: 113-120.
12. Ito M, Hiramatsu H, Kobayashi K, Suzue K, Kawahata M, et al. (2002) NOD/SCID/gamma(c)(null) mouse: an excellent recipient mouse model for engraftment of human cells. Blood 100: 3175-3182.
13. Cao X, Shores EW, Hu-Li J, Anver MR, Kelsall BL, et al. (1995) Defective lymphoid development in mice lacking expression of the common cytokine receptor gamma chain. Immunity 2: 223-238.
14. Sugamura K, Asao H, Kondo M, Tanaka N, Ishii N, et al. (1996) The interleukin-2 receptor gamma chain: its role in the multiple cytokine receptor complexes and T cell development in XSCID. Annu Rev Immunol 14: 179-205.
15. Pearson T, Greiner DL, Shultz LD, (2008) Creation of "humanized" mice to study human immunity. Curr Protoc Immunol 15: Unit 15.21.
16. Wege AK, Melkus MW, Denton PW, Estes JD, Garcia JV, (2008) Functional and phenotypic characterization of the humanized BLT mouse model. Curr Top Microbiol Immunol 324: 149-165.
17. Taneja V, David CS, (2010) Role of HLA class II genes in susceptibility/resistance to inflammatory arthritis: studies with humanized mice. Immunol Rev 233: 62-78.
18. Luckey D, Bastakoty D, Mangalam AK, (2011) Role of HLA class II genes in susceptibility and resistance to multiple sclerosis: studies using HLA transgenic mice. J Autoimmun 37: 122-128.
19. Müller-Hilke B, (2009) HLA class II and autoimmunity: epitope selection vs differential expression. Acta Histochem 111: 379-381.
20. Wong FS, Wen L, (2004) What can the HLA transgenic mouse tell us about autoimmune diabetes? Diabetologia 47: 1476-1487.
21. Park Y, (2007) Functional evaluation of the type 1 diabetes (T1D) susceptibility candidate genes. Diabetes Res Clin Pract 77 (Suppl 1):: S110-5.
22. Faderl S, Kantarjian HM, Talpaz M, Estrov Z, (1998) Clinical significance of cytogenetic abnormalities in adult acute lymphoblastic leukemia. Blood 91: 3995-4019.
23. Lyons AB, Parish CR, (1994) Determination of lymphocyte division by flow cytometry. J Immunol Methods 171: 131-137.
24. Case J, Rice A, Vowels M, (1996) Conditions affecting the isolation of human umbilical cord blood CD34+ cells. J Hematother 5: 255-260.
25. Giarratana M, Kobari L, Lapillonne H, Chalmers D, Kiger L, et al. (2005) Ex vivo generation of fully mature human red blood cells from hematopoietic stem cells. Nat Biotechnol 23: 69-74.
26. O E, Lee BH, Ahn H, Shin J, Kim H, et al. (2011) Efficient nonadhesive ex vivo expansion of early endothelial progenitor cells derived from CD34+ human cord blood fraction for effective therapeutic vascularization. FASEB J 25: 159-169.
27. Choi B, Chun E, Kim M, Kim SY, Kim S, et al. (2011) Human T cell development in the liver of humanized NOD/SCID/IL-2Rγ(null)(NSG) mice generated by intrahepatic injection of CD34(+) human (h) cord blood (CB) cells. Clin Immunol 139: 321-335.
28. Traggiai E, Chicha L, Mazzucchelli L, Bronz L, Piffaretti J, et al. (2004) Development of a human adaptive immune system in cord blood cell-transplanted mice. Science 304: 104-107.
29. Hogan CJ, Shpall EJ, McNulty O, McNiece I, Dick JE, et al. (1997) Engraftment and development of human CD34(+)-enriched cells from umbilical cord blood in NOD/LtSz-scid/scid mice. Blood 90: 85-96.
30. Wang X, Qi Z, Wei H, Tian Z, Sun R, (2011) Characterization of human B cells in umbilical cord blood-transplanted NOD/SCID mice. Transplant immunology.
31. Hiramatsu H, Nishikomori R, Heike T, Ito M, Kobayashi K, et al. (2003) Complete reconstitution of human lymphocytes from cord blood CD34+ cells using the NOD/SCID/gammacnull mice model. Blood 102: 873-880.
32. Roncarolo MG, Carballido JM, Rouleau M, Namikawa R, de Vries JE, (1996) Human T-and B-cell functions in SCID-hu mice. Semin Immunol 8: 207-213.
33. Krowka JF, Sarin S, Namikawa R, McCune JM, Kaneshima H, (1991) Human T cells in the SCID-hu mouse are phenotypically normal and functionally competent. J Immunol 146: 3751-3756.