Risk of stroke and oral anticoagulant use in atrial fibrillation: A cross-sectional survey

British Journal of General Practice

Volumn 62, Issue 603, 2012, Pages

  Holt, Tim A ^e   Hunter, Tina D ^a,b   Gunnarsson, Candace ^b   Khan, Nada ^a   Cload, Paul ^c   Lip, Gregory Y H ^d  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b S2 Statistical Solutions   (United States)

^c GE HEALTHCARE   (United Kingdom)

^d UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^e NONE

Author keywords

Anticoagulants; Atrial fibrillation; Electronic health records; Primary health care; Stroke

Indexed keywords

ANTICOAGULANT AGENT; ANTITHROMBOCYTIC AGENT;

ADULT; AGED; ANTICOAGULANT THERAPY; ARTICLE; CARDIOVASCULAR DISEASE; CEREBROVASCULAR ACCIDENT; COMORBIDITY; CROSS-SECTIONAL STUDY; DRUG INDICATION; FEMALE; GENERAL PRACTICE; HEALTH SURVEY; HEART ATRIUM FIBRILLATION; HIGH RISK PATIENT; HUMAN; HYPERTENSION; MAJOR CLINICAL STUDY; MALE; MEDICAL DECISION MAKING; OUTCOME ASSESSMENT; PRESCRIPTION; PRIMARY MEDICAL CARE; RISK; RISK ASSESSMENT; RISK REDUCTION; THROMBOSIS; THROMBOSIS PREVENTION; UNITED KINGDOM;

AGED; AGED, 80 AND OVER; ALGORITHMS; ANTICOAGULANTS; ATRIAL FIBRILLATION; COMORBIDITY; DRUG UTILIZATION; EPIDEMIOLOGIC METHODS; FEMALE; GENERAL PRACTICE; GREAT BRITAIN; HUMANS; HYPERTENSION; MALE; MIDDLE AGED; PRACTICE GUIDELINES AS TOPIC; RISK ASSESSMENT; STROKE;

EID: 84867408957     PISSN: 09601643     EISSN: None     Source Type: Journal    
DOI: 10.3399/bjgp12X656856     Document Type: Article

References (36)

