Myocardial regeneration: Expanding the repertoire of thymosin β4 in the ischemic heart

Annals of the New York Academy of Sciences

Volumn 1269, Issue 1, 2012, Pages 92-101

  Smart, Nicola ^a   Bollini, Sveva ^a   Dubé, Karina N ^a   Vieira, Joaquim M ^a   Zhou, Bin ^b,c   Riegler, Johannes ^d,e   Price, Anthony N ^f   Lythgoe, Mark F ^d   Davidson, Sean ^e   Yellon, Derek ^e   Pu, William T ^b,c   Riley, Paul R ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b BOSTON CHILDREN S HOSPITAL   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY COLLEGE LONDON   (United Kingdom)

^e UNIVERSITY COLLEGE LONDON   (United Kingdom)

^f IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

De novo cardiomyocytes; EPDCs; Epicardium; Myocardial regeneration; Thymosin 4; Wt1

Indexed keywords

THYMOSIN BETA4;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE ISCHEMIA; HEART MUSCLE REGENERATION; HUMAN; MUSCLE REGENERATION; NONHUMAN; PLEIOTROPY;

EID: 84867342938     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2012.06708.x     Document Type: Article

References (33)

1. Reinecke, H., E. Minami, W.Z. Zhu & M.A. Laflamme 2008. Cardiogenic differentiation and transdifferentiation of progenitor cells. Circ. Res. 103: 1058-1071.
2. Porrello, E.R., A.I. Mahmoud, E. Simpson, et al 2011. Transient regenerative potential of the neonatal mouse heart. Science 331: 1078-1080.
3. Bartunek, J., S. Dimmeler, H. Drexler, et al 2006. The consensus of the task force of the European Society of Cardiology concerning the clinical investigation of the use of autologous adult stem cells for repair of the heart. Eur. Heart J. 27: 1338-1340.
4. Laflamme, M.A. & C.E. Murry 2011. Heart regeneration. Nature 473: 326-335.
5. Wessels, A. & J.M. Perez-Pomares 2004. The epicardium and epicardially derived cells (EPDCs) as cardiac stem cells. Anat. Rec. A Discov. Mol. Cell Evol. Biol. 276: 43-57.
6. Perez-Pomares, J.M., R. Carmona, M. Gonzalez-Iriarte, et al 2002. Origin of coronary endothelial cells from epicardial mesothelium in avian embryos. Int. J. Dev. Biol. 46: 1005-1013.
7. Mikawa, T. & R.G. Gourdie 1996. Pericardial mesoderm generates a population of coronary smooth muscle cells migrating into the heart along with ingrowth of the epicardial organ. Developmental Biol. 174: 221-232.
8. Gittenberger-De Groot, A.C., M.P. Vrancken Peeters, M.M.T. Mentink, et al 1998. Epicardium-derived cells contribute a novel population to the myocardial wall and the atrioventricular cushions. Circulation Res. 82: 1043-1052.
9. Winter, E.M. & A.C. Gittenberger-De Groot 2007. Epicardium-derived cells in cardiogenesis and cardiac regeneration. Cell Mol. Life Sci. 64: 692-703.
10. Lepilina, A., A.N. Coon, K. Kikuchi, et al 2006. A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. Cell 127: 607-619.
11. Smart, N., C.A. Risebro, A.A.D. Melville, et al 2007. Thymosin β4 induces adult epicardial progenitor mobilization and neovascularization. Nature 445: 177-182.
12. Smart, N., C.A. Risebro, J.E. Clark, et al 2010. Thymosin beta4 facilitates epicardial neovascularization of the injured adult heart. Ann. N.Y. Acad. Sci. 1194: 97-104.
13. Zhou, B., L.B. Honor, H. He, et al 2011. Adult mouse epicardium modulates myocardial injury by secreting paracrine factors. J. Clin. Invest 121: 1894-1904.
