Highly Improved copper-mediated michael addition of ethyl bromodifluoroacetate in the presence of protic additive

Synthesis (Germany)

Volumn 44, Issue 20, 2012, Pages 3165-3170

  Kim, Bong Chan ^a,b   Park, Aeri ^a   An, Ji Eun ^a   Lee, Won ^b   Lee, Hee Bong ^a   Shin, Hyunik ^a  

^a LG Chemical Ltd   (South Korea)

^b Sogang University   (South Korea)

Author keywords

copper; coupling; fluorine; Michael addition; protonation

Indexed keywords

MICHAEL ACCEPTORS; MICHAEL ADDITIONS; PROTIC ADDITIVES; ROBUST PROTOCOL;

ADDITION REACTIONS; ADDITIVES; BYPRODUCTS; COUPLINGS; FLUORINE; PROTONATION;

COPPER;

ACETIC ACID; ALCOHOL; BUTANOL; COPPER; ETHYL BROMODIFLUOROACETIC ACID; HALOACID; METHANOL; PROPANOL; PROTIC ADDITIVE; REAGENT; UNCLASSIFIED DRUG; WATER;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION; CHEMICAL STRUCTURE; MICHAEL ADDITION; PHYSICAL CHEMISTRY; PROTON TRANSPORT; REACTION ANALYSIS; REACTION OPTIMIZATION; REPRODUCIBILITY;

EID: 84867328530     PISSN: 00397881     EISSN: 1437210X     Source Type: Journal    
DOI: 10.1055/s-0032-1317134     Document Type: Article

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