Simultaneous determination of esculin and its metabolite esculetin in rat plasma by LC-ESI-MS/MS and its application in pharmacokinetic study

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 907, Issue , 2012, Pages 27-33

  Li, Ying Yi ^a   Song, Ye Ying ^a   Liu, Chang Hui ^a   Huang, Xiao Tao ^a   Zheng, Xia ^a   Li, Neng ^a   Xu, Mei Li ^a   Mi, Sui Qing ^a   Wang, Ning Sheng ^a  

^a GUANGZHOU UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Esculetin; Esculin; LC ESI MS MS; Pharmacokinetic; Rat plasma

Indexed keywords

ANALYTES; ESCULETIN; ESCULIN; INTERNAL STANDARDS; ISOCRATIC ELUTION; LC-ESI-MS/MS; LC-MS/MS; LIMIT OF QUANTIFICATIONS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; MOBILE PHASE; MULTIPLE-REACTION MONITORING MODES; ORAL ADMINISTRATION; PHARMACOKINETIC STUDIES; PLASMA SAMPLES; QUADRATIC REGRESSION; RAT PLASMA; REVERSED PHASE; SCOPOLETIN; SIMULTANEOUS DETERMINATIONS; SOLID-PHASE EXTRACTION; STANDARD CURVES; SWITCHING MODES; TARGET COMPOUND;

BIOMOLECULES; ELECTROSPRAY IONIZATION; FORMIC ACID; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLITES; METHANOL; ORGANIC SOLVENTS; PHARMACOKINETICS; REGRESSION ANALYSIS;

BODY FLUIDS;

ESCULETIN; ESCULIN; FORMIC ACID; METHANOL; SCOPOLETIN; WATER;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG HALF LIFE; LIMIT OF QUANTITATION; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; MONITORING; MULTIPLE REACTION MONITORING; NONHUMAN; PRIORITY JOURNAL; RAT; SENSITIVITY AND SPECIFICITY; SOLID PHASE EXTRACTION; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION;

ANIMALS; CHROMATOGRAPHY, LIQUID; DRUG STABILITY; ESCULIN; LINEAR MODELS; MALE; RATS; RATS, SPRAGUE-DAWLEY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; UMBELLIFERONES;

RATTUS;

EID: 84867400663     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.08.027     Document Type: Article

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