18β-Glycyrrhetinic acid potentiates Hsp90 inhibition-induced apoptosis in human epithelial ovarian carcinoma cells via activation of death receptor and mitochondrial pathway

Molecular and Cellular Biochemistry

Volumn 370, Issue 1-2, 2012, Pages 209-219

  Yang, Jae Chon ^a   Myung, Soon Chul ^b   Kim, Wonyong ^a   Lee, Chung Soo ^a  

^a Chung Ang University   (South Korea)

^b Chung Ang University College of Medicine   (South Korea)

Author keywords

18 glycyrrhetinic acid; Apoptosis related proteins; Epithelial ovarian adenocarcinoma cell lines; Hsp90 inhibition; Promoting effect

Indexed keywords

CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DEATH RECEPTOR; GELDANAMYCIN; GLYCYRRHETINIC ACID; HEAT SHOCK PROTEIN 90 INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN BID; PROTEIN P53; RADICICOL; SURVIVIN;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CARCINOMA CELL; CELL DAMAGE; CELL DEATH; CELL NUCLEUS; DRUG EFFECT; DRUG POTENTIATION; ENZYME ACTIVATION; ENZYME RELEASE; GLYCYRRHIZA; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; OVARY ADENOCARCINOMA; OVARY CARCINOMA; PROTEIN CLEAVAGE; TUMOR SUPPRESSOR GENE;

APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASPASE INHIBITORS; CASPASES; CELL LINE, TUMOR; DNA DAMAGE; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME ACTIVATION; GLYCYRRHETINIC ACID; HSP90 HEAT-SHOCK PROTEINS; HUMANS; MACROLIDES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; NEOPLASMS, GLANDULAR AND EPITHELIAL; OVARIAN NEOPLASMS; RECEPTORS, DEATH DOMAIN; SIGNAL TRANSDUCTION;

GLYCYRRHIZA;

EID: 84867334518     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-012-1412-x     Document Type: Article

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