Common genetic variation contributes significantly to the risk of childhood B-cell precursor acute lymphoblastic leukemia

Leukemia

Volumn 26, Issue 10, 2012, Pages 2212-2215

  Enciso Mora, V ^a   Hosking, F J ^a   Sheridan, E ^b   Kinsey, S E ^b   Lightfoot, T ^c   Roman, E ^c   Irving, J A E ^d   Tomlinson, I P M ^e   Allan, J M ^d   Taylor, M ^f   Greaves, M ^a   Houlston, R S ^a  

^a INSTITUTE OF CANCER RESEARCH   (United Kingdom)

^b ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^c UNIVERSITY OF YORK   (United Kingdom)

^d NEWCASTLE UNIVERSITY   (United Kingdom)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f UNIVERSITY OF MANCHESTER   (United Kingdom)

Author keywords

Acute lymphoblastic leukemia; Heritability; Pediatric

Indexed keywords

ACUTE LYMPHOBLASTIC LEUKEMIA; ARTICLE; CHILD; CHROMOSOME 10Q; CHROMOSOME 14Q; CHROMOSOME 7P; CHROMOSOME 9P; FEMALE; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; HERITABILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PRE B LYMPHOCYTE; PRESCHOOL CHILD; PRIORITY JOURNAL; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM;

EID: 84867401980     PISSN: 08876924     EISSN: 14765551     Source Type: Journal    
DOI: 10.1038/leu.2012.89     Document Type: Article

References (19)

1. Greaves M. Infection, immune responses and the aetiology of childhood leukaemia. Nat Rev Cancer 2006; 6: 193-203. (Pubitemid 43292563)
2. Kaatsch P. Epidemiology of childhood cancer. Cancer Treat Rev 2010; 36: 277-285.
3. Hodgson S, Maher E. A Practical Guide to Human Cancer Genetics. Cambridge University Press: Cambridge, 1999, pp 116-122.
4. Papaemmanuil E, Hosking FJ, Vijayakrishnan J, Price A, Olver B, Sheridan E et al. Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia. Nat Genet 2009; 41: 1006-1010.
5. Trevino LR, Yang W, French D, Hunger SP, Carroll WL, Devidas M et al. Germline genomic variants associated with childhood acute lymphoblastic leukemia. Nat Genet 2009; 41: 1001-1005.
6. Sherborne AL, Hosking FJ, Prasad RB, Kumar R, Koehler R, Vijayakrishnan J et al. Variation in CDKN2A at 9p21.3 influences childhood acute lymphoblastic leukemia risk. Nat Genet 2010; 42: 492-494.
7. Fletcher O, Houlston RS. Architecture of inherited susceptibility to common cancer. Nat Rev Cancer 2010; 10: 353-361.
8. Lee SH, Wray NR, Goddard ME, Visscher PM. Estimating missing heritability for disease from genome-wide association studies. Am J Hum Genet 2011; 88: 294-305.
9. UK Childhood Cancer Study Investigators. The United Kingdom Childhood Cancer Study: objectives, materials and methods. Br J Cancer 2000; 82: 1073-1102.
10. Power C, Elliott J. Cohort profile: 1958 British birth cohort (National Child Development Study). Int J Epidemiol 2006; 35: 34-41. (Pubitemid 43205440)
11. Tomlinson I, Webb E, Carvajal-Carmona L, Broderick P, Kemp Z, Spain S et al. A genome-wide association scan of tag SNPs identifies a susceptibility variant for colorectal cancer at 8q24.21. Nat Genet 2007; 39: 984-988. (Pubitemid 47185182)
12. Purcell S, Neale B, Todd-Brown K, Thomas L, Ferreira MA, Bender D et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am J Hum Genet 2007; 81: 559-575. (Pubitemid 47330214)
13. Yang J, Benyamin B, McEvoy BP, Gordon S, Henders AK, Nyholt DR et al. Common SNPs explain a large proportion of the heritability for human height. Nat Genet 2010; 42: 565-569.
14. Yang J, Lee SH, Goddard ME, Visscher PM. GCTA: a tool for genome-wide complex trait analysis. Am J Hum Genet 2011; 88: 76-82.
15. Wray NR, Yang J, Goddard ME, Visscher PM. The genetic interpretation of area under the ROC curve in genomic profiling. PLoS Genet 2010; 6: e1000864.
16. Hemminki K, Jiang Y. Risks among siblings and twins for childhood acute lymphoid leukaemia: results from the Swedish Family-Cancer Database. Leukemia 2002; 16: 297-298. (Pubitemid 34145149)
17. Zuk O, Hechter E, Sunyaev SR, Lander ES. The mystery of missing heritability: Genetic interactions create phantom heritability. Proc Natl Acad Sci USA 2012; 109: 1193-1198.
18. Sherborne AL, Hemminki K, Kumar R, Bartram CR, Stanulla M, Schrappe M et al. Rationale for an international consortium to study inherited genetic susceptibility to childhood acute lymphoblastic leukemia. Haematologica 2011; 96: 1049-1054.
19. Spencer CC, Su Z, Donnelly P, Marchini J. Designing genome-wide association studies: sample size, power, imputation, and the choice of genotyping chip. PLoS Genet 2009; 5: e1000477.