LC, LC-MS/MS studies for identification and characterization of degradation products of lamotrigine and establishment of mechanistic approach towards degradation

Journal of Liquid Chromatography and Related Technologies

Volumn 35, Issue 16, 2012, Pages 2255-2271

  Mahajan, Anand Avinash ^a   Thaker, Anil Keshavlal ^a   Kale, Sandeep ^b   Mohanraj, Krishnapriya ^c  

^a SVKM s Narsee Monjee Institute of Management Studies   (India)

^b INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

^c BOMBAY COLLEGE OF PHARMACY   (India)

Author keywords

degradation pathway; lamotrigine; LC MSMS; stability indicating method; stress studies; triazine

Indexed keywords

DEGRADATION PATHWAYS; LAMOTRIGINE; LC-MSMS; STABILITY INDICATING METHOD; TRIAZINE;

SEPARATION; THERMAL STRESS;

DEGRADATION;

3 AMINO 6 (2, 3 DICHLOROPHENYL) 1, 2, 4 TRIAZIN 5(4H) ONE; 6 (2, 3 DICHLORO PHENYL) 2 OXY[1, 2, 4]TRIAZINE 3, 5 DIAMINE; 6 (2, 3 DICHLORO PHENYL) 4 OXY[1, 2, 4]TRIAZINE 3, 5 DIAMINE; LAMOTRIGINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DRUG DEGRADATION; DRUG HYDROLYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; OXIDATIVE STRESS; PHOTOLYSIS; TANDEM MASS SPECTROMETRY; TEMPERATURE STRESS;

EID: 84867339688     PISSN: 10826076     EISSN: 1520572X     Source Type: Journal    
DOI: 10.1080/10826076.2011.629395     Document Type: Article

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