1. Go AS, Hylek EM, Phillips KA, et al. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. JAMA 2001; 285(18): 2370-2375. (Pubitemid 32424106)
2. Gage BF, Waterman AD, Shannon W, et al. Validation of clinical classification schemes for predicting stroke. Results from the national registry of atrial fibrillation. JAMA 2001; 285(22): 2864-2870. (Pubitemid 32537350)
3. Olesen JB, Lip GY, Hansen ML, et al. Validation of risk stratification schemes for predicting stroke and thromboembolism in patients with atrial fibrillation: nationwide cohort study. BMJ 2001; 342: d124.
4. Stroke Risk in Atrial Fibrillation Working Group. Comparison of 12 risk stratification schemes to predict stroke in patients with nonvalvular atrial fibrillation. Stroke 2008; 39(6): 1901-1910.
5. Lip GY, Nieuwlaat R, Pisters R, et al. Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation. Chest 2010; 137(2): 263-272.
6. Camm AJ, Kirchhof P, Lip GYH, et al, for the European Society for Cardiology. Guidelines for the management of atrial fibrillation. Eur Heart J 2010; 31(19): 2369-2429.
7. Karthikeyan G, Eikelboom JW. The CHADS2 score for stroke risk stratification in atrial fibrillation - friend or foe? Thromb Haemost 2010; 104(1): 45-48.
8. 2 clinical prediction rule to predict ischaemic stroke. A systematic review and meta-analysis. Thromb Haemost 2011; 106(3): 528-538.
9. Lip GYH, Halperin JL. Improving stroke risk stratification in atrial fibrillation. Am J Med 2010; 123(6): 484-488.
10. Hart RG, Pearce LA, Aguilar MI. Meta-analysis: antithrombotic therapy to prevent stroke in patients who have non-valvular atrial fibrillation. Ann Intern Med 2007; 146(12): 857-867. (Pubitemid 351650486)
11. Ogilvie IM, Newton N, Welner SA, et al. Underuse of oral anticoagulants in atrial fibrillation: a systematic review. Am J Med 2010; 123(7): 638-645e4.
12. Nieuwlaat R, Capucci A, Lip GYH, et al, on behalf of the Euro Heart Survey Investigators. Antithrombotic treatment in real-life atrial fibrillation patients: a report from the Euro Heart Survey on Atrial Fibrillation. Eur Heart J 2006; 27(24): 3018-3026. (Pubitemid 44963431)
13. Sandhu RK, Bakal JA, Ezekowitz JA, McAlister FA. Risk stratification schemes, anticoagulation use and outcomes: the risk-treatment paradox in patients with newly diagnosed non-valvular atrial fibrillation. Heart 2011; 97(24): 2046-2050.
14. Majeed A, Moser K, Carroll K. Trends in the prevalence and management of atrial fibrillation in general practice in England and Wales, 1994-1998: analysis of data from the general practice research database. Heart 2001; 86(3): 284-288. (Pubitemid 32800076)
15. Gallagher AM, Rietbrock S, Plumb J, van Staa TP. Initiation and persistence of warfarin or aspirin in patients with chronic atrial fibrillation in general practice: do the appropriate patients receive stroke prophylaxis? J Thrombosis Haemost 2008; 6(9): 1500-1506.
16. Van Staa TP, Setakis E, Di Tanna GL, et al. A comparison of risk stratification schemes for stroke in 79 884 atrial fibrillation patients in general practice. J Thromb Haemost 2011; 9(1): 39-48.
17. NHS Improvement. Guidance on Risk Assessment and Stroke Prevention for Atrial Fibrillation (GRASP-AF). http://www.improvement.nhs.uk/graspaf/ (accessed 29 Aug 2012).
18. Quan H, Khan N, Hemmelgarn BR, et al. Validation of a case definition to define hypertension using administrative data. Hypertension 2009; 54(6): 1423e8.
19. Tu K, Campbell NRC, Chen Z-L, Cauch-Dudek KJ, McAlister FA. Accuracy of administrative databases in identifying patients with hypertension. Open Med 2007; 1(1): e18-e26.
20. National Institute for Health and Clinical Excellence. CG36: Atrial fibrillation. London: National Institute for Health and Clinical Excellence, 2006.
21. Hippisley-Cox J, Vinogradova Y, Coupland C, Pringle M. Comparison of key practice characteristics between general practices in England and Wales and general practices in the QResearch data. Report to the Health and Social Care Information Centre. Nottingham: University of Nottingham, 2005.
22. NHS The Information Centre. Quality and Outcomes Framework. http: //www.qof.ic.nhs.uk/ (accessed 29 Aug 2012).
23. National Institute for Health and Clinical Excellence. CG127: Hypertension. The clinical management of primary hypertension in adults. London: National Institute for Health and Clinical Excellence, 2011.
24. Man-Son-Hing M, Nichol G, Lau A, Laupacis A. Choosing antithrombotic therapy for elderly patients with atrial fibrillation who are at risk for falls. Arch Intern Med 1999; 159(7): 677-685. (Pubitemid 29177656)
25. Gage BF,Cardinalli AB, Owens DK. The effect of stroke and stroke prophylaxis with aspirin or warfarin on quality of life. Arch Intern Med 1996; 156(16): 1829-1836. (Pubitemid 26295228)
26. MacLean S, Mulla S, Akl EA, Jankowski M, et al. Patient values and preferences in decision making for antithrombotic therapy: a systematic review: Antithrombotic Therapy and Prevention of Thrombosis, 9th edn: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012; 141(2 suppl): e1S-23S.
27. Hollowell J, Ruigomez A, Johansson S, et al. The incidence of bleeding complications associated with warfarin treatment in general practice in the United Kingdom. Br J Gen Pract 2003; 53(489): 312-314. (Pubitemid 36469230)
28. Agarwal S, Hachamovitch R, Menon V. Current trial-associated outcomes with warfarin in prevention of stroke in patients with nonvalvular atrial fibrillation: a meta-analysis. Arch Intern Med 2012; 172(8): 623-631.
29. Olesen JB, Lip GYH, Lindhardsen J, et al. Risks of thromboembolism and bleeding with thromboprophylaxis in patients with atrial fibrillation: a net clinical benefit analysis using a 'real world' nationwide cohort study. Thromb Haemost 2011; 106(4): 739-749.
30. Baglin TP, Cousins D, Keeling DM, et al. Recommendations from the British Committee for Standards in Haematology and National Patient Safety Agency. Br J Haematol 2006; 136(1): 26-29.
31. Mant J, Hobbs FDR, Fletcher K, et al. Warfarin versus aspirin for stroke prevention in atrial fibrillation in the elderly community population: the Birmingham Atrial Fibrillation Treatment of the Aged Study (BAFTA), a randomised controlled trial. Lancet 2007; 370(9586): 493-503. (Pubitemid 47212371)
32. Summary of 2012/13 QOF changes. http://www.nhsemployers.org/ SiteCollectionDocuments/Summary-of-QOF-changes-for-2012-13-mh111111.pdf (accessed 29 Aug 2012).
33. 2 score 0-1: a nationwide cohort study. Thromb Haemost 2012; 107(6): 1172-1179.
34. Stott DJ, Dewar RI, Garratt CJ, et al. RCPE UK Consensus Conference on 'approaching the comprehensive management of atrial fibrillation: evolution or revolution?'. J R Coll Physicians Edinb 2012; 42(1): 34-35.
35. Lin H-J, Wolf PA, Kelly-Hayes M, et al. Stroke severity in atrial fibrillation: the Framingham study. Stroke 1996; 27(10): 1760-1764. (Pubitemid 26332500)
36. James MA, Campbell JL. Better prevention of stroke through screening for atrial fibrillation. Br J Gen Pract 2012; 62(598): 234-235.