Killer cell immunoglobulin-like receptors (KIR) typing by DNA sequencing

Methods in Molecular Biology

Volumn 882, Issue , 2012, Pages 431-468

  Hou, Lihua ^a   Chen, Minghua ^a   Steiner, Noriko ^a   Kariyawasam, Kanthi ^a   Ng, Jennifer ^a   Hurley, Carolyn K ^a  

^a GEORGETOWN UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Alleles; DNA sequencing; Killer immunoglobulin like receptor; Natural killer cell

Indexed keywords

GENOMIC DNA; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DL1; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DL2; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DL3; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DL4; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DL5; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DS1; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DS2; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DS3; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DS4; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 2DS5; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 3DL1; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 3DL2; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 3DL3; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR 3DS1; RESTRICTION ENDONUCLEASE; UNCLASSIFIED DRUG;

AMPLICON; ARTICLE; DIGESTION; DNA SEQUENCE; EXON; GENE AMPLIFICATION; GENE LOCUS; GENETIC DATABASE; GENETIC VARIABILITY; MOLECULAR CLONING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; REFERENCE DATABASE; SEQUENCE ANALYSIS; GENETICS; HUMAN; PHENOTYPE;

HUMANS; PHENOTYPE; RECEPTORS, KIR; SEQUENCE ANALYSIS, DNA;

EID: 84867370500     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-842-9_25     Document Type: Article

References (24)

1. Bashirova AA et al (2006) The killer immunoglobulin-like receptor gene cluster: tuning the genome for Defense. Annu Rev Genomics Hum Genet 7:277-300
2. Sanger F, Nicklen S, Coulson AR (1977) DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci USA 74:5463-5467
3. Khakoo SI, Carrington M (2006) KIR and disease: a model system or system of models? Immunol Rev 214:186-201
4. Tomblyn M et al (2010) Decreased infections in recipients of unrelated donor hematopoietic cell transplantation from donors with an activating KIR genotype. Biol Blood Marrow Transplant 16:1155-1161
5. Cooley S et al (2010) Donor selection for natural killer cell receptor genes leads to superior survival after unrelated transplantation for acute myelogenous leukemia. Blood 116:2411-2419
6. Moesta AK et al (2008) Synergistic polymorphism at two positions distal to the ligandbinding site makes KIR2DL2 a stronger receptor for HLA-C than KIR2DL3. J Immunol 180:3969-3979
7. Yawata M et al (2008) MHC class I-speci ficinhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response. Blood 112:2369-2380
8. Sharma D et al (2009) Dimorphic motifs in D0 and D1 + D2 domains of killer cell Ig-like receptor 3DL1 combine to form receptors with high, moderate, and no avidity for the complex of a peptide derived from HIV and HLAA* 2402. J Immunol 183:4569-4582
9. Martin MP et al (2007) Innate partnership of HLA-B and KIR3DL1 subtypes against HIV-1. Nat Genet 39:733-740
10. Hou L et al (2010) African Americans exhibit a predominant allele in the midst of extensive KIR2DL1 allelic diversity. Tissue Antigens 76:31-34
11. Hou L et al (2010) Thirty allele-level haplotypes centered around KIR2DL5 define the diversity in an African American population. Immunogenetics 62:491-498
12. Hou L et al (2009) In contrast to other stimulatory natural killer cell immunoglobulin-like receptor loci, several KIR2DS5 alleles predominate in African Americans. Hum Immunol 70:733-737
13. Jiang B et al (2010) The profile of KIR3DL1 and KIR3DS1 alleles in an African American population resembles that found in African populations. Tissue Antigens 76:64-66
14. Norman PJ et al (2009) Meiotic recombination generates rich diversity in NK cell receptor genes, alleles, and haplotypes. Genome Res 19:757-769
15. Vilches C, Gardiner CM, Parham P (2000) Gene structure and promoter variation of expressed and nonexpressed variants of the KIR2DL5 gene. J Immunol 165:6416-6421
16. Ordonez D et al (2008) Duplication, mutation and recombination of the human orphan gene KIR2DS3 contribute to the diversity of KIR haplotypes. Genes Immun 9:431-437
17. Gomez-Lozano N et al (2005) The silent KIR3DP1 gene (CD158c) is transcribed and might encode a secreted receptor in a minority of humans, in whom the KIR3DP1, KIR2DL4 and KIR3DL1/KIR3DS1 genes are duplicated. Eur J Immunol 35:16-24
18. Martin MP et al (2003) Cutting edge: expansion of the KIR locus by unequal crossing over. J Immunol 171:2192-2195
19. Uhrberg M et al (1997) Human diversity in killer cell inhibitory receptor genes. Immunity 7:753-763
20. Vilches C et al (2007) Facilitation of KIR genotyping by a PCR-SSP method that amplifies short DNA fragments. Tissue Antigens 70:415-422
21. Gomez-Lozano N, Vilches C (2002) Genotyping of human killer-cell immunoglobulinlike receptor genes by polymerase chain reaction with sequence-speci ficprimers: an update. Tissue Antigens 59:184-193
22. Murdoch S et al (2006) Detailed gene and allele content analysis of three homozygous KIR haplotypes. Tissue Antigens 68:72-77
23. Sun JY, Oki A, Senitzer D (2008) Alleles and intron polymorphism of KIR3DL1 shown by combination of allele group-speci ficprimers and sequencing. Tissue Antigens 72: 578-580
24. Vilches C, Pando MJ, Parham P (2000) Genes encoding human killer-cell Ig-like receptors with D1 and D2 extracellular domains all contain untranslated pseudoexons encoding a third Ig-like domain. Immunogenetics 51:639-646