A method for determining the free (unbound) concentration of ten beta-lactam antibiotics in human plasma using high performance liquid chromatography with ultraviolet detection

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 907, Issue , 2012, Pages 178-184

  Briscoe, Scott E ^a   McWhinney, Brett C ^a   Lipman, Jeffrey ^b,c   Roberts, Jason A ^b,c   Ungerer, Jacobus P J ^a  

^a Chemical Pathology   (Australia)

^b ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

Antibiotics; Beta lactam; Free; HPLC; TDM; Unbound

Indexed keywords

ANALYTES; BENZYLPENICILLIN; BETA-LACTAM; CARBAPENEMS; CEFTRIAXONE; CEPHAZOLIN; CRITICALLY-ILL PATIENTS; FREE; HPLC; HUMAN PLASMAS; INTENSIVE CARE; MEROPENEM; MOBILE PHASIS; PIPERACILLIN; PROTEIN BINDING; SAMPLE PREPARATION METHODS; THERAPEUTIC DRUG MONITORING; ULTRA VIOLET DETECTION; ULTRACENTRIFUGATION; ULTRAVIOLET ABSORBANCE; UNBOUND;

ACETONITRILE; BIOCHEMISTRY; CENTRIFUGATION; COLUMN CHROMATOGRAPHY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PATIENT MONITORING; PLASMA (HUMAN); SEWAGE TREATMENT PLANTS; TIME DIVISION MULTIPLEXING;

ANTIBIOTICS;

ACETONITRILE; AMPICILLIN; BETA LACTAM ANTIBIOTIC; CEFALOTIN; CEFAZOLIN; CEFTRIAXONE; DICLOXACILLIN; ERTAPENEM; FLUCLOXACILLIN; MEROPENEM; PENICILLIN G; PIPERACILLIN;

ACCURACY; ARTICLE; CALIBRATION; CONTROLLED STUDY; CRITICALLY ILL PATIENT; DRUG BLOOD LEVEL; DRUG MONITORING; DRUG PROTEIN BINDING; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN TISSUE; PH; PRIORITY JOURNAL; QUALITY CONTROL;

ANTI-BACTERIAL AGENTS; BETA-LACTAMS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG MONITORING; HUMANS; PROTEIN BINDING; REPRODUCIBILITY OF RESULTS; SPECTROPHOTOMETRY, ULTRAVIOLET;

EID: 84867396881     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.09.016     Document Type: Article

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