Discordance between microcirculatory alterations and arterial pressure in patients with hemodynamic instability

Journal of Critical Care

Volumn 27, Issue 5, 2012, Pages 531.e1-531.e7

  Arnold, Ryan C ^a   Dellinger, R Phillip ^a   Parrillo, Joseph E ^a   Chansky, Michael E ^a   Lotano, Vincent E ^a   McCoy, Jonathan V ^a   Jones, Alan E ^b   Shapiro, Nathan I ^c   Hollenberg, Steven M ^a   Trzeciak, Stephen ^a  

^a Division of Female Pelvic Medicine and Reconstructive Surgery   (United States)

^b CAROLINAS MEDICAL CENTER   (United States)

^c BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Cardiopulmonary bypass; Inflammation; Microcirculation; Resuscitation

Indexed keywords

GLYCERYL TRINITRATE; HYPERTENSIVE AGENT;

ADULT; ARTERIAL PRESSURE; ARTICLE; BLOOD FLOW; CARDIOPULMONARY BYPASS; CLINICAL ARTICLE; COHORT ANALYSIS; DARKFIELD VIDEOMICROSCOPY; FEMALE; HEART HEMODYNAMICS; HEMODYNAMIC PARAMETERS; HUMAN; MALE; MEAN ARTERIAL PRESSURE; MICROCIRCULATION; MICROSCOPY; OBSERVATIONAL STUDY; PROSPECTIVE STUDY;

EID: 84867329937     PISSN: 08839441     EISSN: 15578615     Source Type: Journal    
DOI: 10.1016/j.jcrc.2012.02.007     Document Type: Article

References (17)

1. Trzeciak S., Cinel I., Phillip Dellinger R., Shapiro N.I., Arnold R.C., Parrillo J.E., et al. Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials. Acad Emerg Med 2008, 15(5):399-413.
2. Trzeciak S, Dellinger RP, Parrillo JE, Guglielmi M, Bajaj J, Abate NL. et al. Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival. Ann Emerg Med 2007, 49(1):88-98, 98 e81-2.
3. Trzeciak S., McCoy J.V., Phillip Dellinger R., Arnold R.C., Rizzuto M., Abate N.L., et al. Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis. Intensive Care Med 2008, 34(12):2210-2217.
4. De Backer D., Creteur J., Dubois M.J., Sakr Y., Vincent J.L. Microvascular alterations in patients with acute severe heart failure and cardiogenic shock. Am Heart J 2004, 147(1):91-99.
5. De Backer D., Creteur J., Preiser J.C., Dubois M.J., Vincent J.L. Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 2002, 166(1):98-104.
6. Sakr Y., Dubois M.J., De Backer D., Creteur J., Vincent J.L. Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 2004, 32(9):1825-1831.
7. Hall R.I., Smith M.S., Rocker G. The systemic inflammatory response to cardiopulmonary bypass: pathophysiological, therapeutic, and pharmacological considerations. Anesth Analg 1997, 85(4):766-782.
8. Groner W., Winkelman J.W., Harris A.G., Ince C., Bouma G.J., Messmer K., et al. Orthogonal polarization spectral imaging: a new method for study of the microcirculation. Nat Med 1999, 5(10):1209-1212.
9. Harris A.G., Sinitsina I., Messmer K. The Cytoscan Model E-II, a new reflectance microscope for intravital microscopy: comparison with the standard fluorescence method. J Vasc Res 2000, 37(6):469-476.
10. Mathura K.R., Vollebregt K.C., Boer K., De Graaff J.C., Ubbink D.T., Ince C. Comparison of OPS imaging and conventional capillary microscopy to study the human microcirculation. J Appl Physiol 2001, 91(1):74-78.
11. Boerma E.C., Mathura K.R., van der Voort P.H., Spronk P.E., Ince C. Quantifying bedside-derived imaging of microcirculatory abnormalities in septic patients: a prospective validation study. Crit Care 2005, 9(6):R601-R606.
12. Spronk P.E., Ince C., Gardien M.J., Mathura K.R., Oudemans-van Straaten H.M., Zandstra D.F. Nitroglycerin in septic shock after intravascular volume resuscitation. Lancet 2002, 360(9343):1395-1396.
13. De Backer D., Hollenberg S., Boerma C., Goedhart P., Buchele G., Ospina-Tascon G., et al. How to evaluate the microcirculation: report of a round table conference. Crit Care 2007, 11(5):R101.
14. Arnold R.C., Parrillo J.E., Phillip Dellinger R., Chansky M.E., Shapiro N.I., Lundy D.J., et al. Point-of-care assessment of microvascular blood flow in critically ill patients. Intensive Care Med 2009, 35(10):1761-1766.
15. Bemelmans R.H., Boerma E.C., Barendregt J., Ince C., Rommes J.H., Spronk P.E. Changes in the volume status of haemodialysis patients are reflected in sublingual microvascular perfusion. Nephrol Dial Transplant 2009, 24(11):3487-3492.
16. Boerma E.C., Koopmans M., Konijn A., Kaiferova K., Bakker A.J., van Roon E.N., et al. Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: a double-blind randomized placebo controlled trial. Crit Care Med 2010, 38(1):93-100.
17. Boerma E.C., Ince C. The role of vasoactive agents in the resuscitation of microvascular perfusion and tissue oxygenation in critically ill patients. Intensive care medicine 2010, 36(12):2004-2018.