Toxicokinetics of t-2 toxin, HT-2 toxin and t-2 triol after intravenously administrated t-2 toxin in swine

Journal of Animal and Veterinary Advances

Volumn 11, Issue 12, 2012, Pages 1977-1981

  Sun, Yong Xue ^a   Zhao, Hai Yan ^a   Liu, Yu Jing ^a   Dai, Zhen Qing ^a   Fang, Bing Hu ^a  

^a SOUTH CHINA AGRICULTURAL UNIVERSITY   (China)

Author keywords

Blood; Metabolites; Parameters; Swine; T 2 toxin; Toxicokinetics

Indexed keywords

EID: 84867361462     PISSN: 16805593     EISSN: 1993601X     Source Type: Journal    
DOI: 10.3923/javaa.2012.1977.1981     Document Type: Article

References (27)

1. Beasley, V. R., S.P. Swanson, R.A. Corley, W.B. Buck, G.D. Koritz and H.R. Burmeister, 1985. Pharmacokinetics of the trichothecene mycotoxin, T-2 toxin, in swine and cattle. Toxicon, 24: 13-33.
2. Bernhoft, A., K. Modestas, W. Langseth, C.P. Akesson, LP. Oswald and H.J.S. Larsen, 2000. A study on immunotoxicity of HT-2 and T-2 toxins in minipigs. Proceedings of 10th International IUPAC Symposium onMycotoxins andPhycotoxins, May, 2000, Brazil.
3. Bhat, R.V., S.R. Beedu, Y. Ramakrishna andK.L. Munshi, 1989. Outbreak of t richothecene mycotoxicosis associated with consumption of mold damaged wheat products in kashmir valley, India. Lancet, 333: 35-37.
4. Buck, W.B. and L.M. Cote, 1991. Trichothecene Mycotoxins. In: Toxicology of Plant and Fungal Compounds, Keeler, R.F. andA.T. Tu(Eds.). Marcel Dekker, New York, ISBN: 9780824783754, Pages: 665.
5. Chatterjee, C, R.J. Pawlosky, L. Treeful and C.J. Miroch, 1986. Kinetic study of t-2 toxin metabolites in a cow. J. Food Safety, 8: 25-34.
6. Corley, R.A., S.P. Swanson and W.B. Buck, 1985. Glucoronide conjugates of T-2 toxin and metabolites in swine bile and urine. J. Agric. Food Chem., 33: 1085-1089.
7. Corley, R.A., S.P. Swanson, G.J. Gullo, L. Johnson, V.R. Beasley and W.B. Buck, 1986. Disposition of T-2 toxin, a trichothecene mycotoxin in intramuscularly dosed swine. J. Agric. Food Chem., 34: 868-875.
8. Desjardins, A. E., T.A. Hohn and S.P. McCormick, 1993. Trichothecene biosynthesis in Fusarium species: Chemistry, genetics and significance. Microbiol. Rev., 57: 595-604.
9. Giroir, L.E., 1990. The comparative fate of T-2 toxin in chickens and ducks, and an investigation of kojic acid's toxicity and its possible synergy with aflatoxin in chickens. PhD. Thesis, Texas A and M University.
10. Greenway, LA. and R. Puis, 1976. Fusariotoxicosis from Barley in British Columbia I. Natural occurrence and diagnosis. Can. J. Comp. Med., 40: 12-15.
11. Hsu, I.C., E.B. Smalley, F.M. Strong and W.E. Ribelin, 1972. Identification of T-2 toxin in moldy corn associated with lethal toxicosis in dairy cattle. Applied Microbiol., 24: 684-690.
12. Joffe, A.Z. andB. Yagen, 1978. Intoxication produced by toxic fungi Fusarium poae and F. sporotrichioid.es in chicks. Toxicon, 16: 263-273.
13. Mirocha, C.J. and S. Pathre, 1973. Identification of the toxic principle in a sample of poaefusarin Applied Microbiol., 26: 719-724.
14. Naseem, S.M., LG. Pace andR.W. Wannemacher, 1995. A high-performance liquid chromatographic method for determining [3HJT-2 and its metabolites in biological fluids of the cynomolgous monkey. J. Anal. Toxicol., 19: 151-156.
15. Puis, R. and LA. Greenway, 1976. Fusariotoxicosis from barley in British Columbia.II. Analysis of suspected barley. Can. J. Comp. Med., 40: 16-19.
16. Raisbek, M.F., G.E. Rottinghaus and LD. Kendall, 1991. Effects of Naturally Occurring Mycotoxins on Ruminants. In: Mycotoxins and Animal Foods, Smith, J.E. and R.S. Henderson (Eds.). CRC Press, Boca Raton, Fla, ISBN: 9780849349041, Pages: 875.
17. Schollenberger, M., H.M. Mãler, M. Rufle, S. Suchy, S. Plank and W. Drochner, 2006. Natural occurrence of 16 Fusarium toxins in grains and feedstuffs of plant origin from Germany. Mycopathologia, 161: 43-52.
18. Smtov, A., M. Bialer and B. Yagen, 1986. Pharmacokinetics of T-2 toxin and its metabolite HT-2 toxin, after intravenous administration in dogs. Drug Metab. Dispos., 14: 250-254.
19. Smtov, A., M. Bialer and B. Yagen, 1988. Pharmacokinetics and protein binding of trichothecene mycotoxins, T-2 toxin and HT-2 toxin, in dogs. Toxicon, 26: 153-160.
20. Ueno, Y., K. Ishii, K. Sakai, S. Kanaeda and H. Tsunoda, 1972. Toxicological approaches to the metabolites of Fusaria. IV. Microbial survey on "bean-hulls poisoning of horses " with the isolation of toxic trichothecenes, neosolaniol and T-2 toxin of Fusarium solaniM-l-1. Jpn J. Exp. Med., 42: 187-203.
21. Ueno, Y., 1977. Trichothecenes: Overview Address. In: Mycotoxins in Human and Animal Health, Rodricks, J.V., C.W. Hesseltine andM.A. Mehlman (Eds.). Pathotox, Park Forest South Illinois, USA., pp: 189-228.
22. Visconti, A., L.M. Treeful and C.J. Mirocha, 1985. Identification of ISO-TC-1 as a new T-2 toxin metabolite in cow urine. Biol. Mass Spectrom., 12: 689-694.
23. WHO, 1990. Selected mycotoxins: Ochrotoxins, Trichothecenes, Ergot. World Health Organization, Environment Health Criteria, Geneva.
24. Wang, Z.G., J. Feng and Z. Tong, 1993. Human toxicosis caused by moldy rice contaminated with Fusarium and T-2 toxin. Biomed. Environ. Sci., 6: 65-70.
25. Yagen, B. and M. Bialer, 1993. Metabolism and pharmacokinetics of T-2 toxin and related richothecenes. Drug Metabol. Rev., 25: 281-323.
26. Yoshizawa, T., C.J. Mirocha, J.C. Behrens and S.P. Swanson, 1981. Metabolic fate of T-2 toxin in a lactating cow. Food Cosmet. Toxicol., 19: 31-39.
27. Yoshizawa, T., S.P. Swanson and C.J. Mirocha, 1980. T-2 metabolism in the excreta of broiler chickens administered 3H- labeled T-2 toxin. Applied Environ. Mirobiol, 39: 1172-1177.