Epithelial cell adhesion molecules and epithelial mesenchymal transition (EMT) markers in Ewing's sarcoma family of tumors (ESFTs). Do they offer any prognostic significance?

Virchows Archiv

Volumn 461, Issue 3, 2012, Pages 333-337

  Machado, Isidro ^a   López Guerrero, José A ^a   Navarro, Samuel ^b   Alberghini, Marco ^c   Scotlandi, Katia ^c   Picci, Piero ^c   Llombart Bosch, Antonio ^b  

^a INSTITUTO VALENCIANO DE ONCOLOGÍA   (Spain)

^b UNIVERSITY OF VALENCIA   (Spain)

^c RIZZOLI ORTHOPAEDIC INSTITUTE   (Italy)

Author keywords

Epithelial markers; Ewing's sarcoma; Prognostic significance

Indexed keywords

BIOLOGICAL MARKER; CLAUDIN; CYTOKERATIN 18; CYTOKERATIN 8; CYTOKERATIN AE1; CYTOKERATIN AE3; DESMOGLEIN 1; DESMOPLAKIN; EPITHELIAL CELL ADHESION MOLECULE; GLYCOGEN SYNTHASE KINASE 3BETA; OCCLUDIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN ZO1; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; UVOMORULIN;

ARTICLE; CANCER LOCALIZATION; CANCER PROGNOSIS; CANCER RADIOTHERAPY; CANCER SURVIVAL; DISSEMINATED CANCER; EPITHELIAL MESENCHYMAL TRANSITION; EWING SARCOMA; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOHISTOLOGY; OVERALL SURVIVAL; PRIORITY JOURNAL; PROGRESSION FREE SURVIVAL; PROTEIN EXPRESSION; VALIDITY;

ANTIGENS, NEOPLASM; BONE NEOPLASMS; CELL ADHESION MOLECULES; DESMOPLAKINS; DISEASE-FREE SURVIVAL; EPITHELIAL-MESENCHYMAL TRANSITION; GLYCOGEN SYNTHASE KINASE 3; HUMANS; IMMUNOHISTOCHEMISTRY; PROGNOSIS; SARCOMA, EWING; SPAIN; SURVIVAL RATE; TUMOR MARKERS, BIOLOGICAL;

EID: 84867396353     PISSN: 09456317     EISSN: 14322307     Source Type: Journal    
DOI: 10.1007/s00428-012-1288-x     Document Type: Article

References (14)

1. Folpe AL, Goldblum JR, Rubin BP, Shehata BM, Liu W, Dei Tos AP, Weiss SW (2005) Morphologic and immunophenotypic diversity in Ewing family tumors: a study of 66 genetically confirmed cases. Am J Surg Pathol 29(8):1025-1033 (Pubitemid 41045546)
2. Gu M, Antonescu CR, Guiter G, Huvos AG, Ladanyi M, Zakowski MF (2000) Cytokeratin immunoreactivity in Ewing's sarcoma: prevalence in 50 cases confirmed by molecular diagnostic studies. Am J Surg Pathol 24(3):410-416 (Pubitemid 30127477)
3. Collini P, Sampietro G, Bertulli R, Casali PG, Luksch R, Mezzelani A, Sozzi G, Pilotti S (2001) Cytokeratin immunoreactivity in 41 cases of ES/PNET confirmed by molecular diagnostic studies. Am J Surg Pathol 25(2):273-274 (Pubitemid 32167512)
4. Schuetz AN, Rubin BP, Goldblum JR, Shehata B, Weiss SW, Liu W, Wick MR, Folpe AL (2005) Intercellular junctions in Ewing sarcoma/primitive neuroectodermal tumor: additional evidence of epithelial differentiation. Mod Pathol 18(11):1403-1410 (Pubitemid 41509393)
5. Srivastava A, Rosenberg AE, Selig M, Rubin BP, Nielsen GP (2005) Keratin positive Ewing's sarcoma: an ultrastructural study of 12 cases. Int J Surg Pathol 13(1):43-50 (Pubitemid 40224096)
6. Machado I, Navarro S, López-Guerrero JA, Alberghini M, Picci P, Llombart-Bosch A (2011) Epithelial marker expression does not rule out a diagnosis of Ewing's sarcoma family of tumours. Virchows Arch 459(4):409-414
7. López-Guerrero JA, Machado I, Scotlandi K, Noguera R, Pellín A, Navarro S, Serra M, Calabuig-Fariñas S, Picci P, Llombart-Bosch A (2011) Clinicopathological significance of cell cycle regulation markers in a large series of genetically confirmed Ewing's sarcoma family of tumors. Int J Cancer 128(5):1139-1150
8. Llombart-Bosch A, Machado I, Navarro S, Bertoni F, Bacchini P, Alberghini M, Karzeladze A, Savelov N, Petrov S, Alvarado-Cabrero I, Mihaila D, Terrier P, Lopez-Guerrero JA, Picci P (2009) Histological heterogeneity of Ewing's sarcoma/PNET: an immunohistochemical analysis of 415 genetically confirmed cases with clinical support. Virchows Arch 455(5):397-411
9. Kavalar R, Pohar Marinsek Z, Jereb B, Cagran B, Golouh R (2009) Prognostic value of immunohistochemistry in the Ewing's sarcoma family of tumors. Med Sci Monit 15(8): CR442-CR452
10. Makino T, Yamasaki M, Takeno A, Shirakawa M, Miyata H, Takiguchi S, Nakajima K, Fujiwara Y, Nishida T, Matsuura N, Mori M, Doki Y (2009) Cytokeratins 18 and 8 are poor prognostic markers in patients with squamous cell carcinoma of the oesophagus. Br J Cancer 101(8):1298-1306
11. Papagerakis S, Shabana AH, Pollock BH, Papagerakis P, Depondt J, Berdal A (2009) Altered desmoplakin expression at transcriptional and protein levels provides prognostic information in human oropharyngeal cancer. Hum Pathol 40(9):1320-1329
12. Subramaniam MM, Navarro S, Llombart-Bosch A (2011) Immunohistochemical study of correlation between histologic subtype and expression of epithelial-mesenchymal transition-related proteins in synovial sarcomas. Arch Pathol Lab Med 135(8):1001-1009
13. He H, Chen W, Wang X, Wang C, Liu F, Shen Z, Xu J, Gu J, Sun Y (2012) Snail is an independent prognostic predictor for progression and patient survival of gastric cancer. Cancer Sci. doi:10.1111/j.1349-7006.2012.02295.x
14. Sharili AS, Allen S, Smith K, Hargreaves J, Price J, McGonnell I (2011) Expression of Snail2 in long bone osteosarcomas correlates with tumour malignancy. Tumour Biol 32(3):515-526