Hepatoprotective effects of pycnogenol in a rat model of non-alcoholic steatohepatitis

Phytotherapy Research

Volumn 26, Issue 10, 2012, Pages 1572-1574

  Mei, Lin ^a   Mochizuki, Miyako ^b   Hasegawa, Noboru ^c  

^a JIANGSU UNIVERSITY   (China)

^b Higashiosaka College   (Japan)

^c ISHIKAWA PREFECTURAL NURSING UNIVERSITY   (Japan)

Author keywords

hepatoprotection; methionine choline deficient high fat diet; non alcoholic steatohepatitis; pycnogenol

Indexed keywords

ALANINE AMINOTRANSFERASE; PINUS PINASTER EXTRACT; PLANT EXTRACT; PYCNOGENOL; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BARK; CONTROLLED STUDY; DRUG EFFECT; DRUG EFFICACY; FATTY LIVER; HISTOPATHOLOGY; LIPID ABSORPTION; LIPID STORAGE; LIVER FIBROSIS; LIVER INJURY; LIVER PROTECTION; NONALCOHOLIC FATTY LIVER; NONHUMAN; RAT; TRIACYLGLYCEROL BLOOD LEVEL;

ALANINE TRANSAMINASE; ANIMALS; DIET, HIGH-FAT; FATTY LIVER; FLAVONOIDS; LIVER; OXIDATIVE STRESS; PINUS; RATS; RATS, SPRAGUE-DAWLEY; TRIGLYCERIDES;

PINUS PINASTER; RATTUS;

EID: 84867337704     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.4602     Document Type: Article

References (8)

1. Ahn TH, Yang YS, Lee JC, et al., 2007. Ameliorative effects of pycnogenol on carbon tetrachloride-induced hepatic oxidative damage in rats. Phytother Res 21: 1015-1019.
2. Anstee QM, Concas D, Kudo H, et al., 2010. Impact of pan-caspase inhibition in animal models of established steatosis and non-alcoholic steatohepatitis. J Hepatol 53: 542-550.
3. Day CP, James OF,. 1998. Steatohepatitis: a tale of two 'hits'? Gastroenterology 114: 842-845.
4. Folch J, Lees M, Sloane Stanley GH,. 1957. A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem 226: 497-509.
5. Hasegawa N,. 2000. Inhibition of lipogenesis by pycnogenol. Phytother Res 14: 472-473.
6. Heather O,. 2010. Scientific and Clinical Monograph for Pycnogenol. American Botanical Council: Austin, TX.
7. Nakamoto K, Takayama F, Mankura M, et al., 2009. Beneficial effects of fermented green tea extract in a rat model of non-alcoholic steatohepatitis. J Clin Biochem Nutr 44: 239-246.
8. Siler-Marsiglio KI, Shaw G, Heaton MB,. 2004. Pycnogenol and vitamin E inhibit ethanol-induced apoptosis in rat cerebellar granule cells. J Neurobiol 59: 261-271.