14. Zhou, B., Q. Ma, S. Rajagopal, et al 2008. Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature 454: 109-113.
15. Smart, N., S. Bollini, K.N. Dube, et al 2011. De novo cardiomyocytes from within the activated adult heart after injury. Nature 474: 640-644.
16. Smart, N. & P.R. Riley 2009. Derivation of epicardium-derived progenitor cells (EPDCs) from adult epicardium. Curr. Protoc. Stem Cell Biol. Chapter 2: Unit2C.
17. Moretti, A., L. Caron, A. Nakano, et al 2006. Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. Cell 127: 1151-1165.
18. Zhou, B., L.B. Honor, Q. Ma, et al 2011. Thymosin beta 4 treatment after myocardial infarction does not reprogram epicardial cells into cardiomyocytes. J. Mol. Cell Cardiol. 52: 43-47.
19. Bock-Marquette, I., A. Saxena, M.D. White, et al 2004. Thymosin β4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature 432: 466-472.
20. Bock-Marquette, I., S. Shrivastava, G.C. Pipes, et al 2009. Thymosin beta4 mediated PKC activation is essential to initiate the embryonic coronary developmental program and epicardial progenitor cell activation in adult mice in vivo. J. Mol. Cell Cardiol. 46: 728-738.
21. Sutton, M.G. & N. Sharpe 2000. Left ventricular remodeling after myocardial infarction: pathophysiology and therapy. Circulation 101: 2981-2988.
22. Frangogiannis, N.G. 2006. Targeting the inflammatory response in healing myocardial infarcts. Curr. Med. Chem. 13: 1877-1893.
23. Frohm, M., H. Gunne, A.C. Bergman, et al 1996. Biochemical and antibacterial analysis of human wound and blister fluid. Eur. J. Biochem. 237: 86-92.
24. Sosne, G., C. Chan, K. Thai, et al 2001. Thymosin beta 4 promotes corneal wound healing and modulates inflammatory mediators in vivo. Exp. Eye Res. 72: 605-608.
25. Girardi, M., M.A. Sherling, R.B. Filler, et al 2003. Anti-inflammatory effects in the skin of thymosin-beta4 splice-variants. Immunology 109: 1-7.
26. Sosne, G., E.A. Szliter, R. Barrett, et al 2002. Thymosin beta 4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury. Exp. Eye Res. 74: 293-299.
27. Badamchian, M., M.O. Fagarasan, R.L. Danner, et al 2003. Thymosin beta(4) reduces lethality and down-regulates inflammatory mediators in endotoxin-induced septic shock. Int. Immunopharmacol. 3: 1225-1233.
28. Zhang, J., Z.G. Zhang, D. Morris, et al 2009. Neurological functional recovery after thymosin beta4 treatment in mice with experimental auto encephalomyelitis. Neuroscience 164: 1887-1893.
29. Sosne, G., P. Qiu, P.L. Christopherson & M.K. Wheater 2007. Thymosin beta 4 suppression of corneal NFkappaB: a potential anti-inflammatory pathway. Exp. Eye Res. 84: 663-669.
30. Sopko, N., Y. Qin, A. Finan, et al 2011. Significance of thymosin beta4 and implication of PINCH-1-ILK-alpha-parvin (PIP) complex in human dilated cardiomyopathy. PLoS One 6: e20184.
31. Qiu, P., M.K. Wheater, Y. Qiu & G. Sosne 2011. Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK. FASEB J. 25: 1815-1826.
32. Peng, H., O.A. Carretero, L. Raij, et al 2001. Antifibrotic effects of N-acetyl-seryl-aspartyl-Lysyl-proline on the heart and kidney in aldosterone-salt hypertensive rats. Hypertension 37: 794-800.
33. Qian, L., Y. Huang, C.I. Spencer, et al 2012. In vivo reprogramming of murine cardiac fibroblasts into induced cardiomyocytes. Nature 485: 593-598.