Axitinib targeted cancer stemlike cells to enhance efficacy of chemotherapeutic drugs via inhibiting the drug transport function of ABCG2.

Molecular medicine (Cambridge, Mass.)

Volumn 18, Issue , 2012, Pages 887-898

  Wang, Fang ^a   Mi, Yan jun ^b   Chen, Xing Gui ^b   Wu, Xing ping ^b   Liu, Zhenguo ^b   Chen, Shu peng ^b   Liang, Yong ju ^b   Cheng, Chao ^b   To, Kenneth Kin Wah ^b   Fu, Li wu ^b  

^a SUN YAT SEN UNIVERSITY   (China)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; ABCG2 PROTEIN, HUMAN; ANTINEOPLASTIC AGENT; AXITINIB; IMIDAZOLE DERIVATIVE; INDAZOLE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE B; TUMOR PROTEIN;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CANCER STEM CELL; DRUG ANTAGONISM; DRUG EFFECT; DRUG RESISTANCE; DRUG SCREENING; FEMALE; GENE EXPRESSION REGULATION; GENETICS; HUMAN; MALE; METABOLISM; MOUSE; NEOPLASM; NONOBESE DIABETIC MOUSE; NUDE MOUSE; PHOSPHORYLATION; SCID MOUSE; TRANSPORT AT THE CELLULAR LEVEL; TUMOR CELL LINE;

ANIMALS; ANTINEOPLASTIC AGENTS; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; CELL LINE, TUMOR; DRUG RESISTANCE, NEOPLASM; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMIDAZOLES; INDAZOLES; MALE; MICE; MICE, INBRED BALB C; MICE, INBRED NOD; MICE, NUDE; MICE, SCID; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NEOPLASM PROTEINS; NEOPLASMS; NEOPLASTIC STEM CELLS; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MLCS; MLOWN;

EID: 84867375477     PISSN: None     EISSN: 15283658     Source Type: Journal    
DOI: 10.2119/molmed.2011.00444     Document Type: Article

References (0)